Sant Pau - Institut de Recerca

Principales líneas de investigación

Morbimortalidad, inflamación de bajo grado y riesgo cardiovascular en pacientes que han sufrido acromegalia o síndrome de Cushing.
ERCUSYN: Registro Europeo del Síndrome de Cushing. Iniciado con financiación de SANCO, Programa Público de Salud europeo.
Estudio de las características neurorradiológicas y neuropsicológicas del síndrome de Cushing y la acromegalia
Calidad de vida relacionada con la salud (CVRS) en el síndrome de Cushing y la acromegalia.
Etiología de la cardiopatía en la acromegalia y su relación con la composición del cuerpo.
Rol de los telómeros en las enfermedades endocrinas.

Retos

Investigar la correlación neuropsicológica, neuroradiológicos y clínica de los pacientes con hipercortisolismo endógeno (provocado por el síndrome de Cushing). Estudios similares para acromegalia.
Correlacionar el estado neuropsicológico y el ritmo circadiano del cortisol en pacientes con hipercortisolismo (síndrome de Cushing) y sin hipercortisolismo (adenomas de la hipófisis no funcionantes) en comparación con controles sanos.
Evaluar la morbilidad y mortalidad a largo plazo en pacientes que han sufrido síndrome de Cushing o acromegalia en los últimos 25 años.
Evaluar los factores que influyen en la calidad de vida de los pacientes con síndrome de Cushing y acromegalia.
Analizar y actualizar la base de datos europea de pacientes con síndrome de Cushing (ERCUSYN), que a finales de 2015 incluía más de 1.300 pacientes de 59 centros en 29 países.
Realizar análisis moleculares in vitro de adenomas de la hipófisis operados en el marco del estudio REMAH (Registro Molecular de Adenomas de la Hipófisis), patrocinado por la Sociedad Española de Endocrinología y Nutrición.
Investigar la correlación de la longitud de los telómeros y otros parámetros clínicos y bioquímicos en pacientes con síndrome de Cushing.

Coordinación del grupo

WEBB YOUDALE, SUSANA UAB
swebb@santpau.cat

Miembros

Asla Roca, Queralt FGS
Aulinas Maso, Anna FGS
Gil Ortega, Joan CIBERER
Mateu Salat, Manuel IR
Santos Vives, Alicia IR

Publicaciones 2023

(JIF 2022)

-Amodru V, Ferriere A, Tabarin A, Castinetti F, Tsagarakis S, Toth M, Feelders RA, Webb SM, Reincke M, Netea R, Kastelan D, Elenkova A, Maiter D, Ragnarsson O, Santos A, Valass E, ERCUSYN GRP. Cushing’s syndrome in the elderly: data from the European Registry on Cushing’s syndrome. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2023; 188(4). DOI:10.1093/ejendo/lvad008. PMID:36749009. IF:5,800 (Q1/3D). Document type: Article.

-Asla Q, Sarda H, Segui N, de Pinillos GM, Mazarico I, Capel I, Rives J, Suarez J, avila V, Torres MM, Saigi I, Palacios N, Urgell E, Webb SM, Fernandez M, Oriola J, Mora M, Tondo M, Aulinas A. Clinical and outcome comparison of genetically positive vs. negative patients in a large cohort of suspected familial hypocalciuric hypercalcemia. ENDOCRINE. 2023; DOI:10.1007/s12020-023-03560-y. PMID:38214877. IF:3,700 (Q3/6D). Document type: Article.

-Aulinas A, Muhammed M, Becker KR, Asanza E, Hauser K, Stern C, Gydus J, Holmes T, Murray HB, Breithaupt L, Micali N, Misra M, Eddy KT, Thomas JJ, Lawson EA. Oxytocin response to food intake in avoidant/restrictive food intake disorder. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2023; 189(2). DOI:10.1093/ejendo/lvad087. PMID:37474111. IF:5,800 (Q1/3D). Document type: Article.

-Biagetti B, Iglesias P, Villar R, Moure MD, Paja M, Araujo M, Ares J, Alvarez C, Vicente A, Guivernau EA, Novoa I, Perez FG, Camara R, Lecumberri B, Gomez CG, Bernabeu I, Manjon L, Gaztambide S, Cordido F, Webb SM, Menendez EL, Diez JJ, Simo R, Puig M. Mortality in Acromegaly Diagnosed in Older Individuals in Spain Is Higher in Women Compared to the General Spanish Population. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2023; 108(9). DOI:10.1210/clinem/dgad141. PMID:36916151. IF:5,800 (Q1/3D). Document type: Article.

-Gil J, Marques M, Valassi E, Serra G, Salinas I, Xifra G, Casano P, Carrato C, Biagetti B, Sesmilo G, Marcos J, Rodriguez H, Rueda A, Aulinas A, Blanco A, Hostalot C, Simó A, Munoz F, Rico M, Ibanez J, Cordero E, Webb SM, Jordà M, Puig M. Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors. Frontiers in Endocrinology. 2023; 14:1129213. DOI:10.3389/fendo.2023.1129213. PMID:37033229. IF:5,200 (Q1/3D). Document type: Article.

-Marques M, Gil J, Jordà M, Puig M. Predictors of Response to Treatment with First-Generation Somatostatin Receptor Ligands in Patients with Acromegaly. ARCHIVES OF MEDICAL RESEARCH. 2023; 54(8):102924. DOI:10.1016/j.arcmed.2023.102924. PMID:38042683. IF:7,700 (Q1/2D). Document type: Article.

-Marques M, Gil J, Valassi E, Hernández M, Biagetti B, Giménez O, Martínez S, Carrato C, Pons L, Villar R, Araujo M, Blanco C, Simón I, Simó A, Xifra G, Vázquez F, Pavón I, García R, Zavala R, Hanzu FA, Mora M, Aulinas A, Vilarrasa N, Librizzi S, Calatayud M, de Miguel P, Alvarez C, Picó A, Sampedro M, Salinas I, Fajardo C, Cámara R, Bernabéu I, Jordà M, Webb SM, Marazuela M, Puig M. Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly. Frontiers in Endocrinology. 2023; 14:1269787. DOI:10.3389/fendo.2023.1269787. PMID:38027102. IF:5,200 (Q1/3D). Document type: Article.

-O’Toole D, Kunz PL, Webb SM, Goldstein G, Khawaja S, McDonnell M, Boiziau S, Gueguen D, Houchard A, Jr A, Prebtani A. PRESTO 2: An International Survey to Evaluate Patients’ Injection Experiences with the Latest Devices/Formulations of Long-Acting Somatostatin Analog Therapies for Neuroendocrine Tumors or Acromegaly. ADVANCES IN THERAPY. 2023; 40(2). DOI:10.1007/s12325-022-02360-6. PMID:36502449. IF:3,800 (Q2/4D). Document type: Article.

-Santos A, Nalin C, Bortolotti G, Dominguez E, Daniela G, Cortesi L, Pagani M, Momblan M, Gich I, Webb SM, Trevisan R, Resmini E. The effect of mindfulness therapy in acromegaly, a pilot study. CLINICAL ENDOCRINOLOGY. 2023; 98(3). DOI:10.1111/cen.14844. PMID:36342059. IF:3,200 (Q3/7D). Document type: Article.

-Valassi E, Manichanh C, Amodru V, Fernández PG, Gaztambide S, Yanez F, Martel L, Puig M, Webb SM. Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk. Frontiers in Endocrinology. 2023; 14:1074757. DOI:10.3389/fendo.2023.1074757. PMID:37342265. IF:5,200 (Q1/3D). Document type: Article.

-Webb SM, Valassi E. Quality of life in pituitary diseases. Endocrinologia Diabetes y Nutricion. 2023; 70(7). DOI:10.1016/j.endien.2023.03.021. PMID:37516611. IF:1,900 (Q4/9D). Document type: Editorial Material.

Publicaciones 2022

(JIF 2022)

Aibar JA, Oladotun M, Asencio C, Valassi E, Webb S, Gras JR, Monserrat J, Ribo PT, Munoz F. Complication Rates after Endoscopic Transsphenoidal Surgery for ACTH-Secreting Pituitary Adenomas: A Comparative Analysis with GH and Nonfunctioning Adenomas. Journal of Neurological Surgery Part B-Skull Base. 2022; 83. DOI:10.1055/s-0041-1725029. PMID:35832977. IF:0,9 (Q4/9D). Document type: Article.
Arendt J, Aulinas A.2022 Oct 30. Physiology of the Pineal Gland and Melatonin.In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–.PMID: 31841296 Free Books & Documents. Document type: Review.
Asla Q, Sarda H, Lerma E, Hanzu FA, Rodrigo MT, Urgell E, Perez JI, Webb SM, Aulinas A. 11-Deoxycorticosterone Producing Adrenal Hyperplasia as a Very Unusual Cause of Endocrine Hypertension: Case Report and Systematic Review of the Literature. Frontiers in Endocrinology. 2022; 13:846865. DOI:10.3389/fendo.2022.846865. PMID:35432204. IF:5,2 (Q1/3D). Document type: Review.
Aulinas A, Stantonyonge N, Garcia A, Adelantado JM, Medina C, Espinos JJ, Lopez E, Webb SM, Corcoy R. Hypopituitarism and pregnancy: clinical characteristics, management and pregnancy outcome. 2022; 25(2). DOI:10.1007/s11102-021-01196-7. PMID:34846622. IF:3,8 (Q2/5D). Document type: Article.
Biagetti B, Iglesias P, Villar R, Moure MD, Paja M, Araujo M, Ares J, Alvarez C, Vicente A, Guivernau EA, Novoa I, Perez FG, Camara R, Lecumberri B, Gomez CG, Bernabeu I, Manjon L, Gaztambide S, Cordido F, Webb SM, Menendez EL, Diez JJ, Simo R, Puig M. Factors associated with therapeutic response in acromegaly diagnosed in the elderly in Spain. Frontiers in Endocrinology. 2022; 13:984877. DOI:10.3389/fendo.2022.984877. PMID:36187107. IF:5,2 (Q1/3D). Document type: Article.
Gil J, Marques M, Sampedro M, Webb SM, Serra G, Salinas I, Blanco A, Valassi E, Carrato C, Pico A, Garcia A, Martel L, Sardon T, Simo A, Biagetti B, Villabona C, Camara R, Fajardo C, Alvarez C, Lamas C, Alvarez CV, Bernabeu I, Marazuela M, Jorda M, Puig M. Data mining analyses for precision medicine in acromegaly: a proof of concept. Scientific Reports. 2022; 12(1):8979. DOI:10.1038/s41598-022-12955-2. PMID:35643771. IF:4,6 (Q2/3D). Document type: Article.
Gil J, Marques M, Valassi E, Garcia A, Serra G, Hostalot C, Fajardo C, Carrato C, Bernabeu I, Marazuela M, Rodriguez H, Camara R, Salinas I, Lamas C, Biagetti B, Simo A, Webb SM, Pico A, Jorda M, Puig M, REMAH I. Implications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response. Biomedicines. 2022; 10(2):460. DOI:10.3390/biomedicines10020460. PMID:35203668. IF:4,7 (Q1/3D). Document type: Article.
Luque J, Mendes I, Gomez B, Morte B, de Heredia ML, Herreras E, Corrochano V, Bueren J, Gallano P, Artuch R, Fillat C, Perez LA, Montoliu L, Carracedo A, Millan JM, Webb SM, Palau F, Lapunzina P. CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative. CLINICAL GENETICS. 2022; 101(5-6). DOI:10.1111/cge.14113. PMID:35060122. IF:3,5 (Q2/4D). Document type: Review.
Pardo JC, de Porras VR, Gil J, Font A, Puig M, Jorda M. Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer. 2022; 14(4):851. DOI:10.3390/nu14040851. PMID:35215499. IF:5,9 (Q1/2D). Document type: Article.
Pupier E, Santos A, Etchamendy N, Lavielle A, Ferriere A, Marighetto A, Resmini E, Cota D, Webb SM, Tabarin A. Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission. Frontiers in Endocrinology. 2022; 13:934347. DOI:10.3389/fendo.2022.934347. PMID:36004342. IF:5,2 (Q1/3D). Document type: Article.
Salvatori R, Maffei P, Webb SM, Brue T, Loftus J, Valluri SR, Gomez R, Wajnrajch MP, Fleseriu M. Patient-reported outcomes in patients with acromegaly treated with pegvisomant in the ACROSTUDY extension: A real-world experience. 2022; 25(3). DOI:10.1007/s11102-022-01206-2. PMID:35022929. IF:3,8 (Q2/5D). Document type: Article.
Santos A, Crespo I, Perez A, Beltran M, Puebla M, Garcia J. Attachment-Based Compassion Therapy for Reducing Anxiety and Depression in Fibromyalgia. International Journal of Environmental Research and Public Health. 2022; 19(13):8152. DOI:10.3390/ijerph19138152. PMID:35805810. Document type: Article.
Tritos NA, Fazeli PK, McCormack A, Mallea SM, Pineyro MM, Christ M, Frara S, Labadzhyan A, Ioachimescu AG, Shimon I, Takahashi Y, Gurnell M, Fleseriu M, Valassi E, Wierman ME. Pituitary Society Delphi Survey: An international perspective on endocrine management of patients undergoing transsphenoidal surgery for pituitary adenomas. 2022; 25(1). DOI:10.1007/s11102-021-01170-3. PMID:34283370. IF:3,8 (Q2/5D). Document type: Article.
Valassi E, Castinetti F, Ferriere A, Tsagarakis S, Feelders RA, Netea RT, Droste M, Strasburger CJ, Maiter D, Kastelan D, Chanson P, Webb SM, Demtröder F, Pirags V, Chabre O, Franz H, Santos A, Reincke M. Corticotroph tumor progression after bilateral adrenalectomy: data from ERCUSYN. ENDOCRINE-RELATED CANCER. 2022; 29(12). DOI:10.1530/ERC-22-0074. PMID:36197784. IF:3,9 (Q2/5D). Document type: Article.
van FM, Kaya M, Pelsma ICM, Cannegieter SC, Huisman MV, van BJM, Feelders RA, Stochholm K, Fliers E, Castinetti F, Brue T, Bertherat J, Scaroni C, Colao A, Giordano R, Druce MR, Beckers A, Spranger J, Driessens N, Maiter D, Feldt U, Feelders R, Webb SM, Dattani M, Husebye E, Zilaitiene B, Gaztambide S, Gatto F, Ferone D, Persani L, Chiodini I, Höybye C, Pereira AM, Biermasz NR, et al. Current clinical practice for thromboprophylaxis management in patients with Cushing’s syndrome across reference centers of the European Reference Network on Rare Endocrine Conditions (Endo-ERN). Orphanet Journal of Rare Diseases. 2022; 17(1):178. DOI:10.1186/s13023-022-02320-x. PMID:35505430. IF:3,7 (Q2/4D). Document type: Article.
Webb SM, Kristensen J, Nordenstrom A, Vitali D, Amodru V, Wiehe LK, Bolz M. Patient journey experiences may contribute to improve healthcare for patients with rare endocrine diseases. Endocrine Connections. 2022; 11(12):e220385. DOI:10.1530/EC-22-0385. PMID:36228311. IF:2,9 (Q3/8D). Document type: Review.
Webb SM, Valassi E. Consequences of Cushing’s Syndrome: Health Versus Personal Costs. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2022; 107(9). DOI:10.1210/clinem/dgac269. PMID:35511590. IF:5,8 (Q1/3D). Document type: Editorial material.
Webb SM, Valassi E. Quality of life impairment after a diagnosis of Cushing’s syndrome. 2022; 25(5)DOI:10.1007/s11102-022-01245-9. PMID:35767164. IF:3,8 (Q2/5D). Document type: Article.

Publicaciones 2021

Aulinas A, Stantonyonge N, Garcia A, Adelantado JM, Medina C, Espinos JJ, Lopez E, Webb SM, Corcoy R. Hypopituitarism and pregnancy: clinical characteristics, management and pregnancy outcome. Pituitary. 2022; 25(2). DOI:10.1007/s11102-021-01196-7. PMID:34846622. IF:3,599.
Biagetti B, Aulinas A, Casteras A, Pérez-Hoyos S, Simó R. HOMA-IR in acromegaly: a systematic review and meta-analysis. Pituitary. 2021;24(2):146-158. DOI:10.1007/s11102-020-01092-6. PMID: 33085039. IF:3,599.
Calderon-Mediavilla M, Vila-Badia R, Dolz M, Butjosa A, Barajas A, Del Cacho N, Sánchez B, Pardo M, Baños I, Usall J, Ochoa S; GENIPE Group; PROFEP Group [Santos A, Nuñez C]. Depressive symptoms and their relationship with negative and other psychotic symptoms in early onset psychosis. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY. 2021;30(9):1383-1390. DOI:10.1007/s00787-020-01618-0. PMID: 32865655. IF:5,349.
de La Piscina IM, Najera NP, Rica I, Gaztambide S, Webb SM, Santos A, Moure MD, Fano MP, Hernandez MI, Chueca MJ, Hernandez LC, Soto A, Valdes N, Castano L, Hispanic A. Clinical and genetic characteristics in patients under 30 years with sporadic pituitary adenomas. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 185(4). DOI:10.1530/EJE-21-0075. PMID:34313605. IF:6,558.
Fleseriu M, Auchus R, Bancos I, Ben A, Bertherat J, Biermasz NR, Boguszewski CL, Bronstein MD, Buchfelder M, Carmichael JD, Casanueva FF, Castinetti F, Chanson P, Findling J, Gadelha M, Geer EB, Giustina A, Grossman A, Gurnell M, Ho K, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Kelly DF, Lacroix A, McCormack A, Melmed S, et al. [Valassi E, Webb SM]. Consensus on diagnosis and management of Cushing’s disease: a guideline update. Lancet Diabetes & Endocrinology. 2021; 9(12). DOI:10.1016/S2213-8587(21)00235-7. PMID:34687601. IF:44,867.
Gil J, Marques M, Jorda M, Fajardo C, Garcia A, Sampedro M, Serra G, Salinas I, Blanco A, Valassi E, Sesmilo G, Carrato C, Camara R, Lamas C, Casano P, Alvarez CV, Bernabeu I, Webb SM, Pico A, Marazuela M, Puig M, Santos A, Vida JI. Molecular determinants of enhanced response to somatostatin receptor ligands after debulking in large GH-producing adenomas. CLINICAL ENDOCRINOLOGY. 2021; 94(5). DOI:10.1111/cen.14339. PMID:32978826. IF:3,523.
Iglesias P, Nocete I, Rodriguez MDM, Venegas E, Ares J, Biagetti B, Berrocal VR, Guerrero F, Vicente A, Villar R, Cordido F, Paja M, Glerean M, Rivera NG, Fuentes ED, Blanco C, Alvarez C, Martin T, Webb SM, Bernabeu I, Villabona C, Soto A, Gaztambide S, Diez JJ. Craniopharyngioma in the Elderly: A Multicenter and Nationwide Study in Spain. NEUROENDOCRINOLOGY. 2021; 111(10). DOI:10.1159/000512161. PMID:33040060. IF:5,135.
Iglesias P, Peiro I, Biagetti B, Paja M, Cobo DA, Gomez CG, Mateu M, Genua I, Majem M, Riudavets M, Gavira J, Lamas C, Pombo AF, Guerrero F, Villabona C, Agricola JMC, Webb SM, Diez JJ. Immunotherapy-induced isolated ACTH deficiency in cancer therapy. ENDOCRINE-RELATED CANCER. 2021; 28(12). DOI:10.1530/ERC-21-0228. PMID:34609950. IF:5,900.
Lee RS, Zandi PP, Santos A, Aulinas A, Carey JL, Webb SM, McCaul ME, Resmini E, Wand GS. Cross-species Association Between Telomere Length and Glucocorticoid Exposure. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2021; 106(12). DOI:10.1210/clinem/dgab519. PMID:34265046. IF:6,134.
Losa M, Resmini E, Barzaghi LR, Albano L, Bailo M, Webb SM, Mortini P. Resistance to first-generation somatostatin receptor ligands does not impair the results of gamma knife radiosurgery in acromegaly. CLINICAL ENDOCRINOLOGY. 2021; 95(6). DOI:10.1111/cen.14547. PMID:34219264. IF:3,523.
Luger A, Broersen L, Biermasz NR, Biller BMK, Buchfelder M, Chanson P, Jorgensen J, Kelestimur F, Llahana S, Maiter D, Mintziori G, Petraglia F, Verkauskiene R, Webb SM, Dekkers OM. ESE Clinical Practice Guideline on functioning and nonfunctioning pituitary adenomas in pregnancy. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 185(3). DOI:10.1530/EJE-21-0462. PMID:34425558. IF:6,558.
Martel L, Alonso A, Bascunana H, Diaz J, Llauger J, Nunez C, Montesinos P, Webb SM, Valassi E. Prevalence of sarcopenia after remission of hypercortisolism and its impact on HRQoL. CLINICAL ENDOCRINOLOGY. 2021; 95(5). DOI:10.1111/cen.14568. PMID:34323296. IF:3,523.
Martel L, Alonso J, Bascunana H, Diaz J, Llauger J, Nunez C, Montesinos P, Webb SM, Valassi E. Intramuscular fatty infiltration and physical function in controlled acromegaly. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 185(1). DOI:10.1530/EJE-21-0209. PMID:33950861. IF:6,558.
Martel L, Jorgensen J, Korbonits M, Johannsson G, Webb SM, ESE AGHD Study Pan GRP. ESE audit on management of adult growth hormone deficiency in clinical practice. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 184(2). DOI:10.1530/EJE-20-1180. PMID:33320830. IF:6,558.
Mc M, Crespo I, Webb SM, Valassi E. Quality of life in Cushing’s syndrome. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM. 2021; 35(1):101505. DOI:10.1016/j.beem.2021.101505. IF:5,667.
Nan MN, Roig R, Martinez S, Rives J, Urgell E, Espinos JJ, Tirado M, Carreras G, Aulinas A, Webb SM, Corcoy R, Blanco F, Tondo M. Comprehensive Genetic Testing of CYP21A2: A Retrospective Analysis in Patients with Suspected Congenital Adrenal Hyperplasia. Journal of Clinical Medicine. 2021; 10(6):1183. DOI:10.3390/jcm10061183. PMID:33809035. IF:4,964.
Reincke M, Albani A, Assie G, Bancos I, Brue T, Buchfelder M, Chabre O, Ceccato F, Daniele A, Detomas M, Di G, Elenkova A, Findling J, Grossman AB, Gomez CE, Heaney AP, Honegger J, Karavitaki N, Lacroix A, Laws ER, Losa M, Murakami M, Newell J, Giraldi FP, Perez LG, Pivonello R, Rainey WE, Sbiera S, Schopohl J, Stratakis CA, Theodoropoulou M, et al. [Valassi E]. Corticotroph tumor progression after bilateral adrenalectomy (Nelson’s syndrome): systematic review and expert consensus recommendations. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 184(2). DOI:10.1530/EJE-20-1088. PMID:33444221. IF:6,558.
Santos A, Webb SM, Resmini E. Psychological complications of Cushing’s syndrome. Current Opinion in Endocrinology Diabetes and Obesity. 2021; 28(3). DOI:10.1097/MED.0000000000000633. PMID:33764929. IF:3,626.
Valassi E. Pituitary disease and pregnancy. Endocrinologia Diabetes y Nutricion. 2021; 68(3). DOI:10.1016/j.endinu.2020.07.007. PMID:33358152. IF:1,833.
Webb SM, Kristensen J, Vitali D, van S, van C, Santos A, Nordenstrom A. EndoERN patient survey on their perception of health care experience and of unmet needs for rare endocrine diseases. ENDOCRINE. 2021; 71(3). DOI:10.1007/s12020-021-02625-0. PMID:33544353. IF:3,925.

Presentación

Principales líneas de investigación

Morbimortalidad, inflamación de bajo grado y riesgo cardiovascular en pacientes que han sufrido acromegalia o síndrome de Cushing.
ERCUSYN: Registro Europeo del Síndrome de Cushing. Iniciado con financiación de SANCO, Programa Público de Salud europeo.
Estudio de las características neurorradiológicas y neuropsicológicas del síndrome de Cushing y la acromegalia
Calidad de vida relacionada con la salud (CVRS) en el síndrome de Cushing y la acromegalia.
Etiología de la cardiopatía en la acromegalia y su relación con la composición del cuerpo.
Rol de los telómeros en las enfermedades endocrinas.

Retos

Investigar la correlación neuropsicológica, neuroradiológicos y clínica de los pacientes con hipercortisolismo endógeno (provocado por el síndrome de Cushing). Estudios similares para acromegalia.
Correlacionar el estado neuropsicológico y el ritmo circadiano del cortisol en pacientes con hipercortisolismo (síndrome de Cushing) y sin hipercortisolismo (adenomas de la hipófisis no funcionantes) en comparación con controles sanos.
Evaluar la morbilidad y mortalidad a largo plazo en pacientes que han sufrido síndrome de Cushing o acromegalia en los últimos 25 años.
Evaluar los factores que influyen en la calidad de vida de los pacientes con síndrome de Cushing y acromegalia.
Analizar y actualizar la base de datos europea de pacientes con síndrome de Cushing (ERCUSYN), que a finales de 2015 incluía más de 1.300 pacientes de 59 centros en 29 países.
Realizar análisis moleculares in vitro de adenomas de la hipófisis operados en el marco del estudio REMAH (Registro Molecular de Adenomas de la Hipófisis), patrocinado por la Sociedad Española de Endocrinología y Nutrición.
Investigar la correlación de la longitud de los telómeros y otros parámetros clínicos y bioquímicos en pacientes con síndrome de Cushing.

Equipo

Coordinación del grupo

WEBB YOUDALE, SUSANA UAB
swebb@santpau.cat

Miembros

Asla Roca, Queralt FGS
Aulinas Maso, Anna FGS
Gil Ortega, Joan CIBERER
Mateu Salat, Manuel IR
Santos Vives, Alicia IR

Producción científica

Publicaciones 2023

(JIF 2022)

Publicaciones 2022

(JIF 2022)

Aibar JA, Oladotun M, Asencio C, Valassi E, Webb S, Gras JR, Monserrat J, Ribo PT, Munoz F. Complication Rates after Endoscopic Transsphenoidal Surgery for ACTH-Secreting Pituitary Adenomas: A Comparative Analysis with GH and Nonfunctioning Adenomas. Journal of Neurological Surgery Part B-Skull Base. 2022; 83. DOI:10.1055/s-0041-1725029. PMID:35832977. IF:0,9 (Q4/9D). Document type: Article.
Arendt J, Aulinas A.2022 Oct 30. Physiology of the Pineal Gland and Melatonin.In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–.PMID: 31841296 Free Books & Documents. Document type: Review.
Asla Q, Sarda H, Lerma E, Hanzu FA, Rodrigo MT, Urgell E, Perez JI, Webb SM, Aulinas A. 11-Deoxycorticosterone Producing Adrenal Hyperplasia as a Very Unusual Cause of Endocrine Hypertension: Case Report and Systematic Review of the Literature. Frontiers in Endocrinology. 2022; 13:846865. DOI:10.3389/fendo.2022.846865. PMID:35432204. IF:5,2 (Q1/3D). Document type: Review.
Aulinas A, Stantonyonge N, Garcia A, Adelantado JM, Medina C, Espinos JJ, Lopez E, Webb SM, Corcoy R. Hypopituitarism and pregnancy: clinical characteristics, management and pregnancy outcome. 2022; 25(2). DOI:10.1007/s11102-021-01196-7. PMID:34846622. IF:3,8 (Q2/5D). Document type: Article.
Biagetti B, Iglesias P, Villar R, Moure MD, Paja M, Araujo M, Ares J, Alvarez C, Vicente A, Guivernau EA, Novoa I, Perez FG, Camara R, Lecumberri B, Gomez CG, Bernabeu I, Manjon L, Gaztambide S, Cordido F, Webb SM, Menendez EL, Diez JJ, Simo R, Puig M. Factors associated with therapeutic response in acromegaly diagnosed in the elderly in Spain. Frontiers in Endocrinology. 2022; 13:984877. DOI:10.3389/fendo.2022.984877. PMID:36187107. IF:5,2 (Q1/3D). Document type: Article.
Gil J, Marques M, Sampedro M, Webb SM, Serra G, Salinas I, Blanco A, Valassi E, Carrato C, Pico A, Garcia A, Martel L, Sardon T, Simo A, Biagetti B, Villabona C, Camara R, Fajardo C, Alvarez C, Lamas C, Alvarez CV, Bernabeu I, Marazuela M, Jorda M, Puig M. Data mining analyses for precision medicine in acromegaly: a proof of concept. Scientific Reports. 2022; 12(1):8979. DOI:10.1038/s41598-022-12955-2. PMID:35643771. IF:4,6 (Q2/3D). Document type: Article.
Gil J, Marques M, Valassi E, Garcia A, Serra G, Hostalot C, Fajardo C, Carrato C, Bernabeu I, Marazuela M, Rodriguez H, Camara R, Salinas I, Lamas C, Biagetti B, Simo A, Webb SM, Pico A, Jorda M, Puig M, REMAH I. Implications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response. Biomedicines. 2022; 10(2):460. DOI:10.3390/biomedicines10020460. PMID:35203668. IF:4,7 (Q1/3D). Document type: Article.
Luque J, Mendes I, Gomez B, Morte B, de Heredia ML, Herreras E, Corrochano V, Bueren J, Gallano P, Artuch R, Fillat C, Perez LA, Montoliu L, Carracedo A, Millan JM, Webb SM, Palau F, Lapunzina P. CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative. CLINICAL GENETICS. 2022; 101(5-6). DOI:10.1111/cge.14113. PMID:35060122. IF:3,5 (Q2/4D). Document type: Review.
Pardo JC, de Porras VR, Gil J, Font A, Puig M, Jorda M. Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer. 2022; 14(4):851. DOI:10.3390/nu14040851. PMID:35215499. IF:5,9 (Q1/2D). Document type: Article.
Pupier E, Santos A, Etchamendy N, Lavielle A, Ferriere A, Marighetto A, Resmini E, Cota D, Webb SM, Tabarin A. Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission. Frontiers in Endocrinology. 2022; 13:934347. DOI:10.3389/fendo.2022.934347. PMID:36004342. IF:5,2 (Q1/3D). Document type: Article.
Salvatori R, Maffei P, Webb SM, Brue T, Loftus J, Valluri SR, Gomez R, Wajnrajch MP, Fleseriu M. Patient-reported outcomes in patients with acromegaly treated with pegvisomant in the ACROSTUDY extension: A real-world experience. 2022; 25(3). DOI:10.1007/s11102-022-01206-2. PMID:35022929. IF:3,8 (Q2/5D). Document type: Article.
Santos A, Crespo I, Perez A, Beltran M, Puebla M, Garcia J. Attachment-Based Compassion Therapy for Reducing Anxiety and Depression in Fibromyalgia. International Journal of Environmental Research and Public Health. 2022; 19(13):8152. DOI:10.3390/ijerph19138152. PMID:35805810. Document type: Article.
Tritos NA, Fazeli PK, McCormack A, Mallea SM, Pineyro MM, Christ M, Frara S, Labadzhyan A, Ioachimescu AG, Shimon I, Takahashi Y, Gurnell M, Fleseriu M, Valassi E, Wierman ME. Pituitary Society Delphi Survey: An international perspective on endocrine management of patients undergoing transsphenoidal surgery for pituitary adenomas. 2022; 25(1). DOI:10.1007/s11102-021-01170-3. PMID:34283370. IF:3,8 (Q2/5D). Document type: Article.
Valassi E, Castinetti F, Ferriere A, Tsagarakis S, Feelders RA, Netea RT, Droste M, Strasburger CJ, Maiter D, Kastelan D, Chanson P, Webb SM, Demtröder F, Pirags V, Chabre O, Franz H, Santos A, Reincke M. Corticotroph tumor progression after bilateral adrenalectomy: data from ERCUSYN. ENDOCRINE-RELATED CANCER. 2022; 29(12). DOI:10.1530/ERC-22-0074. PMID:36197784. IF:3,9 (Q2/5D). Document type: Article.
van FM, Kaya M, Pelsma ICM, Cannegieter SC, Huisman MV, van BJM, Feelders RA, Stochholm K, Fliers E, Castinetti F, Brue T, Bertherat J, Scaroni C, Colao A, Giordano R, Druce MR, Beckers A, Spranger J, Driessens N, Maiter D, Feldt U, Feelders R, Webb SM, Dattani M, Husebye E, Zilaitiene B, Gaztambide S, Gatto F, Ferone D, Persani L, Chiodini I, Höybye C, Pereira AM, Biermasz NR, et al. Current clinical practice for thromboprophylaxis management in patients with Cushing’s syndrome across reference centers of the European Reference Network on Rare Endocrine Conditions (Endo-ERN). Orphanet Journal of Rare Diseases. 2022; 17(1):178. DOI:10.1186/s13023-022-02320-x. PMID:35505430. IF:3,7 (Q2/4D). Document type: Article.
Webb SM, Kristensen J, Nordenstrom A, Vitali D, Amodru V, Wiehe LK, Bolz M. Patient journey experiences may contribute to improve healthcare for patients with rare endocrine diseases. Endocrine Connections. 2022; 11(12):e220385. DOI:10.1530/EC-22-0385. PMID:36228311. IF:2,9 (Q3/8D). Document type: Review.
Webb SM, Valassi E. Consequences of Cushing’s Syndrome: Health Versus Personal Costs. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2022; 107(9). DOI:10.1210/clinem/dgac269. PMID:35511590. IF:5,8 (Q1/3D). Document type: Editorial material.
Webb SM, Valassi E. Quality of life impairment after a diagnosis of Cushing’s syndrome. 2022; 25(5)DOI:10.1007/s11102-022-01245-9. PMID:35767164. IF:3,8 (Q2/5D). Document type: Article.

Publicaciones 2021

Aulinas A, Stantonyonge N, Garcia A, Adelantado JM, Medina C, Espinos JJ, Lopez E, Webb SM, Corcoy R. Hypopituitarism and pregnancy: clinical characteristics, management and pregnancy outcome. Pituitary. 2022; 25(2). DOI:10.1007/s11102-021-01196-7. PMID:34846622. IF:3,599.
Biagetti B, Aulinas A, Casteras A, Pérez-Hoyos S, Simó R. HOMA-IR in acromegaly: a systematic review and meta-analysis. Pituitary. 2021;24(2):146-158. DOI:10.1007/s11102-020-01092-6. PMID: 33085039. IF:3,599.
Calderon-Mediavilla M, Vila-Badia R, Dolz M, Butjosa A, Barajas A, Del Cacho N, Sánchez B, Pardo M, Baños I, Usall J, Ochoa S; GENIPE Group; PROFEP Group [Santos A, Nuñez C]. Depressive symptoms and their relationship with negative and other psychotic symptoms in early onset psychosis. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY. 2021;30(9):1383-1390. DOI:10.1007/s00787-020-01618-0. PMID: 32865655. IF:5,349.
de La Piscina IM, Najera NP, Rica I, Gaztambide S, Webb SM, Santos A, Moure MD, Fano MP, Hernandez MI, Chueca MJ, Hernandez LC, Soto A, Valdes N, Castano L, Hispanic A. Clinical and genetic characteristics in patients under 30 years with sporadic pituitary adenomas. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 185(4). DOI:10.1530/EJE-21-0075. PMID:34313605. IF:6,558.
Fleseriu M, Auchus R, Bancos I, Ben A, Bertherat J, Biermasz NR, Boguszewski CL, Bronstein MD, Buchfelder M, Carmichael JD, Casanueva FF, Castinetti F, Chanson P, Findling J, Gadelha M, Geer EB, Giustina A, Grossman A, Gurnell M, Ho K, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Kelly DF, Lacroix A, McCormack A, Melmed S, et al. [Valassi E, Webb SM]. Consensus on diagnosis and management of Cushing’s disease: a guideline update. Lancet Diabetes & Endocrinology. 2021; 9(12). DOI:10.1016/S2213-8587(21)00235-7. PMID:34687601. IF:44,867.
Gil J, Marques M, Jorda M, Fajardo C, Garcia A, Sampedro M, Serra G, Salinas I, Blanco A, Valassi E, Sesmilo G, Carrato C, Camara R, Lamas C, Casano P, Alvarez CV, Bernabeu I, Webb SM, Pico A, Marazuela M, Puig M, Santos A, Vida JI. Molecular determinants of enhanced response to somatostatin receptor ligands after debulking in large GH-producing adenomas. CLINICAL ENDOCRINOLOGY. 2021; 94(5). DOI:10.1111/cen.14339. PMID:32978826. IF:3,523.
Iglesias P, Nocete I, Rodriguez MDM, Venegas E, Ares J, Biagetti B, Berrocal VR, Guerrero F, Vicente A, Villar R, Cordido F, Paja M, Glerean M, Rivera NG, Fuentes ED, Blanco C, Alvarez C, Martin T, Webb SM, Bernabeu I, Villabona C, Soto A, Gaztambide S, Diez JJ. Craniopharyngioma in the Elderly: A Multicenter and Nationwide Study in Spain. NEUROENDOCRINOLOGY. 2021; 111(10). DOI:10.1159/000512161. PMID:33040060. IF:5,135.
Iglesias P, Peiro I, Biagetti B, Paja M, Cobo DA, Gomez CG, Mateu M, Genua I, Majem M, Riudavets M, Gavira J, Lamas C, Pombo AF, Guerrero F, Villabona C, Agricola JMC, Webb SM, Diez JJ. Immunotherapy-induced isolated ACTH deficiency in cancer therapy. ENDOCRINE-RELATED CANCER. 2021; 28(12). DOI:10.1530/ERC-21-0228. PMID:34609950. IF:5,900.
Lee RS, Zandi PP, Santos A, Aulinas A, Carey JL, Webb SM, McCaul ME, Resmini E, Wand GS. Cross-species Association Between Telomere Length and Glucocorticoid Exposure. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2021; 106(12). DOI:10.1210/clinem/dgab519. PMID:34265046. IF:6,134.
Losa M, Resmini E, Barzaghi LR, Albano L, Bailo M, Webb SM, Mortini P. Resistance to first-generation somatostatin receptor ligands does not impair the results of gamma knife radiosurgery in acromegaly. CLINICAL ENDOCRINOLOGY. 2021; 95(6). DOI:10.1111/cen.14547. PMID:34219264. IF:3,523.
Luger A, Broersen L, Biermasz NR, Biller BMK, Buchfelder M, Chanson P, Jorgensen J, Kelestimur F, Llahana S, Maiter D, Mintziori G, Petraglia F, Verkauskiene R, Webb SM, Dekkers OM. ESE Clinical Practice Guideline on functioning and nonfunctioning pituitary adenomas in pregnancy. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 185(3). DOI:10.1530/EJE-21-0462. PMID:34425558. IF:6,558.
Martel L, Alonso A, Bascunana H, Diaz J, Llauger J, Nunez C, Montesinos P, Webb SM, Valassi E. Prevalence of sarcopenia after remission of hypercortisolism and its impact on HRQoL. CLINICAL ENDOCRINOLOGY. 2021; 95(5). DOI:10.1111/cen.14568. PMID:34323296. IF:3,523.
Martel L, Alonso J, Bascunana H, Diaz J, Llauger J, Nunez C, Montesinos P, Webb SM, Valassi E. Intramuscular fatty infiltration and physical function in controlled acromegaly. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 185(1). DOI:10.1530/EJE-21-0209. PMID:33950861. IF:6,558.
Martel L, Jorgensen J, Korbonits M, Johannsson G, Webb SM, ESE AGHD Study Pan GRP. ESE audit on management of adult growth hormone deficiency in clinical practice. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 184(2). DOI:10.1530/EJE-20-1180. PMID:33320830. IF:6,558.
Mc M, Crespo I, Webb SM, Valassi E. Quality of life in Cushing’s syndrome. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM. 2021; 35(1):101505. DOI:10.1016/j.beem.2021.101505. IF:5,667.
Nan MN, Roig R, Martinez S, Rives J, Urgell E, Espinos JJ, Tirado M, Carreras G, Aulinas A, Webb SM, Corcoy R, Blanco F, Tondo M. Comprehensive Genetic Testing of CYP21A2: A Retrospective Analysis in Patients with Suspected Congenital Adrenal Hyperplasia. Journal of Clinical Medicine. 2021; 10(6):1183. DOI:10.3390/jcm10061183. PMID:33809035. IF:4,964.
Reincke M, Albani A, Assie G, Bancos I, Brue T, Buchfelder M, Chabre O, Ceccato F, Daniele A, Detomas M, Di G, Elenkova A, Findling J, Grossman AB, Gomez CE, Heaney AP, Honegger J, Karavitaki N, Lacroix A, Laws ER, Losa M, Murakami M, Newell J, Giraldi FP, Perez LG, Pivonello R, Rainey WE, Sbiera S, Schopohl J, Stratakis CA, Theodoropoulou M, et al. [Valassi E]. Corticotroph tumor progression after bilateral adrenalectomy (Nelson’s syndrome): systematic review and expert consensus recommendations. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 184(2). DOI:10.1530/EJE-20-1088. PMID:33444221. IF:6,558.
Santos A, Webb SM, Resmini E. Psychological complications of Cushing’s syndrome. Current Opinion in Endocrinology Diabetes and Obesity. 2021; 28(3). DOI:10.1097/MED.0000000000000633. PMID:33764929. IF:3,626.
Valassi E. Pituitary disease and pregnancy. Endocrinologia Diabetes y Nutricion. 2021; 68(3). DOI:10.1016/j.endinu.2020.07.007. PMID:33358152. IF:1,833.
Webb SM, Kristensen J, Vitali D, van S, van C, Santos A, Nordenstrom A. EndoERN patient survey on their perception of health care experience and of unmet needs for rare endocrine diseases. ENDOCRINE. 2021; 71(3). DOI:10.1007/s12020-021-02625-0. PMID:33544353. IF:3,925.

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Publicaciones 2021

Principales líneas de investigación

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Publicaciones 2022

Publicaciones 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau