Sant Pau - Institut de Recerca

Principales líneas de investigación

Genética aplicada a la infertilidad masculina.
Optimización del diagnóstico genético preimplantación y de las técnicas de fertilización in vitro.
Investigación clínica en nuevos procedimientos quirúrgicos, medicamentos y dispositivos médicos aplicados a las enfermedades y condiciones andrológicas (disfunción sexual masculina, hipogonadismo, enfermedad de Peyronie, eyaculación precoz, enfermedades de transmisión sexual).

Retos

Nuestro equipo multidisciplinar de profesionales desarrolla investigación traslacional en el campo del diagnóstico y tratamiento de los trastornos andrológicos. Para mejorar nuestro conocimiento y con ello mejorar la salud de los pacientes, buscamos el mantenimiento de proyectos activos, desarrollar nuevas líneas de investigación, aumentar el número de publicaciones internacionales, la formación de profesionales y aumentar las colaboraciones científicas.

Coordinación del grupo

RUIZ CASTAÑE, EDUARD F. PUIGVERT
eruiz@fundacio-puigvert.es

Miembros

De Rocco Ponce, Maurizio F. PUIGVERT
Gonzalez Fernandez, Monica F. PUIGVERT
Krausz, Csilla Gabriella F. PUIGVERT
Maestre Loren, Francesc F. PUIGVERT
Martinez Pasarell, Olga F. PUIGVERT
Sanchez Curbelo, Josvany F. PUIGVERT
Sarquella Geli, Joaquim F. PUIGVERT
Spinelli, Matilde F. PUIGVERT
Vives Suñe, Alvaro F. PUIGVERT

Publicaciones 2023

(JIF 2022)

-Borràs J, Alonso C, Vives A, Palou J. Neisseria meningitidis and the increase of oral sex. A case report. Revista Internacional de Andrologia. 2023; 21(1):100323. DOI:10.1016/j.androl.2021.02.010. PMID:36307367. IF:0,800 (Q4/10D). Document type: Article.

-Chan D, Oros K, Riera A, Krausz C, O’Flaherty C, Chan P, Robaire B, Trasler JM. Sperm DNA methylome abnormalities occur both pre- and post-treatment in men with Hodgkin disease and testicular cancer. Clinical Epigenetics. 2023; 15(1):5. DOI:10.1186/s13148-022-01417-1. PMID:36611168. IF:5,700 (Q1/2D). Document type: Article.

-Farnetani G, Fino MG, Cioppi F, Riera A, Tamburrino L, Vannucci M, Rosta V, Vinci S, Casamonti E, Turki L, Degl’Innocenti S, Spinelli M, Marchiani S, Lotti F, Muratori M, Krausz C. Long-term effect of cytotoxic treatments on sperm DNA fragmentation in patients affected by testicular germ cell tumor. Andrology. 2023; 11(8). DOI:10.1111/andr.13429. PMID:36932666. IF:4,500 (Q1/3D). Document type: Article.

-Ferre A, Santiago L, Sánchez JF, López O, Sánchez J, Sumoy L, Bassas L, Larriba S. 3’IsomiR Species Composition Affects Reliable Quantification of miRNA/isomiR Variants by Poly(A) RT-qPCR: Impact on Small RNA-Seq Profiling Validation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(20):15436. DOI:10.3390/ijms242015436. PMID:37895116. IF:5,600 (Q1/3D). Document type: Article.

-Jacques C, Alarcón M, Barbera MJ, Fuertes I, Martin G, Lopez J, Vives Á, Rodriguez R, Ros M, Rius C, De Olalla PG. Epidemiological Characteristics and Factors Associated with Repeat Sexually Transmitted Infections in Barcelona, Spain Over a Decade. ARCHIVES OF SEXUAL BEHAVIOR. 2023; DOI:10.1007/s10508-023-02711-6. PMID:37875628. IF:3,800 (Q1/2D). Document type: Article.

-Kimmins S, Anderson RA, Barratt CLR, Behre HM, Catford SR, De Jonge CJ, Delbes G, Eisenberg ML, Garrido N, Houston BJ, Jorgensen N, Krausz C, Lismer A, Mclachlan RI, Minhas S, Moss T, Pacey A, Priskorn L, Schlatt S, Trasler J, Trasande L, Tüttelmann F, Vazquez MH, Veltman JA, Zhang F, O’Bryan MK. Frequency, morbidity and equity – the case for increased research on male fertility. Nature Reviews Urology. 2023; DOI:10.1038/s41585-023-00820-4. PMID:37828407. IF:15,300 (Q1/1D). Document type: Article.

-Krausz C, Navarro P, Wilke M, Tüttelmann F. EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions: State of the art 2023. Andrology. 2023; DOI:10.1111/andr.13514. PMID:37674303. IF:4,500 (Q1/3D). Document type: Review.

-Larriba S, Sánchez JF, Pluvinet R, López O, Bassas L, Sumoy L. Seminal extracellular vesicle sncRNA sequencing reveals altered miRNA/isomiR profiles as sperm retrieval biomarkers for azoospermia. Andrology. 2023; DOI:10.1111/andr.13461. PMID:37245055. IF:4,500 (Q1/3D). Document type: Article.

-Larriba S, Vigues F, Bassas L. Using Small Non-Coding RNAs in Extracellular Vesicles of Semen as Biomarkers of Male Reproductive System Health: Opportunities and Challenges. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(6):5447. DOI:10.3390/ijms24065447. PMID:36982521. IF:5,600 (Q1/3D). Document type: Review.

-Plata L, Lopez O, Bassas L, Larriba S. Experimental validation of seminal miR-31-5p as biomarker for azoospermia and evaluation of the effect of preanalytical variables. Andrology. 2023; 11(4). DOI:10.1111/andr.13286. PMID:36057114. IF:4,500 (Q1/3D). Document type: Article.

-Shah R, Agarwal A, Kavoussi P, Rambhatla A, Saleh R, Cannarella R, Harraz AM, Boitrelle F, Kuroda S, Hamoda T, Zini A, Ko E, Calik G, Toprak T, Kandil H, Gul M, Parekh N, Russo GI, Tadros N, Kadioglu A, Arafa M, Chung E, Rajmil O, Dimitriadis F, Malhotra V, Salvio G, Henkel R, Le TV, Sogutdelen E, Vij S, Alarbid A, Gudeloglu A, Tsujimura A, Calogero AE, El Meliegy A, Crafa A, Kalkanli A, Baser A, Hazir B, Giulioni C, Cho CL, Ho CCK, Salzano C, Zylbersztejn DS, Tien DMB, Pescatori E, Borges E, Serefoglu EC, Sais E, Huyghe E, Ceyhan E, Caroppo E, Castiglioni F, Bahar F, Gokalp F, Lombardo F, Gadda F, Duarsa GWK, Pinggera GM, Busetto GM, Balercia G, Cito G, Blecher G, Franco G, Liguori G, Elbardisi H, Keskin H, Lin H, Taniguchi H, Park HJ, Ziouziou I, de la Rosette J, Hotaling J, Ramsay J, Molina JMC, KL, Bocu K, Khalafalla K, Bowa K, Okada K, Nagao K, Chiba K, Hakim L, Makarounis K, Hehemann M, Pena MR, Falcone M, Bendayan M, Martinez M, Timpano M, Altan M, Fode M, Al MS, Gilani M, Soebadi MA, Gherabi N, Sofikitis N, Birowo P, Kothari P, Sindhwani P, Javed Q, Ambar RF, Kosgi R, Abou R, Adriansjah R, Condorelli RA, La Vignera S, Micic S, Kim SHK, Fukuhara S, Ahn ST, Mostafa T, Ong TA, Takeshima T, Amano T, Barrett T, Arslan U, Karthikeyan VS, Atmoko W, Yumura Y, Yuan YM, Kato Y, Jezek D, Cheng BKC, Hatzichristodoulou G, Dy J, Castane ER, El AI, Bakircioglu ME, Nguyen Q, Sarikaya S, Boeri L, Tan R, Moussa MA, El A, Alali H, Alhathal N, Osman Y, Perovic D, Sajadi H, Akhavizadegan H, Vucinic M, Kattan S, Kattan MS, Mogharabian N, Phuoc NHV, Ngoo KS, Alkandari MH, Alsuhaibani S, Sokolakis I, Babaei M, King MS, Diemer T, Gava MM, Henrique R, Silva R, Paul GM, Mierzwa TC, Glina S, Siddiqi K, Wu H, Wurzacher J, Farkouh A, Son H, Minhas S, Lee J, Magsanoc N, Capogrosso P, Albano GJ, Lewis S, Jayasena CN, Alvarez JG, Teo C, Smith RP, Chua JB, Jensen CFS, Parekattil S, Finelli R, Durairajanayagam D, Karna KK, Ahmed A, Evenson D, Umemoto Y, Puigvert A, Ceker G, Colpi GM, Global F. Consensus and Diversity in the Management of Varicocele for Male Infertility: Results of a Global Practice Survey and Comparison with Guidelines and Recommendations. World Journal of Mens Health. 2023; 41(1):wjmh.220048. DOI:10.5534/wjmh.220048. PMID:35791302. IF:4,800 (Q1/2D). Document type: Article.

-Wyrwoll MJ, van der Heijden GW, Krausz C, Aston KI, Kliesch S, McLachlan R, Ramos L, Conrad DF, O’Bryan MK, Veltman JA, Tüttelmann F. Improved phenotypic classification of male infertility to promote discovery of genetic causes. Nature Reviews Urology. 2023; DOI:10.1038/s41585-023-00816-0. PMID:37723288. IF:15,300 (Q1/1D). Document type: Article.

Publicaciones 2022

(JIF 2022)

Bjorndahl L, Barratt CLR, Mortimer D, Agarwal A, Aitken RJ, Alvarez JG, Aneck N, Arver S, Baldi E, Bassas L, Boitrelle F, Bornman R, Carrell DT, Castilla JA, Parra GC, Check JH, Cuasnicu PS, Darney SP, de Jager C, De Jonge CJ, Drevet JR, Drobnis EZ, Du SS, Eisenberg ML, Esteves SC, Evgeni EA, Ferlin A, Garrido N, Giwercman A, Goovaerts I, Haugen TB, et al. Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology. HUMAN REPRODUCTION. 2022; 37(11). DOI:10.1093/humrep/deac189. PMID:36112046. IF:6,1 (Q1/1D). Document type: Review.
Cervan M, Bossini L, Guzman A, Rivera R, Garrido N, Lujan S, Romeu G, Santos S, Castilla JA, Gonzalvo MC, Clavero A, Vicente FJ, Maldonado V, Gonzalez S, Rodriguez I, Burgos M, Jimenez R, Pinto MG, Pereira I, Nunes J, Sanchez J, Lopez O, Pereira I, Marques PI, Carvalho F, Barros A, Bassas L, Seixas S, Goncalves J, Larriba S, Lopes AM, Carmona FD, Palomino RJ, IVIRMA GRP, Lisbon GRP. Common Variation in the PIN1 Locus Increases the Genetic Risk to Suffer from Sertoli Cell-Only Syndrome. Journal of Personalized Medicine. 2022; 12(6):932. DOI:10.3390/jpm12060932. PMID:35743717. Document type: Article.
Cervan M, Bossini L, Guzman A, Rivera R, Garrido N, Lujan S, Romeu G, Santos S, Castilla JA, Gonzalvo MD, Clavero A, Maldonado V, Vicente FJ, Burgos M, Jimenez R, Gonzalez S, Sanchez J, Lopez O, Pereira I, Marques PI, Carvalho F, Barros A, Bassas L, Seixas S, Goncalves J, Larriba S, Lopes AM, Palomino RJ, Carmona FD, IVIRMA GRP, Lisbon GRP. Common genetic variation in KATNAL1 non-coding regions is involved in the susceptibility to severe phenotypes of male infertility. Andrology. 2022; 10(7). DOI:10.1111/andr.13221. PMID:35752927. IF:4,5 (Q1/2D). Document type: Article.
Cervan M, Tuttelmann F, Lopes AM, Bossini L, Rivera R, Garrido N, Lujan S, Romeu G, Santos S, Castilla JA, Gonzalvo MC, Clavero A, Maldonado V, Vicente FJ, Gonzalez S, Guzman A, Burgos M, Jimenez R, Pacheco A, Gonzalez C, Gomez S, Amoros D, Aguilar J, Quintana F, Calhaz C, Aguiar A, Nunes J, Sousa S, Pereira I, Pinto MG, Correia S, Sanchez J, Lopez O, Martin J, Pereira I, Marques PI, Carvalho F, Barros A, Gromoll J, Bassas L, Seixas S, Goncalves J, Larriba S, Kliesch S, Palomino RJ, Carmona FD. Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility. Communications Biology. 2022; 5(1):1220. DOI:10.1038/s42003-022-04192-0. PMID:36357561. IF:5,9 (Q1/2D). Document type: Article.
Fernandez A, Ribas J, Garcia A, Garcia S, Martinez O, Navarro J, Oliver M, Benet J. TMT-Based Proteomic Analysis of Human Spermatozoa from Unexplained Recurrent Miscarriage Patients before and after Oral Antioxidant Treatment. 2022; 10(8):2014. DOI:10.3390/biomedicines10082014. PMID:36009561. IF:4,7 (Q1/3D). Document type: Article.
Garcia B, Martinez JI, Sarquella J, Justo J, Garcia E, Fernandez E, Ruiz E, Romero J. Peyronie’s Disease Questionnaire (PDQ): Spanish translation and validation. INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH. 2022; 34(5). DOI:10.1038/s41443-021-00460-5. PMID:34282285. IF:2,6 (Q3/6D). Document type: Article.
Gasanz C, Moreno D, Villegas JF, Peraza MF, Sarquella J, Ruiz E, Sanchez J. Effect of tadalafil 5 mg daily treatment on penile haemodynamics in patients with erectile dysfunction. Revista Internacional de Andrologia. 2022; 20(1). DOI:10.1016/j.androl.2020.08.002. PMID:33358311. IF:0,8 (Q4/10D). Document type: Article.
Guzman A, Gonzalez S, Cervan M, Rivera R, Garrido N, Lujan S, Santos S, Castilla JA, Gonzalvo MC, Clavero A, Vicente FJ, Maldonado V, Villegas J, Burgos M, Jimenez R, Pinto MG, Pereira I, Nunes J, Sanchez J, Lopez O, Pereira I, Marques PI, Carvalho F, Barros A, Bassas L, Seixas S, Goncalves J, Lopes AM, Larriba S, Palomino RJ, Carmona FD, Bossini L, IVIRMA GRP, Lisbon GRP. Contribution of TEX15 genetic variants to the risk of developing severe non-obstructive oligozoospermia. Frontiers in Cell and Developmental Biology. 2022; 10:1089782. DOI:10.3389/fcell.2022.1089782. PMID:36589743. IF:5,5 (Q1/2D). Document type: Article.
Houston BJ, Lopes AM, Laan M, Nagirnaja L, O’Connor AE, Merriner DJ, Nguyen J, Punab M, Riera A, Krausz C, Aston KI, Conrad DF, O’Bryan MK. DDB1-and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is not essential for male fertility in mice. DEVELOPMENTAL BIOLOGY. 2022; 490. DOI:10.1016/j.ydbio.2022.07.006. PMID:35850260. IF:2,7 (Q2/5D). Document type: Article.
Houston BJ, Riera A, Wyrwoll MJ, Salas A, Xavier MJ, Nagirnaja L, Friedrich C, Conrad DF, Aston KI, Krausz C, Tuttelmann F, O’Bryan MK, Veltman JA, Oud MS. A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships. HUMAN REPRODUCTION UPDATE. 2022; 28(1). DOI:10.1093/humupd/dmab030. PMID:34498060. IF:6,1 (Q1/1D). Document type: Review.
Jannini EA, Krausz C. Educational activities of the European Academy of Andrology. 2022; 10. DOI:10.1111/andr.13246. PMID:36217715. IF:4,5 (Q1/2D). Document type: Article.
Lopez O, Bossini L, Carmona FD, Bassas L, Larriba S. Genome-wide compound heterozygote analysis highlights DPY19L2 alleles in a non-consanguineous Spanish family with total globozoospermia. REPRODUCTIVE BIOMEDICINE ONLINE. 2022; 45(2). DOI:10.1016/j.rbmo.2022.03.035. PMID:35610156. IF:4 (Q1/2D). Document type: Article.
Maestre F, Lopez X, Castillo JA, Cosentino M. Stress and coping in times of pandemic: Longitudinal follow-up of a group of medical patients. Ansiedad Y Estres-Anxiety And Stress. 2022; 28(2). DOI:10.5093/anyes2022a13. Document type: Article.
Minambres I, Sarda H, Urgell E, Genua I, Ramos A, Fernandez S, Balague C, Sanchez JL, Bassas L, Perez A. Obesity Surgery Improves Hypogonadism and Sexual Function in Men without Effects in Sperm Quality. Journal of Clinical Medicine. 2022; 11(17):5126. DOI:10.3390/jcm11175126. PMID:36079056. IF:3,9 (Q2/4D). Document type: Article.
Nagirnaja L, Lopes AM, Charng WL, Miller B, Stakaitis R, Golubickaite I, Stendahl A, Luan TPC, Friedrich C, Mahyari E, Fadial E, Kasak L, Vigh K, Oud MS, Xavier MJ, Cheers SR, James ER, Guo JT, Jenkins TG, Riera A, Barros A, Carvalho F, Fernandes S, Goncalves J, Gurnett CA, Jorgensen N, Jezek D, Jungheim ES, Kliesch S, McLachlan RI, Omurtag KR, Pilatz A, Sandlow J, Smith J, Eisenberg ML, Hotaling JM, Jarvi KA, Punab M, Rajpert E, Carrell DT, Krausz C, Laan M, O’Bryan MK, Schlegel PN, Tuttelmann F, Veltman JA, Almstrup K, Aston KI, Conrad DF. Diverse monogenic subforms of human spermatogenic failure. Nature Communications. 2022; 13(1):7953. DOI:10.1038/s41467-022-35661-z. PMID:36572685. IF:16,6 (Q1/1D). Document type: Article.
Nieschlag E, Forti G, Wu F, Toppari J, Krausz C. History of the European Academy of Andrology. 2022; 10. DOI:10.1111/andr.13244. PMID:36217713. IF:4,5 (Q1/2D). Document type: Article.
Oud MS, Smits RM, Smith HE, Mastrorosa FK, Holt GS, Houston BJ, de Vries PF, Alobaidi BKS, Batty LE, Ismail H, Greenwood J, Sheth H, Mikulasova A, Astuti GDN, Gilissen C, McEleny K, Turner H, Coxhead J, Cockell S, Braat DDM, Fleischer K, D’Hauwers KWM, Schaafsma E, Carrell DT, Hotaling JM, Jenkins TG, McLachlan R, Schlegel PN, Eisenberg ML, et al. [Krausz C, Riera-Escamilla A]. A de novo paradigm for male infertility. Nature Communications. 2022; 13(1):154. DOI:10.1038/s41467-021-27132-8. PMID:35013161. IF:16,6 (Q1/1D). Document type: Article.
Palmisano F, Boeri L, Ievoli R, Sanchez J, Spinelli MG, Gregori A, Granata AM, Ruiz E, Montanari E, Sarquella J. Ten-year experience with penile prosthetic surgery for the treatment of erectile dysfunction: outcomes of a tertiary referral center and predictors of early prosthetic infection. ASIAN JOURNAL OF ANDROLOGY. 2022; 24(1). DOI:10.4103/aja.aja_27_21. PMID:33975985. IF:2,9 (Q2/4D). Document type: Article.
Riera A, Vockel M, Nagirnaja L, Xavier MJ, Carbonell A, Moreno D, Pybus M, Farnetani G, Rosta V, Cioppi F, Friedrich C, Oud MS, van der Heijden GW, Soave A, Diemer T, Ars E, Sanchez J, Kliesch S, O’Bryan MK, Ruiz E, Azorin F, Veltman JA, Aston KI, Conrad DF, Tuttelmann F, Krausz C, GEMINI C. Large-scale analyses of the X chromosome in 2,354 infertile men discover recurrently affected genes associated with spermatogenic failure. AMERICAN JOURNAL OF HUMAN GENETICS. 2022; 109(8). DOI:10.1016/j.ajhg.2022.06.007. PMID:35809576. IF:9,8 (Q1/1D). Document type: Article.
Santaballa A, Marquez C, Rodriguez A, Rovirosa A, Vazquez L, Zeberio I, Andres M, Bassas L, Ceballos E, Domingo J, Manau D. Multidisciplinary consensus on the criteria for fertility preservation in cancer patients. Clinical & Translational Oncology. 2022; 24(2). DOI:10.1007/s12094-021-02699-2. PMID:34635959. IF:3,4 (Q3/6D). Document type: Article.

Publicaciones 2021

Arrom LM, Girabent M, Gonzalez M, Palou J, Errando C, Ramirez I. Development and validation of a short version of the Female Sexual Function Index in the Spanish population. BMC Womens Health. 2021; 21(1):63. DOI:10.1186/s12905-021-01213-8. PMID:33573647. IF:2,742.
Capalbo A, Poli M, Riera A, Shukla V, Hoffding MK, Krausz C, Hoffmann ER, Simon C. Preconception genome medicine: current state and future perspectives to improve infertility diagnosis and reproductive and health outcomes based on individual genomic data. HUMAN REPRODUCTION UPDATE. 2021; 27(2). DOI:10.1093/humupd/dmaa044. PMID:33197264. IF:17,179.
Cervan M, Bossini L, Rivera R, Garrido N, Lujan S, Romeu G, Santos S, Castilla JA, Gonzalvo MD, Clavero A, Vicente FJ, Guzman A, Burgos M, Barrionuevo FJ, Jimenez R, Sanchez J, Lopez O, Peraza MF, Pereira I, Marques PI, Carvalho F, Barros A, Bassas L, Seixas S, Goncalves J, Larriba S, Lopes AM, Carmona FD, Palomino RJ. Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort. Andrology. 2021; 9(4). DOI:10.1111/andr.13009. PMID:33784440. IF:4,456.
Cervan M, Bossini L, Rivera R, Garrido N, Lujan S, Romeu G, Santos S, Castilla JA, Gonzalvo MC, Clavero A, Vicente FJ, Guzman A, Costa C, Llinares I, Khantham C, Burgos M, Barrionuevo FJ, Jimenez R, Sanchez J, Lopez O, Peraza MF, Pereira I, Marques PI, Carvalho F, Barros A, Bassas L, Seixas S, Goncalves J, Larriba S, Lopes AM, Palomino RJ, Carmona FD; IVIRMA GRP, Lisbon GRP. Evaluation of Male Fertility-Associated Loci in a European Population of Patients with Severe Spermatogenic Impairment. Journal of Personalized Medicine. 2021; 11(1):22. DOI:10.3390/jpm11010022. PMID:33383876. IF:3,508.
Hardy JJ, Wyrwoll MJ, Mcfadden W, Malcher A, Rotte N, Pollock NC, Munyoki S, Veroli MV, Houston BJ, Xavier MJ, Kasak L, Punab M, Laan M, Kliesch S, Schlegel P, Jaffe T, Hwang K, Vukina J, Brieno MA, Orwig K, Yanowitz J, Buszczak M, Veltman JA, Oud M, Nagirnaja L, Olszewska M, O’Bryan MK, Conrad DF, Kurpisz M, Tuttelmann F, Yatsenko AN, Krausz CG; GEMINI C. Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure. HUMAN GENETICS. 2021; 140(8). DOI:10.1007/s00439-021-02287-y. PMID:33963445. IF:5,881.
Lotti F, Frizza F, Balercia G, Barbonetti A, Behre HM, Calogero AE, Cremers JF, Francavilla F, Isidori AM, Kliesch S, La Vignera S, Lenzi A, Marcou M, Pilatz A, Poolamets O, Punab M, Godoy MFP, Rajmil O, Salvio G, Shaeer O, Weidner W, Maseroli E, Cipriani S, Baldi E, Degl’Innocenti S, Danza G, Caldini AL, Terreni A, Boni L, Krausz C, Maggi M. The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: Scrotal ultrasound reference ranges and associations with clinical, seminal, and biochemical characteristics. Andrology. 2021; 9(2). DOI:10.1111/andr.12951. PMID:33244893. IF:4,456.
Maestre F, Castillo JA, Lopez X, Sarquella J, Andres A, Cifre I. Psychological Distress in Erectile Dysfunction: The Moderating Role of Attachment. Sexual Medicine. 2021; 9(5):100436. DOI:10.1016/j.esxm.2021.100436. PMID:34517209. IF:2,523.
Salas-Huetos A, Tüttelmann F, Wyrwoll MJ, Kliesch S, Lopes AM, Goncalves J, Boyden SE, Wöste M, Hotaling JM; GEMINI Consortium, Nagirnaja L, Conrad DF, Carrell DT, Aston KI [Krausz CG]. Disruption of human meiotic telomere complex genes TERB1, TERB2 and MAJIN in men with non-obstructive azoospermia. Human Genetics. 2021;140(1):217-227. DOI:10.1007/s00439-020-02236-1. Erratum in: Human Genetics. 2020. PMID: 33211200. IF:5,881.
Vinay J, Moreno D, Rajmil O, Ruiz-Castañe E, Sanchez-Curbelo J. Penile low intensity shock wave treatment for PDE5I refractory erectile dysfunction: a randomized double-blind sham-controlled clinical trial. WORLD JOURNAL OF UROLOGY. 2021;39(6):2217-2222. DOI:10.1007/s00345-020-03373-y. PMID: 32696128. IF:3,661.
Vives A, da GVM, Alonso C, Suarez JB, Palmisano F, Cosentino M. Haemophilus urethritis in males: A series of 30 cases. Revista Internacional de Andrologia. 2021; 19(3). DOI:10.1016/j.androl.2020.01.002. PMID:32563585. IF:0,660.
Vockel M, Riera-Escamilla A, Tüttelmann F, Krausz C. The X chromosome and male infertility. Human Genetics. 2021;140(1):203-215. DOI:10.1007/s00439-019-02101-w. PMID: 31875237. IF:5,881.

Grup consolidat de l’Institut d’Investigació Biomèdica Sant Pau que pertany a

Presentación

Principales líneas de investigación

Genética aplicada a la infertilidad masculina.
Optimización del diagnóstico genético preimplantación y de las técnicas de fertilización in vitro.
Investigación clínica en nuevos procedimientos quirúrgicos, medicamentos y dispositivos médicos aplicados a las enfermedades y condiciones andrológicas (disfunción sexual masculina, hipogonadismo, enfermedad de Peyronie, eyaculación precoz, enfermedades de transmisión sexual).

Retos

Nuestro equipo multidisciplinar de profesionales desarrolla investigación traslacional en el campo del diagnóstico y tratamiento de los trastornos andrológicos. Para mejorar nuestro conocimiento y con ello mejorar la salud de los pacientes, buscamos el mantenimiento de proyectos activos, desarrollar nuevas líneas de investigación, aumentar el número de publicaciones internacionales, la formación de profesionales y aumentar las colaboraciones científicas.

Equipo

Coordinación del grupo

RUIZ CASTAÑE, EDUARD F. PUIGVERT
eruiz@fundacio-puigvert.es

Miembros

Producción científica

Publicaciones 2023

(JIF 2022)

Publicaciones 2022

(JIF 2022)

Bjorndahl L, Barratt CLR, Mortimer D, Agarwal A, Aitken RJ, Alvarez JG, Aneck N, Arver S, Baldi E, Bassas L, Boitrelle F, Bornman R, Carrell DT, Castilla JA, Parra GC, Check JH, Cuasnicu PS, Darney SP, de Jager C, De Jonge CJ, Drevet JR, Drobnis EZ, Du SS, Eisenberg ML, Esteves SC, Evgeni EA, Ferlin A, Garrido N, Giwercman A, Goovaerts I, Haugen TB, et al. Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology. HUMAN REPRODUCTION. 2022; 37(11). DOI:10.1093/humrep/deac189. PMID:36112046. IF:6,1 (Q1/1D). Document type: Review.
Cervan M, Bossini L, Guzman A, Rivera R, Garrido N, Lujan S, Romeu G, Santos S, Castilla JA, Gonzalvo MC, Clavero A, Vicente FJ, Maldonado V, Gonzalez S, Rodriguez I, Burgos M, Jimenez R, Pinto MG, Pereira I, Nunes J, Sanchez J, Lopez O, Pereira I, Marques PI, Carvalho F, Barros A, Bassas L, Seixas S, Goncalves J, Larriba S, Lopes AM, Carmona FD, Palomino RJ, IVIRMA GRP, Lisbon GRP. Common Variation in the PIN1 Locus Increases the Genetic Risk to Suffer from Sertoli Cell-Only Syndrome. Journal of Personalized Medicine. 2022; 12(6):932. DOI:10.3390/jpm12060932. PMID:35743717. Document type: Article.
Cervan M, Bossini L, Guzman A, Rivera R, Garrido N, Lujan S, Romeu G, Santos S, Castilla JA, Gonzalvo MD, Clavero A, Maldonado V, Vicente FJ, Burgos M, Jimenez R, Gonzalez S, Sanchez J, Lopez O, Pereira I, Marques PI, Carvalho F, Barros A, Bassas L, Seixas S, Goncalves J, Larriba S, Lopes AM, Palomino RJ, Carmona FD, IVIRMA GRP, Lisbon GRP. Common genetic variation in KATNAL1 non-coding regions is involved in the susceptibility to severe phenotypes of male infertility. Andrology. 2022; 10(7). DOI:10.1111/andr.13221. PMID:35752927. IF:4,5 (Q1/2D). Document type: Article.
Cervan M, Tuttelmann F, Lopes AM, Bossini L, Rivera R, Garrido N, Lujan S, Romeu G, Santos S, Castilla JA, Gonzalvo MC, Clavero A, Maldonado V, Vicente FJ, Gonzalez S, Guzman A, Burgos M, Jimenez R, Pacheco A, Gonzalez C, Gomez S, Amoros D, Aguilar J, Quintana F, Calhaz C, Aguiar A, Nunes J, Sousa S, Pereira I, Pinto MG, Correia S, Sanchez J, Lopez O, Martin J, Pereira I, Marques PI, Carvalho F, Barros A, Gromoll J, Bassas L, Seixas S, Goncalves J, Larriba S, Kliesch S, Palomino RJ, Carmona FD. Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility. Communications Biology. 2022; 5(1):1220. DOI:10.1038/s42003-022-04192-0. PMID:36357561. IF:5,9 (Q1/2D). Document type: Article.
Fernandez A, Ribas J, Garcia A, Garcia S, Martinez O, Navarro J, Oliver M, Benet J. TMT-Based Proteomic Analysis of Human Spermatozoa from Unexplained Recurrent Miscarriage Patients before and after Oral Antioxidant Treatment. 2022; 10(8):2014. DOI:10.3390/biomedicines10082014. PMID:36009561. IF:4,7 (Q1/3D). Document type: Article.
Garcia B, Martinez JI, Sarquella J, Justo J, Garcia E, Fernandez E, Ruiz E, Romero J. Peyronie’s Disease Questionnaire (PDQ): Spanish translation and validation. INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH. 2022; 34(5). DOI:10.1038/s41443-021-00460-5. PMID:34282285. IF:2,6 (Q3/6D). Document type: Article.
Gasanz C, Moreno D, Villegas JF, Peraza MF, Sarquella J, Ruiz E, Sanchez J. Effect of tadalafil 5 mg daily treatment on penile haemodynamics in patients with erectile dysfunction. Revista Internacional de Andrologia. 2022; 20(1). DOI:10.1016/j.androl.2020.08.002. PMID:33358311. IF:0,8 (Q4/10D). Document type: Article.
Guzman A, Gonzalez S, Cervan M, Rivera R, Garrido N, Lujan S, Santos S, Castilla JA, Gonzalvo MC, Clavero A, Vicente FJ, Maldonado V, Villegas J, Burgos M, Jimenez R, Pinto MG, Pereira I, Nunes J, Sanchez J, Lopez O, Pereira I, Marques PI, Carvalho F, Barros A, Bassas L, Seixas S, Goncalves J, Lopes AM, Larriba S, Palomino RJ, Carmona FD, Bossini L, IVIRMA GRP, Lisbon GRP. Contribution of TEX15 genetic variants to the risk of developing severe non-obstructive oligozoospermia. Frontiers in Cell and Developmental Biology. 2022; 10:1089782. DOI:10.3389/fcell.2022.1089782. PMID:36589743. IF:5,5 (Q1/2D). Document type: Article.
Houston BJ, Lopes AM, Laan M, Nagirnaja L, O’Connor AE, Merriner DJ, Nguyen J, Punab M, Riera A, Krausz C, Aston KI, Conrad DF, O’Bryan MK. DDB1-and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is not essential for male fertility in mice. DEVELOPMENTAL BIOLOGY. 2022; 490. DOI:10.1016/j.ydbio.2022.07.006. PMID:35850260. IF:2,7 (Q2/5D). Document type: Article.
Houston BJ, Riera A, Wyrwoll MJ, Salas A, Xavier MJ, Nagirnaja L, Friedrich C, Conrad DF, Aston KI, Krausz C, Tuttelmann F, O’Bryan MK, Veltman JA, Oud MS. A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships. HUMAN REPRODUCTION UPDATE. 2022; 28(1). DOI:10.1093/humupd/dmab030. PMID:34498060. IF:6,1 (Q1/1D). Document type: Review.
Jannini EA, Krausz C. Educational activities of the European Academy of Andrology. 2022; 10. DOI:10.1111/andr.13246. PMID:36217715. IF:4,5 (Q1/2D). Document type: Article.
Lopez O, Bossini L, Carmona FD, Bassas L, Larriba S. Genome-wide compound heterozygote analysis highlights DPY19L2 alleles in a non-consanguineous Spanish family with total globozoospermia. REPRODUCTIVE BIOMEDICINE ONLINE. 2022; 45(2). DOI:10.1016/j.rbmo.2022.03.035. PMID:35610156. IF:4 (Q1/2D). Document type: Article.
Maestre F, Lopez X, Castillo JA, Cosentino M. Stress and coping in times of pandemic: Longitudinal follow-up of a group of medical patients. Ansiedad Y Estres-Anxiety And Stress. 2022; 28(2). DOI:10.5093/anyes2022a13. Document type: Article.
Minambres I, Sarda H, Urgell E, Genua I, Ramos A, Fernandez S, Balague C, Sanchez JL, Bassas L, Perez A. Obesity Surgery Improves Hypogonadism and Sexual Function in Men without Effects in Sperm Quality. Journal of Clinical Medicine. 2022; 11(17):5126. DOI:10.3390/jcm11175126. PMID:36079056. IF:3,9 (Q2/4D). Document type: Article.
Nagirnaja L, Lopes AM, Charng WL, Miller B, Stakaitis R, Golubickaite I, Stendahl A, Luan TPC, Friedrich C, Mahyari E, Fadial E, Kasak L, Vigh K, Oud MS, Xavier MJ, Cheers SR, James ER, Guo JT, Jenkins TG, Riera A, Barros A, Carvalho F, Fernandes S, Goncalves J, Gurnett CA, Jorgensen N, Jezek D, Jungheim ES, Kliesch S, McLachlan RI, Omurtag KR, Pilatz A, Sandlow J, Smith J, Eisenberg ML, Hotaling JM, Jarvi KA, Punab M, Rajpert E, Carrell DT, Krausz C, Laan M, O’Bryan MK, Schlegel PN, Tuttelmann F, Veltman JA, Almstrup K, Aston KI, Conrad DF. Diverse monogenic subforms of human spermatogenic failure. Nature Communications. 2022; 13(1):7953. DOI:10.1038/s41467-022-35661-z. PMID:36572685. IF:16,6 (Q1/1D). Document type: Article.
Nieschlag E, Forti G, Wu F, Toppari J, Krausz C. History of the European Academy of Andrology. 2022; 10. DOI:10.1111/andr.13244. PMID:36217713. IF:4,5 (Q1/2D). Document type: Article.
Oud MS, Smits RM, Smith HE, Mastrorosa FK, Holt GS, Houston BJ, de Vries PF, Alobaidi BKS, Batty LE, Ismail H, Greenwood J, Sheth H, Mikulasova A, Astuti GDN, Gilissen C, McEleny K, Turner H, Coxhead J, Cockell S, Braat DDM, Fleischer K, D’Hauwers KWM, Schaafsma E, Carrell DT, Hotaling JM, Jenkins TG, McLachlan R, Schlegel PN, Eisenberg ML, et al. [Krausz C, Riera-Escamilla A]. A de novo paradigm for male infertility. Nature Communications. 2022; 13(1):154. DOI:10.1038/s41467-021-27132-8. PMID:35013161. IF:16,6 (Q1/1D). Document type: Article.
Palmisano F, Boeri L, Ievoli R, Sanchez J, Spinelli MG, Gregori A, Granata AM, Ruiz E, Montanari E, Sarquella J. Ten-year experience with penile prosthetic surgery for the treatment of erectile dysfunction: outcomes of a tertiary referral center and predictors of early prosthetic infection. ASIAN JOURNAL OF ANDROLOGY. 2022; 24(1). DOI:10.4103/aja.aja_27_21. PMID:33975985. IF:2,9 (Q2/4D). Document type: Article.
Riera A, Vockel M, Nagirnaja L, Xavier MJ, Carbonell A, Moreno D, Pybus M, Farnetani G, Rosta V, Cioppi F, Friedrich C, Oud MS, van der Heijden GW, Soave A, Diemer T, Ars E, Sanchez J, Kliesch S, O’Bryan MK, Ruiz E, Azorin F, Veltman JA, Aston KI, Conrad DF, Tuttelmann F, Krausz C, GEMINI C. Large-scale analyses of the X chromosome in 2,354 infertile men discover recurrently affected genes associated with spermatogenic failure. AMERICAN JOURNAL OF HUMAN GENETICS. 2022; 109(8). DOI:10.1016/j.ajhg.2022.06.007. PMID:35809576. IF:9,8 (Q1/1D). Document type: Article.
Santaballa A, Marquez C, Rodriguez A, Rovirosa A, Vazquez L, Zeberio I, Andres M, Bassas L, Ceballos E, Domingo J, Manau D. Multidisciplinary consensus on the criteria for fertility preservation in cancer patients. Clinical & Translational Oncology. 2022; 24(2). DOI:10.1007/s12094-021-02699-2. PMID:34635959. IF:3,4 (Q3/6D). Document type: Article.

Publicaciones 2021

Arrom LM, Girabent M, Gonzalez M, Palou J, Errando C, Ramirez I. Development and validation of a short version of the Female Sexual Function Index in the Spanish population. BMC Womens Health. 2021; 21(1):63. DOI:10.1186/s12905-021-01213-8. PMID:33573647. IF:2,742.
Capalbo A, Poli M, Riera A, Shukla V, Hoffding MK, Krausz C, Hoffmann ER, Simon C. Preconception genome medicine: current state and future perspectives to improve infertility diagnosis and reproductive and health outcomes based on individual genomic data. HUMAN REPRODUCTION UPDATE. 2021; 27(2). DOI:10.1093/humupd/dmaa044. PMID:33197264. IF:17,179.
Cervan M, Bossini L, Rivera R, Garrido N, Lujan S, Romeu G, Santos S, Castilla JA, Gonzalvo MD, Clavero A, Vicente FJ, Guzman A, Burgos M, Barrionuevo FJ, Jimenez R, Sanchez J, Lopez O, Peraza MF, Pereira I, Marques PI, Carvalho F, Barros A, Bassas L, Seixas S, Goncalves J, Larriba S, Lopes AM, Carmona FD, Palomino RJ. Effect and in silico characterization of genetic variants associated with severe spermatogenic disorders in a large Iberian cohort. Andrology. 2021; 9(4). DOI:10.1111/andr.13009. PMID:33784440. IF:4,456.
Cervan M, Bossini L, Rivera R, Garrido N, Lujan S, Romeu G, Santos S, Castilla JA, Gonzalvo MC, Clavero A, Vicente FJ, Guzman A, Costa C, Llinares I, Khantham C, Burgos M, Barrionuevo FJ, Jimenez R, Sanchez J, Lopez O, Peraza MF, Pereira I, Marques PI, Carvalho F, Barros A, Bassas L, Seixas S, Goncalves J, Larriba S, Lopes AM, Palomino RJ, Carmona FD; IVIRMA GRP, Lisbon GRP. Evaluation of Male Fertility-Associated Loci in a European Population of Patients with Severe Spermatogenic Impairment. Journal of Personalized Medicine. 2021; 11(1):22. DOI:10.3390/jpm11010022. PMID:33383876. IF:3,508.
Hardy JJ, Wyrwoll MJ, Mcfadden W, Malcher A, Rotte N, Pollock NC, Munyoki S, Veroli MV, Houston BJ, Xavier MJ, Kasak L, Punab M, Laan M, Kliesch S, Schlegel P, Jaffe T, Hwang K, Vukina J, Brieno MA, Orwig K, Yanowitz J, Buszczak M, Veltman JA, Oud M, Nagirnaja L, Olszewska M, O’Bryan MK, Conrad DF, Kurpisz M, Tuttelmann F, Yatsenko AN, Krausz CG; GEMINI C. Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure. HUMAN GENETICS. 2021; 140(8). DOI:10.1007/s00439-021-02287-y. PMID:33963445. IF:5,881.
Lotti F, Frizza F, Balercia G, Barbonetti A, Behre HM, Calogero AE, Cremers JF, Francavilla F, Isidori AM, Kliesch S, La Vignera S, Lenzi A, Marcou M, Pilatz A, Poolamets O, Punab M, Godoy MFP, Rajmil O, Salvio G, Shaeer O, Weidner W, Maseroli E, Cipriani S, Baldi E, Degl’Innocenti S, Danza G, Caldini AL, Terreni A, Boni L, Krausz C, Maggi M. The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: Scrotal ultrasound reference ranges and associations with clinical, seminal, and biochemical characteristics. Andrology. 2021; 9(2). DOI:10.1111/andr.12951. PMID:33244893. IF:4,456.
Maestre F, Castillo JA, Lopez X, Sarquella J, Andres A, Cifre I. Psychological Distress in Erectile Dysfunction: The Moderating Role of Attachment. Sexual Medicine. 2021; 9(5):100436. DOI:10.1016/j.esxm.2021.100436. PMID:34517209. IF:2,523.
Salas-Huetos A, Tüttelmann F, Wyrwoll MJ, Kliesch S, Lopes AM, Goncalves J, Boyden SE, Wöste M, Hotaling JM; GEMINI Consortium, Nagirnaja L, Conrad DF, Carrell DT, Aston KI [Krausz CG]. Disruption of human meiotic telomere complex genes TERB1, TERB2 and MAJIN in men with non-obstructive azoospermia. Human Genetics. 2021;140(1):217-227. DOI:10.1007/s00439-020-02236-1. Erratum in: Human Genetics. 2020. PMID: 33211200. IF:5,881.
Vinay J, Moreno D, Rajmil O, Ruiz-Castañe E, Sanchez-Curbelo J. Penile low intensity shock wave treatment for PDE5I refractory erectile dysfunction: a randomized double-blind sham-controlled clinical trial. WORLD JOURNAL OF UROLOGY. 2021;39(6):2217-2222. DOI:10.1007/s00345-020-03373-y. PMID: 32696128. IF:3,661.
Vives A, da GVM, Alonso C, Suarez JB, Palmisano F, Cosentino M. Haemophilus urethritis in males: A series of 30 cases. Revista Internacional de Andrologia. 2021; 19(3). DOI:10.1016/j.androl.2020.01.002. PMID:32563585. IF:0,660.
Vockel M, Riera-Escamilla A, Tüttelmann F, Krausz C. The X chromosome and male infertility. Human Genetics. 2021;140(1):203-215. DOI:10.1007/s00439-019-02101-w. PMID: 31875237. IF:5,881.

GRUPOS ASOCIADOS

Andrología

Principales líneas de investigación

Retos

Coordinación del grupo

Miembros

Publicaciones 2023

Publicaciones 2022

Publicaciones 2021

Principales líneas de investigación

Retos

Coordinación del grupo

Miembros

Publicaciones 2023

Publicaciones 2022

Publicaciones 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau