Sant Pau - Institut de Recerca

Principales líneas de investigación

Estudio del sistema inmunitario natural en el desarrollo de los procesos autoimmunològics e inflamatorios.
Respuesta inmunológica y evolución clínica en el tratamiento con inmunomoduladores.
Análisis del papel de los autoanticuerpos, componentes del sistema inmunitario adaptativo, en la patogénesis de los procesos autoinmunes y su utilidad como marcadores de diagnóstico y pronóstico en estas enfermedades.
Estudio de los mecanismos implicados en las inmunodeficiencias.
Estudio de subpoblaciones de linfocitos relacionadas con el rechazo crónico del injerto en pacientes cardíacos post-trasplantados.

Retos

Implicación de las células y moléculas de la respuesta inmunológica innata en el desarrollo y control de procesos inflamatorios, en la aparición de fenómenos autoinmunes, inmunodeficiencias, infecciones, enfermedades cardiovasculares y desarrollo de tumores.
Implicación de la señalización TLR y STAT en las enfermedades inflamatorias.
Involucración de los factores de transcripción de la familia STAT en respuesta a superantígenos.
Estudio de los mecanismos involucrados en la inmunodeficiencia causada por alteraciones de la molécula CD8a.
Implicación de los adipocitos perivasculares y las rutas de señalización TLF en el desarrollo de aterosclerosis.
Inflamación y rechazo en trasplantes de corazón.
Efectos de los tratamientos inmunobiológicos en variables inmunológicas.
Análisis de la evolución de los parámetros inmunológicos y su correlación con la respuesta clínica al tratamiento con inmunomoduladores.
Efectos del rituximab, tocilizamab y adalimumab en las variables inmunológicas y su correlación con la respuesta clínica en pacientes con enfermedades inflamatorias.

Coordinación del grupo

VIDAL ALCORISA, SILVIA IR
svidal@santpau.cat

Miembros

Calahorro Aguilar, Veronica FGS
Calvet Lacruz, Anna FGS
Canto Naves, Elisabeth IR
De La Calle Martin, Oscar FGS
Franco Leyva, Teresa FGS
Juarez Rubio, Candido FGS
Lynton Pons, Elionor FGS
Mariscal Rodriguez, Anais FGS
Martinez Martinez, Laura FGS
Moga Naranjo, Maria Esther FGS
Mulet Gual, Maria IR
Ortiz De Juana, Maria Angels IR
Osuna Gomez, Ruben IR
Sang Park, Hye FGS

Publicaciones 2023

(JIF 2022)

-Albiol N, Lynton E, Aso O, Moga E, Vidal S, Gomez L, Santiago JA, Triquell M, Roch N, Lazaro E, Gonzalez I, Lopez J, Esquirol A, Sierra J, Martino R, Garcia I. mRNA-1273 SARS-CoV-2 vaccine in recently transplanted allogeneic hematopoietic cell transplant recipients: Dynamics of cellular and humoral immune responses and booster effect. LEUKEMIA RESEARCH. 2023; 132:107347. DOI:10.1016/j.leukres.2023.107347. PMID:37356281. IF:2,700 (Q3/7D). Document type: Article.

-Blanco Y, Escudero D, Lleixà C, Llufriu S, Egri N, García RR, Alba M, Aguilar E, Artola M, Aldea Novo M, Alvarez S, Caballero E, Cabrera-Maqueda JM, Fonseca E, Guasp M, Hernando A, Martinez-Hernandez E, Olivé-Cirera G, Lopez-Contreras J, Martín-Aguilar L, Martinez-Martinez L, Rombauts A, Rodés M, Sabater L, Sepulveda M, Solana E, Tejada-Illa C, Vidal-Fernández N, Vilella A, Fortuny C, Armangué T, Dalmau JO, Querol L, Saiz A. mRNA COVID-19 Vaccination Does Not Exacerbate Symptoms or Trigger Neural Antibody Responses in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2023; 10(6):e200163. DOI: 10.1212/NXI.0000000000200163. PMID: 37679040. IF:8,800 (Q1/1D). Document type: Article.

-Canto E, Anguera G, Jimenez N, Mellado B, Ramirez O, Mariscal A, Maroto P, Vidal S. Association between the Immunophenotype of Peripheral Blood from mCRPC Patients and the Outcomes of Radium-223 Treatment. Diagnostics. 2023; 13(13):2222. DOI:10.3390/diagnostics13132222. PMID:37443615. IF:3,600 (Q2/4D). Document type: Article.

-d’Alessandro M, Gangi S, Soccio P, Canto E, Osuna R, Bergantini L, Cameli P, Fabbri G, Croce S, Scioscia G, Montuori G, Fanetti M, Moriondo G, Mezzasalma F, Castillo D, Lacedonia D, Vidal S, Bargagli E. The Effects of Interstitial Lung Diseases on Alveolar Extracellular Vesicles Profile: A Multicenter Study. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(4):4071. DOI:10.3390/ijms24044071. PMID:36835481. IF:5,600 (Q1/3D). Document type: Article.

-García B, Van Den Rym A, Martinez L, Franco T, Pérez JJ, Markle J, Cubillos C, Marín AV, Recio MJ, Regueiro JR, Navarro A, Mestre C, Ferreras C, Martín C, Mena R, de la Calle C, López A, Fernández M, Pérez A, López E, Sánchez S, Casanova J-L, Martínez R, de la Calle O, Pérez de Diego R. Inherited human ezrin deficiency impairs adaptive immunity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023; 152(4):997-1009.e11. DOI:10.1016/j.jaci.2023.05.022. PMID:37301410. IF:14,200 (Q1/1D). Document type: Article.

-Laghi L, Román E, Lan Q, Nieto JC, Canalda A, Poca M, Sánchez MB, Clària J, Alvarado E, Cuyàs B, Sánchez E, Vidal S, Guarner C, Escorsell À, Manichanh C, Soriano G. A multistrain probiotic increases the serum glutamine/glutamate ratio in patients with cirrhosis: a metabolomic analysis. Hepatology Communications. 2023; 7(4):e0072. DOI:10.1097/HC9.0000000000000072. PMID:37026745. IF:5,100 (Q2/3D). Document type: Letter.

-Lleixà C, Caballero M, Pascual E, Martín L, Vidal N, Tejada C, Valdés E, Zárate E, Vesperinas A, Collet R, Franco T, Martínez L, Moga E, Cortés E, Rojas R, Gómez B, Gil A, González C, Brieva L, Martínez S, Querol L. Antibodies against the flotillin-1/2 complex in patients with multiple sclerosis. Brain Communications. 2023; 5(2):fcad109. DOI:10.1093/braincomms/fcad109. PMID:37091585. Document type: Article.

-Martinez L, Irure J, Jurado A, Roy G, Montes MA, Barrios Y, Rodriguez B, Vergara E, Prada A, Rojo R, Vargas ML, G. Laboratory and clinical practices in antinuclear antibody detection and related antigens: recommendations from a Spanish multicentre survey. IMMUNOLOGIC RESEARCH. 2023; 71(5)DOI:10.1007/s12026-023-09389-x. PMID:37195550. IF:4,400 (Q2/5D). Document type: Article.

-Mulet M, Osuna R, Zamora C, Artesero I, Arús M, Vera P, Cordón A, Vilalta N, San P, Abril A, Moliné A, Morán I, López J, Vidal S. Dysregulated neutrophil extracellular traps formation in sepsis. IMMUNOLOGY. 2023; 170(3)DOI:10.1111/imm.13676. PMID:37381594. IF:6,400 (Q2/3D). Document type: Article.

-Navarro V, Puig L, Vidal S, Ramírez J, Llamas M, Fernández C, Almodóvar R, Pinto JA, Galíndez E, Zarco P, Joven B, Gratacós J, Juanola X, Blanco R, Arias S, Sanz J, Queiro R, Canete JD. The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases. Frontiers in Immunology. 2023; 14:1191782. DOI:10.3389/fimmu.2023.1191782. PMID:37600764. IF:7,300 (Q1/3D). Document type: Review.

-Osuna R, Barril S, Mulet M, Atenza CZ, Millan P, Pardessus A, Brough DE, Sabzevari H, Semnani RT, Castillo D, Vidal S. The immunoregulatory role of IL-35 in patients with interstitial lung disease. IMMUNOLOGY. 2023; 168(4)DOI:10.1111/imm.13596. PMID:36273280. IF:6,400 (Q2/3D). Document type: Article.

-Osuna R, Castellvi I, Mulet M, Ortiz MA, Brough DE, Sabzevari H, Semnani RT, Vidal S. Impaired Regulation by IL-35 in Systemic Sclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(13):10567. DOI:10.3390/ijms241310567. PMID:37445745. IF:5,600 (Q1/3D). Document type: Article.

-Pérez S, Grijota MD, Anibarro L, Rabuñal R, Sabria J, Gijón P, Pomar V, García M, Domínguez Á, Trigo M, Santos MJ, Cebollero A, Rodríguez S, Moga E, Penas A, Martos C, Ruiz MJ, Garcia EI, Alcaide F, Santin M. Reversions of QuantiFERON-TB Gold Plus in tuberculosis contact investigation: A prospective multicentre cohort study. PLoS One. 2023; 18(8):e0285917. DOI:10.1371/journal.pone.0285917. PMID:37647315. IF:3,700 (Q2/4D). Document type: Article.

Publicaciones 2022

(JIF 2022)

Alserawan L, Anguera G, Atenza CZ, Lopez JS, Martinez L, Melia MR, Sullivan I, Joaquin AB, Tarruella MM, Vidal S. Association between Changes in the Patterns of Antinuclear Autoantibodies during Immune Checkpoint Inhibition Therapy and the Development of Severe Immune Related Adverse Events. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(20):12641. DOI:10.3390/ijms232012641. PMID:36293498. IF:5,6 (Q1/3D). Document type: Article.
Atenza CZ, Anguera G, Melia MR, De Lamo LA, Sullivan I, Joaquin AB, Lopez JS, Ortiz MA, Mulet M, Vidal S, Majem M. The integration of systemic and tumor PD-L1 as a predictive biomarker of clinical outcomes in patients with advanced NSCLC treated with PD-(L)1blockade agents. CANCER IMMUNOLOGY IMMUNOTHERAPY. 2022; 71(8). DOI:10.1007/s00262-021-03107-y. PMID:34984538. IF:5,8 (Q1/3D). Document type: Article.
Caballero M, Álvarez R, Moga E, Rojas R, Turon J, Querol L, Olivé M, Reyes D, Illa I, Gallardo E, Cortés E. Rituximab in myasthenia gravis: efficacy, associated infections and risk of induced hypogammaglobulinemia. NEUROMUSCULAR DISORDERS. 2022; 32(8). DOI:10.1016/j.nmd.2022.06.006. PMID:35811274. IF:2,8 (Q3/6D). Document type: Article.
Castellvi I, Castillo D, Corominas H, Mariscal A, Orozco S, Benito N, Pomar V, Baucells A, Mur I, de la Rosa D, Lobo D, Millan AM, de Sosa NH, Filella D, Matas L, Martinez L, Juarez C, Casademont J, Domingo P. Krebs von den Lungen-6 glycoprotein circulating levels are not useful as prognostic marker in COVID-19 pneumonia: A large prospective cohort study. Frontiers in Medicine. 2022; 9:973918. DOI:10.3389/fmed.2022.973918. PMID:36004366. IF:3,9 (Q2/4D). Document type: Article.
Castellví I, Vidal S, Valenzuela C. Autoimmunity in the Study of Interstitial Lung Disease: Are Serological Test Enough?. ARCHIVOS DE BRONCONEUMOLOGIA. 2022; 58(8). DOI:10.1016/j.arbres.2021.08.016. PMID:35312568. IF:8 (Q1/2D). Document type: Editorial material.
Curto E, Mateus EF, Crespo A, Osuna R, Ujaldon C, Garcia A, Galvan P, Soto L, Ramos D, Plaza V. Identification of Two Eosinophil Subsets in Induced Sputum from Patients with Allergic Asthma According to CD15 and CD66b Expression. International Journal of Environmental Research and Public Health. 2022; 19(20):13400. DOI:10.3390/ijerph192013400. PMID:36293979. Document type: Article.
Franco T, Torres OH, Saez ME, Boera G, Santos Á, Clotet S, Albert D, El Y, Agustí M, Casademont J, Juárez C, Martínez L. Early differentiated CD28(+) CD27(+) T lymphocytes as a biomarker for short and long-term outcomes in older patients with pneumonia. JOURNAL OF LEUKOCYTE BIOLOGY. 2022; 112(5). DOI:10.1002/JLB.5MA0422-370R. PMID:35748037. IF:65,5 (Q2/3D). Document type: Article.
Mariscal A, Zamora C, Diaz C, Ortiz MA, de Agustin JJ, Reina D, Estrada P, Moya P, Corominas H, Vidal S. Increase of Circulating Monocyte-Platelet Conjugates in Rheumatoid Arthritis Responders to IL-6 Blockage. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(10):5748. DOI:10.3390/ijms23105748. PMID:35628558. IF:5,6 (Q1/3D). Document type: Article.
Martín L, Lleixà C, Pascual E, Caballero M, Martínez L, Díaz J, Rojas R, Cortés E, Turon J, de Luna N, Suárez X, Gallardo E, Rajabally Y, Scotton S, Jacobs BC, Baars A, Cortese A, Vegezzi E, Höftberger R, Zimprich F, Roesler C, Nobile E, Liberatore G, Hiew FL, Martínez A, Carvajal A, Piñar R, Usón M, Albertí O, López MÁ, Márquez F, Pardo J, Muñoz L, Cabrera M, Ortiz N, Bartolomé M, Duman Ö, Bril V, Segura D, Pitarokoili K, Steen C, Illa I, Querol L. Clinical and Laboratory Features in Anti-NF155 Autoimmune Nodopathy. Neurology-Neuroimmunology & Neuroinflammation. 2022; 9(1):e1098. DOI:10.1212/NXI.0000000000001098. PMID:34728497. IF:8,8 (Q1/1D). Document type: Article.
Moga E, Lynton E, Domingo P. The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection. Frontiers in Immunology. 2022; 13:904686. DOI:10.3389/fimmu.2022.904686. PMID:35833134. IF:7,3 (Q1/3D). Document type: Review.
Mulet M, Osuna R, Zamora C, Porcel JM, Nieto JC, Perea L, Pajares V, Munoz AM, Calvo N, Sorolla MA, Vidal S. Influence of Malignant Pleural Fluid from Lung Adenocarcinoma Patients on Neutrophil Response. 2022; 14(10):2529. DOI:10.3390/cancers14102529. PMID:35626131. IF:5,2 (Q2/3D). Document type: Article.
Pero M, Castells C, Alserawan L, Casani L, Juan JO, Jorba I, Pérez ML, Moga E, Otero J, López P, Badimon L, Vilarrodona A, Porta O. Comparison of a human acellular dermal matrix and a polypropylene mesh for pelvic floor reconstruction: a randomized trial study in a rabbit model. Scientific Reports. 2022; 12(1):20698. DOI:10.1038/s41598-022-22190-4. PMID:36450745. IF:4,6 (Q2/3D). Document type: Article.
Reyes D, Lopez J, Moga E, Pla F, Lynton E, Rojas R, Turon J, Querol L, Olive M, Alvarez R, Caballero M, Carbayo A, Vesperinas A, Domingo P, Illa I, Gallardo E, Cortes E. Immune Response and Safety of SARS-CoV-2 mRNA-1273 Vaccine in Patients With Myasthenia Gravis. Neurology-Neuroimmunology & Neuroinflammation. 2022; 9(4):e200002. DOI:10.1212/NXI.0000000000200002. PMID:35728947. IF:8,8 (Q1/1D). Document type: Article.
Serra S, López-Granados L, Sisinni L, Serna JV, Martínez-Martínez L, Fernández de Gamarra E, de la Calle O, Badell I. Chronic hypogammaglobulinemia after allogeneic stem cell transplantation and their treatment with subcutanaeos inmunoglobulin in pediatric patients. ANALES DE PEDIATRIA. 2022; 97(2). DOI:10.1016/j.anpedi.2021.08.011. PMID:35869014. IF:2,1 (Q3/6D). Document type: Article.
Simoes AM, Holmstrom MO, Aehnlich P, Rahbech A, Radziwon A, Zamora C, Klausen TW, Skov V, Kjaer L, Ellervik C, El Fassi D, Vidal S, Hasselbalch HC, Andersen MH, Straten PT. Patients With Myeloproliferative Neoplasms Harbor High Frequencies of CD8 T Cell-Platelet Aggregates Associated With T Cell Suppression. Frontiers in Immunology. 2022; 13:866610. DOI:10.3389/fimmu.2022.866610. PMID:35603202. IF:7,3 (Q1/3D). Document type: Article.

Publicaciones 2021

Alserawan L, Penacoba P, Echevarria S, Castillo D, Ortiz E, Martinez L, Naranjo EM, Domingo P, Castellvi I, Juarez C, Mariscal A. Growth Differentiation Factor 15 (GDF-15): A Novel Biomarker Associated with Poorer Respiratory Function in COVID-19. Diagnostics. 2021; 11(11):1998. DOI:10.3390/diagnostics11111998. PMID:34829345. IF:3,992.
Canto E, Faba OR, Zamora C, Mulet M, Garcia MS, Palomino A, Anguera G, Breda A, Maroto P, Vidal S. Immunological Status of Bladder Cancer Patients Based on Urine Leukocyte Composition at Radical Cystectomy. Biomedicines. 2021; 9(9):1125. DOI:10.3390/biomedicines9091125. PMID:34572311. IF:4,757.
d’Alessandro M, Bergantini L, Bargagli E, Vidal S. Extracellular Vesicles in Pulmonary Fibrosis Models and Biological Fluids of Interstitial Lung Disease Patients: A Scoping Review. Life-Basel. 2021; 11(12):1401. DOI:10.3390/life11121401. PMID:34947932. IF:3,251.
Diaz C, Ortiz MA, Garcia A, Jeria S, Sainz L, Fernandez S, Corominas H, Vidal S. The inflammatory role of silent urate crystal deposition in intercritical gout. RHEUMATOLOGY. 2021; 60(11). DOI:10.1093/rheumatology/keab335. PMID:33839783. IF:7,046.
González-Manso A, Agut-Busquet E, Romaní J, Vilarrasa E, Bittencourt F, Mensa A, Cantó E, Aróstegui JI, Vidal S. Hidradenitis Suppurativa: Proposal of Classification in Two Endotypes with Two-Step Cluster Analysis. Dermatology. 2021;237(3):365-371. DOI:10.1159/000511045. PMID: 33171462. IF:5,197.
Isola I, Moreno DF, Moga E, Mena MP, Tovar N, Rodriguez LG, Oliver A, Salgado MC, Braso F, Yague J, Cibeira MT, Prat A, Rosinol L, Blade J, de Larrea CF. Immunoparesis defined by heavy/light chain pair suppression in smoldering multiple myeloma shows initial isotype specificity and involves other isotypes in advanced disease. ANNALS OF HEMATOLOGY. 2021; 100(12). DOI:10.1007/s00277-021-04653-2. PMID:34463804. IF:4,030.
Lleixa C, Martin L, Pascual E, Franco T, Caballero M, De Luna N, Gallardo E, Suarez X, Martinez L, Diaz J, Rojas R, Cortes E, Turon J, Casasnovas C, Homedes C, Gutierrez G, Jimeno MC, Berciano J, Sedano MJ, Garcia T, Pardo J, Marquez C, Rojas I, Jerico I, Martinez E, de la Tassa GM, Dominguez C, Juarez C, Illa I, Querol L. Autoantibody screening in Guillain-Barre syndrome. Journal of Neuroinflammation. 2021; 18(1):251. DOI:10.1186/s12974-021-02301-0. PMID:34719386. IF:9,587.
Magallares B, Lobo D, Castellvi I, Moya P, Gich I, Martinez L, Park H, Millan AM, Laiz A, Diaz C, Fernandez S, Corominas H. Assessment of EULAR/ACR-2019, SLICC-2012 and ACR-1997 Classification Criteria in SLE with Longstanding Disease. Journal of Clinical Medicine. 2021; 10(11):2377. DOI:10.3390/jcm10112377. PMID:34071275. IF:4,964.
Mariscal A, Milan M, Baucells A, Martinez MA, Guillen AG, Trallero E, Alvarado M, Martinez L, Alserawan L, Franco T, Sanz MT, Vinas L, Corominas H, Juarez C, Castellvi I, Selva A. Anti-TIF-1 gamma Antibody Detection Using a Commercial Kit vs In-House Immunoblot: Usefulness in Clinical Practice. Frontiers in Immunology. 2021; 11:625896. DOI:10.3389/fimmu.2020.625896. PMID:33613568. IF:8,786.
Mariscal A, Zamora C, Magallares B, Salman TC, Ortiz MA, Diaz C, Castellvi I, Corominas H, Vidal S. Phenotypic and Functional Consequences of PLT Binding to Monocytes and Its Association with Clinical Features in SLE. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(9):4719. DOI:10.3390/ijms22094719. PMID:33947017. IF:6,208.
Murillo JD, Diaz C, Ortiz MA, Coras R, Gil P, Pedersen A, Corominas H, Vidal S, Guma M. Metabolomics profiling predicts outcome of tocilizumab in rheumatoid arthritis: an exploratory study. Metabolomics. 2021; 17(9):74. DOI:10.1007/s11306-021-01822-2. PMID:34402961. IF:4,747.
Osuna R, Arqueros C, Galano C, Mulet M, Zamora C, Barnadas A, Vidal S. Effector Mechanisms of CD8+HLA-DR+ T Cells in Breast Cancer Patients Who Respond to Neoadjuvant Chemotherapy. Cancers. 2021; 13(24):6167. DOI:10.3390/cancers13246167. PMID:34944786. IF:6,575.
Pascual E, Fehmi J, Lleixa C, Martin L, Devaux J, Hoftberger R, Delmont E, Doppler K, Sommer C, Radunovic A, Carvajal A, Smyth S, Williams L, Mazanec R, Potockova V, Hinds N, Cassereau J, Viala K, Lefilliatre M, Nicolas G, Foley P, Leypoldt F, Keddie S, Lunn MP, Zimprich F, Nunkoo VS, Loscher WN, Martinez L, Diaz J, Rojas R, Illa I, Rinaldi S, Querol L. Antibodies to the Caspr1/contactin-1 complex in chronic inflammatory demyelinating polyradiculoneuropathy. BRAIN. 2021; 144. PMID:33880507. IF:15,255.
Perea L, Canto E, Suarez G, Aliberti S, Chalmers JD, Sibila O, Vidal S. A Cluster Analysis of Bronchiectasis Patients Based on the Airway Immune Profile. CHEST. 2021; 159(5). DOI:10.1016/j.chest.2020.11.011. PMID:33217421. IF:10,262.
Perea L, Rodriguez L, Nieto JC, Zamora C, Canto E, Soriano G, Poca M, Blanco P, Navarro F, Muniesa M, Vidal S. Bacteriophages immunomodulate the response of monocytes. EXPERIMENTAL BIOLOGY AND MEDICINE. 2021; 246(11). DOI:10.1177/1535370221995154. PMID:33641443. IF:4,088.
Perez S, Pallares N, Grijota MD, Sanchez A, Barcia L, Campos S, Pomar V, Rabunal R, Balcells ME, Gazel D, Montiel N, Vicente D, Goic I, Schon T, Paues J, Marekovic I, Cacho J, Barac A, Goletti D, Garcia M, Barcala JM, Tortola MT, Anibarro L, Suarez I, Moga E, Gude MJ, Naves R, Karsligil T, Martin T, Stevanovic G, Trigo M, Rubio V, Karaoglan I, Bayram N, et al. Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study. Microbiology Spectrum. 2021; 9(3):e00972-21. DOI:10.1128/Spectrum.00972-21. PMID:34756079. IF:9,043.
Pero M, Casani L, Castells C, Perez ML, Naranjo EM, Juan O, De Lamo LA, Lopez P, Serrat AV, Badimon L, Roda OP. Rabbit as an animal model for the study of biological grafts in pelvic floor dysfunctions. Scientific Reports. 2021; 11(1):10545. DOI:10.1038/s41598-021-89698-z. PMID:34006889. IF:4,996.
Piquero-Casals J, Martínez-Martínez L, Alomar A, Rozas-Muñoz E, Juarez C, Puig L. LRP1/CD91 is highly expressed in monocytes from patients with vitiligo – even after repigmentation. Experimental Dermatolgy. 2021;30(3):390-395. DOI:10.1111/exd.14249. PMID: 33249636. IF:4,511.
Román E, Parramón M, Flavià M, Gely C, Poca M, Gallego A, Santesmases R, Hernández E, Nieto JC, Urgell E, Alvarado-Tapias E, Vidal S, Ferrero-Gregori A, Vargas V, Guarner C, Soriano G. Frailty in outpatients with cirrhosis: A prospective observational study. Liver International. 2021;41(2):357-368. DOI:10.1111/liv.14694. PMID: 33030788. IF:8,754.
Roman E, Poca M, Amoros G, Rosell J, Gely C, Nieto JC, Vidal S, Urgell E, Ferrero A, Alvarado E, Cuyas B, Hernandez E, Santesmases R, Guarner C, Escorsell A, Soriano G. Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis. Scientific Reports. 2021; 11(1):20415. DOI:10.1038/s41598-021-99199-8. PMID:34650096. IF:4,996.
Vidal S, Puig L, Carrascosa JM, Gonzalez A, Ruiz JC, Velasco AM. From Messengers to Receptors in Psoriasis: The Role of IL-17RA in Disease and Treatment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(13):6740. DOI:10.3390/ijms22136740. PMID:34201664. IF:6,208.
Zamora C, Canto E, Vidal S. The Dual Role of Platelets in the Cardiovascular Risk of Chronic Inflammation. Frontiers in Immunology. 2021; 12:625181. DOI:10.3389/fimmu.2021.625181. PMID:33868242. IF:8,786.
Zamora C, Riudavets M, Anguera G, Alserawan L, Sullivan I, Barba A, Serra J, Ortiz MA, Gallardo P, Perea L, Gavira J, Barnadas A, Majem M, Vidal S. Circulating leukocyte-platelet complexes as a predictive biomarker for the development of immune-related adverse events in advanced non-small cell lung cancer patients receiving anti-PD-(L)1 blocking agents. CANCER IMMUNOLOGY IMMUNOTHERAPY. 2021; 70(6). DOI:10.1007/s00262-020-02793-4. PMID:33388994. IF:6,630.

2017 Scientific Report -Inflammatory Diseases

Presentación

Principales líneas de investigación

Estudio del sistema inmunitario natural en el desarrollo de los procesos autoimmunològics e inflamatorios.
Respuesta inmunológica y evolución clínica en el tratamiento con inmunomoduladores.
Análisis del papel de los autoanticuerpos, componentes del sistema inmunitario adaptativo, en la patogénesis de los procesos autoinmunes y su utilidad como marcadores de diagnóstico y pronóstico en estas enfermedades.
Estudio de los mecanismos implicados en las inmunodeficiencias.
Estudio de subpoblaciones de linfocitos relacionadas con el rechazo crónico del injerto en pacientes cardíacos post-trasplantados.

Retos

Implicación de las células y moléculas de la respuesta inmunológica innata en el desarrollo y control de procesos inflamatorios, en la aparición de fenómenos autoinmunes, inmunodeficiencias, infecciones, enfermedades cardiovasculares y desarrollo de tumores.
Implicación de la señalización TLR y STAT en las enfermedades inflamatorias.
Involucración de los factores de transcripción de la familia STAT en respuesta a superantígenos.
Estudio de los mecanismos involucrados en la inmunodeficiencia causada por alteraciones de la molécula CD8a.
Implicación de los adipocitos perivasculares y las rutas de señalización TLF en el desarrollo de aterosclerosis.
Inflamación y rechazo en trasplantes de corazón.
Efectos de los tratamientos inmunobiológicos en variables inmunológicas.
Análisis de la evolución de los parámetros inmunológicos y su correlación con la respuesta clínica al tratamiento con inmunomoduladores.
Efectos del rituximab, tocilizamab y adalimumab en las variables inmunológicas y su correlación con la respuesta clínica en pacientes con enfermedades inflamatorias.

Equipo

Coordinación del grupo

VIDAL ALCORISA, SILVIA IR
svidal@santpau.cat

Miembros

Producción científica

Publicaciones 2023

(JIF 2022)

Publicaciones 2022

(JIF 2022)

Alserawan L, Anguera G, Atenza CZ, Lopez JS, Martinez L, Melia MR, Sullivan I, Joaquin AB, Tarruella MM, Vidal S. Association between Changes in the Patterns of Antinuclear Autoantibodies during Immune Checkpoint Inhibition Therapy and the Development of Severe Immune Related Adverse Events. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(20):12641. DOI:10.3390/ijms232012641. PMID:36293498. IF:5,6 (Q1/3D). Document type: Article.
Atenza CZ, Anguera G, Melia MR, De Lamo LA, Sullivan I, Joaquin AB, Lopez JS, Ortiz MA, Mulet M, Vidal S, Majem M. The integration of systemic and tumor PD-L1 as a predictive biomarker of clinical outcomes in patients with advanced NSCLC treated with PD-(L)1blockade agents. CANCER IMMUNOLOGY IMMUNOTHERAPY. 2022; 71(8). DOI:10.1007/s00262-021-03107-y. PMID:34984538. IF:5,8 (Q1/3D). Document type: Article.
Caballero M, Álvarez R, Moga E, Rojas R, Turon J, Querol L, Olivé M, Reyes D, Illa I, Gallardo E, Cortés E. Rituximab in myasthenia gravis: efficacy, associated infections and risk of induced hypogammaglobulinemia. NEUROMUSCULAR DISORDERS. 2022; 32(8). DOI:10.1016/j.nmd.2022.06.006. PMID:35811274. IF:2,8 (Q3/6D). Document type: Article.
Castellvi I, Castillo D, Corominas H, Mariscal A, Orozco S, Benito N, Pomar V, Baucells A, Mur I, de la Rosa D, Lobo D, Millan AM, de Sosa NH, Filella D, Matas L, Martinez L, Juarez C, Casademont J, Domingo P. Krebs von den Lungen-6 glycoprotein circulating levels are not useful as prognostic marker in COVID-19 pneumonia: A large prospective cohort study. Frontiers in Medicine. 2022; 9:973918. DOI:10.3389/fmed.2022.973918. PMID:36004366. IF:3,9 (Q2/4D). Document type: Article.
Castellví I, Vidal S, Valenzuela C. Autoimmunity in the Study of Interstitial Lung Disease: Are Serological Test Enough?. ARCHIVOS DE BRONCONEUMOLOGIA. 2022; 58(8). DOI:10.1016/j.arbres.2021.08.016. PMID:35312568. IF:8 (Q1/2D). Document type: Editorial material.
Curto E, Mateus EF, Crespo A, Osuna R, Ujaldon C, Garcia A, Galvan P, Soto L, Ramos D, Plaza V. Identification of Two Eosinophil Subsets in Induced Sputum from Patients with Allergic Asthma According to CD15 and CD66b Expression. International Journal of Environmental Research and Public Health. 2022; 19(20):13400. DOI:10.3390/ijerph192013400. PMID:36293979. Document type: Article.
Franco T, Torres OH, Saez ME, Boera G, Santos Á, Clotet S, Albert D, El Y, Agustí M, Casademont J, Juárez C, Martínez L. Early differentiated CD28(+) CD27(+) T lymphocytes as a biomarker for short and long-term outcomes in older patients with pneumonia. JOURNAL OF LEUKOCYTE BIOLOGY. 2022; 112(5). DOI:10.1002/JLB.5MA0422-370R. PMID:35748037. IF:65,5 (Q2/3D). Document type: Article.
Mariscal A, Zamora C, Diaz C, Ortiz MA, de Agustin JJ, Reina D, Estrada P, Moya P, Corominas H, Vidal S. Increase of Circulating Monocyte-Platelet Conjugates in Rheumatoid Arthritis Responders to IL-6 Blockage. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(10):5748. DOI:10.3390/ijms23105748. PMID:35628558. IF:5,6 (Q1/3D). Document type: Article.
Martín L, Lleixà C, Pascual E, Caballero M, Martínez L, Díaz J, Rojas R, Cortés E, Turon J, de Luna N, Suárez X, Gallardo E, Rajabally Y, Scotton S, Jacobs BC, Baars A, Cortese A, Vegezzi E, Höftberger R, Zimprich F, Roesler C, Nobile E, Liberatore G, Hiew FL, Martínez A, Carvajal A, Piñar R, Usón M, Albertí O, López MÁ, Márquez F, Pardo J, Muñoz L, Cabrera M, Ortiz N, Bartolomé M, Duman Ö, Bril V, Segura D, Pitarokoili K, Steen C, Illa I, Querol L. Clinical and Laboratory Features in Anti-NF155 Autoimmune Nodopathy. Neurology-Neuroimmunology & Neuroinflammation. 2022; 9(1):e1098. DOI:10.1212/NXI.0000000000001098. PMID:34728497. IF:8,8 (Q1/1D). Document type: Article.
Moga E, Lynton E, Domingo P. The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection. Frontiers in Immunology. 2022; 13:904686. DOI:10.3389/fimmu.2022.904686. PMID:35833134. IF:7,3 (Q1/3D). Document type: Review.
Mulet M, Osuna R, Zamora C, Porcel JM, Nieto JC, Perea L, Pajares V, Munoz AM, Calvo N, Sorolla MA, Vidal S. Influence of Malignant Pleural Fluid from Lung Adenocarcinoma Patients on Neutrophil Response. 2022; 14(10):2529. DOI:10.3390/cancers14102529. PMID:35626131. IF:5,2 (Q2/3D). Document type: Article.
Pero M, Castells C, Alserawan L, Casani L, Juan JO, Jorba I, Pérez ML, Moga E, Otero J, López P, Badimon L, Vilarrodona A, Porta O. Comparison of a human acellular dermal matrix and a polypropylene mesh for pelvic floor reconstruction: a randomized trial study in a rabbit model. Scientific Reports. 2022; 12(1):20698. DOI:10.1038/s41598-022-22190-4. PMID:36450745. IF:4,6 (Q2/3D). Document type: Article.
Reyes D, Lopez J, Moga E, Pla F, Lynton E, Rojas R, Turon J, Querol L, Olive M, Alvarez R, Caballero M, Carbayo A, Vesperinas A, Domingo P, Illa I, Gallardo E, Cortes E. Immune Response and Safety of SARS-CoV-2 mRNA-1273 Vaccine in Patients With Myasthenia Gravis. Neurology-Neuroimmunology & Neuroinflammation. 2022; 9(4):e200002. DOI:10.1212/NXI.0000000000200002. PMID:35728947. IF:8,8 (Q1/1D). Document type: Article.
Serra S, López-Granados L, Sisinni L, Serna JV, Martínez-Martínez L, Fernández de Gamarra E, de la Calle O, Badell I. Chronic hypogammaglobulinemia after allogeneic stem cell transplantation and their treatment with subcutanaeos inmunoglobulin in pediatric patients. ANALES DE PEDIATRIA. 2022; 97(2). DOI:10.1016/j.anpedi.2021.08.011. PMID:35869014. IF:2,1 (Q3/6D). Document type: Article.
Simoes AM, Holmstrom MO, Aehnlich P, Rahbech A, Radziwon A, Zamora C, Klausen TW, Skov V, Kjaer L, Ellervik C, El Fassi D, Vidal S, Hasselbalch HC, Andersen MH, Straten PT. Patients With Myeloproliferative Neoplasms Harbor High Frequencies of CD8 T Cell-Platelet Aggregates Associated With T Cell Suppression. Frontiers in Immunology. 2022; 13:866610. DOI:10.3389/fimmu.2022.866610. PMID:35603202. IF:7,3 (Q1/3D). Document type: Article.

Publicaciones 2021

Alserawan L, Penacoba P, Echevarria S, Castillo D, Ortiz E, Martinez L, Naranjo EM, Domingo P, Castellvi I, Juarez C, Mariscal A. Growth Differentiation Factor 15 (GDF-15): A Novel Biomarker Associated with Poorer Respiratory Function in COVID-19. Diagnostics. 2021; 11(11):1998. DOI:10.3390/diagnostics11111998. PMID:34829345. IF:3,992.
Canto E, Faba OR, Zamora C, Mulet M, Garcia MS, Palomino A, Anguera G, Breda A, Maroto P, Vidal S. Immunological Status of Bladder Cancer Patients Based on Urine Leukocyte Composition at Radical Cystectomy. Biomedicines. 2021; 9(9):1125. DOI:10.3390/biomedicines9091125. PMID:34572311. IF:4,757.
d’Alessandro M, Bergantini L, Bargagli E, Vidal S. Extracellular Vesicles in Pulmonary Fibrosis Models and Biological Fluids of Interstitial Lung Disease Patients: A Scoping Review. Life-Basel. 2021; 11(12):1401. DOI:10.3390/life11121401. PMID:34947932. IF:3,251.
Diaz C, Ortiz MA, Garcia A, Jeria S, Sainz L, Fernandez S, Corominas H, Vidal S. The inflammatory role of silent urate crystal deposition in intercritical gout. RHEUMATOLOGY. 2021; 60(11). DOI:10.1093/rheumatology/keab335. PMID:33839783. IF:7,046.
González-Manso A, Agut-Busquet E, Romaní J, Vilarrasa E, Bittencourt F, Mensa A, Cantó E, Aróstegui JI, Vidal S. Hidradenitis Suppurativa: Proposal of Classification in Two Endotypes with Two-Step Cluster Analysis. Dermatology. 2021;237(3):365-371. DOI:10.1159/000511045. PMID: 33171462. IF:5,197.
Isola I, Moreno DF, Moga E, Mena MP, Tovar N, Rodriguez LG, Oliver A, Salgado MC, Braso F, Yague J, Cibeira MT, Prat A, Rosinol L, Blade J, de Larrea CF. Immunoparesis defined by heavy/light chain pair suppression in smoldering multiple myeloma shows initial isotype specificity and involves other isotypes in advanced disease. ANNALS OF HEMATOLOGY. 2021; 100(12). DOI:10.1007/s00277-021-04653-2. PMID:34463804. IF:4,030.
Lleixa C, Martin L, Pascual E, Franco T, Caballero M, De Luna N, Gallardo E, Suarez X, Martinez L, Diaz J, Rojas R, Cortes E, Turon J, Casasnovas C, Homedes C, Gutierrez G, Jimeno MC, Berciano J, Sedano MJ, Garcia T, Pardo J, Marquez C, Rojas I, Jerico I, Martinez E, de la Tassa GM, Dominguez C, Juarez C, Illa I, Querol L. Autoantibody screening in Guillain-Barre syndrome. Journal of Neuroinflammation. 2021; 18(1):251. DOI:10.1186/s12974-021-02301-0. PMID:34719386. IF:9,587.
Magallares B, Lobo D, Castellvi I, Moya P, Gich I, Martinez L, Park H, Millan AM, Laiz A, Diaz C, Fernandez S, Corominas H. Assessment of EULAR/ACR-2019, SLICC-2012 and ACR-1997 Classification Criteria in SLE with Longstanding Disease. Journal of Clinical Medicine. 2021; 10(11):2377. DOI:10.3390/jcm10112377. PMID:34071275. IF:4,964.
Mariscal A, Milan M, Baucells A, Martinez MA, Guillen AG, Trallero E, Alvarado M, Martinez L, Alserawan L, Franco T, Sanz MT, Vinas L, Corominas H, Juarez C, Castellvi I, Selva A. Anti-TIF-1 gamma Antibody Detection Using a Commercial Kit vs In-House Immunoblot: Usefulness in Clinical Practice. Frontiers in Immunology. 2021; 11:625896. DOI:10.3389/fimmu.2020.625896. PMID:33613568. IF:8,786.
Mariscal A, Zamora C, Magallares B, Salman TC, Ortiz MA, Diaz C, Castellvi I, Corominas H, Vidal S. Phenotypic and Functional Consequences of PLT Binding to Monocytes and Its Association with Clinical Features in SLE. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(9):4719. DOI:10.3390/ijms22094719. PMID:33947017. IF:6,208.
Murillo JD, Diaz C, Ortiz MA, Coras R, Gil P, Pedersen A, Corominas H, Vidal S, Guma M. Metabolomics profiling predicts outcome of tocilizumab in rheumatoid arthritis: an exploratory study. Metabolomics. 2021; 17(9):74. DOI:10.1007/s11306-021-01822-2. PMID:34402961. IF:4,747.
Osuna R, Arqueros C, Galano C, Mulet M, Zamora C, Barnadas A, Vidal S. Effector Mechanisms of CD8+HLA-DR+ T Cells in Breast Cancer Patients Who Respond to Neoadjuvant Chemotherapy. Cancers. 2021; 13(24):6167. DOI:10.3390/cancers13246167. PMID:34944786. IF:6,575.
Pascual E, Fehmi J, Lleixa C, Martin L, Devaux J, Hoftberger R, Delmont E, Doppler K, Sommer C, Radunovic A, Carvajal A, Smyth S, Williams L, Mazanec R, Potockova V, Hinds N, Cassereau J, Viala K, Lefilliatre M, Nicolas G, Foley P, Leypoldt F, Keddie S, Lunn MP, Zimprich F, Nunkoo VS, Loscher WN, Martinez L, Diaz J, Rojas R, Illa I, Rinaldi S, Querol L. Antibodies to the Caspr1/contactin-1 complex in chronic inflammatory demyelinating polyradiculoneuropathy. BRAIN. 2021; 144. PMID:33880507. IF:15,255.
Perea L, Canto E, Suarez G, Aliberti S, Chalmers JD, Sibila O, Vidal S. A Cluster Analysis of Bronchiectasis Patients Based on the Airway Immune Profile. CHEST. 2021; 159(5). DOI:10.1016/j.chest.2020.11.011. PMID:33217421. IF:10,262.
Perea L, Rodriguez L, Nieto JC, Zamora C, Canto E, Soriano G, Poca M, Blanco P, Navarro F, Muniesa M, Vidal S. Bacteriophages immunomodulate the response of monocytes. EXPERIMENTAL BIOLOGY AND MEDICINE. 2021; 246(11). DOI:10.1177/1535370221995154. PMID:33641443. IF:4,088.
Perez S, Pallares N, Grijota MD, Sanchez A, Barcia L, Campos S, Pomar V, Rabunal R, Balcells ME, Gazel D, Montiel N, Vicente D, Goic I, Schon T, Paues J, Marekovic I, Cacho J, Barac A, Goletti D, Garcia M, Barcala JM, Tortola MT, Anibarro L, Suarez I, Moga E, Gude MJ, Naves R, Karsligil T, Martin T, Stevanovic G, Trigo M, Rubio V, Karaoglan I, Bayram N, et al. Identification of Recent Tuberculosis Exposure Using QuantiFERON-TB Gold Plus, a Multicenter Study. Microbiology Spectrum. 2021; 9(3):e00972-21. DOI:10.1128/Spectrum.00972-21. PMID:34756079. IF:9,043.
Pero M, Casani L, Castells C, Perez ML, Naranjo EM, Juan O, De Lamo LA, Lopez P, Serrat AV, Badimon L, Roda OP. Rabbit as an animal model for the study of biological grafts in pelvic floor dysfunctions. Scientific Reports. 2021; 11(1):10545. DOI:10.1038/s41598-021-89698-z. PMID:34006889. IF:4,996.
Piquero-Casals J, Martínez-Martínez L, Alomar A, Rozas-Muñoz E, Juarez C, Puig L. LRP1/CD91 is highly expressed in monocytes from patients with vitiligo – even after repigmentation. Experimental Dermatolgy. 2021;30(3):390-395. DOI:10.1111/exd.14249. PMID: 33249636. IF:4,511.
Román E, Parramón M, Flavià M, Gely C, Poca M, Gallego A, Santesmases R, Hernández E, Nieto JC, Urgell E, Alvarado-Tapias E, Vidal S, Ferrero-Gregori A, Vargas V, Guarner C, Soriano G. Frailty in outpatients with cirrhosis: A prospective observational study. Liver International. 2021;41(2):357-368. DOI:10.1111/liv.14694. PMID: 33030788. IF:8,754.
Roman E, Poca M, Amoros G, Rosell J, Gely C, Nieto JC, Vidal S, Urgell E, Ferrero A, Alvarado E, Cuyas B, Hernandez E, Santesmases R, Guarner C, Escorsell A, Soriano G. Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis. Scientific Reports. 2021; 11(1):20415. DOI:10.1038/s41598-021-99199-8. PMID:34650096. IF:4,996.
Vidal S, Puig L, Carrascosa JM, Gonzalez A, Ruiz JC, Velasco AM. From Messengers to Receptors in Psoriasis: The Role of IL-17RA in Disease and Treatment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(13):6740. DOI:10.3390/ijms22136740. PMID:34201664. IF:6,208.
Zamora C, Canto E, Vidal S. The Dual Role of Platelets in the Cardiovascular Risk of Chronic Inflammation. Frontiers in Immunology. 2021; 12:625181. DOI:10.3389/fimmu.2021.625181. PMID:33868242. IF:8,786.
Zamora C, Riudavets M, Anguera G, Alserawan L, Sullivan I, Barba A, Serra J, Ortiz MA, Gallardo P, Perea L, Gavira J, Barnadas A, Majem M, Vidal S. Circulating leukocyte-platelet complexes as a predictive biomarker for the development of immune-related adverse events in advanced non-small cell lung cancer patients receiving anti-PD-(L)1 blocking agents. CANCER IMMUNOLOGY IMMUNOTHERAPY. 2021; 70(6). DOI:10.1007/s00262-020-02793-4. PMID:33388994. IF:6,630.

MEDICINA TRANSLACIONAL

Enfermedades Inflamatorias

Principales líneas de investigación

Retos

Coordinación del grupo

Miembros

Publicaciones 2023

Publicaciones 2022

Publicaciones 2021

Principales líneas de investigación

Retos

Coordinación del grupo

Miembros

Publicaciones 2023

Publicaciones 2022

Publicaciones 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau