Sant Pau - Institut de Recerca

Principales líneas de investigación

Oncología

Nuevos métodos de diagnóstico basados en la identificación y visualización de dianas moleculares que emplean mecanismos metabólicos, sistemas de receptores, la hipoxia, la angiogénesis y la apoptosis.
Nuevas aplicaciones para la detección del ganglio centinela y modelos de cirugía radioguiada.

Investigación cardiovascular

Nuevos métodos para la evaluación no invasiva de la cardiopatía isquémica y la insuficiencia cardiaca.
Estudios funcionales cardiovasculares.
Nuevos métodos para la evaluación de la inervación cardíaca.

Neuroimagen funcional

Desarrollo de nuevos métodos de diagnóstico por imagen funcional para la evaluación de las enfermedades neurodegenerativas (Parkinson, Parkinson-Plus, Alzheimer, MCI).
Estudios del sistema dopaminérgico utilizando IBZM y DaTscan.

Retos

Introducir nuevas tecnologías para la investigación clínica (teniendo en cuenta que las técnicas de imagen están evolucionando muy rápidamente hacia sistemas multimodales que integren biológica, molecular, anatómica y funcional de la información en un solo examen) e incluyen estas tecnologías, principalmente PET / CT y PET / MR, en la búsqueda de nuestro hospital.

Nuevas técnicas de imagen molecular

Desarrollar nuevas tecnologías híbridas de imagen molecular, principalmente PET / CT y PET / MR, sobre la base de modelos de imagen molecular preclínicos y clínicos desarrollados mediante SPECT y tecnologías de medicina nuclear convencionales.

Biomarcadores PET de imagen

Desarrollar nuevos trazadores radiactivos PET para ser utilizados como biomarcadores en nuevas tecnologías de imagen, a partir de nuestra experiencia con trazadores radiactivos para ver dianas diagnósticas y terapéuticas in vivo.

Coordinación del grupo

FLOTATS GIRALT, ALBERT FGS
aflotats@santpau.cat

Miembros

Calls Calahorro, Marc FGS
Camacho Marti, Maria Del Valle FGS
Castejon Echevarne, Simona FGS
Duch Renom, Joan FGS
Fernandez Leon, Alejandro FGS
Soldevila Lozano, Cristina FGS
Stefaneli Normandi, Patricia FGS
Torres Quintana, Maria Paula FGS
Velasco Nuño, Monica FGS

Publicaciones 2023

(JIF 2022)

-Bugani V, Battistelli L, Sansovini M, Monti M, Paganelli G, Gich I, Flotats A, Erba PA, Blay JY, la Fougere C, Van H, Charalambous A, Herrmann K, Giordano A, Gyorke T, Deroose C, Matteucci F, Carrio I. Radioligand therapies in cancer: mapping the educational landscape in Europe. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2023; 50(9). DOI:10.1007/s00259-023-06217-0. PMID:37058168. IF:9,100 (Q1/1D). Document type: Article.

-Carrió I. Standing on the shoulders of giants: 50 years of EJNM and EJNMMI. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2023; 50(12). DOI:10.1007/s00259-023-06359-1. PMID:37535109. IF:9,100 (Q1/1D). Document type: Editorial Material.

-Garcia E, Camps P, Puig N, Fernández A, Aguilera A, Benitez A, Solé A, Vilades D, Sanchez JL, Martí J, Jiménez E, Benitez S, Llorente V. Soluble low-density lipoprotein receptor-related protein 1 as a surrogate marker of carotid plaque inflammation assessed by 18F-FDG PET in patients with a recent ischemic stroke. Journal of Translational Medicine. 2023; 21(1):131. DOI:10.1186/s12967-022-03867-w. PMID:36805772. IF:7,400 (Q1/3D). Document type: Article.

-Gorey S, McCabe JJ, Camps P, Giannotti N, McNulty JP, Barry M, Cassidy T, Cronin S, Dolan E, Fernández A, Foley S, Harbison J, O’Connell M, Williams DJ, Marnane M, Martí J, Kelly PJ. Symptomatic Carotid Atheroma Inflammation Lumen-stenosis score compared with Oxford and Essen risk scores to predict recurrent stroke in symptomatic carotid stenosis. European Stroke Journal. 2023; :23969873231186911. DOI:10.1177/23969873231186911. PMID:37480278. IF:6,100 (Q1/2D). Document type: Article.

-Gorey S, McCabe JJ, Camps-Renom P, Giannotti N, McNulty JP, Barry M, Cassidy T, Cronin S, Dolan E, Fernández-León A, Foley S, Harbison J, O’Connell M, Williams DJ, Marnane M, Martí-Fabregas J, Kelly PJ. Symptomatic Carotid Atheroma Inflammation Lumen-stenosis score compared with Oxford and Essen risk scores to predict recurrent stroke in symptomatic carotid stenosis. Eur Stroke J. 2023; 8(4):1064-1070. DOI: 10.1177/23969873231186911. PMID: 37480278. Document type: Article.

-Holgado A, León X, Quer M, Camacho V, Fernández A. Association between maximum standarised uptake value (SUV) and local control in patients with oropharyngeal carcinoma treated with radiotherapy. Acta Otorrinolaringologica Espanola. 2023; 74(4). DOI:10.1016/j.otorri.2022.05.004. PMID:37149130. Document type: Article.

-Horta-Barba A, Martinez-Horta S, Sampedro F, Pérez-Pérez J, Camacho V, Pagonabarraga J, Kulisevsky J. Structural and metabolic brain correlates of arithmetic word-problem solving in Huntington’s disease. J Neurosci Res. 2023; 101(6):990-999. DOI: 10.1002/jnr.25174. PMID: 36807154. IF:4,200 (Q2/D4). Document type: Article.

-Iulita MF, Bejanin A, Vilaplana E, Carmona M, Benejam B, Videla L, Barroeta I, Fernández S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Gimenez S, González S, Torres S, El Bennadi SE, Padilla C, Aranha MR, Estelles T, Illán I, Belbin O, Valle N, Camacho V, Blessing E, Osorio RS, Videla S, Lehmann S, Holland AJ, Zetterberg H, Blennow K, Alcolea D, Clarimón J, Zaman SH, Blesa R, Lleó A, Fortea J. Association of biological sex with clinical outcomes and biomarkers of Alzheimer’s disease in adults with Down syndrome. Brain Communications. 2023; 5(2):fcad074. DOI:10.1093/braincomms/fcad074. PMID:37056479. Document type: Article.

-Mansour N, Nekolla SG, Reyes E, Angelidis G, Georgoulias P, Anagnostopoulos C, Bravo P, Bruno I, Flotats A, Fuentes F, Sciagra R, Keng F, Kessler L, Papathanasiou M, Soman P, Rischpler C. Multi-center study of inter-rater reproducibility, image quality, and diagnostic accuracy of CZT versus conventional SPECT myocardial perfusion imaging. JOURNAL OF NUCLEAR CARDIOLOGY. 2023; 30(2). DOI:10.1007/s12350-022-03054-w. PMID:35799039. IF:2,400 (Q3/6D). Document type: Article.

-Puig N, Camps P, Sole A, Aguilera A, Jimenez E, Fernandez A, Camacho M, Guasch M, Marin R, Marti J, Martinez A, Prats L, Casoni F, Perez B, Jimenez F, Sanchez JL, Benitez S. Electronegative LDL Is Associated with Plaque Vulnerability in Patients with Ischemic Stroke and Carotid Atherosclerosis. Antioxidants. 2023; 12(2):438. DOI:10.3390/antiox12020438. PMID:36829998. IF:7,000 (Q1/1D). Document type: Article.

-Stockbauer A, Beyer L, Huber M, Kreuzer A, Palleis C, Katzdobler S, Rauchmann BS, Morbelli S, Chincarini A, Bruffaerts R, Vandenberghe R, Kramberger MG, Trost M, Garibotto V, Nicastro N, Lathuilière A, Lemstra AW, van BNM, Pilotto A, Padovani A, Ochoa MA, Davidsson A, Camacho V, Peira E, Bauckneht M, Pardini M, Sambuceti G, Aarsland D, Nobili F, Gross M, Vöglein J, Perneczky R, Pogarell O, Buerger K, Franzmeier N, Danek A, Levin J, Höglinger GU, Bartenstein P, Cumming P, Rominger A, Brendel M. Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2023; DOI:10.1007/s00259-023-06493-w. PMID:37971501. IF:9,100 (Q1/1D). Document type: Article.

-Tian M, Zuo C, Civelek AC, Carrio I, Watanabe Y, Kang KW, Murakami K, Garibotto V, Prior JO, Barthel H, Guan Y, Lu J, Zhou R, Jin C, Wu S, Zhang X, Zhong Y, Zhang H, Molecular Imaging (. International Nuclear Medicine Consensus on the Clinical Use of Amyloid Positron Emission Tomography in Alzheimer’s Disease. PHENOMICS. 2023; 3(4). DOI:10.1007/s43657-022-00068-9. PMID:37589025. Document type: Article.

Publicaciones 2022

(JIF 2022)

Abouzian S, Camacho V, Sabate A, Stefaneli P, Sizova M, Gich I, Lopez D, Duch J, Fernandez A, Estorch M, Carrio I, Flotats A. Audiovisual intervention alleviates anxiety of patients during PET/CT imaging. NUKLEARMEDIZIN-NUCLEAR MEDICINE. 2022; 61(04). DOI:10.1055/a-1759-4062. PMID:35931063. IF:1,5 (Q4/9D). Document type: Article.
Arbizu J, Perez JG, Hilario A, Grande AG, Rubi S, Camacho V. Update on the diagnosis of encephalitis. Revista Espanola de Medicina Nuclear e Imagen Molecular. 2022; 41(4). DOI:10.1016/j.remnie.2022.05.003. PMID:35701317. IF:1,2 (Q4/9D). Document type: Article.
Camps P, McCabe J, Marti J, Giannotti N, Fernandez A, McNulty JP, Baron JC, Barry M, Coutts SB, Cronin S, Delgado R, Dolan E, Foley S, Guasch M, Guisado D, Harbison JA, Horgan G, Kavanagh EC, Marnane M, Martinez A, McDonnell C, Sharma VK, Williams D, Connell MO, Murphy S, Prats L, Kelly PJ. Association of Plaque Inflammation With Stroke Recurrence in Patients With Unproven Benefit From Carotid Revascularization. NEUROLOGY. 2022; 99(2). DOI:10.1212/WNL.0000000000200525. PMID:35418461. IF:9,9 (Q1/1D). Document type: Article.
Casasayas M, Garcia J, Gomez B, Medina V, Fernandez A, Quer M, Leon X. Low skeletal muscle mass assessed directly from the 3rd cervical vertebra can predict pharyngocutaneous fistula risk after total laryngectomy in the male population. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2022; 279(2). DOI:10.1007/s00405-021-07127-3. PMID:34665301. IF:2,6 (Q2/3D). Document type: Article.
Etminani K, Soliman A, Davidsson A, Chang JR, Martinez B, Byttner S, Camacho V, Bauckneht M, Stegeran R, Ressner M, Agudelo M, Chincarini A, Brendel M, Rominger A, Bruffaerts R, Vandenberghe R, Kramberger MG, Trost M, Nicastro N, Frisoni GB, Lemstra AW, van BNM, Pilotto A, Padovani A, Morbelli S, Aarsland D, Nobili F, Garibotto V, Ochoa M. A 3D deep learning model to predict the diagnosis of dementia with Lewy bodies, Alzheimer’s disease, and mild cognitive impairment using brain 18F-FDG PET. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2022; 49(2). DOI:10.1007/s00259-021-05483-0. PMID:34328531. IF:9,1 (Q1/1D). Document type: Article.
Gomez A, Camacho V. Early phase amyloid PET or «two birds with one Stone «. Revista Espanola de Medicina Nuclear e Imagen Molecular. 2022; 41(4). DOI:10.1016/j.remn.2022.06.001. PMID:35760462. IF:1,2 (Q4/9D). Document type: Editorial material.
Heeman F, Moscoso A, Camacho V, van M, Grothe MJ, Lin L, Mainta I, Ribaldi F, Devous MD, SR, Pontecorvo MJ, Frisoni GB, Garibotto V, Schöll M. Relationship between [18F]flortaucipir PET visual patterns and neurodegeneration. Alzheimers & Dementia. 2022; 18:e067143. DOI:10.1002/alz.067143. IF:14 (Q1/1D). Document type: Note.
López DA, Carrió I, Flotats A. Digital PET vs Analog PET: Clinical Implications?. SEMINARS IN NUCLEAR MEDICINE. 2022; 52(3). DOI:10.1053/j.semnuclmed.2021.10.004. PMID:34836617. IF:4,9 (Q1/2D). Document type: Review.
Moscoso A, Heeman F, Camacho V, van M, Grothe MJ, Lin L, Mainta I, Ribaldi F, Devous MD, SR, Pontecorvo MJ, Frisoni GB, Garibotto V, Schöll M. Prevalence and longitudinal clinical outcomes of negative, moderate, and advanced 18F-flortaucipir PET visual patterns in aging and Alzheimer’s disease. Alzheimers & Dementia. 2022; 18:e068009. DOI:10.1002/alz.068009. IF:14 (Q1/1D). Document type: Note.
Ona G, Sampedro F, Romero S, Valle M, Camacho V, Migliorelli C, Mananas MA, Antonijoan RM, Puntes M, Coimbra J, Ballester MR, Garrido M, Riba J. The Kappa Opioid Receptor and the Sleep of Reason: Cortico-Subcortical Imbalance Following Salvinorin-A. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2022; 25(1)DOI:10.1093/ijnp/pyab063. PMID:34537829. IF:4,8 (Q1/3D). Document type: Article.
Puig N, Camps P, Camacho M, Aguilera A, Jimenez F, Fernandez A, Marin R, Marti J, Sanchez JL, Jimenez E, Benitez S. Plasma sICAM-1 as a Biomarker of Carotid Plaque Inflammation in Patients with a Recent Ischemic Stroke. Translational Stroke Research. 2022; 13(5). DOI:10.1007/s12975-022-01002-x. PMID:35237947. IF:6,9 (Q1/1D). Document type: Article.
Sizova M, Camacho V, Sampedro F, Sabate A, Abouzian S, Stefaneli P, Duch J, Fernandez A, Lopez DA, Estorch M, Carrio I, Flotats A. Brain metabolic changes in patients with disseminated malignant melanoma under immunotherapy. MELANOMA RESEARCH. 2022; 32(5). DOI:10.1097/CMR.0000000000000835. PMID:35703175. IF:2,2 (Q3/7D). Document type: Article.
Soliman A, Chang JR, Etminani K, Byttner S, Davidsson A, Martinez B, Camacho V, Bauckneht M, Stegeran R, Ressner M, Agudelo M, Chincarini A, Brendel M, Rominger A, Bruffaerts R, Vandenberghe R, Kramberger MG, Trost M, Nicastro N, Frisoni GB, Lemstra AW, van BNM, Pilotto A, Padovani A, Morbelli S, Aarsland D, Nobili F, Garibotto V, Ochoa M, Alzheimer’s Dis Neuroimaging I. Adopting transfer learning for neuroimaging: a comparative analysis with a custom 3D convolution neural network model. BMC Medical Informatics and Decision Making. 2022; 22(SUPPL 6):318. DOI:10.1186/s12911-022-02054-7. PMID:36476613. IF:3,5 (Q3/6D). Document type: Article.
Tian M, Civelek AC, Carrio I, Watanabe Y, Kang KW, Murakami K, Garibotto V, Prior JO, Barthel H, Zhou R, Hou HF, Dou XF, Jin CT, Zuo CT, Zhang H, Mol Imaging TA. International consensus on the use of tau PET imaging agent F-18-flortaucipir in Alzheimer’s disease. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2022; 49(3). DOI:10.1007/s00259-021-05673-w. PMID:34978595. IF:9,1 (Q1/1D). Document type: Article.

Publicaciones 2021

Bauckneht M, Chincarini A, Brendel M, Rominger A, Beyer L, Bruffaerts R, Vandenberghe R, Kramberger MG, Trost M, Garibotto V, Nicastro N, Frisoni GB, Lemstra AW, Berckel BNM, Pilotto A, Padovani A, Ochoa MA, Davidsson A, Camacho V, Peira E, Arnaldi D, Pardini M, Donegani MI, Raffa S, Miceli A, Sambuceti G, Aarsland D, Nobili F, Morbelli S. Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European-DLB consortium project. Alzheimers & Dementia. 2021; 17(8). DOI:10.1002/alz.12294. PMID:33528089. IF:16,655.
Bejanin A, Iulita MF, Vilaplana E, Carmona M, Benejam B, Videla L, Barroeta I, Fernandez S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Gimenez S, Gonzalez S, Munoz L, Padilla C, Aranha MR, Estelles T, Illan I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Zetterberg H, et al. [Alcolea D, Clarimon J, Blesa R, Lleo A, Fortea J]. Association of Apolipoprotein E epsilon 4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome. JAMA Neurology. 2021; 78(8). DOI:10.1001/jamaneurol.2021.1893. PMID:34228042. IF:29,907.
Fuentes F, Lopez DA, Flotats A, Camacho V, Sizova M, Abouzian S, Duch J, Fernandez A, Estorch M, Carrio I. Digital versus analog PET/CT in patients with known or suspected liver metastases. NUCLEAR MEDICINE COMMUNICATIONS. 2021; 42(4). DOI:10.1097/MNM.0000000000001341. PMID:33306635. IF:1,698.
Hirschfeld CB, Dondi M, Pascual TNB, Mercuri M, Vitola J, Karthikeyan G, Better N, Mahmarian JJ, Bouyoucef SE, Hee-Seung Bom H, Lele V, Magboo VPC, Alexánderson E, Allam AH, Al-Mallah MH, Flotats A, Jerome S, Kaufmann PA, Luxenburg O, Underwood SR, Rehani MM, Vassileva J, Paez D, Einstein AJ; INCAPS Investigators Group. Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging: Findings From INCAPS. JACC-Cardiovascular Imaging. 2021;14(3):657-665. DOI:10.1016/j.jcmg.2020.06.029. PMID: 32828783. IF:16,051.
Hirschfeld CB, Mercuri M, Pascual TNB, Karthikeyan G, Vitola JV, Mahmarian JJ, Better N, Bouyoucef SE, Bom HHS, Lele V, Magboo VPC, Alexanderson E, Allam AH, Al MH, Dorbala S, Flotats A, Jerome S, Kaufmann PA, Luxenburg O, Shaw LJ, Underwood SR, Rehani MM, Paez D, Dondi M, Einstein AJ. Worldwide Variation in the Use of Nuclear Cardiology Camera Technology, Reconstruction Software, and Imaging Protocols. JACC-Cardiovascular Imaging. 2021; 14(9). DOI:10.1016/j.jcmg.2020.11.011. PMID:33454257. IF:16,051.
Lleo A, Zetterberg H, Pegueroles J, Karikari TK, Carmona M, Ashton NJ, Montal V, Barroeta I, Lantero J, Videla L, Altuna M, Benejam B, Fernandez S, Valldeneu S, Garzon D, Bejanin A, Iulita MF, Camacho V, Medrano S, Belbin O, Clarimon J, Lehmann S, Alcolea D, Blesa R, Blennow K, Fortea J. Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome. Nature Communications. 2021; 12(1):4304. DOI:10.1038/s41467-021-24319-x. PMID:34262030. IF:17,694.
McCabe JJ, Camps P, Giannotti N, McNulty JP, Coveney S, Murphy S, Barry M, Harbison J, Cronin S, Williams D, Horgan G, Dolan E, Cassidy T, McDonnell C, Kavanagh E, Foley S, Collins S, O’Connell M, Fernandez A, Delgado R, Marnane M, Marti J, Kelly PJ. Carotid Plaque Inflammation Imaged by PET and Prediction of Recurrent Stroke at 5 Years. NEUROLOGY. 2021; 97(23). DOI:10.1212/WNL.0000000000012909. PMID:34610991. IF:11,800.
Moya P, Leon AF, Corica ME, Marti VC, Lopez DA, Castellvi I, Corominas H. «The added value of 18f-FDG PET/CT in the assessment of onset and steroid resistant polimyalgia rheumatica». PLoS One. 2021; 16(9):e0255131. DOI:10.1371/journal.pone.0255131. PMID:34559822. IF:3,752.
Ovcaricek PP, Giovanella L, Gasset IC, Hindie E, Huellner MW, Luster M, Piccardo A, Weber T, Talbot JN, Verburg FA. The EANM practice guidelines for parathyroid imaging. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2021; 48(9). DOI:10.1007/s00259-021-05334-y. PMID:33839893. IF:10,057.
Pegueroles J, Montal V, Bejanin A, Vilaplana E, Aranha M, Santos MA, Alcolea D, Carrio I, Camacho V, Blesa R, Lleo A, Fortea J. AMYQ: An index to standardize quantitative amyloid load across PET tracers. Alzheimers & Dementia. 2021; 17(9). DOI:10.1002/alz.12317. PMID:33797846. IF:16,655.
Pons G, Abdelfattah U, Sarria J, Duch J, Masia J. Reverse Lymph Node Mapping Using Indocyanine Green Lymphography: A Step Forward in Minimizing Donor-Site Morbidity in Vascularized Lymph Node Transfer. PLASTIC AND RECONSTRUCTIVE SURGERY. 2021; 147(2). DOI:10.1097/PRS.0000000000007585. PMID:33565822. IF:5,169.
Sampedro F, Marin J, Martinez S, Camacho V, Lopez DA, Pagonabarraga J, Kulisevsky J. Extrastriatal SPECT-DAT uptake correlates with clinical and biological features of de novo Parkinson’s disease. NEUROBIOLOGY OF AGING. 2021; 97. DOI:10.1016/j.neurobiolaging.2020.10.016. PMID:33212336. IF:5,133.
Sampedro F, Stantonyonge N, Martínez-Horta S, Nan N, Camacho V, Chico A. Increased cerebral FDG-PET uptake in type 1 diabetes patients with impaired awareness of hypoglycaemia. JOURNAL OF NEUROENDOCRINOLOGY. 2021;33(1):e12910. DOI:10.1111/jne.12910. PMID: 33176042. IF:3,870.
Tian M, Watanabe Y, Kang KW, Murakami K, Chiti A, Carrio I, Civelek AC, Feng JH, Zhu YK, Zhou R, Wu S, Zhu JM, Ding Y, Zhang K, Zhang H, Mol Imaging TA. International consensus on the use of [F-18]-FDG PET/CT in pediatric patients affected by epilepsy. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2021; 48(12). DOI:10.1007/s00259-021-05524-8. PMID:34453559. IF:10,057.

Presentación

Principales líneas de investigación

Oncología

Nuevos métodos de diagnóstico basados en la identificación y visualización de dianas moleculares que emplean mecanismos metabólicos, sistemas de receptores, la hipoxia, la angiogénesis y la apoptosis.
Nuevas aplicaciones para la detección del ganglio centinela y modelos de cirugía radioguiada.

Investigación cardiovascular

Nuevos métodos para la evaluación no invasiva de la cardiopatía isquémica y la insuficiencia cardiaca.
Estudios funcionales cardiovasculares.
Nuevos métodos para la evaluación de la inervación cardíaca.

Neuroimagen funcional

Desarrollo de nuevos métodos de diagnóstico por imagen funcional para la evaluación de las enfermedades neurodegenerativas (Parkinson, Parkinson-Plus, Alzheimer, MCI).
Estudios del sistema dopaminérgico utilizando IBZM y DaTscan.

Retos

Introducir nuevas tecnologías para la investigación clínica (teniendo en cuenta que las técnicas de imagen están evolucionando muy rápidamente hacia sistemas multimodales que integren biológica, molecular, anatómica y funcional de la información en un solo examen) e incluyen estas tecnologías, principalmente PET / CT y PET / MR, en la búsqueda de nuestro hospital.

Nuevas técnicas de imagen molecular

Desarrollar nuevas tecnologías híbridas de imagen molecular, principalmente PET / CT y PET / MR, sobre la base de modelos de imagen molecular preclínicos y clínicos desarrollados mediante SPECT y tecnologías de medicina nuclear convencionales.

Biomarcadores PET de imagen

Desarrollar nuevos trazadores radiactivos PET para ser utilizados como biomarcadores en nuevas tecnologías de imagen, a partir de nuestra experiencia con trazadores radiactivos para ver dianas diagnósticas y terapéuticas in vivo.

Equipo

Coordinación del grupo

FLOTATS GIRALT, ALBERT FGS
aflotats@santpau.cat

Miembros

Producción científica

Publicaciones 2023

(JIF 2022)

Publicaciones 2022

(JIF 2022)

Abouzian S, Camacho V, Sabate A, Stefaneli P, Sizova M, Gich I, Lopez D, Duch J, Fernandez A, Estorch M, Carrio I, Flotats A. Audiovisual intervention alleviates anxiety of patients during PET/CT imaging. NUKLEARMEDIZIN-NUCLEAR MEDICINE. 2022; 61(04). DOI:10.1055/a-1759-4062. PMID:35931063. IF:1,5 (Q4/9D). Document type: Article.
Arbizu J, Perez JG, Hilario A, Grande AG, Rubi S, Camacho V. Update on the diagnosis of encephalitis. Revista Espanola de Medicina Nuclear e Imagen Molecular. 2022; 41(4). DOI:10.1016/j.remnie.2022.05.003. PMID:35701317. IF:1,2 (Q4/9D). Document type: Article.
Camps P, McCabe J, Marti J, Giannotti N, Fernandez A, McNulty JP, Baron JC, Barry M, Coutts SB, Cronin S, Delgado R, Dolan E, Foley S, Guasch M, Guisado D, Harbison JA, Horgan G, Kavanagh EC, Marnane M, Martinez A, McDonnell C, Sharma VK, Williams D, Connell MO, Murphy S, Prats L, Kelly PJ. Association of Plaque Inflammation With Stroke Recurrence in Patients With Unproven Benefit From Carotid Revascularization. NEUROLOGY. 2022; 99(2). DOI:10.1212/WNL.0000000000200525. PMID:35418461. IF:9,9 (Q1/1D). Document type: Article.
Casasayas M, Garcia J, Gomez B, Medina V, Fernandez A, Quer M, Leon X. Low skeletal muscle mass assessed directly from the 3rd cervical vertebra can predict pharyngocutaneous fistula risk after total laryngectomy in the male population. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2022; 279(2). DOI:10.1007/s00405-021-07127-3. PMID:34665301. IF:2,6 (Q2/3D). Document type: Article.
Etminani K, Soliman A, Davidsson A, Chang JR, Martinez B, Byttner S, Camacho V, Bauckneht M, Stegeran R, Ressner M, Agudelo M, Chincarini A, Brendel M, Rominger A, Bruffaerts R, Vandenberghe R, Kramberger MG, Trost M, Nicastro N, Frisoni GB, Lemstra AW, van BNM, Pilotto A, Padovani A, Morbelli S, Aarsland D, Nobili F, Garibotto V, Ochoa M. A 3D deep learning model to predict the diagnosis of dementia with Lewy bodies, Alzheimer’s disease, and mild cognitive impairment using brain 18F-FDG PET. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2022; 49(2). DOI:10.1007/s00259-021-05483-0. PMID:34328531. IF:9,1 (Q1/1D). Document type: Article.
Gomez A, Camacho V. Early phase amyloid PET or «two birds with one Stone «. Revista Espanola de Medicina Nuclear e Imagen Molecular. 2022; 41(4). DOI:10.1016/j.remn.2022.06.001. PMID:35760462. IF:1,2 (Q4/9D). Document type: Editorial material.
Heeman F, Moscoso A, Camacho V, van M, Grothe MJ, Lin L, Mainta I, Ribaldi F, Devous MD, SR, Pontecorvo MJ, Frisoni GB, Garibotto V, Schöll M. Relationship between [18F]flortaucipir PET visual patterns and neurodegeneration. Alzheimers & Dementia. 2022; 18:e067143. DOI:10.1002/alz.067143. IF:14 (Q1/1D). Document type: Note.
López DA, Carrió I, Flotats A. Digital PET vs Analog PET: Clinical Implications?. SEMINARS IN NUCLEAR MEDICINE. 2022; 52(3). DOI:10.1053/j.semnuclmed.2021.10.004. PMID:34836617. IF:4,9 (Q1/2D). Document type: Review.
Moscoso A, Heeman F, Camacho V, van M, Grothe MJ, Lin L, Mainta I, Ribaldi F, Devous MD, SR, Pontecorvo MJ, Frisoni GB, Garibotto V, Schöll M. Prevalence and longitudinal clinical outcomes of negative, moderate, and advanced 18F-flortaucipir PET visual patterns in aging and Alzheimer’s disease. Alzheimers & Dementia. 2022; 18:e068009. DOI:10.1002/alz.068009. IF:14 (Q1/1D). Document type: Note.
Ona G, Sampedro F, Romero S, Valle M, Camacho V, Migliorelli C, Mananas MA, Antonijoan RM, Puntes M, Coimbra J, Ballester MR, Garrido M, Riba J. The Kappa Opioid Receptor and the Sleep of Reason: Cortico-Subcortical Imbalance Following Salvinorin-A. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2022; 25(1)DOI:10.1093/ijnp/pyab063. PMID:34537829. IF:4,8 (Q1/3D). Document type: Article.
Puig N, Camps P, Camacho M, Aguilera A, Jimenez F, Fernandez A, Marin R, Marti J, Sanchez JL, Jimenez E, Benitez S. Plasma sICAM-1 as a Biomarker of Carotid Plaque Inflammation in Patients with a Recent Ischemic Stroke. Translational Stroke Research. 2022; 13(5). DOI:10.1007/s12975-022-01002-x. PMID:35237947. IF:6,9 (Q1/1D). Document type: Article.
Sizova M, Camacho V, Sampedro F, Sabate A, Abouzian S, Stefaneli P, Duch J, Fernandez A, Lopez DA, Estorch M, Carrio I, Flotats A. Brain metabolic changes in patients with disseminated malignant melanoma under immunotherapy. MELANOMA RESEARCH. 2022; 32(5). DOI:10.1097/CMR.0000000000000835. PMID:35703175. IF:2,2 (Q3/7D). Document type: Article.
Soliman A, Chang JR, Etminani K, Byttner S, Davidsson A, Martinez B, Camacho V, Bauckneht M, Stegeran R, Ressner M, Agudelo M, Chincarini A, Brendel M, Rominger A, Bruffaerts R, Vandenberghe R, Kramberger MG, Trost M, Nicastro N, Frisoni GB, Lemstra AW, van BNM, Pilotto A, Padovani A, Morbelli S, Aarsland D, Nobili F, Garibotto V, Ochoa M, Alzheimer’s Dis Neuroimaging I. Adopting transfer learning for neuroimaging: a comparative analysis with a custom 3D convolution neural network model. BMC Medical Informatics and Decision Making. 2022; 22(SUPPL 6):318. DOI:10.1186/s12911-022-02054-7. PMID:36476613. IF:3,5 (Q3/6D). Document type: Article.
Tian M, Civelek AC, Carrio I, Watanabe Y, Kang KW, Murakami K, Garibotto V, Prior JO, Barthel H, Zhou R, Hou HF, Dou XF, Jin CT, Zuo CT, Zhang H, Mol Imaging TA. International consensus on the use of tau PET imaging agent F-18-flortaucipir in Alzheimer’s disease. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2022; 49(3). DOI:10.1007/s00259-021-05673-w. PMID:34978595. IF:9,1 (Q1/1D). Document type: Article.

Publicaciones 2021

Bauckneht M, Chincarini A, Brendel M, Rominger A, Beyer L, Bruffaerts R, Vandenberghe R, Kramberger MG, Trost M, Garibotto V, Nicastro N, Frisoni GB, Lemstra AW, Berckel BNM, Pilotto A, Padovani A, Ochoa MA, Davidsson A, Camacho V, Peira E, Arnaldi D, Pardini M, Donegani MI, Raffa S, Miceli A, Sambuceti G, Aarsland D, Nobili F, Morbelli S. Associations among education, age, and the dementia with Lewy bodies (DLB) metabolic pattern: A European-DLB consortium project. Alzheimers & Dementia. 2021; 17(8). DOI:10.1002/alz.12294. PMID:33528089. IF:16,655.
Bejanin A, Iulita MF, Vilaplana E, Carmona M, Benejam B, Videla L, Barroeta I, Fernandez S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Gimenez S, Gonzalez S, Munoz L, Padilla C, Aranha MR, Estelles T, Illan I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Zetterberg H, et al. [Alcolea D, Clarimon J, Blesa R, Lleo A, Fortea J]. Association of Apolipoprotein E epsilon 4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome. JAMA Neurology. 2021; 78(8). DOI:10.1001/jamaneurol.2021.1893. PMID:34228042. IF:29,907.
Fuentes F, Lopez DA, Flotats A, Camacho V, Sizova M, Abouzian S, Duch J, Fernandez A, Estorch M, Carrio I. Digital versus analog PET/CT in patients with known or suspected liver metastases. NUCLEAR MEDICINE COMMUNICATIONS. 2021; 42(4). DOI:10.1097/MNM.0000000000001341. PMID:33306635. IF:1,698.
Hirschfeld CB, Dondi M, Pascual TNB, Mercuri M, Vitola J, Karthikeyan G, Better N, Mahmarian JJ, Bouyoucef SE, Hee-Seung Bom H, Lele V, Magboo VPC, Alexánderson E, Allam AH, Al-Mallah MH, Flotats A, Jerome S, Kaufmann PA, Luxenburg O, Underwood SR, Rehani MM, Vassileva J, Paez D, Einstein AJ; INCAPS Investigators Group. Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging: Findings From INCAPS. JACC-Cardiovascular Imaging. 2021;14(3):657-665. DOI:10.1016/j.jcmg.2020.06.029. PMID: 32828783. IF:16,051.
Hirschfeld CB, Mercuri M, Pascual TNB, Karthikeyan G, Vitola JV, Mahmarian JJ, Better N, Bouyoucef SE, Bom HHS, Lele V, Magboo VPC, Alexanderson E, Allam AH, Al MH, Dorbala S, Flotats A, Jerome S, Kaufmann PA, Luxenburg O, Shaw LJ, Underwood SR, Rehani MM, Paez D, Dondi M, Einstein AJ. Worldwide Variation in the Use of Nuclear Cardiology Camera Technology, Reconstruction Software, and Imaging Protocols. JACC-Cardiovascular Imaging. 2021; 14(9). DOI:10.1016/j.jcmg.2020.11.011. PMID:33454257. IF:16,051.
Lleo A, Zetterberg H, Pegueroles J, Karikari TK, Carmona M, Ashton NJ, Montal V, Barroeta I, Lantero J, Videla L, Altuna M, Benejam B, Fernandez S, Valldeneu S, Garzon D, Bejanin A, Iulita MF, Camacho V, Medrano S, Belbin O, Clarimon J, Lehmann S, Alcolea D, Blesa R, Blennow K, Fortea J. Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome. Nature Communications. 2021; 12(1):4304. DOI:10.1038/s41467-021-24319-x. PMID:34262030. IF:17,694.
McCabe JJ, Camps P, Giannotti N, McNulty JP, Coveney S, Murphy S, Barry M, Harbison J, Cronin S, Williams D, Horgan G, Dolan E, Cassidy T, McDonnell C, Kavanagh E, Foley S, Collins S, O’Connell M, Fernandez A, Delgado R, Marnane M, Marti J, Kelly PJ. Carotid Plaque Inflammation Imaged by PET and Prediction of Recurrent Stroke at 5 Years. NEUROLOGY. 2021; 97(23). DOI:10.1212/WNL.0000000000012909. PMID:34610991. IF:11,800.
Moya P, Leon AF, Corica ME, Marti VC, Lopez DA, Castellvi I, Corominas H. «The added value of 18f-FDG PET/CT in the assessment of onset and steroid resistant polimyalgia rheumatica». PLoS One. 2021; 16(9):e0255131. DOI:10.1371/journal.pone.0255131. PMID:34559822. IF:3,752.
Ovcaricek PP, Giovanella L, Gasset IC, Hindie E, Huellner MW, Luster M, Piccardo A, Weber T, Talbot JN, Verburg FA. The EANM practice guidelines for parathyroid imaging. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2021; 48(9). DOI:10.1007/s00259-021-05334-y. PMID:33839893. IF:10,057.
Pegueroles J, Montal V, Bejanin A, Vilaplana E, Aranha M, Santos MA, Alcolea D, Carrio I, Camacho V, Blesa R, Lleo A, Fortea J. AMYQ: An index to standardize quantitative amyloid load across PET tracers. Alzheimers & Dementia. 2021; 17(9). DOI:10.1002/alz.12317. PMID:33797846. IF:16,655.
Pons G, Abdelfattah U, Sarria J, Duch J, Masia J. Reverse Lymph Node Mapping Using Indocyanine Green Lymphography: A Step Forward in Minimizing Donor-Site Morbidity in Vascularized Lymph Node Transfer. PLASTIC AND RECONSTRUCTIVE SURGERY. 2021; 147(2). DOI:10.1097/PRS.0000000000007585. PMID:33565822. IF:5,169.
Sampedro F, Marin J, Martinez S, Camacho V, Lopez DA, Pagonabarraga J, Kulisevsky J. Extrastriatal SPECT-DAT uptake correlates with clinical and biological features of de novo Parkinson’s disease. NEUROBIOLOGY OF AGING. 2021; 97. DOI:10.1016/j.neurobiolaging.2020.10.016. PMID:33212336. IF:5,133.
Sampedro F, Stantonyonge N, Martínez-Horta S, Nan N, Camacho V, Chico A. Increased cerebral FDG-PET uptake in type 1 diabetes patients with impaired awareness of hypoglycaemia. JOURNAL OF NEUROENDOCRINOLOGY. 2021;33(1):e12910. DOI:10.1111/jne.12910. PMID: 33176042. IF:3,870.
Tian M, Watanabe Y, Kang KW, Murakami K, Chiti A, Carrio I, Civelek AC, Feng JH, Zhu YK, Zhou R, Wu S, Zhu JM, Ding Y, Zhang K, Zhang H, Mol Imaging TA. International consensus on the use of [F-18]-FDG PET/CT in pediatric patients affected by epilepsy. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2021; 48(12). DOI:10.1007/s00259-021-05524-8. PMID:34453559. IF:10,057.

GRUPOS ASOCIADOS

Medicina Nuclear

Principales líneas de investigación

Oncología

Investigación cardiovascular

Neuroimagen funcional

Retos

Nuevas técnicas de imagen molecular

Biomarcadores PET de imagen

Coordinación del grupo

Miembros

Publicaciones 2023

Publicaciones 2022

Publicaciones 2021

Principales líneas de investigación

Oncología

Investigación cardiovascular

Neuroimagen funcional

Retos

Nuevas técnicas de imagen molecular

Biomarcadores PET de imagen

Coordinación del grupo

Miembros

Publicaciones 2023

Publicaciones 2022

Publicaciones 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau