Sant Pau - Institut de Recerca

Principales líneas de investigación

Predictores genéticos y moleculares de la respuesta al cáncer de cabeza y cuello.
Mecanismos moleculares de la inflamación en cáncer de cabeza y cuello.
Cirugía endoscópica nasosinusal: innovaciones técnicas en la base del cráneo.
Oído interno: aspectos relacionados con la sordera severa, implantes cocleares y cirugía de tumores otoneurológica.

Retos

Promover la investigación clínica y traslacional en cáncer de cabeza y cuello utilizando el Big Data.
Estudiar en profundidad los aspectos clínicos relevantes e investigar aspectos traslacionales como predictores genéticos y moleculares.

Coordinación del grupo

QUER AGUSTI, MIQUEL FGS
mquer@santpau.cat

Miembros

Casasayas Plass, Maria FGS
De Juan Beltran, Julia FGS
Gras Cabrerizo, Juan Ramon FGS
Holgado Clua, Anna FGS
Kolanczak, Katarzyna Alicja FGS
Leon Vintro, Xavier FGS
Lopez Vilas, Montserrat FGS
Orus Dotu, Cesar FGS
Pujol Olmo, Albert FGS
Valero Mayor, Cristina FGS
Vazquez Lopez, Cristina FGS
Venegas Pizarro, Maria Del Prado FGS

Publicaciones 2023

(JIF 2023)

-Chiesa CM, González JA, Genden EM, Piazza C, Guntinas O, Vander V, Kowalski LP, López F, Quer M, Rodrigo JP, Sanabria Á, Fernández V, Suárez C, Cohen O, de Bree R, Shaha AR, Makitie AA, Ferlito A. Complications related to the Cook-Swarz implantable Doppler probe use in head and neck microvascular reconstruction: a systematic review. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2023; 280(1). DOI:10.1007/s00405-022-07577-3. PMID:35941283. IF:1,900 (Q2/3D). Document type: Review.

-Chiesa CM, González JA, Larruscain E, Sistiaga JA, Quer M, León X, Martínez P, López C, Mayo M, Medela A. Facial nerve palsy following parotid gland surgery: A machine learning prediction outcome approach. World Journal Of Otorhinolaryngology – Head And Neck Surgery. 2023; 9(4). DOI:10.1002/wjo2.94. Document type: Article.

-Holgado A, León X, Quer M, Camacho V, Fernández A. Association between maximum standarised uptake value (SUV) and local control in patients with oropharyngeal carcinoma treated with radiotherapy. Acta Otorrinolaringologica Espanola. 2023; 74(4). DOI:10.1016/j.otorri.2022.05.004. PMID:37149130. IF:0,900 (Q3/8D). Document type: Article.

-Laccourreye O, Mirghani H, Guiquerro S, Quer M, Giraud P. Perception of survival/laryngeal preservation trade-off in advanced T-stage laryngeal cancer. European Annals of Otorhinolaryngology-Head and Neck Diseases. 2023; 140(2). DOI:10.1016/j.anorl.2022.12.008. PMID:36642664. IF:1,900 (Q2/3D). Document type: Review.

-León X, Bague S, Holgado A, Quer M, Terra X, Camacho M, Aviltes FX. Relationship between transcriptional expression of pyruvate dehydrogenase and local control of disease in patients with oral cavity carcinomas. Acta Otorrinolaringologica Espanola. 2023; 74(6). DOI:10.1016/j.otorri.2023.05.001. IF:0,900 (Q3/8D). Document type: Article.

-León X, Farré N, Montezuma L, Holgado A, Vásquez R, Neumann E, Quer M. Results of radiotherapy in oropharyngeal carcinomas. Acta Otorrinolaringologica Espanola. 2023; 74(3). DOI:10.1016/j.otorri.2022.04.002. PMID:37149134. IF:0,900 (Q3/8D). Document type: Article.

-León X, Gimenez A, de Juan J, Rodríguez C, Quer M, Pujol A. Is long-term screening for lung cancer justified in patients with head and neck carcinoma?. Acta Otorrinolaringologica Espanola. 2023; 74(5). DOI:10.1016/j.otorri.2022.05.005. PMID:36241026. IF:0,900 (Q3/8D). Document type: Article.

-León X, Llansana A, Pérez L, García J, Valero C, Quer M, Camacho M. Predictive capacity of FAT1 transcriptional expression in patients with head and neck squamous cell carcinomas treated with radiotherapy. Acta Otorrinolaringologica Espanola. 2023; 74(6). DOI:10.1016/j.otorri.2023.03.003. PMID:37931687. IF:0,900 (Q3/8D). Document type: Article.

-León X, Pujals G, Sauter B, Neumann E, Pujol A, Quer M. Differential characteristics of patients with squamous cell carcinoma of the head and neck with no history of tobacco or alcohol use. Acta Otorrinolaringologica Espanola. 2023; 74(1). DOI:10.1016/j.otorri.2022.02.003. PMID:36709798. IF:0,900 (Q3/8D). Document type: Article.

-Puiggrós IV, Moreno EG, Dotu CO, Agustí M, Díaz FL. Diagnostic Efficacy of High-Resolution Computed Tomography Densitometry for Diagnosing Otosclerosis. OTOLOGY & NEUROTOLOGY. 2023; 44(10). DOI:10.1097/MAO.0000000000004012. PMID:37733986. IF:1,900 (Q2/3D). Document type: Article.

-Pujol A, Llansana A, Pérez L, Sauter B, Quer M, León X. Second esophageal neoplasms after head and neck index tumor: Incidence, risk factors and prognosis. Acta Otorrinolaringologica Espanola. 2023; 74(6). DOI:10.1016/j.otoeng.2022.10.009. PMID:37149128. IF:0,900 (Q3/8D). Document type: Article.

-Pujol A, Llansana A, Pérez L, Sauter B, Quer M, León X. Second esophageal neoplasms after head and neck index tumor: Incidence, risk factors and prognosis. Acta Otorrinolaringologica Espanola. 2023; 74(6). DOI:10.1016/j.otorri.2022.10.005. IF:0,900 (Q3/8D). Document type: Article.

-Rodrigo JP, Sánchez M, Triantafyllou A, de Bree R, Mäkitie AA, Franchi A, Hellquist H, Saba NF, Stenman G, Takes RP, Valero C, Zidar N, Ferlito A. Neutrophil to Lymphocyte Ratio in Oropharyngeal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis †. Cancers. 2023; 15(3):802. DOI:10.3390/cancers15030802. PMID:36765760. IF:4,500 (Q1/3D). Document type: Review

-Sansa A, Valero C, Holgado A, Vásquez R, Quer M, Patel SG, León X. External validation of the H-index (host index) in patients with head and neck squamous cell carcinomas. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2023; 45(1). DOI:10.1002/hed.27224. PMID:36225167. IF:2,300 (Q1/3D). Document type: Article.

Publicaciones 2022

(JIF 2022)

Aibar JA, Oladotun M, Asencio C, Valassi E, Webb S, Gras JR, Monserrat J, Ribo PT, Munoz F. Complication Rates after Endoscopic Transsphenoidal Surgery for ACTH-Secreting Pituitary Adenomas: A Comparative Analysis with GH and Nonfunctioning Adenomas. Journal of Neurological Surgery Part B-Skull Base. 2022; 83. DOI:10.1055/s-0041-1725029. PMID:35832977. IF:0,9 (Q4/9D). Document type: Article.
Alias L, de Heredia ML, Luna S, Cliville N, Gonzalez L, Gallano P, de Juan J, Pujol A, Diez S, Boronat S, Orus C, Lasa A, Venegas MD. Case report: De novo pathogenic variant in WFS1 causes Wolfram-like syndrome debuting with congenital bilateral deafness. Frontiers in Genetics. 2022; 13:1024742. DOI:10.3389/fgene.2022.998898. PMID:36330437. IF:3,7 (Q2/4D). Document type: Article.
Bague S, Leon X, Terra X, Lejeune M, Camacho M, Aviles FX. Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2022; 44(11). DOI:10.1002/hed.27161. PMID:36207788. IF:2,9 (Q1/2D). Document type: Article.
Camacho M, Leon X, Pujol A, Montezuma L, Quer M, Garcia J. Prognostic value of transcriptional expression of fibronectin type III domain-containing 4 (FNDC4) in head and neck carcinoma patients treated with chemoradiotherapy. Clinical & Translational Oncology. 2022; 24(11). DOI:10.1007/s12094-022-02870-3. PMID:35752749. IF:3,4 (Q3/6D). Document type: Article.
Casasayas M, Garcia J, Gomez B, Medina V, Fernandez A, Quer M, Leon X. Low skeletal muscle mass assessed directly from the 3rd cervical vertebra can predict pharyngocutaneous fistula risk after total laryngectomy in the male population. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2022; 279(2). DOI:10.1007/s00405-021-07127-3. PMID:34665301. IF:2,6 (Q2/3D). Document type: Article.
Casasayas M, Sansa A, Garcia J, Venegas MD, Quer M, Leon X. Pharyngocutaneous fistula in irradiated patients: systematic review and our experience. JOURNAL OF LARYNGOLOGY AND OTOLOGY. 2022; 136(11):PII S0022215121004370. DOI:10.1017/S0022215121004370. PMID:35791885. IF:1,7 (Q3/7D). Document type: Review.
Fernandez M, Nunez T, Zamora P, Masia J, Leon X. The extended SCIP flap: An anatomical and clinical study of a new SCIP flap design. Journal of Plastic Reconstructive and Aesthetic Surgery. 2022; 75(9). DOI:10.1016/j.bjps.2022.06.021. PMID:35961925. IF:2,7 (Q2/4D). Document type: Article.
Gras JR, Martel M, Villatoro JC, De la Torre FR, Mirapeix R, Carrera A, Montserrat JR, Pujol A, Massegur H. «The Accessory Ethmoidal Canal Does Not Necessarily Contain an Arterial Structure». ENT-EAR NOSE & THROAT JOURNAL. 2022; 101(2_SUPPL):01455613211049656. DOI:10.1177/01455613211049656. PMID:34666559. IF:1,3 (Q4/9D). Document type: Article.
Leon X, Garcia J, Pujol A, de Juan J, Vasquez R, Quer M, Camacho M. Relationship between the transcriptional expression of PIM1 and local control in patients with head and neck squamous cell carcinomas treated with radiotherapy. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2022; 279(7). DOI:10.1007/s00405-021-07223-4. PMID:34993612. IF:2,6 (Q2/3D). Document type: Article.
Leon X, Venegas MD, Casasayas M, Rodriguez C, Neumann ED, Holgado A, Quer M. Prognostic value of the nodal yield in elective neck dissections in patients with head and neck carcinomas. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2022; 279(2). DOI:10.1007/s00405-021-06819-0. PMID:33938992. IF:2,6 (Q2/3D). Document type: Article.
Lop J, Venegas MD, Pujol A, Sauter B, Vasquez R, Casasayas M, Quer M, Leon X. Causes of long-term mortality in patients with head and neck squamous cell carcinomas. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2022; 279(7). DOI:10.1007/s00405-021-07211-8. PMID:34905065. IF:2,6 (Q2/3D). Document type: Article.
Lopez F, Shah JP, Beitler JJ, Snyderman CH, Lund V, Piazza C, Makitie AA, Guntinas O, Rodrigo JP, Kowalski LP, Quer M, Shaha A, Homma A, Sanabria A, Ferrarotto R, Lee A, Lee VHF, Rinaldo A, Ferlito A. The Selective Role of Open and Endoscopic Approaches for Sinonasal Malignant Tumours. ADVANCES IN THERAPY. 2022; 39(6). DOI:10.1007/s12325-022-02080-x. PMID:35352310. IF:3,8 (Q2/5D). Document type: Review.
Meler C, Aviles FX, Vilaseca I, Terra X, Bragado P, Fuster G, Vintro XL, Camacho M. Semaphorin-3F/Neuropilin-2 Transcriptional Expression as a Predictive Biomarker of Occult Lymph Node Metastases in HNSCC. 2022; 14(9):2259. DOI:10.3390/cancers14092259. PMID:35565388. IF:5,2 (Q2/3D). Document type: Article.
Mena M, Wang X, Tous S, Quiros B, Clavero O, Alejo M, Morey F, Taberna M, Vintro XL, Rubio BL, Alos L, Mehanna H, Quint W, Pawlita M, Tommasino M, Pavon MA, Munoz N, De Sanjose S, Bosch FX, Alemany L, ICO Int Head Neck Canc Study HPVG. Concordance of p16(INK4a) and E6*I mRNA among HPV-DNA-Positive Oropharyngeal, Laryngeal, and Oral Cavity Carcinomas from the ICO International Study. Cancers. 2022; 14(15):3787. DOI:10.3390/cancers14153787. PMID:35954451. IF:5,2 (Q2/3D). Document type: Article.
Moreno R, Mariño F, Kaen A, Gras JR, Mata N, González J, Villacampa JM, Cárdenas Ruiz E, Monjas I, Del Cuvillo A, García A, Maza JM, Fernández de Liesa R, Sánchez S, Alobid I. Usefulness of endonasal flaps and grafts in skull base surgery. Consensus document. Acta Otorrinolaringologica Espanola. 2022; 73(5). DOI:10.1016/j.otoeng.2021.02.004. PMID:36031110. Document type: Review/Practice guideline.
Moreno R, Mariño F, Kaen A, Gras JR, Mata N, González J, Villacampa JM, Cárdenas Ruiz E, Monjas I, del Cuvillo A, García A, Maza JM, Fernández de Liesa R, Sánchez S, Alobid I. Usefulness of endonasal flaps and grafts in skull base surgery. Consensus document. Acta Otorrinolaringologica Espanola. 2022; 73(5). DOI:10.1016/j.otorri.2021.02.005. PMID:34330369. Document type: Article.
Rioja E, Arroyo I, Alamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sanchez L, Quer M, Villaverde A, Vazquez E, Leon X, Alba L, Mangues R. CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022; 41(1):49. DOI:10.1186/s13046-022-02267-8. PMID:35120582. IF:11,3 (Q1/1D). Document type: Article.
Rioja E, Arroyo I, Álamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sánchez L, Quer M, Villaverde A, Vázquez E, Mangues R, Alba L, León X. Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4(+) head and neck squamous cell carcinoma tumors. Acta Pharmaceutica Sinica B. 2022; 12(5). DOI:10.1016/j.apsb.2021.09.030. PMID:35646535. IF:14,5 (Q1/1D). Document type: Article.
Rioja E, Gallardo A, Arroyo I, Alamo P, Casanova I, Unzueta U, Serna N, Sanchez L, Quer M, Villaverde A, Vazquez E, Leon X, Alba L, Mangues R. A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model. 2022; 14(4):887. DOI:10.3390/pharmaceutics14040887. PMID:35456719. IF:5,4 (Q1/2D). Document type: Article.
Rojas MJ, Gras JR, Aviles FX, Malvehy J, Arance AM, Castillo P, Barreiro A, Podlipnik S, Lopez M, Alobid I, Sprekelsen MB, Puig S, Langdon C. Sinonasal mucosal melanomas: defining profiles for better survival outcomes. 2022; 60(5). DOI:10.4193/Rhin21.251. PMID:36184882. IF:7,2 (Q1/1D). Document type: Article.

Publicaciones 2021

Aibar JA, Munoz F, Asencio C, Montserrat J, Gras JR, Mirapeix RM. Intracavernous Branches of the Internal Carotid Artery Through an Endoscopic Endonasal Approach: Anatomical Study and Review of the Literature. World Neurosurgery. 2021; 151. DOI:10.1016/j.wneu.2021.04.046. PMID:33887498. IF:2,210.
Asimakopoulos P, Shaha AR, Nixon IJ, Shah JP, Randolph GW, Angelos P, Zafereo ME, Kowalski LP, Hartl DM, Olsen KD, Rodrigo JP, Vander V, Makitie AA, Sanabria A, Suarez C, Quer M, Civantos FJ, Robbins KT, Guntinas O, Hamoir M, Rinaldo A, Ferlito A. Management of the Neck in Well-Differentiated Thyroid Cancer. Current Oncology Reports. 2021; 23(1):1. DOI:10.1007/s11912-020-00997-6. PMID:33190176. IF:5,945.
Avilés-Jurado FX, Muñoz C, Meler C, Flores JC, Gumà J, Benaiges E, Mora J, Camacho M, León X, Vilaseca I, Terra X. Circulating microRNAs modulating glycolysis as non-invasive prognostic biomarkers of HNSCC. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021;278(5):1585-1594. DOI:10.1007/s00405-020-06240-z. PMID: 32737645. IF:3,236.
Cobiella R, Quinones S, Aragones P, Leon X, Abramovic A, Vazquez T, Sanudo JR, Maranillo E, Olewnik L, de Blas CS, Parkin I, Konschake M. Anatomic mapping of the collateral branches of the external carotid artery with regard to daily clinical practice. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER. 2021; 238:151789. DOI:10.1016/j.aanat.2021.151789. PMID:34214605. IF:2,976.
Cobiella R, Quinones S, Konschake M, Aragones P, Leon X, Vazquez T, Sanudo J, Maranillo E. The carotid axis revisited. Scientific Reports. 2021; 11(1):13847. DOI:10.1038/s41598-021-93397-0. PMID:34226652. IF:4,996.
Eckel HE, Simo R, Quer M, Odell E, Paleri V, Klussmann JP, Remacle M, Sjögren E, Piazza C. European Laryngological Society position paper on laryngeal dysplasia Part II: diagnosis, treatment, and follow-up. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021;278(6):1723-1732. DOI:10.1007/s00405-020-06406-9. PMID: 33058010. IF:3,236.
Furlano M, Martinez V, Pybus M, Arce Y, Crespi J, Venegas MD, Bullich G, Domingo A, Ayasreh N, Benito S, Lorente L, Ruiz P, Gonzalez VL, Arlandis R, Cabello E, Torres F, Guirado L, Ars E, Torra R. Clinical and Genetic Features of Autosomal Dominant Alport Syndrome: A Cohort Study. AMERICAN JOURNAL OF KIDNEY DISEASES. 2021; 78(4). DOI:10.1053/j.ajkd.2021.02.326. PMID:33838161. IF:11,072.
Gil LSP, Vintro XL, Fernandez SL, Garcia CV, Playa GP, Garrido MF, Ayala JM. The Effect of Perioperative Blood Transfusions on Microvascular Anastomoses. Journal of Clinical Medicine. 2021; 10(6):1333. DOI:10.3390/jcm10061333. PMID:33807085. IF:4,964.
Gras JR, Rodriguez F, Gomez B, Cubero JM, Martel M, Granell E, Lopez M, Montserrat JR, Massegur H. Management of Patients With Graves Orbitopathy Using Endonasal Endoscopic Techniques. JOURNAL OF CRANIOFACIAL SURGERY. 2021; 32(4). DOI:10.1097/SCS.0000000000007107. PMID:33170828. IF:1,172.
Guntinas-Lichius O, Thielker J, Robbins KT, Olsen KD, Shaha AR, Mäkitie AA, de Bree R, Vander Poorten V, Quer M, Rinaldo A, Kowalski LP, Rodrigo JP, Hamoir M, Ferlito A. Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2021;43(3):997-1008. DOI:10.1002/hed.26541. PMID: 33169420. IF:3,821.
Hitt R, Iglesias L, López-Pousa A, Berrocal-Jaime A, Grau JJ, García-Girón C, Martínez-Trufero J, Guix M, Lambea-Sorrosal J, Del Barco-Morillo E, León-Vintró X, Cunquero-Tomas AJ, Baste N, Ocaña A, Cruz-Hernández JJ; the Spanish Head and Neck Cancer Cooperative Group (TTCC). Long-term outcomes of induction chemotherapy followed by chemoradiotherapy vs chemoradiotherapy alone as treatment of unresectable head and neck cancer: follow-up of the Spanish Head and Neck Cancer Group (TTCC) 2503 Trial. Clinical & Translational Oncology. 2021;23(4):764-772. DOI:10.1007/s12094-020-02467-8. PMID: 32797376. IF:3,340.
Koller T, Kinast N, Castellanos AG, Garcia SP, Iglesias PP, Vintro XL, Arranz JM, Seto NV, Garcia MVM, Moreno AB, Aznar J, Albaladejo GE, Diaz M. Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry. Scandinavian Journal of Trauma Resuscitation & Emergency Medicine. 2021; 29(1):57. DOI:10.1186/s13049-021-00867-5. PMID:33836790. IF:3,803.
Leon X, Orus C, Casasayas M, Neumann E, Holgado A, Quer M. Trends in disease-specific survival of head and neck squamous cell carcinoma patients treated in a single institution over a 30-year period. ORAL ONCOLOGY. 2021; 115:105184. DOI:10.1016/j.oraloncology.2021.105184. PMID:33581504. IF:5,972.
Leon X, Venegas M, Pujol A, Bulboa C, Llansana A, Casasayas M, Quer M, Camacho M. Predictive value of transcriptional expression of Kruppel-like factor-6 (KLF6) in head and neck carcinoma patients treated with radiotherapy. Clinical & Translational Oncology. 2021; 23(12). DOI:10.1007/s12094-021-02651-4. PMID:34061320. IF:3,340.
Martin C, Bernal M, Molina CP, Bartolome M, Orus C, Escamilla Y. Risk of contagion of SARS-CoV-2 among otorhinolaryngologists in Spain during the «Two waves». EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021; 278(9). DOI:10.1007/s00405-020-06582-8. PMID:33464400. IF:3,236.
Neumann ED, Sansa A, Casasayas M, Gutierrez A, Quer M, Leon X. Prognostic capacity of the weighted lymph node ratio in head and neck squamous cell carcinoma patients treated with salvage neck dissection. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021; 278(10). DOI:10.1007/s00405-020-06598-0. PMID:33452917. IF:3,236.
Olive J, Lopez O, Quer M, Marquez N, Kirchner H. Evidence of otitis media and mastoiditis in a Medieval Islamic skeleton from Spain and possible implications for ancient surgical treatment of the condition. International Journal of Paleopathology. 2021; 32. DOI:10.1016/j.ijpp.2020.10.009. PMID:33232880. IF:1,448.
Piazza C, Paderno A, Sjogren EV, Bradley PJ, Eckel HE, Makitie A, Matar N, Paleri V, Peretti G, Puxeddu R, Quer M, Remacle M, Vander V, Vilaseca I, Simo R. Salvage carbon dioxide transoral laser microsurgery for laryngeal cancer after (chemo)radiotherapy: a European Laryngological Society consensus statement. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021; 278(11). DOI:10.1007/s00405-021-06957-5. PMID:34226992. IF:3,236.
Prats A, Tobed M, Villacampa JM, Aguero A, Garcia C, Tato JI, Rodriganez L, Holguera VD, Hernandez E, Poletti D, Simonetti G, Villarraga V, Meler C, Barrueco AS, Chiesa C, Casasayas M, Parente P, Mata N, Rello J, Castro P, Prieto D, Vilaseca I, Aviles FX. Timing of elective tracheotomy and duration of mechanical ventilation among patients admitted to intensive care with severe COVID-19: A multicenter prospective cohort study. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2021; 43(12). DOI:10.1002/hed.26863. PMID:34524714. IF:3,821.
Quer M, Hernandez JC, Silver CE, Casasayas M, Simo R, Vander V, Guntinas O, Bradley PJ, Tong W, Rodrigo JP, Makitie AA, Rinaldo A, Kowalski LP, Sanabria A, de Bree R, Takes RP, Lopez F, Olsen KD, Shaha AR, Ferlito A. Current Trends and Controversies in the Management of Warthin Tumor of the Parotid Gland. Diagnostics. 2021; 11(8):1467. DOI:10.3390/diagnostics11081467. PMID:34441400. IF:3,992.
Sansa A, Venegas MD, Valero C, Pardo L, Aviles FX, Terra X, Quer M, Leon X. The aspartate aminotransaminase/alanine aminotransaminase (De Ritis) ratio predicts sensitivity to radiotherapy in head and neck carcinoma patients. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2021; 43(7). DOI:10.1002/hed.26673. PMID:33675096. IF:3,821.
Terra X, Ceperuelo V, Merma C, Benaiges E, Bosch R, Castillo P, Flores JC, Leon X, Valduvieco I, Baste N, Camara M, Lejeune M, Guma J, Vendrell J, Vilaseca I, Fernandez S, Aviles FX. Succinate Pathway in Head and Neck Squamous Cell Carcinoma: Potential as a Diagnostic and Prognostic Marker. Cancers. 2021; 13(7):1653. DOI:10.3390/cancers13071653. PMID:33916314. IF:6,575.

2017 Scientific Report – Ear, Nose and Throat Cancers

Presentación

Principales líneas de investigación

Predictores genéticos y moleculares de la respuesta al cáncer de cabeza y cuello.
Mecanismos moleculares de la inflamación en cáncer de cabeza y cuello.
Cirugía endoscópica nasosinusal: innovaciones técnicas en la base del cráneo.
Oído interno: aspectos relacionados con la sordera severa, implantes cocleares y cirugía de tumores otoneurológica.

Retos

Promover la investigación clínica y traslacional en cáncer de cabeza y cuello utilizando el Big Data.
Estudiar en profundidad los aspectos clínicos relevantes e investigar aspectos traslacionales como predictores genéticos y moleculares.

Equipo

Coordinación del grupo

QUER AGUSTI, MIQUEL FGS
mquer@santpau.cat

Miembros

Producción científica

Publicaciones 2023

(JIF 2023)

-Pujol A, Llansana A, Pérez L, Sauter B, Quer M, León X. Second esophageal neoplasms after head and neck index tumor: Incidence, risk factors and prognosis. Acta Otorrinolaringologica Espanola. 2023; 74(6). DOI:10.1016/j.otorri.2022.10.005. IF:0,900 (Q3/8D). Document type: Article.

Publicaciones 2022

(JIF 2022)

Aibar JA, Oladotun M, Asencio C, Valassi E, Webb S, Gras JR, Monserrat J, Ribo PT, Munoz F. Complication Rates after Endoscopic Transsphenoidal Surgery for ACTH-Secreting Pituitary Adenomas: A Comparative Analysis with GH and Nonfunctioning Adenomas. Journal of Neurological Surgery Part B-Skull Base. 2022; 83. DOI:10.1055/s-0041-1725029. PMID:35832977. IF:0,9 (Q4/9D). Document type: Article.
Alias L, de Heredia ML, Luna S, Cliville N, Gonzalez L, Gallano P, de Juan J, Pujol A, Diez S, Boronat S, Orus C, Lasa A, Venegas MD. Case report: De novo pathogenic variant in WFS1 causes Wolfram-like syndrome debuting with congenital bilateral deafness. Frontiers in Genetics. 2022; 13:1024742. DOI:10.3389/fgene.2022.998898. PMID:36330437. IF:3,7 (Q2/4D). Document type: Article.
Bague S, Leon X, Terra X, Lejeune M, Camacho M, Aviles FX. Prognostic capacity of the transcriptional expression of lactate dehydrogenase A in patients with head and neck squamous cell carcinoma. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2022; 44(11). DOI:10.1002/hed.27161. PMID:36207788. IF:2,9 (Q1/2D). Document type: Article.
Camacho M, Leon X, Pujol A, Montezuma L, Quer M, Garcia J. Prognostic value of transcriptional expression of fibronectin type III domain-containing 4 (FNDC4) in head and neck carcinoma patients treated with chemoradiotherapy. Clinical & Translational Oncology. 2022; 24(11). DOI:10.1007/s12094-022-02870-3. PMID:35752749. IF:3,4 (Q3/6D). Document type: Article.
Casasayas M, Garcia J, Gomez B, Medina V, Fernandez A, Quer M, Leon X. Low skeletal muscle mass assessed directly from the 3rd cervical vertebra can predict pharyngocutaneous fistula risk after total laryngectomy in the male population. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2022; 279(2). DOI:10.1007/s00405-021-07127-3. PMID:34665301. IF:2,6 (Q2/3D). Document type: Article.
Casasayas M, Sansa A, Garcia J, Venegas MD, Quer M, Leon X. Pharyngocutaneous fistula in irradiated patients: systematic review and our experience. JOURNAL OF LARYNGOLOGY AND OTOLOGY. 2022; 136(11):PII S0022215121004370. DOI:10.1017/S0022215121004370. PMID:35791885. IF:1,7 (Q3/7D). Document type: Review.
Fernandez M, Nunez T, Zamora P, Masia J, Leon X. The extended SCIP flap: An anatomical and clinical study of a new SCIP flap design. Journal of Plastic Reconstructive and Aesthetic Surgery. 2022; 75(9). DOI:10.1016/j.bjps.2022.06.021. PMID:35961925. IF:2,7 (Q2/4D). Document type: Article.
Gras JR, Martel M, Villatoro JC, De la Torre FR, Mirapeix R, Carrera A, Montserrat JR, Pujol A, Massegur H. «The Accessory Ethmoidal Canal Does Not Necessarily Contain an Arterial Structure». ENT-EAR NOSE & THROAT JOURNAL. 2022; 101(2_SUPPL):01455613211049656. DOI:10.1177/01455613211049656. PMID:34666559. IF:1,3 (Q4/9D). Document type: Article.
Leon X, Garcia J, Pujol A, de Juan J, Vasquez R, Quer M, Camacho M. Relationship between the transcriptional expression of PIM1 and local control in patients with head and neck squamous cell carcinomas treated with radiotherapy. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2022; 279(7). DOI:10.1007/s00405-021-07223-4. PMID:34993612. IF:2,6 (Q2/3D). Document type: Article.
Leon X, Venegas MD, Casasayas M, Rodriguez C, Neumann ED, Holgado A, Quer M. Prognostic value of the nodal yield in elective neck dissections in patients with head and neck carcinomas. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2022; 279(2). DOI:10.1007/s00405-021-06819-0. PMID:33938992. IF:2,6 (Q2/3D). Document type: Article.
Lop J, Venegas MD, Pujol A, Sauter B, Vasquez R, Casasayas M, Quer M, Leon X. Causes of long-term mortality in patients with head and neck squamous cell carcinomas. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2022; 279(7). DOI:10.1007/s00405-021-07211-8. PMID:34905065. IF:2,6 (Q2/3D). Document type: Article.
Lopez F, Shah JP, Beitler JJ, Snyderman CH, Lund V, Piazza C, Makitie AA, Guntinas O, Rodrigo JP, Kowalski LP, Quer M, Shaha A, Homma A, Sanabria A, Ferrarotto R, Lee A, Lee VHF, Rinaldo A, Ferlito A. The Selective Role of Open and Endoscopic Approaches for Sinonasal Malignant Tumours. ADVANCES IN THERAPY. 2022; 39(6). DOI:10.1007/s12325-022-02080-x. PMID:35352310. IF:3,8 (Q2/5D). Document type: Review.
Meler C, Aviles FX, Vilaseca I, Terra X, Bragado P, Fuster G, Vintro XL, Camacho M. Semaphorin-3F/Neuropilin-2 Transcriptional Expression as a Predictive Biomarker of Occult Lymph Node Metastases in HNSCC. 2022; 14(9):2259. DOI:10.3390/cancers14092259. PMID:35565388. IF:5,2 (Q2/3D). Document type: Article.
Mena M, Wang X, Tous S, Quiros B, Clavero O, Alejo M, Morey F, Taberna M, Vintro XL, Rubio BL, Alos L, Mehanna H, Quint W, Pawlita M, Tommasino M, Pavon MA, Munoz N, De Sanjose S, Bosch FX, Alemany L, ICO Int Head Neck Canc Study HPVG. Concordance of p16(INK4a) and E6*I mRNA among HPV-DNA-Positive Oropharyngeal, Laryngeal, and Oral Cavity Carcinomas from the ICO International Study. Cancers. 2022; 14(15):3787. DOI:10.3390/cancers14153787. PMID:35954451. IF:5,2 (Q2/3D). Document type: Article.
Moreno R, Mariño F, Kaen A, Gras JR, Mata N, González J, Villacampa JM, Cárdenas Ruiz E, Monjas I, Del Cuvillo A, García A, Maza JM, Fernández de Liesa R, Sánchez S, Alobid I. Usefulness of endonasal flaps and grafts in skull base surgery. Consensus document. Acta Otorrinolaringologica Espanola. 2022; 73(5). DOI:10.1016/j.otoeng.2021.02.004. PMID:36031110. Document type: Review/Practice guideline.
Moreno R, Mariño F, Kaen A, Gras JR, Mata N, González J, Villacampa JM, Cárdenas Ruiz E, Monjas I, del Cuvillo A, García A, Maza JM, Fernández de Liesa R, Sánchez S, Alobid I. Usefulness of endonasal flaps and grafts in skull base surgery. Consensus document. Acta Otorrinolaringologica Espanola. 2022; 73(5). DOI:10.1016/j.otorri.2021.02.005. PMID:34330369. Document type: Article.
Rioja E, Arroyo I, Alamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sanchez L, Quer M, Villaverde A, Vazquez E, Leon X, Alba L, Mangues R. CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022; 41(1):49. DOI:10.1186/s13046-022-02267-8. PMID:35120582. IF:11,3 (Q1/1D). Document type: Article.
Rioja E, Arroyo I, Álamo P, Casanova I, Gallardo A, Unzueta U, Serna N, Sánchez L, Quer M, Villaverde A, Vázquez E, Mangues R, Alba L, León X. Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4(+) head and neck squamous cell carcinoma tumors. Acta Pharmaceutica Sinica B. 2022; 12(5). DOI:10.1016/j.apsb.2021.09.030. PMID:35646535. IF:14,5 (Q1/1D). Document type: Article.
Rioja E, Gallardo A, Arroyo I, Alamo P, Casanova I, Unzueta U, Serna N, Sanchez L, Quer M, Villaverde A, Vazquez E, Leon X, Alba L, Mangues R. A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model. 2022; 14(4):887. DOI:10.3390/pharmaceutics14040887. PMID:35456719. IF:5,4 (Q1/2D). Document type: Article.
Rojas MJ, Gras JR, Aviles FX, Malvehy J, Arance AM, Castillo P, Barreiro A, Podlipnik S, Lopez M, Alobid I, Sprekelsen MB, Puig S, Langdon C. Sinonasal mucosal melanomas: defining profiles for better survival outcomes. 2022; 60(5). DOI:10.4193/Rhin21.251. PMID:36184882. IF:7,2 (Q1/1D). Document type: Article.

Publicaciones 2021

Aibar JA, Munoz F, Asencio C, Montserrat J, Gras JR, Mirapeix RM. Intracavernous Branches of the Internal Carotid Artery Through an Endoscopic Endonasal Approach: Anatomical Study and Review of the Literature. World Neurosurgery. 2021; 151. DOI:10.1016/j.wneu.2021.04.046. PMID:33887498. IF:2,210.
Asimakopoulos P, Shaha AR, Nixon IJ, Shah JP, Randolph GW, Angelos P, Zafereo ME, Kowalski LP, Hartl DM, Olsen KD, Rodrigo JP, Vander V, Makitie AA, Sanabria A, Suarez C, Quer M, Civantos FJ, Robbins KT, Guntinas O, Hamoir M, Rinaldo A, Ferlito A. Management of the Neck in Well-Differentiated Thyroid Cancer. Current Oncology Reports. 2021; 23(1):1. DOI:10.1007/s11912-020-00997-6. PMID:33190176. IF:5,945.
Avilés-Jurado FX, Muñoz C, Meler C, Flores JC, Gumà J, Benaiges E, Mora J, Camacho M, León X, Vilaseca I, Terra X. Circulating microRNAs modulating glycolysis as non-invasive prognostic biomarkers of HNSCC. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021;278(5):1585-1594. DOI:10.1007/s00405-020-06240-z. PMID: 32737645. IF:3,236.
Cobiella R, Quinones S, Aragones P, Leon X, Abramovic A, Vazquez T, Sanudo JR, Maranillo E, Olewnik L, de Blas CS, Parkin I, Konschake M. Anatomic mapping of the collateral branches of the external carotid artery with regard to daily clinical practice. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER. 2021; 238:151789. DOI:10.1016/j.aanat.2021.151789. PMID:34214605. IF:2,976.
Cobiella R, Quinones S, Konschake M, Aragones P, Leon X, Vazquez T, Sanudo J, Maranillo E. The carotid axis revisited. Scientific Reports. 2021; 11(1):13847. DOI:10.1038/s41598-021-93397-0. PMID:34226652. IF:4,996.
Eckel HE, Simo R, Quer M, Odell E, Paleri V, Klussmann JP, Remacle M, Sjögren E, Piazza C. European Laryngological Society position paper on laryngeal dysplasia Part II: diagnosis, treatment, and follow-up. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021;278(6):1723-1732. DOI:10.1007/s00405-020-06406-9. PMID: 33058010. IF:3,236.
Furlano M, Martinez V, Pybus M, Arce Y, Crespi J, Venegas MD, Bullich G, Domingo A, Ayasreh N, Benito S, Lorente L, Ruiz P, Gonzalez VL, Arlandis R, Cabello E, Torres F, Guirado L, Ars E, Torra R. Clinical and Genetic Features of Autosomal Dominant Alport Syndrome: A Cohort Study. AMERICAN JOURNAL OF KIDNEY DISEASES. 2021; 78(4). DOI:10.1053/j.ajkd.2021.02.326. PMID:33838161. IF:11,072.
Gil LSP, Vintro XL, Fernandez SL, Garcia CV, Playa GP, Garrido MF, Ayala JM. The Effect of Perioperative Blood Transfusions on Microvascular Anastomoses. Journal of Clinical Medicine. 2021; 10(6):1333. DOI:10.3390/jcm10061333. PMID:33807085. IF:4,964.
Gras JR, Rodriguez F, Gomez B, Cubero JM, Martel M, Granell E, Lopez M, Montserrat JR, Massegur H. Management of Patients With Graves Orbitopathy Using Endonasal Endoscopic Techniques. JOURNAL OF CRANIOFACIAL SURGERY. 2021; 32(4). DOI:10.1097/SCS.0000000000007107. PMID:33170828. IF:1,172.
Guntinas-Lichius O, Thielker J, Robbins KT, Olsen KD, Shaha AR, Mäkitie AA, de Bree R, Vander Poorten V, Quer M, Rinaldo A, Kowalski LP, Rodrigo JP, Hamoir M, Ferlito A. Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2021;43(3):997-1008. DOI:10.1002/hed.26541. PMID: 33169420. IF:3,821.
Hitt R, Iglesias L, López-Pousa A, Berrocal-Jaime A, Grau JJ, García-Girón C, Martínez-Trufero J, Guix M, Lambea-Sorrosal J, Del Barco-Morillo E, León-Vintró X, Cunquero-Tomas AJ, Baste N, Ocaña A, Cruz-Hernández JJ; the Spanish Head and Neck Cancer Cooperative Group (TTCC). Long-term outcomes of induction chemotherapy followed by chemoradiotherapy vs chemoradiotherapy alone as treatment of unresectable head and neck cancer: follow-up of the Spanish Head and Neck Cancer Group (TTCC) 2503 Trial. Clinical & Translational Oncology. 2021;23(4):764-772. DOI:10.1007/s12094-020-02467-8. PMID: 32797376. IF:3,340.
Koller T, Kinast N, Castellanos AG, Garcia SP, Iglesias PP, Vintro XL, Arranz JM, Seto NV, Garcia MVM, Moreno AB, Aznar J, Albaladejo GE, Diaz M. Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry. Scandinavian Journal of Trauma Resuscitation & Emergency Medicine. 2021; 29(1):57. DOI:10.1186/s13049-021-00867-5. PMID:33836790. IF:3,803.
Leon X, Orus C, Casasayas M, Neumann E, Holgado A, Quer M. Trends in disease-specific survival of head and neck squamous cell carcinoma patients treated in a single institution over a 30-year period. ORAL ONCOLOGY. 2021; 115:105184. DOI:10.1016/j.oraloncology.2021.105184. PMID:33581504. IF:5,972.
Leon X, Venegas M, Pujol A, Bulboa C, Llansana A, Casasayas M, Quer M, Camacho M. Predictive value of transcriptional expression of Kruppel-like factor-6 (KLF6) in head and neck carcinoma patients treated with radiotherapy. Clinical & Translational Oncology. 2021; 23(12). DOI:10.1007/s12094-021-02651-4. PMID:34061320. IF:3,340.
Martin C, Bernal M, Molina CP, Bartolome M, Orus C, Escamilla Y. Risk of contagion of SARS-CoV-2 among otorhinolaryngologists in Spain during the «Two waves». EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021; 278(9). DOI:10.1007/s00405-020-06582-8. PMID:33464400. IF:3,236.
Neumann ED, Sansa A, Casasayas M, Gutierrez A, Quer M, Leon X. Prognostic capacity of the weighted lymph node ratio in head and neck squamous cell carcinoma patients treated with salvage neck dissection. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021; 278(10). DOI:10.1007/s00405-020-06598-0. PMID:33452917. IF:3,236.
Olive J, Lopez O, Quer M, Marquez N, Kirchner H. Evidence of otitis media and mastoiditis in a Medieval Islamic skeleton from Spain and possible implications for ancient surgical treatment of the condition. International Journal of Paleopathology. 2021; 32. DOI:10.1016/j.ijpp.2020.10.009. PMID:33232880. IF:1,448.
Piazza C, Paderno A, Sjogren EV, Bradley PJ, Eckel HE, Makitie A, Matar N, Paleri V, Peretti G, Puxeddu R, Quer M, Remacle M, Vander V, Vilaseca I, Simo R. Salvage carbon dioxide transoral laser microsurgery for laryngeal cancer after (chemo)radiotherapy: a European Laryngological Society consensus statement. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY. 2021; 278(11). DOI:10.1007/s00405-021-06957-5. PMID:34226992. IF:3,236.
Prats A, Tobed M, Villacampa JM, Aguero A, Garcia C, Tato JI, Rodriganez L, Holguera VD, Hernandez E, Poletti D, Simonetti G, Villarraga V, Meler C, Barrueco AS, Chiesa C, Casasayas M, Parente P, Mata N, Rello J, Castro P, Prieto D, Vilaseca I, Aviles FX. Timing of elective tracheotomy and duration of mechanical ventilation among patients admitted to intensive care with severe COVID-19: A multicenter prospective cohort study. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2021; 43(12). DOI:10.1002/hed.26863. PMID:34524714. IF:3,821.
Quer M, Hernandez JC, Silver CE, Casasayas M, Simo R, Vander V, Guntinas O, Bradley PJ, Tong W, Rodrigo JP, Makitie AA, Rinaldo A, Kowalski LP, Sanabria A, de Bree R, Takes RP, Lopez F, Olsen KD, Shaha AR, Ferlito A. Current Trends and Controversies in the Management of Warthin Tumor of the Parotid Gland. Diagnostics. 2021; 11(8):1467. DOI:10.3390/diagnostics11081467. PMID:34441400. IF:3,992.
Sansa A, Venegas MD, Valero C, Pardo L, Aviles FX, Terra X, Quer M, Leon X. The aspartate aminotransaminase/alanine aminotransaminase (De Ritis) ratio predicts sensitivity to radiotherapy in head and neck carcinoma patients. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2021; 43(7). DOI:10.1002/hed.26673. PMID:33675096. IF:3,821.
Terra X, Ceperuelo V, Merma C, Benaiges E, Bosch R, Castillo P, Flores JC, Leon X, Valduvieco I, Baste N, Camara M, Lejeune M, Guma J, Vendrell J, Vilaseca I, Fernandez S, Aviles FX. Succinate Pathway in Head and Neck Squamous Cell Carcinoma: Potential as a Diagnostic and Prognostic Marker. Cancers. 2021; 13(7):1653. DOI:10.3390/cancers13071653. PMID:33916314. IF:6,575.

ENFERMEDADES ONCO-HEMATOLóGICAS

Otorrinolaringología y Cáncer de Cabeza y Cuello

Principales líneas de investigación

Retos

Coordinación del grupo

Miembros

Publicaciones 2023

Publicaciones 2022

Publicaciones 2021

Principales líneas de investigación

Retos

Coordinación del grupo

Miembros

Publicaciones 2023

Publicaciones 2022

Publicaciones 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau