Services

Biomedical Signal and Image Analysis Laboratory and Experimental Design Support in Neuroscience

Presentation

Service dedicated to supporting the design, execution, analysis, and writing of scientific projects that require the use of biomedical signals and images such as electroencephalography and neuroimaging, or the use of neuropsychological assessment tests and other measures for evaluating cognitive functioning.

Services

The research objectives of different medical specialties and external entities not directly related to neurology, neuropsychology, or neuroscience may require the use of advanced techniques for analyzing biomedical signals and images (EEG, MRI, PET), molecular neurodegeneration biomarkers, and statistical analysis.

Additionally, the lack of knowledge on specific aspects of neuroscience research methodology may mean that interested groups require expert scientific advice regarding the experimental design of studies and the administration of appropriate tests to answer the research questions.

LAB-DEN addresses all these needs, which can be schematically divided into:

  • Support in the experimental design of studies focused on evaluating the impact of specific diseases on nervous system functioning and/or integrity and related processes (e.g., cognitive processes).
  • Analysis of biomedical signals and images acquired in research contexts (EEG signals and evoked potentials, structural and functional MRI, molecular neuroimaging).
  • Multimodal analysis of molecular neurodegeneration biomarkers obtained from peripheral blood (neurofilament, TAU, pTAU) and neuroimaging.
  • Support in the acquisition of biomedical signals and images.
  • Administration and scoring of cognitive assessment tests and batteries.
  • Design of specific experimental paradigms.
  • Statistical analysis and interpretation of results.
  • Advising on manuscript writing and project preparation for research funding applications.
  • Complete writing of manuscripts and research projects.

Responsibles

Contact mail: abayesp@santpau.cat

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Jaime Kulisevsky Bojarski

Scientific Responsible

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Saul Indra Martinez Horta

Technical Responsible

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Frederic Sampedro Santalo

Manager Responsible

Experience and Trajectory

  • Sampedro F, Marin-Lahoz J, Martinez-Horta S, et al. Extrastriatal SPECT-DAT uptake correlates with clinical and biological features of de novo Parkinson's disease. Neurobiol Aging. 2021;97:120-128.
  • Sampedro F, Stantonyonge N, Martinez-Horta S, et al. Increased plasma neurofilament light chain levels in patients with type-1 diabetes with impaired awareness of hypoglycemia. BMJ Open Diabetes Res Care. 2020;8(1).
  • Martinez-Horta S, Sampedro F, Horta-Barba A, et al. Structural brain correlates of dementia in Huntington's disease. Neuroimage Clin. 2020;28:102415.
  • Martinez-Horta S, Riba J, de Bobadilla RF, et al. Apathy in Parkinson's disease: neurophysiological evidence of impaired incentive processing. J Neurosci. 2014;34(17):5918-5926.
  • Sampedro F, Marin-Lahoz J, Martinez-Horta S, Pagonabarraga J, Kulisevsky J. Dopaminergic degeneration induces early posterior cortical thinning in Parkinson's disease. Neurobiol Dis. 2019;124:29-35.

Equipment

Equipment involved in providing the service:

  • 32-channel EEG/ERP recording system (BrainAMPS)
  • EEG/ERP recording software Brain Vision Recorder
  • Advanced EEG/ERP analysis workstation (Brain Vision Analyzer, EEGLab, Loreta)
  • Advanced neuroimaging analysis workstation (SPM, FreeSurfer, FSL, CONN, MRIcron, Matlab, TrackViz)
  • Standardized neuropsychological assessment batteries
  • Stimulus presentation system synchronized with EEG and fMRI recording (Presentation)