Sant Pau - Institut de Recerca

Principals línies de recerca

La identificació de nous biomarcadors de l’aterotrombosi i la cardiopatia isquèmica amb l’ús potencial diagnòstic i pronòstic es basa en estudis de cultius cel·lulars, models animals de malaltia cardiovascular i mostres humanes de pacients amb factors de risc de malaltia cardíaca coronària.

Reptes

Avançar en la investigació amb l’objectiu d’identificar i caracteritzar nous biomarcadors de dany vascular, malaltia aterotrombòtica i/o isquèmica, síndromes coronàries i cerebrovasculars, utilitzant tècniques postgenòmica.
Generar nova informació sobre els biomarcadors solubles potencials (en sèrum, plasma) i en micropartícules que circulen en la sang, així com en estudis en sang i/o cèl·lules vasculars incloure tècniques proteòmiques i lipidòmiques basades en cromatografia de líquids i electroforesi bidimensional, sistemes de matriu d’anticossos i espectrometria de masses.
Validar biomarcadors identificats en el diagnòstic i pronòstic de la malaltia cardiovascular i/o cerebrovascular utilitzant tècniques específiques quantitatives (microscopi confocal, ELISA, assaigs multiplex, etc.).
Caracteritzar els mecanismes moleculars i funcionals de biomarcadors seleccionats en patologia cardiovascular (biologia de sistemes).
Consolidar la plataforma lipidòmica.
Dirigir el Biobanc en el projecte europeu SAFE-T.

Coordinació del grup

PADRO CAPMANY, TERESA IR
tpadro@santpau.cat

Membres

Cabre Fernandez, Paula IR
De Santisteban Vilaplana, Victoria Marta IR
Garcia Arguinzonis, Maisa Ines IR
Gomez-pardo Arellano, Montserrat IR

Publicacions 2023

(JIF 2023)

-Antoniades C, Tousoulis D, Vavlukis M, Fleming I, Duncker DJ, Eringa E, Manfrini O, Antonopoulos AS, Oikonomou E, Padro T, Trifunovic D, De Luca G, Guzik T, Cenko E, Djordjevic A, Crea F. Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers A clinical consensus statement from the European Society of Cardiology Working Group on Coronary Pathophysiology and Micro-circulation. EUROPEAN HEART JOURNAL. 2023; 44(38). DOI:10.1093/eurheartj/ehad484. PMID:37599464. IF:38,100 (Q1/1D). Document type: Article.

-Badimon L, Vilahur G, Padro T, Mendieta G. Cardiovascular residual risk: aetiology, lipids and inflammation. Revista Espanola De Cardiologia Suplementos. 2023; 23DOI:10.1016/S1131-3587(23)00008-0. Document type: Article.

-Badimon L, Padro T, Vilahur G. Chapter 27: Moving from reactive to preventive medicine. Aging. 2023; 663-681. DOI: 10.1016/B978-0-12-823761-8.00003-3. Document type: Book Chapter.

-Benincasa G, Suades R, Padrò T, Badimon L, Napoli C. Bioinformatic platforms for clinical stratification of natural history of atherosclerotic cardiovascular diseases. European Heart Journal-Cardiovascular Pharmacotherapy. 2023; 9(8). DOI:10.1093/ehjcvp/pvad059. PMID:37562936. IF:5,400 (Q1/1D). Document type: Article.

-Borrell M, Luquero A, Vilahur G, Padró T, Badimon L. Canonical Wnt pathway and the LDL receptor superfamily in neuronal cholesterol homeostasis and function. CARDIOVASCULAR RESEARCH. 2023; DOI:10.1093/cvr/cvad159. PMID:37882606. IF:10,400 (Q1/1D). Document type: Article.

-Cordero A, Munoz N, Padro T, Vilahur G, Bertomeu V, Escribano D, Flores E, Zuazola P, Badimon L. HDL Function and Size in Patients with On-Target LDL Plasma Levels and a First-Onset ACS. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(6):5391. DOI:10.3390/ijms24065391. PMID:36982465. IF:4,900 (Q1/3D). Document type: Article.

-de Isla LP, Diaz JL, Romero MJ, Muniz O, Mediavilla JD, Argueso R, Munoz JS, Rubio P, Alvarez P, Ponte P, Manas D, Gutierrez LS, Cepeda JM, Casanas M, Fuentes F, Guijarro C, Barba MA, Cerezo AS, Padro T, Mata P, SAFEHEART GRP. Alirocumab and Coronary Atherosclerosis in Asymptomatic Patients with Familial Hypercholesterolemia: The ARCHITECT Study. CIRCULATION. 2023; 147(19). DOI:10.1161/CIRCULATIONAHA.122.062557. PMID:37009731. IF:35,600 (Q1/1D). Document type: Article.

-Gallinat A, Vilahur G, Padro T, Badimon L. Effects of Antioxidants in Fermented Beverages in Tissue Transcriptomics: Effect of Beer Intake on Myocardial Tissue after Oxidative Injury. Antioxidants. 2023; 12(5):1096. DOI:10.3390/antiox12051096. PMID:37237963. IF:6,000 (Q1/2D). Document type: Article.

-Garcia MC, Padro T, Munoz N, Bianchi M, Alvarez L, Badimon L, Corbella E, Pinto X. Dysfunctional antioxidant capacity of high-density lipoprotein in rheumatoid arthritis. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2023; 53(8):e13999. DOI:10.1111/eci.13999. PMID:36994808. IF:4,400 (Q1/2D). Document type: Article.

-Haller PM, Gossling A, Magnussen C, Brenner H, Schottker B, Iacoviello L, Costanzo S, Kee F, Koenig W, Linneberg A, Sujana C, Thorand B, Salomaa V, Niiranen TJ, Soderberg S, Volzke H, Dorr M, Sans S, Padro T, Felix SB, Nauck M, Petersmann A, Palmieri L, Donfrancesco C, De Ponti R, Veronesi G, Ferrario MM, Kuulasmaa K, Zeller T, Ojeda FM, Blankenberg S, Westermann D, BiomarCaRE C. Biomarker-based prediction of fatal and non-fatal cardiovascular outcomes in individuals with diabetes mellitus. European Journal of Preventive Cardiology. 2023; 30(12). DOI:10.1093/eurjpc/zwad122. PMID:37079290. IF:8,400 (Q1/1D). Document type: Article.

-López A, Padro T, Villaplana VD, Muñoz N, Pérez A, Vilahur G, Badimon L. Vascular and Platelet Effects of Tomato Soffritto Intake in Overweight and Obese Subjects. Nutrients. 2023; 15(24):5084. DOI:10.3390/nu15245084. PMID:38140343. IF:4,800 (Q1/2D). Document type: Article.

-Padro T, Cenko E, Tousoulis D. The ESC Working Group on Coronary Pathophysiology and Microcirculation. EUROPEAN HEART JOURNAL. 2023; 44(46). DOI:10.1093/eurheartj/ehad650. PMID:37772387. IF:38,100 (Q1/1D). Document type: News Item.

-Padro T, López A, Pérez A, Vilahur G, Badimon L. Dietary ?3 Fatty Acids and Phytosterols in the Modulation of the HDL Lipidome: A Longitudinal Crossover Clinical Study. Nutrients. 2023; 15(16):3637. DOI:10.3390/nu15163637. PMID:37630826. IF:4,800 (Q1/2D). Document type: Article.

-Radike M, Sutelman P, Ben S, Gutiérrez M, Mendieta G, Alcover S, Casaní L, Arderiu G, Borrell M, Padró T, Badimon L, Vilahur G. A comprehensive and longitudinal cardiac magnetic resonance imaging study of the impact of coronary ischemia duration on myocardial damage in a highly translatable animal model. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2023; 53(1):e13860. DOI:10.1111/eci.13860. PMID:35986736. IF:4,400 (Q1/2D). Document type: Article.

-Schoch L, Alcover S, Padró T, Ben S, Mendieta G, Badimon L, Vilahur G. Update of HDL in atherosclerotic cardiovascular disease. Clinica E Investigacion En Arteriosclerosis. 2023; 35(6). DOI:10.1016/j.arteri.2023.10.002. PMID:37940388. IF:1,900 (Q3/6D). Document type: Review.

-Suades R, Vilella A, Padro T, Mirabet S, Badimon L. Red Blood Cells and Endothelium Derived Circulating Extracellular Vesicles in Health and Chronic Heart Failure: A Focus on Phosphatidylserine Dynamics in Vesiculation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(14):11824. DOI:10.3390/ijms241411824. PMID:37511585. IF:4,900 (Q1/3D). Document type: Article.

-Vilella A, Cordero A, Mirabet S, Munoz N, Suades R, Padro T, Badimon L. Platelet-Released Extracellular Vesicle Characteristics Differ in Chronic and in Acute Heart Disease. THROMBOSIS AND HAEMOSTASIS. 2023; 123(9). DOI:10.1055/s-0043-57017. PMID:37075787. IF:5,000 (Q1/2D). Document type: Article.

Publicacions 2022

(JIF 2022)

Badimon L, Padro T, Arderiu G, Vilahur G, Borrell M, Suades R. Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets. IMMUNOLOGICAL REVIEWS. 2022; 312(1). DOI:10.1111/imr.13127. PMID:35996799. IF:8,7 (Q1/2D). Document type: Review.
Badimon L, Padro T, Vilahur G. Moving from reactive to preventive medicine. In: Aging: From Fundamental Biology To Societal Impact. Elsevier. 2022. p. 663-681. Document type: Book chapter.
Cubedo J, Padro T, Vilahur G, Crea F, Storey RF, Sendon JLL, Kaski JC, Sionis A, Sans J, Fernandez E, Gallinat A, Badimon L. Glycosylated apolipoprotein J in cardiac ischaemia: molecular processing and circulating levels in patients with acute ischaemic events. EUROPEAN HEART JOURNAL. 2022; 43(2). DOI:10.1093/eurheartj/ehab691. PMID:34580705. IF:39,3 (Q1/1D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Urinary Proteomic Signature in Acute Decompensated Heart Failure: Advances into Molecular Pathophysiology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(4):2344. DOI:10.3390/ijms23042344. PMID:35216460. IF:5,6 (Q1/3D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Vitamin D Binding Protein and Renal Injury in Acute Decompensated Heart Failure. Frontiers in Cardiovascular Medicine. 2022; 9:829490. DOI:10.3389/fcvm.2022.829490. PMID:35757319. IF:3,6 (Q2/5D). Document type: Article.
Evans PC, Davidson SM, Wojta J, Back M, Bollini S, Brittan M, Catapano AL, Chaudhry B, Cluitmans M, Gnecchi M, Guzik TJ, Hoefer I, Madonna R, Monteiro JP, Morawietz H, Osto E, Padro T, Sluimer JC, Tocchetti CG, Van der Heiden K, Vilahur G, Waltenberger J, Weber C. From novel discovery tools and biomarkers to precision medicine-basic cardiovascular science highlights of 2021/22. CARDIOVASCULAR RESEARCH. 2022; 118(13). DOI:10.1093/cvr/cvac114. PMID:35899362. IF:10,8 (Q1/1D). Document type: Review.
Gallinat A, Mendieta G, Vilahur G, Padro T, Badimon L. DJ-1 administration exerts cardioprotection in a mouse model of acute myocardial infarction. Frontiers in Pharmacology. 2022; 13:1002755. DOI:10.3389/fphar.2022.1002755. PMID:36210822. IF:5,6 (Q1/2D). Document type: Article.
Gallinat A, Vilahur G, Padro T, Badimon L. Network-Assisted Systems Biology Analysis of the Mitochondrial Proteome in a Pre-Clinical Model of Ischemia, Revascularization and Post-Conditioning. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(4):2087. DOI:10.3390/ijms23042087. PMID:35216205. IF:5,6 (Q1/3D). Document type: Article.
Koller A, Laughlin MH, Cenko E, de Wit C, Toth K, Bugiardini R, Trifunovits D, Vavlukis M, Manfrini O, Lelbach A, Dornyei G, Padro T, Badimon L, Tousoulis D, Gielen S, Duncker DJ. Functional and structural adaptations of the coronary macro- and microvasculature to regular aerobic exercise by activation of physiological, cellular, and molecular mechanisms: ESC Working Group on Coronary Pathophysiology and Microcirculation position paper. CARDIOVASCULAR RESEARCH. 2022; 118(2). DOI:10.1093/cvr/cvab246. PMID:34358290. IF:10,8 (Q1/1D). Document type: Review.
Oskarsson V, Eliasson M, Salomaa V, Reinikainen J, Mannisto S, Palmieri L, Donfrancesco C, Sans S, Costanzo S, de Gaetano G, Iacoviello L, Veronesi G, Ferrario MM, Padro T, Thorand B, Huth C, Zeller T, Blankenberg S, Anderson AS, Tunstall H, Kuulasmaa K, Soderberg S. Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium. BRITISH JOURNAL OF NUTRITION. 2022; 128(11):PII S0007114521005080. DOI:10.1017/S0007114521005080. PMID:34933700. IF:3,6 (Q3/6D). Document type: Article.
Pérez de Isla L, Watts GF, Muñiz O, Díaz JL, Alonso R, Zambón D, Fuentes F, Mauri M, Padró T, Vidal JI, Barba MA, Ruiz E, Michán A, Mediavilla JD, Hernandez AM, Romero MJ, Badimon L, Mata P. A resilient type of familial hypercholesterolaemia: case-control follow-up of genetically characterized older patients in the SAFEHEART cohort. European Journal of Preventive Cardiology. 2022; 29(5). DOI:10.1093/eurjpc/zwab185. PMID:34864959. IF:8,3 (Q1/2D). Document type: Article.
Schoch L, Sutelman P, Suades R, Casani L, Padro T, Badimon L, Vilahur G. Hypercholesterolemia-Induced HDL Dysfunction Can Be Reversed: The Impact of Diet and Statin Treatment in a Preclinical Animal Model. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(15):8596. DOI:10.3390/ijms23158596. PMID:35955730. IF:5,6 (Q1/3D). Document type: Article.
Suades R, Greco MF, Padro T, Badimon L. Extracellular Vesicles as Drivers of Immunoinflammation in Atherothrombosis. 2022; 11(11):1845. DOI:10.3390/cells11111845. PMID:35681540. IF:6 (Q2/4D). Document type: Review.
Suades R, Padro T, Vilahur G, Badimon L. Platelet-released extracellular vesicles: the effects of thrombin activation. CELLULAR AND MOLECULAR LIFE SCIENCES. 2022; 79(3):190. DOI:10.1007/s00018-022-04222-4. PMID:35288766. IF:8 (Q1/2D). Document type: Article.
Tousoulis D, Guzik T, Padro T, Duncker DJ, De Luca G, Eringa E, Vavlukis M, Antonopoulos AS, Katsimichas T, Cenko E, Djordjevic A, Fleming I, Manfrini O, Trifunovic D, Antoniades C, Crea F. Mechanisms, therapeutic implications, and methodological challenges of gut microbiota and cardiovascular diseases: a position paper by the ESC Working Group on Coronary Pathophysiology and Microcirculation. CARDIOVASCULAR RESEARCH. 2022; 118(16). DOI:10.1093/cvr/cvac057. PMID:35420126. IF:10,8 (Q1/1D). Document type: Review.
Vilahur G, Sutelman P, Ben S, Mendieta G, Radike M, Schoch L, Casani L, Borrell M, Padro T, Badimon L. Supplementation With Spirulina Reduces Infarct Size and Ameliorates Cardiac Function in a Pig Model of STEMI. Frontiers in Pharmacology. 2022; 13:891801. DOI:10.3389/fphar.2022.891801. PMID:35592428. IF:5,6 (Q1/2D). Document type: Article.
Vilella A, Gallinat A, Escate R, Mirabet S, Padró T, Badimon L. Systems Biology in Chronic Heart Failure—Identification of Potential miRNA Regulators. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(23):15226. DOI:10.3390/ijms232315226. PMID:36499552. IF:5,6 (Q1/3D). Document type: Article.
Vilella A, Padro T, Roig E, Mirabet S, Badimon L. New factors in heart failure pathophysiology: Immunity cells release of extracellular vesicles. IF:3,6 (Q2/5D). 2022; 9:939625. DOI:10.3389/fcvm.2022.939625. PMID:36407432. IF:5,846 (Q2/4D). Document type: Article.

Publicacions 2021

Arauna D, Chiva-Blanch G, Padro T, Fuentes E, Palomo I, Badimon L. Frail older adults show a distinct plasma microvesicle profile suggesting a prothrombotic and proinflammatory phenotype. JOURNAL OF CELLULAR PHYSIOLOGY. 2021; 236(3):2099-2108. DOI: 10.1002/jcp.29996. PMID: 32749745. IF:6,513.
Cenko E, Badimon L, Bugiardini R, Claeys MJ, De Luca G, de Wit C, Derumeaux G, Dorobantu M, Duncker DJ, Eringa EC, Gorog DA, Hassager C, Heinzel FR, Huber K, Manfrini O, Milicic D, Oikonomou E, Padro T, Trifunovic D, Vasiljevic Z, Vavlukis M, Vilahur G, Tousoulis D. Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA). CARDIOVASCULAR RESEARCH. 2021; 117(14). DOI:10.1093/cvr/cvab298. PMID:34528075. IF:13,081.
Chiva G, Pena E, Cubedo J, Garcia M, Pane A, Gil PA, Perez A, Ortega E, Padro T, Badimon L. Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2 alpha and platelet aggregation in diabetic and normal platelets. Translational Research. 2021; 235. DOI:10.1016/j.trsl.2021.04.003. PMID:33887528. IF:10,171.
Chiva G, Vilella A, Padro T, Formiga F, Ferrer A, Badimon L. Functional and Cognitive Decline Is Associated With Increased Endothelial Cell Inflammation and Platelet Activation: Liquid Biopsy of Microvesicles in Community- Dwelling Octogenarians. Frontiers in Cell and Developmental Biology. 2021; 9:716435. DOI:10.3389/fcell.2021.716435. IF:6,081.
Davidson SM, Padro T, Bollini S, Vilahur G, Duncker DJ, Evans PC, Guzik T, Hoefer IE, Waltenberger J, Wojta J, Weber C. Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart. CARDIOVASCULAR RESEARCH. 2021; 117(10). DOI:10.1093/cvr/cvab200. PMID:34114614. IF:13,081.
Escate R, Padro T, Suades R, Camino S, Muniz O, Diaz JL, Sionis A, Mata P, Badimon L. High miR-133a levels in the circulation anticipates presentation of clinical events in familial hypercholesterolaemia patients. CARDIOVASCULAR RESEARCH. 2021; 117(1). DOI:10.1093/cvr/cvaa039. PMID:32061123. IF:13,081.
Flores EJ, Ortega L, Cepas PL, Giacchi G, Padro T, Badimon L, Sabate M, Brugaletta S. Endothelial Progenitor Cell Function in Patients With Coronary Chronic Total Occlusion and its Relationship With Collateral Circulation. JOURNAL OF INVASIVE CARDIOLOGY. 2021; 33(10). PMID:34544035. IF:1,711.
Garcia M, Diaz E, Pena E, Escate R, Juan O, Mata P, Badimon L, Padro T. Alternative C3 Complement System: Lipids and Atherosclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(10):5122. DOI:10.3390/ijms22105122. PMID:34066088. IF:6,208.
Munoz N, Escate R, Badimon L, Padro T. Moderate Beer Intake Downregulates Inflammasome Pathway Gene Expression in Human Macrophages. Biology-Basel. 2021; 10(11):1159. DOI:10.3390/biology10111159. PMID:34827151. IF:5,168.
Padro T, Munoz N, Pena E, Badimon L. Sex Differences and Emerging New Risk Factors for Atherosclerosis and Its Throm-botic Complications. CURRENT PHARMACEUTICAL DESIGN. 2021; 27(29). DOI:10.2174/1381612826666201118094209. PMID:33213315. IF:3,310.
Perez de Isla L, Alonso R, de Diego JJG, Muniz O, Diaz JL, Zambon D, Miramontes JP, Fuentes F, de Andres R, Werenitzky J, Padro T, Saltijeral A, Mata P. Coronary plaque burden, plaque characterization and their prognostic implications in familial hypercholesterolemia: A computed tomographic angiography study. ATHEROSCLEROSIS. 2021; 317. DOI:10.1016/j.atherosclerosis.2020.11.012. PMID:33261814. IF:6,847.
Perez de Isla L, Watts GF, Alonso R, Diaz JL, Muniz O, Zambon D, Fuentes F, de Andres R, Padro T, Lopez J, Mata P. Lipoprotein(a), LDL-cholesterol, and hypertension: predictors of the need for aortic valve replacement in familial hypercholesterolaemia. EUROPEAN HEART JOURNAL. 2021; 42(22). DOI:10.1093/eurheartj/ehaa1066. PMID:33437997. IF:35,855.
Rodriguez L, Badimon L, Mendez D, Padro T, Vilahur G, Pena E, Carrasco B, Vogel H, Palomo I, Fuentes E. Antiplatelet Activity of Isorhamnetin via Mitochondrial Regulation. Antioxidants. 2021; 10(5):666. DOI:10.3390/antiox10050666. PMID:33922903. IF:7,675.

Scientific Reports

presentació

Principals línies de recerca

La identificació de nous biomarcadors de l’aterotrombosi i la cardiopatia isquèmica amb l’ús potencial diagnòstic i pronòstic es basa en estudis de cultius cel·lulars, models animals de malaltia cardiovascular i mostres humanes de pacients amb factors de risc de malaltia cardíaca coronària.

Reptes

Avançar en la investigació amb l’objectiu d’identificar i caracteritzar nous biomarcadors de dany vascular, malaltia aterotrombòtica i/o isquèmica, síndromes coronàries i cerebrovasculars, utilitzant tècniques postgenòmica.
Generar nova informació sobre els biomarcadors solubles potencials (en sèrum, plasma) i en micropartícules que circulen en la sang, així com en estudis en sang i/o cèl·lules vasculars incloure tècniques proteòmiques i lipidòmiques basades en cromatografia de líquids i electroforesi bidimensional, sistemes de matriu d’anticossos i espectrometria de masses.
Validar biomarcadors identificats en el diagnòstic i pronòstic de la malaltia cardiovascular i/o cerebrovascular utilitzant tècniques específiques quantitatives (microscopi confocal, ELISA, assaigs multiplex, etc.).
Caracteritzar els mecanismes moleculars i funcionals de biomarcadors seleccionats en patologia cardiovascular (biologia de sistemes).
Consolidar la plataforma lipidòmica.
Dirigir el Biobanc en el projecte europeu SAFE-T.

equip

Coordinació del grup

PADRO CAPMANY, TERESA IR
tpadro@santpau.cat

Membres

Cabre Fernandez, Paula IR
De Santisteban Vilaplana, Victoria Marta IR
Garcia Arguinzonis, Maisa Ines IR
Gomez-pardo Arellano, Montserrat IR

producció científica

Publicacions 2023

(JIF 2023)

-Badimon L, Padro T, Vilahur G. Chapter 27: Moving from reactive to preventive medicine. Aging. 2023; 663-681. DOI: 10.1016/B978-0-12-823761-8.00003-3. Document type: Book Chapter.

Publicacions 2022

(JIF 2022)

Badimon L, Padro T, Arderiu G, Vilahur G, Borrell M, Suades R. Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets. IMMUNOLOGICAL REVIEWS. 2022; 312(1). DOI:10.1111/imr.13127. PMID:35996799. IF:8,7 (Q1/2D). Document type: Review.
Badimon L, Padro T, Vilahur G. Moving from reactive to preventive medicine. In: Aging: From Fundamental Biology To Societal Impact. Elsevier. 2022. p. 663-681. Document type: Book chapter.
Cubedo J, Padro T, Vilahur G, Crea F, Storey RF, Sendon JLL, Kaski JC, Sionis A, Sans J, Fernandez E, Gallinat A, Badimon L. Glycosylated apolipoprotein J in cardiac ischaemia: molecular processing and circulating levels in patients with acute ischaemic events. EUROPEAN HEART JOURNAL. 2022; 43(2). DOI:10.1093/eurheartj/ehab691. PMID:34580705. IF:39,3 (Q1/1D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Urinary Proteomic Signature in Acute Decompensated Heart Failure: Advances into Molecular Pathophysiology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(4):2344. DOI:10.3390/ijms23042344. PMID:35216460. IF:5,6 (Q1/3D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Vitamin D Binding Protein and Renal Injury in Acute Decompensated Heart Failure. Frontiers in Cardiovascular Medicine. 2022; 9:829490. DOI:10.3389/fcvm.2022.829490. PMID:35757319. IF:3,6 (Q2/5D). Document type: Article.
Evans PC, Davidson SM, Wojta J, Back M, Bollini S, Brittan M, Catapano AL, Chaudhry B, Cluitmans M, Gnecchi M, Guzik TJ, Hoefer I, Madonna R, Monteiro JP, Morawietz H, Osto E, Padro T, Sluimer JC, Tocchetti CG, Van der Heiden K, Vilahur G, Waltenberger J, Weber C. From novel discovery tools and biomarkers to precision medicine-basic cardiovascular science highlights of 2021/22. CARDIOVASCULAR RESEARCH. 2022; 118(13). DOI:10.1093/cvr/cvac114. PMID:35899362. IF:10,8 (Q1/1D). Document type: Review.
Gallinat A, Mendieta G, Vilahur G, Padro T, Badimon L. DJ-1 administration exerts cardioprotection in a mouse model of acute myocardial infarction. Frontiers in Pharmacology. 2022; 13:1002755. DOI:10.3389/fphar.2022.1002755. PMID:36210822. IF:5,6 (Q1/2D). Document type: Article.
Gallinat A, Vilahur G, Padro T, Badimon L. Network-Assisted Systems Biology Analysis of the Mitochondrial Proteome in a Pre-Clinical Model of Ischemia, Revascularization and Post-Conditioning. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(4):2087. DOI:10.3390/ijms23042087. PMID:35216205. IF:5,6 (Q1/3D). Document type: Article.
Koller A, Laughlin MH, Cenko E, de Wit C, Toth K, Bugiardini R, Trifunovits D, Vavlukis M, Manfrini O, Lelbach A, Dornyei G, Padro T, Badimon L, Tousoulis D, Gielen S, Duncker DJ. Functional and structural adaptations of the coronary macro- and microvasculature to regular aerobic exercise by activation of physiological, cellular, and molecular mechanisms: ESC Working Group on Coronary Pathophysiology and Microcirculation position paper. CARDIOVASCULAR RESEARCH. 2022; 118(2). DOI:10.1093/cvr/cvab246. PMID:34358290. IF:10,8 (Q1/1D). Document type: Review.
Oskarsson V, Eliasson M, Salomaa V, Reinikainen J, Mannisto S, Palmieri L, Donfrancesco C, Sans S, Costanzo S, de Gaetano G, Iacoviello L, Veronesi G, Ferrario MM, Padro T, Thorand B, Huth C, Zeller T, Blankenberg S, Anderson AS, Tunstall H, Kuulasmaa K, Soderberg S. Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium. BRITISH JOURNAL OF NUTRITION. 2022; 128(11):PII S0007114521005080. DOI:10.1017/S0007114521005080. PMID:34933700. IF:3,6 (Q3/6D). Document type: Article.
Pérez de Isla L, Watts GF, Muñiz O, Díaz JL, Alonso R, Zambón D, Fuentes F, Mauri M, Padró T, Vidal JI, Barba MA, Ruiz E, Michán A, Mediavilla JD, Hernandez AM, Romero MJ, Badimon L, Mata P. A resilient type of familial hypercholesterolaemia: case-control follow-up of genetically characterized older patients in the SAFEHEART cohort. European Journal of Preventive Cardiology. 2022; 29(5). DOI:10.1093/eurjpc/zwab185. PMID:34864959. IF:8,3 (Q1/2D). Document type: Article.
Schoch L, Sutelman P, Suades R, Casani L, Padro T, Badimon L, Vilahur G. Hypercholesterolemia-Induced HDL Dysfunction Can Be Reversed: The Impact of Diet and Statin Treatment in a Preclinical Animal Model. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(15):8596. DOI:10.3390/ijms23158596. PMID:35955730. IF:5,6 (Q1/3D). Document type: Article.
Suades R, Greco MF, Padro T, Badimon L. Extracellular Vesicles as Drivers of Immunoinflammation in Atherothrombosis. 2022; 11(11):1845. DOI:10.3390/cells11111845. PMID:35681540. IF:6 (Q2/4D). Document type: Review.
Suades R, Padro T, Vilahur G, Badimon L. Platelet-released extracellular vesicles: the effects of thrombin activation. CELLULAR AND MOLECULAR LIFE SCIENCES. 2022; 79(3):190. DOI:10.1007/s00018-022-04222-4. PMID:35288766. IF:8 (Q1/2D). Document type: Article.
Tousoulis D, Guzik T, Padro T, Duncker DJ, De Luca G, Eringa E, Vavlukis M, Antonopoulos AS, Katsimichas T, Cenko E, Djordjevic A, Fleming I, Manfrini O, Trifunovic D, Antoniades C, Crea F. Mechanisms, therapeutic implications, and methodological challenges of gut microbiota and cardiovascular diseases: a position paper by the ESC Working Group on Coronary Pathophysiology and Microcirculation. CARDIOVASCULAR RESEARCH. 2022; 118(16). DOI:10.1093/cvr/cvac057. PMID:35420126. IF:10,8 (Q1/1D). Document type: Review.
Vilahur G, Sutelman P, Ben S, Mendieta G, Radike M, Schoch L, Casani L, Borrell M, Padro T, Badimon L. Supplementation With Spirulina Reduces Infarct Size and Ameliorates Cardiac Function in a Pig Model of STEMI. Frontiers in Pharmacology. 2022; 13:891801. DOI:10.3389/fphar.2022.891801. PMID:35592428. IF:5,6 (Q1/2D). Document type: Article.
Vilella A, Gallinat A, Escate R, Mirabet S, Padró T, Badimon L. Systems Biology in Chronic Heart Failure—Identification of Potential miRNA Regulators. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(23):15226. DOI:10.3390/ijms232315226. PMID:36499552. IF:5,6 (Q1/3D). Document type: Article.
Vilella A, Padro T, Roig E, Mirabet S, Badimon L. New factors in heart failure pathophysiology: Immunity cells release of extracellular vesicles. IF:3,6 (Q2/5D). 2022; 9:939625. DOI:10.3389/fcvm.2022.939625. PMID:36407432. IF:5,846 (Q2/4D). Document type: Article.

Publicacions 2021

Arauna D, Chiva-Blanch G, Padro T, Fuentes E, Palomo I, Badimon L. Frail older adults show a distinct plasma microvesicle profile suggesting a prothrombotic and proinflammatory phenotype. JOURNAL OF CELLULAR PHYSIOLOGY. 2021; 236(3):2099-2108. DOI: 10.1002/jcp.29996. PMID: 32749745. IF:6,513.
Cenko E, Badimon L, Bugiardini R, Claeys MJ, De Luca G, de Wit C, Derumeaux G, Dorobantu M, Duncker DJ, Eringa EC, Gorog DA, Hassager C, Heinzel FR, Huber K, Manfrini O, Milicic D, Oikonomou E, Padro T, Trifunovic D, Vasiljevic Z, Vavlukis M, Vilahur G, Tousoulis D. Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA). CARDIOVASCULAR RESEARCH. 2021; 117(14). DOI:10.1093/cvr/cvab298. PMID:34528075. IF:13,081.
Chiva G, Pena E, Cubedo J, Garcia M, Pane A, Gil PA, Perez A, Ortega E, Padro T, Badimon L. Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2 alpha and platelet aggregation in diabetic and normal platelets. Translational Research. 2021; 235. DOI:10.1016/j.trsl.2021.04.003. PMID:33887528. IF:10,171.
Chiva G, Vilella A, Padro T, Formiga F, Ferrer A, Badimon L. Functional and Cognitive Decline Is Associated With Increased Endothelial Cell Inflammation and Platelet Activation: Liquid Biopsy of Microvesicles in Community- Dwelling Octogenarians. Frontiers in Cell and Developmental Biology. 2021; 9:716435. DOI:10.3389/fcell.2021.716435. IF:6,081.
Davidson SM, Padro T, Bollini S, Vilahur G, Duncker DJ, Evans PC, Guzik T, Hoefer IE, Waltenberger J, Wojta J, Weber C. Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart. CARDIOVASCULAR RESEARCH. 2021; 117(10). DOI:10.1093/cvr/cvab200. PMID:34114614. IF:13,081.
Escate R, Padro T, Suades R, Camino S, Muniz O, Diaz JL, Sionis A, Mata P, Badimon L. High miR-133a levels in the circulation anticipates presentation of clinical events in familial hypercholesterolaemia patients. CARDIOVASCULAR RESEARCH. 2021; 117(1). DOI:10.1093/cvr/cvaa039. PMID:32061123. IF:13,081.
Flores EJ, Ortega L, Cepas PL, Giacchi G, Padro T, Badimon L, Sabate M, Brugaletta S. Endothelial Progenitor Cell Function in Patients With Coronary Chronic Total Occlusion and its Relationship With Collateral Circulation. JOURNAL OF INVASIVE CARDIOLOGY. 2021; 33(10). PMID:34544035. IF:1,711.
Garcia M, Diaz E, Pena E, Escate R, Juan O, Mata P, Badimon L, Padro T. Alternative C3 Complement System: Lipids and Atherosclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(10):5122. DOI:10.3390/ijms22105122. PMID:34066088. IF:6,208.
Munoz N, Escate R, Badimon L, Padro T. Moderate Beer Intake Downregulates Inflammasome Pathway Gene Expression in Human Macrophages. Biology-Basel. 2021; 10(11):1159. DOI:10.3390/biology10111159. PMID:34827151. IF:5,168.
Padro T, Munoz N, Pena E, Badimon L. Sex Differences and Emerging New Risk Factors for Atherosclerosis and Its Throm-botic Complications. CURRENT PHARMACEUTICAL DESIGN. 2021; 27(29). DOI:10.2174/1381612826666201118094209. PMID:33213315. IF:3,310.
Perez de Isla L, Alonso R, de Diego JJG, Muniz O, Diaz JL, Zambon D, Miramontes JP, Fuentes F, de Andres R, Werenitzky J, Padro T, Saltijeral A, Mata P. Coronary plaque burden, plaque characterization and their prognostic implications in familial hypercholesterolemia: A computed tomographic angiography study. ATHEROSCLEROSIS. 2021; 317. DOI:10.1016/j.atherosclerosis.2020.11.012. PMID:33261814. IF:6,847.
Perez de Isla L, Watts GF, Alonso R, Diaz JL, Muniz O, Zambon D, Fuentes F, de Andres R, Padro T, Lopez J, Mata P. Lipoprotein(a), LDL-cholesterol, and hypertension: predictors of the need for aortic valve replacement in familial hypercholesterolaemia. EUROPEAN HEART JOURNAL. 2021; 42(22). DOI:10.1093/eurheartj/ehaa1066. PMID:33437997. IF:35,855.
Rodriguez L, Badimon L, Mendez D, Padro T, Vilahur G, Pena E, Carrasco B, Vogel H, Palomo I, Fuentes E. Antiplatelet Activity of Isorhamnetin via Mitochondrial Regulation. Antioxidants. 2021; 10(5):666. DOI:10.3390/antiox10050666. PMID:33922903. IF:7,675.

MALALTIES CARDIOVASCULARS

Biomarcadors de l’Evolució de la Malaltia Cardiovascular

Principals línies de recerca

Reptes

Coordinació del grup

Membres

Publicacions 2023

Publicacions 2022

Publicacions 2021

Principals línies de recerca

Reptes

Coordinació del grup

Membres

Publicacions 2023

Publicacions 2022

Publicacions 2021

Institut de recerca de l’hospital de la santa creu i sant pau