Sant Pau - Institut de Recerca

Principals línies de recerca

Desenvolupament de nous models animals de la malaltia disseminada en els tumors sòlids i neoplàsies hematològiques per a l’estudi mecanicista de la metàstasi i el desenvolupament preclínic de fàrmacs.
Identificació de biomarcadors pronòstics en el carcinoma de cap i coll de cèl·lules escamoses i la seva validació funcional.
Desenvolupament de nanoconjugats per a l’administració dirigida de fàrmacs antitumorals o toxines de les cèl·lules mare metastàsiques.

Reptes

Obtenir fons per garantir l’ocupació estable d’investigadors d’alt nivell, atreure postdoctorats i reforçar la col·laboració amb els clínics actuals.
Desenvolupar marcadors moleculars per a la presa de decisions terapèutiques en el càncer de cap i coll.
Aconseguir efectes antimetastàsics per dirigir fàrmacs antitumorals a la metàstasi de cèl·lules mare en tumors sòlids i neoplàsies hematològiques.
Millorar la col·laboració i la participació internacional en xarxes comunitàries i projectes industrials.

Coordinació del grup

MANGUES BAFALLUY, RAMON IR
rmangues@santpau.cat

Membres

Alamo Vargas, Patricia Virginia NANOLIGENT
Alba Castellon, Lorena IR
Arena, Lourdes Alien IR
Casanova Riga, Isolda IJC
Diez Serrano, Alvaro IR
Garcia Leon, Annabel CIBER
Mendoza Fernandez, Julian Ignacio CIBER
Miranda Tovar, Eva IR
Navas Jimenez, Luis Carlos IR
Otero Mateo, Marc IR
Romero Perez, Ines IR
Rueda Matas, Ariana IR
Sierra Cruz, Marta IR
Unzueta Elorza, Ugutz IR

Publicacions 2024

(JIF 2024)

-Favaro MTP, Alamo P, Roher N, Chillon M, Lascorz J, Márquez M, Corchero JL, Mendoza R, Martínez C, Ferrer N, Ferreira LCS, Mangues R, Vázquez E, Parladé E, Villaverde A. Zinc-Assisted Microscale Granules Made of the SARS-CoV-2 Spike Protein Trigger Neutralizing, Antivirus Antibody Responses. ACS Materials Letters. 2024; 6(3). DOI:10.1021/acsmaterialslett.3c01643. IF:8,700 (Q1/2D). Document type: Article.

-Favaro MTP, López H, Voltà E, Alba L, Sánchez JM, Casanova I, Unzueta U, Mangues R, Villaverde A, Vázquez E. Lyophilization of biomimetic amyloids preserves their regulatable, endocrine-like functions for nanoparticle release. Applied Materials Today. 2024; 39:102348. DOI:10.1016/j.apmt.2024.102348. IF:6,900 (Q1/3D). Document type: Article.

-López H, Tsimbouri PM, Jayawarna V, Rigou I, Serna N, Voltà E, Unzueta U, Salmeron M, Vázquez E, Dalby MJ, Villaverde A. Hybrid Micro-/Nanoprotein Platform Provides Endocrine-like and Extracellular Matrix-like Cell Delivery of Growth Factors. ACS Applied Materials & Interfaces. 2024; 16(26). DOI:10.1021/acsami.4c01210. PMID:38888932. IF:8,200 (Q1/2D). Document type: Article.

-Parladé E, García A, Voltà E, Unzueta U, Mangues R, Casanova I, Villaverde A, Váquez E. Paradoxical cell targeting of calreticulin-empowered, protein-only nanoparticles. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2024; 202:114410. DOI:10.1016/j.ejpb.2024.114410. PMID:39004320. IF:4,300 (Q1/2D). Document type: Article.

-Sánchez JM, López H, Parladé E, Somma AD, Livieri AL, Alamo P, Mangues R, Unzueta U, Villaverde A, Vázquez E. Structural Stabilization of Clinically Oriented Oligomeric Proteins During their Transit through Synthetic Secretory Amyloids. Advanced Science. 2024; 11(21). DOI:10.1002/advs.202309427. PMID:38501900. IF:14,100 (Q1/1D). Document type: Article.

-Virgili AC, Salazar J, Gallardo A, López A, Terés R, Bagué S, Orellana R, Fumagalli C, Mangues R, Alba L, Unzueta U, Casanova I, Sebio A. CXCR4 Expression as a Prognostic Biomarker in Soft Tissue Sarcomas. Diagnostics. 2024; 14(11):1195. DOI:10.3390/diagnostics14111195. PMID:38893721. IF:3,300 (Q1/2D). Document type: Article.

Publicacions 2023

(JIF 2023)

-Álamo P, Parladé E, Favaro MTP, Gallardo A, Mendoza R, Ferreira LCS, Roher N, Mangues R, Villaverde A, Vázquez E. Probing the Biosafety of Implantable Artificial Secretory Granules for the Sustained Release of Bioactive Proteins. ACS Applied Materials & Interfaces. 2023; 15(33). DOI:10.1021/acsami.3c08643. PMID:37614001. IF:8,500 (Q1/2D). Document type: Article.

-López H, Rueda A, Martínez C, Sánchez L, Carratalá JV, Atienza J, Parladé E, Sánchez JM, Serna N, Voltà E, Ferrer N, Reverter D, Mangues R, Villaverde A, Vázquez E, Unzueta U. Biofabrication of Self-Assembling Covalent Protein Nanoparticles through Histidine-Templated Cysteine Coupling. ACS Sustainable Chemistry & Engineering. 2023; 11(10). DOI:10.1021/acssuschemeng.2c06635. IF:7,100 (Q1/2D). Document type: Article.

-Martinez C, Alba L, Carrasco LI, Serna N, Imedio L, Gallardo A, Casanova I, Unzueta U, Vazquez E, Mangues R, Villaverde A. Lymphocyte infiltration and antitumoral effect promoted by cytotoxic inflammatory proteins formulated as self-assembling, protein-only nanoparticles. BIOMEDICINE & PHARMACOTHERAPY. 2023; 164:114976. DOI:10.1016/j.biopha.2023.114976. PMID:37276641. IF:6,900 (Q1/1D). Document type: Article.

-Medina E, García A, Gallardo A, Álamo P, Alba L, Unzueta U, Villaverde A, Vázquez E, Casanova I, Mangues R. Potent Anticancer Activity of CXCR4-Targeted Nanostructured Toxins in Aggressive Endometrial Cancer Models. Cancers. 2023; 15(1):85. DOI:10.3390/cancers15010085. PMID:36612081. IF:4,500 (Q1/3D). Document type: Article.

-Nunez Y, Garcia A, Falgas A, Serna N, Sanchez L, Garrido A, Sierra J, Gallardo A, Unzueta U, Vazquez E, Villaverde A, Mangues R, Casanova I. T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo. Pharmaceutics. 2023; 15(3):727. DOI:10.3390/pharmaceutics15030727. PMID:36986589. IF:4,900 (Q1/2D). Document type: Article.

-Parladé E, Sánchez JM, López H, Unzueta U, Villaverde A, Vázquez E. Protein features instruct the secretion dynamics from metal-supported synthetic amyloids. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2023; 250:126164. DOI:10.1016/j.ijbiomac.2023.126164. PMID:37549767. IF:7,700 (Q1/1D). Document type: Article.

-Rueda A, Mendoza JI, Alba L, Parladé E, Voltà E, Paez D, Aviño A, Eritja R, Vázquez E, Villaverde A, Mangues R, Unzueta U. Site-directed cysteine coupling of disulfide-containing non-antibody carrier proteins (THIOCAPs). Science China-Materials. 2023; 66(10). DOI:10.1007/s40843-023-2571-6. IF:6,800 (Q1/3D). Document type: Article.

– Serna N, López H, Aceituno P, Rojas M, Parladé E, Voltà E, Martínez C, Sánchez JM, Di A, Carratalá JV, Livieri AL, Ferrer N, Vázquez E, Unzueta U, Roher N, Villaverde A. Efficient Delivery of Antimicrobial Peptides in an Innovative, Slow-Release Pharmacological Formulation. Pharmaceutics. 2023; 15(11):2632. DOI:10.3390/pharmaceutics15112632. PMID:38004610. IF:4,900 (Q1/2D). Document type: Article.

-Voltà E, Alba L, Serna N, Casanova I, López H, Gallardo A, Sánchez A, Villaverde A, Unzueta U, Vázquez E, Mangues R. High-precision targeting and destruction of cancer-associated PDGFR-ß(+) stromal fibroblasts through self-assembling, protein-only nanoparticles. Acta Biomaterialia. 2023; 170. DOI:10.1016/j.actbio.2023.09.001. PMID:37683965. IF:9,400 (Q1/1D). Document type: Article.

-Voltà E, Parladé E, Serna N, Villaverde A, Vazquez E, Unzueta U. Endosomal escape for cell-targeted proteins. Going out after going in. BIOTECHNOLOGY ADVANCES. 2023; 63:108103. DOI:10.1016/j.biotechadv.2023.108103. PMID:36702197. IF:12,100 (Q1/1D). Document type: Review.

Publicacions 2022

(JIF 2022)

Barguilla I, Unzueta U, Carratala JV, Cano-Garrido O, Villaverde A, Hernandez A, Ferrer-Miralles N. Toxicity Profiling of Bacterial Inclusion Bodies in Human Caco-2 Cells. Frontiers in Bioengineering and Biotechnology. 2022; 10:842256. DOI:10.3389/fbioe.2022.842256. PMID:35573225. IF:5,7 (Q1/3D). Document type: Article.
Cano-Garrido O, Serna N, Unzueta U, Parlad E, Mangues R, Villaverde A, Vazquez E. Protein scaffolds in human clinics. BIOTECHNOLOGY ADVANCES. 2022; 61:108032. DOI:10.1016/j.biotechadv.2022.108032. PMID:36089254. IF:16 (Q1/1D). Document type: Review.
Falgàs A, Garcia-Leon A, Núñez Y, Serna N, Sánchez L, Unzueta U, Voltà E, Aragó M, Álamo P, Alba-Castellón L, Sierra J, Gallardo A, Villaverde A, Vázquez E, Mangues R, Casanova I. A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4(+) lymphoma cells without toxicity in immunocompromised and immunocompetent mice. BIOMEDICINE & PHARMACOTHERAPY. 2022; 150:112940. DOI:10.1016/j.biopha.2022.112940. PMID:35421785. IF:7,5 (Q1/1D). Document type: Article.
López H, Voltà E, Parladé E, Villaverde A, Vázquez E, Unzueta U. Insights on the emerging biotechnology of histidine-rich peptides. BIOTECHNOLOGY ADVANCES. 2022; 54:107817. DOI:10.1016/j.biotechadv.2021.107817. PMID:34418503. IF:16 (Q1/1D). Document type: Review.
Medina E, Cespedes MV, Gallardo A, Rioja-Blanco E, Pavon MA, Asensio L, Farre L, Alba-Castellón L, Unzueta U, Villaverde A, Vazquez E, Casanova I, Mangues R. Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease. Biomedicines. 2022; 10(7):1680. DOI:10.3390/biomedicines10071680. PMID:35884987. IF:4,7 (Q1/3D). Document type: Article.
Pallares V, Unzueta U, Falgas A, Avino A, Nunez Y, Garcia-Leon A, Sánchez-García L, Serna N, Gallardo A, Alba-Castellón L, Alamo P, Sierra J, Cedo L, Eritja R, Villaverde A, Vazquez E, Casanova I, Mangues R. A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model. BIOMATERIALS. 2022; 280:121258. DOI:10.1016/j.biomaterials.2021.121258. PMID:34847435. IF:14 (Q1/1D). Document type: Article.
Parlade E, Volta-Duran E, Cano-Garrido O, Sanchez JM, Unzueta U, López-Laguna H, Serna N, Cano M, Rodríguez-Mariscal M, Vazquez E, Villaverde A. An In Silico Methodology That Facilitates Decision Making in the Engineering of Nanoscale Protein Materials. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(9):4958. DOI:10.3390/ijms23094958. PMID:35563346. IF:5,6 (Q1/3D). Document type: Article.
Parra AM, Perez A, Gris I, Bonel GC, Carrasco LM, Mokhtari K, Garcia L, Lupianez JA, Rufino EE. Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(13):7053. DOI:10.3390/ijms23137053. PMID:35806065. IF:5,6 (Q1/3D). Document type: Article.
Rioja-Blanco E, Arroyo I, Alamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sánchez-García L, Quer M, Villaverde A, Vazquez E, Leon X, Alba-Castellón L, Mangues R. CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022; 41(1):49. DOI:10.1186/s13046-022-02267-8. PMID:35120582. IF:11,3 (Q1/1D). Document type: Article.
Rioja-Blanco E, Arroyo I, Álamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sánchez-García L, Quer M, Villaverde A, Vázquez E, Mangues R, Alba-Castellón L, León X. Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4(+) head and neck squamous cell carcinoma tumors. Acta Pharmaceutica Sinica B. 2022; 12(5). DOI:10.1016/j.apsb.2021.09.030. PMID:35646535. IF:14,5 (Q1/1D). Document type: Article.
Rioja-Blanco E, Gallardo A, Arroyo I, Alamo P, Casanova I, Unzueta U, Serna N, Sánchez-García L, Quer M, Villaverde A, Vazquez E, Leon X, Alba-Castellón L, Mangues R. A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model. Pharmaceutics. 2022; 14(4):887. DOI:10.3390/pharmaceutics14040887. PMID:35456719. IF:5,4 (Q1/2D). Document type: Article.
Sala R, Rioja-Blanco E, Serna N, Sánchez-García L, Alamo P, Alba-Castellón L, Casanova I, Lopez A, Unzueta U, Cespedes MV, Vazquez E, Villaverde A, Mangues R. GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases. DRUG DELIVERY. 2022; 29(1). DOI:10.1080/10717544.2022.2069302. PMID:35532120. IF:6 (Q1/2D). Document type: Article.
Sanchez JM, Carratala JV, Serna N, Unzueta U, Nolan V, Sánchez-Chardi A, Volta-Duran E, López-Laguna H, Ferrer-Miralles N, Villaverde A, Vazquez E. The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies. Pharmaceutics. 2022; 14(3):602. DOI:10.3390/pharmaceutics14030602. PMID:35335976. IF:5,4 (Q1/2D). Document type: Article.
Serna N, Falgas A, Garcia-Leon A, Unzueta U, Nunez Y, Sánchez-Chardi A, Martínez-Torró C, Mangues R, Vazquez E, Casanova I, Villaverde A. Time-Prolonged Release of Tumor-Targeted Protein-MMAE Nanoconjugates from Implantable Hybrid Materials. 2022; 14(1):192. DOI:10.3390/pharmaceutics14010192. PMID:35057088. IF:5,4 (Q1/2D). Document type: Article.
Serna N, Pallares V, Unzueta U, Garcia-Leon A, Volta-Duran E, Sánchez-Chardi A, Parlade E, Rueda A, Casanova I, Falgas A, Alba-Castellón L, Sierra J, Villaverde A, Vazquez E, Mangues R. Engineering non-antibody human proteins as efficient scaffolds for selective, receptor-targeted drug delivery. JOURNAL OF CONTROLLED RELEASE. 2022; 343. DOI:10.1016/j.jconrel.2022.01.017. PMID:35051493. IF:10,8 (Q1/1D). Document type: Article.
Unzueta U, Sanchez JM, Garcia-Fruitos E, Seras J. Editorial: High added-value nanoparticles: Rethinking and recycling cell protein waste. Frontiers in Bioengineering and Biotechnology. 2022; 10:1018014. DOI:10.3389/fbioe.2022.1018014. PMID:36131721. IF:5,7 (Q1/3D). Document type: Editorial material.
Volta-Duran E, Sanchez JM, H, Parlade E, Sánchez-García L, Sánchez-Chardi A, de Marco A, Unzueta U, Vazquez E, Villaverde A. The spectrum of building block conformers sustains the biophysical properties of clinically-oriented self-assembling protein nanoparticles. Science China-Materials. 2022; 65(6). DOI:10.1007/s40843-021-1914-0. IF:8,1 (Q1/2D). Document type: Article.
Volta-Duran E, Sanchez JM, Parlade E, Serna N, Vazquez E, Unzueta U, Villaverde A. The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles. 2022; 14(12):2644. DOI:10.3390/pharmaceutics14122644. PMID:36559138. IF:5,4 (Q1/2D). Document type: Article.

Publicacions 2021

Alamo P, Cedano J, Conchillo O, Cano O, Alba L, Serna N, Avino A, Carrasco LM, Sanchez A, Martinez C, Gallardo A, Cano M, Eritja R, Villaverde A, Mangues R, Vazquez E, Unzueta U. Rational engineering of a human GFP-like protein scaffold for humanized targeted nanomedicines. Acta Biomaterialia. 2021; 130. DOI:10.1016/j.actbio.2021.06.001. PMID:34116228. IF:10,633.
Alamo P, Parlade E, Lopez H, Volta E, Unzueta U, Vazquez E, Mangues R, Villaverde A. Ion-dependent slow protein release from in vivo disintegrating micro-granules. DRUG DELIVERY. 2021; 28(1). DOI:10.1080/10717544.2021.1998249. PMID:34747685. IF:6,819.
Cano O, Alamo P, Sanchez L, Falgas A, Sanchez A, Serna N, Parlade E, Unzueta U, Roldan M, Volta E, Casanova I, Villaverde A, Mangues R, Vazquez E. Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4(+) Cancers. Cancers. 2021; 13(12):2929. DOI:10.3390/cancers13122929. PMID:34208189. IF:6,575.
Falgas A, Pallares V, Unzueta U, Nunez Y, Sierra J, Gallardo A, Alba L, Mangues MA, Alamo P, Villaverde A, Vazquez E, Mangues R, Casanova I. Specific Cytotoxic Effect of an Auristatin Nanoconjugate Towards CXCR4(+) Diffuse Large B-Cell Lymphoma Cells. International Journal of Nanomedicine. 2021; 16DOI:10.2147/IJN.S289733. PMID:33716502. IF:7,033.
Lopez H, Parlade E, Alamo P, Sanchez JM, Volta E, Serna N, Sanchez L, Cano O, Sanchez A, Villaverde A, Mangues R, Unzueta U, Vazquez E. In Vitro Fabrication of Microscale Secretory Granules. ADVANCED FUNCTIONAL MATERIALS. 2021; 31(21):2100914. DOI:10.1002/adfm.202100914. IF:19,924.
Lopez H, Sanchez JM, Carratala JV, Rojas M, Sanchez L, Parlade E, Sanchez A, Volta E, Serna N, Cano O, Flores S, Ferrer N, Nolan V, de Marco A, Roher N, Unzueta U, Vazquez E, Villaverde A. Biofabrication of functional protein nanoparticles through simple His-tag engineering. ACS Sustainable Chemistry & Engineering. 2021; 9(36). DOI:10.1021/acssuschemeng.1c04256. PMID:34603855. IF:9,224.
Pallares V, Nunez Y, Sanchez L, Falgas A, Serna N, Unzueta U, Gallardo A, Alba L, Alamo P, Sierra J, Villaverde A, Vazquez E, Casanova I, Mangues R. Antineoplastic effect of a diphtheria toxin-based nanoparticle targeting acute myeloid leukemia cells overexpressing CXCR4. JOURNAL OF CONTROLLED RELEASE. 2021; 335. DOI:10.1016/j.jconrel.2021.05.014. PMID:34004204. IF:11,467.
Sanchez JM, Lopez H, Serna N, Unzueta U, Clop PD, Villaverde A, Vazquez E. Engineering the Performance of Artificial Inclusion Bodies Built of Catalytic beta-Galactosidase. ACS Sustainable Chemistry & Engineering. 2021; 9(6). DOI:10.1021/acssuschemeng.0c08345. IF:9,224.
Sanchez L, Volta E, Parlade E, Mazzega E, Sanchez A, Serna N, Lopez H, Mitstorfer M, Unzueta U, Vazquez E, Villaverde A, de Marco A. Self-Assembled Nanobodies as Selectively Targeted, Nanostructured, and Multivalent Materials. ACS Applied Materials & Interfaces. 2021; 13(25). DOI:10.1021/acsami.1c08092. PMID:34129336. IF:10,383.
Serna N, Carratala JV, Conchillo O, Martinez C, Unzueta U, Mangues R, Ferrer N, Daura X, Vazquez E, Villaverde A. Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4. Pharmaceutics. 2021; 13(11):1922. DOI:10.3390/pharmaceutics13111922. PMID:34834337. IF:6,525.
Volta E, Serna N, Sanchez L, Avino A, Sanchez JM, Lopez H, Cano O, Casanova I, Mangues R, Eritja R, Vazquez E, Villaverde A, Unzueta U. Design and engineering of tumor-targeted, dual-acting cytotoxic nanoparticles. Acta Biomaterialia. 2021; 119. DOI:10.1016/j.actbio.2020.11.018. PMID:33189955. IF:10,633.

2017 Scientific Report -Oncogenesis and Antitumour

Finançament Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR):

DESENVOLUPAMENT D’UN NANOCONJUGAT ANTIMETASTÀTIC DIRIGIT A CÈL·LULES MARE METASTÀTIQUES CXCR4+ (2014 PROD 00055)

Promoure el desenvolupament tecnològic, la innovació i una investigació de qualitat

Aquest projecte està cofinançat pel Fons Europeu de Desenvolupament Regional (FEDER) de la Unió Europea en el marc del Programa operatiu FEDER de Catalunya 2014-2020 amb un ajut de 49.750,00€

U18. Plataforma de Nanotoxicologia (NANBIOSIS):

Aquests equips i serveis constitueixen la unitat 18 de NANBIOSIS, la infraestructura integrada de producció i caracterizació de nanomaterials, biomaterials i sistemes en biomedicina, del CIBER-BBN i el Centro de Cirugía de Mínima invasión Jesús Usón, que ha sigut reconegut per MINECO com Infraestructura Científico-Tecnológica Singular (ICTS).

presentació

Principals línies de recerca

Desenvolupament de nous models animals de la malaltia disseminada en els tumors sòlids i neoplàsies hematològiques per a l’estudi mecanicista de la metàstasi i el desenvolupament preclínic de fàrmacs.
Identificació de biomarcadors pronòstics en el carcinoma de cap i coll de cèl·lules escamoses i la seva validació funcional.
Desenvolupament de nanoconjugats per a l’administració dirigida de fàrmacs antitumorals o toxines de les cèl·lules mare metastàsiques.

Reptes

Obtenir fons per garantir l’ocupació estable d’investigadors d’alt nivell, atreure postdoctorats i reforçar la col·laboració amb els clínics actuals.
Desenvolupar marcadors moleculars per a la presa de decisions terapèutiques en el càncer de cap i coll.
Aconseguir efectes antimetastàsics per dirigir fàrmacs antitumorals a la metàstasi de cèl·lules mare en tumors sòlids i neoplàsies hematològiques.
Millorar la col·laboració i la participació internacional en xarxes comunitàries i projectes industrials.

equip

Coordinació del grup

MANGUES BAFALLUY, RAMON IR
rmangues@santpau.cat

Membres

producció científica

Barguilla I, Unzueta U, Carratala JV, Cano-Garrido O, Villaverde A, Hernandez A, Ferrer-Miralles N. Toxicity Profiling of Bacterial Inclusion Bodies in Human Caco-2 Cells. Frontiers in Bioengineering and Biotechnology. 2022; 10:842256. DOI:10.3389/fbioe.2022.842256. PMID:35573225. IF:5,7 (Q1/3D). Document type: Article.
Cano-Garrido O, Serna N, Unzueta U, Parlad E, Mangues R, Villaverde A, Vazquez E. Protein scaffolds in human clinics. BIOTECHNOLOGY ADVANCES. 2022; 61:108032. DOI:10.1016/j.biotechadv.2022.108032. PMID:36089254. IF:16 (Q1/1D). Document type: Review.
Falgàs A, Garcia-Leon A, Núñez Y, Serna N, Sánchez L, Unzueta U, Voltà E, Aragó M, Álamo P, Alba-Castellón L, Sierra J, Gallardo A, Villaverde A, Vázquez E, Mangues R, Casanova I. A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4(+) lymphoma cells without toxicity in immunocompromised and immunocompetent mice. BIOMEDICINE & PHARMACOTHERAPY. 2022; 150:112940. DOI:10.1016/j.biopha.2022.112940. PMID:35421785. IF:7,5 (Q1/1D). Document type: Article.
López H, Voltà E, Parladé E, Villaverde A, Vázquez E, Unzueta U. Insights on the emerging biotechnology of histidine-rich peptides. BIOTECHNOLOGY ADVANCES. 2022; 54:107817. DOI:10.1016/j.biotechadv.2021.107817. PMID:34418503. IF:16 (Q1/1D). Document type: Review.
Medina E, Cespedes MV, Gallardo A, Rioja-Blanco E, Pavon MA, Asensio L, Farre L, Alba-Castellón L, Unzueta U, Villaverde A, Vazquez E, Casanova I, Mangues R. Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease. Biomedicines. 2022; 10(7):1680. DOI:10.3390/biomedicines10071680. PMID:35884987. IF:4,7 (Q1/3D). Document type: Article.
Pallares V, Unzueta U, Falgas A, Avino A, Nunez Y, Garcia-Leon A, Sánchez-García L, Serna N, Gallardo A, Alba-Castellón L, Alamo P, Sierra J, Cedo L, Eritja R, Villaverde A, Vazquez E, Casanova I, Mangues R. A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model. BIOMATERIALS. 2022; 280:121258. DOI:10.1016/j.biomaterials.2021.121258. PMID:34847435. IF:14 (Q1/1D). Document type: Article.
Parlade E, Volta-Duran E, Cano-Garrido O, Sanchez JM, Unzueta U, López-Laguna H, Serna N, Cano M, Rodríguez-Mariscal M, Vazquez E, Villaverde A. An In Silico Methodology That Facilitates Decision Making in the Engineering of Nanoscale Protein Materials. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(9):4958. DOI:10.3390/ijms23094958. PMID:35563346. IF:5,6 (Q1/3D). Document type: Article.
Parra AM, Perez A, Gris I, Bonel GC, Carrasco LM, Mokhtari K, Garcia L, Lupianez JA, Rufino EE. Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(13):7053. DOI:10.3390/ijms23137053. PMID:35806065. IF:5,6 (Q1/3D). Document type: Article.
Rioja-Blanco E, Arroyo I, Alamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sánchez-García L, Quer M, Villaverde A, Vazquez E, Leon X, Alba-Castellón L, Mangues R. CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022; 41(1):49. DOI:10.1186/s13046-022-02267-8. PMID:35120582. IF:11,3 (Q1/1D). Document type: Article.
Rioja-Blanco E, Arroyo I, Álamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sánchez-García L, Quer M, Villaverde A, Vázquez E, Mangues R, Alba-Castellón L, León X. Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4(+) head and neck squamous cell carcinoma tumors. Acta Pharmaceutica Sinica B. 2022; 12(5). DOI:10.1016/j.apsb.2021.09.030. PMID:35646535. IF:14,5 (Q1/1D). Document type: Article.
Rioja-Blanco E, Gallardo A, Arroyo I, Alamo P, Casanova I, Unzueta U, Serna N, Sánchez-García L, Quer M, Villaverde A, Vazquez E, Leon X, Alba-Castellón L, Mangues R. A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model. Pharmaceutics. 2022; 14(4):887. DOI:10.3390/pharmaceutics14040887. PMID:35456719. IF:5,4 (Q1/2D). Document type: Article.
Sala R, Rioja-Blanco E, Serna N, Sánchez-García L, Alamo P, Alba-Castellón L, Casanova I, Lopez A, Unzueta U, Cespedes MV, Vazquez E, Villaverde A, Mangues R. GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases. DRUG DELIVERY. 2022; 29(1). DOI:10.1080/10717544.2022.2069302. PMID:35532120. IF:6 (Q1/2D). Document type: Article.
Sanchez JM, Carratala JV, Serna N, Unzueta U, Nolan V, Sánchez-Chardi A, Volta-Duran E, López-Laguna H, Ferrer-Miralles N, Villaverde A, Vazquez E. The Poly-Histidine Tag H6 Mediates Structural and Functional Properties of Disintegrating, Protein-Releasing Inclusion Bodies. Pharmaceutics. 2022; 14(3):602. DOI:10.3390/pharmaceutics14030602. PMID:35335976. IF:5,4 (Q1/2D). Document type: Article.
Serna N, Falgas A, Garcia-Leon A, Unzueta U, Nunez Y, Sánchez-Chardi A, Martínez-Torró C, Mangues R, Vazquez E, Casanova I, Villaverde A. Time-Prolonged Release of Tumor-Targeted Protein-MMAE Nanoconjugates from Implantable Hybrid Materials. 2022; 14(1):192. DOI:10.3390/pharmaceutics14010192. PMID:35057088. IF:5,4 (Q1/2D). Document type: Article.
Serna N, Pallares V, Unzueta U, Garcia-Leon A, Volta-Duran E, Sánchez-Chardi A, Parlade E, Rueda A, Casanova I, Falgas A, Alba-Castellón L, Sierra J, Villaverde A, Vazquez E, Mangues R. Engineering non-antibody human proteins as efficient scaffolds for selective, receptor-targeted drug delivery. JOURNAL OF CONTROLLED RELEASE. 2022; 343. DOI:10.1016/j.jconrel.2022.01.017. PMID:35051493. IF:10,8 (Q1/1D). Document type: Article.
Unzueta U, Sanchez JM, Garcia-Fruitos E, Seras J. Editorial: High added-value nanoparticles: Rethinking and recycling cell protein waste. Frontiers in Bioengineering and Biotechnology. 2022; 10:1018014. DOI:10.3389/fbioe.2022.1018014. PMID:36131721. IF:5,7 (Q1/3D). Document type: Editorial material.
Volta-Duran E, Sanchez JM, H, Parlade E, Sánchez-García L, Sánchez-Chardi A, de Marco A, Unzueta U, Vazquez E, Villaverde A. The spectrum of building block conformers sustains the biophysical properties of clinically-oriented self-assembling protein nanoparticles. Science China-Materials. 2022; 65(6). DOI:10.1007/s40843-021-1914-0. IF:8,1 (Q1/2D). Document type: Article.
Volta-Duran E, Sanchez JM, Parlade E, Serna N, Vazquez E, Unzueta U, Villaverde A. The Diphtheria Toxin Translocation Domain Impairs Receptor Selectivity in Cancer Cell-Targeted Protein Nanoparticles. 2022; 14(12):2644. DOI:10.3390/pharmaceutics14122644. PMID:36559138. IF:5,4 (Q1/2D). Document type: Article.

Publicacions 2021

Alamo P, Cedano J, Conchillo O, Cano O, Alba L, Serna N, Avino A, Carrasco LM, Sanchez A, Martinez C, Gallardo A, Cano M, Eritja R, Villaverde A, Mangues R, Vazquez E, Unzueta U. Rational engineering of a human GFP-like protein scaffold for humanized targeted nanomedicines. Acta Biomaterialia. 2021; 130. DOI:10.1016/j.actbio.2021.06.001. PMID:34116228. IF:10,633.
Alamo P, Parlade E, Lopez H, Volta E, Unzueta U, Vazquez E, Mangues R, Villaverde A. Ion-dependent slow protein release from in vivo disintegrating micro-granules. DRUG DELIVERY. 2021; 28(1). DOI:10.1080/10717544.2021.1998249. PMID:34747685. IF:6,819.
Cano O, Alamo P, Sanchez L, Falgas A, Sanchez A, Serna N, Parlade E, Unzueta U, Roldan M, Volta E, Casanova I, Villaverde A, Mangues R, Vazquez E. Biparatopic Protein Nanoparticles for the Precision Therapy of CXCR4(+) Cancers. Cancers. 2021; 13(12):2929. DOI:10.3390/cancers13122929. PMID:34208189. IF:6,575.
Falgas A, Pallares V, Unzueta U, Nunez Y, Sierra J, Gallardo A, Alba L, Mangues MA, Alamo P, Villaverde A, Vazquez E, Mangues R, Casanova I. Specific Cytotoxic Effect of an Auristatin Nanoconjugate Towards CXCR4(+) Diffuse Large B-Cell Lymphoma Cells. International Journal of Nanomedicine. 2021; 16DOI:10.2147/IJN.S289733. PMID:33716502. IF:7,033.
Lopez H, Parlade E, Alamo P, Sanchez JM, Volta E, Serna N, Sanchez L, Cano O, Sanchez A, Villaverde A, Mangues R, Unzueta U, Vazquez E. In Vitro Fabrication of Microscale Secretory Granules. ADVANCED FUNCTIONAL MATERIALS. 2021; 31(21):2100914. DOI:10.1002/adfm.202100914. IF:19,924.
Lopez H, Sanchez JM, Carratala JV, Rojas M, Sanchez L, Parlade E, Sanchez A, Volta E, Serna N, Cano O, Flores S, Ferrer N, Nolan V, de Marco A, Roher N, Unzueta U, Vazquez E, Villaverde A. Biofabrication of functional protein nanoparticles through simple His-tag engineering. ACS Sustainable Chemistry & Engineering. 2021; 9(36). DOI:10.1021/acssuschemeng.1c04256. PMID:34603855. IF:9,224.
Pallares V, Nunez Y, Sanchez L, Falgas A, Serna N, Unzueta U, Gallardo A, Alba L, Alamo P, Sierra J, Villaverde A, Vazquez E, Casanova I, Mangues R. Antineoplastic effect of a diphtheria toxin-based nanoparticle targeting acute myeloid leukemia cells overexpressing CXCR4. JOURNAL OF CONTROLLED RELEASE. 2021; 335. DOI:10.1016/j.jconrel.2021.05.014. PMID:34004204. IF:11,467.
Sanchez JM, Lopez H, Serna N, Unzueta U, Clop PD, Villaverde A, Vazquez E. Engineering the Performance of Artificial Inclusion Bodies Built of Catalytic beta-Galactosidase. ACS Sustainable Chemistry & Engineering. 2021; 9(6). DOI:10.1021/acssuschemeng.0c08345. IF:9,224.
Sanchez L, Volta E, Parlade E, Mazzega E, Sanchez A, Serna N, Lopez H, Mitstorfer M, Unzueta U, Vazquez E, Villaverde A, de Marco A. Self-Assembled Nanobodies as Selectively Targeted, Nanostructured, and Multivalent Materials. ACS Applied Materials & Interfaces. 2021; 13(25). DOI:10.1021/acsami.1c08092. PMID:34129336. IF:10,383.
Serna N, Carratala JV, Conchillo O, Martinez C, Unzueta U, Mangues R, Ferrer N, Daura X, Vazquez E, Villaverde A. Antibacterial Activity of T22, a Specific Peptidic Ligand of the Tumoral Marker CXCR4. Pharmaceutics. 2021; 13(11):1922. DOI:10.3390/pharmaceutics13111922. PMID:34834337. IF:6,525.
Volta E, Serna N, Sanchez L, Avino A, Sanchez JM, Lopez H, Cano O, Casanova I, Mangues R, Eritja R, Vazquez E, Villaverde A, Unzueta U. Design and engineering of tumor-targeted, dual-acting cytotoxic nanoparticles. Acta Biomaterialia. 2021; 119. DOI:10.1016/j.actbio.2020.11.018. PMID:33189955. IF:10,633.

MALALTIES ONCO-HEMATOLòGIQUES

Oncogénesis i farmacs antitumorals

Principals línies de recerca

Reptes

Coordinació del grup

Membres

Publicacions 2024

Publicacions 2023

Publicacions 2022

Publicacions 2021

2017 Scientific Report -Oncogenesis and Antitumour

Finançament Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR):

U18. Plataforma de Nanotoxicologia (NANBIOSIS):

Principals línies de recerca

Reptes

Coordinació del grup

Membres

Publicacions 2024

Publicacions 2023

Publicacions 2022

Publicacions 2021

Institut de recerca de l’hospital de la santa creu i sant pau