Sant Pau - Institut de Recerca

Tissue procurement, clinical application, ethics and regulation.

Tissue decellularization approaches for clinical applications.
Cell-based therapy for ocular diseases.
3D bioimpression and biocompatible substrates.
Ex-vivo cell expansion for regenerative purposes.

Challenges

Optimization and improvement of technical procedures related to the donor and tissues. Advances in the elaboration of criteria, regulation and ethics for donor and tissues.
Technical excellence related to the processing cells, tissues and advanced therapies medical products (ATMP).
The development of new approaches and ATMPs for regenerative medicine.

Coordinación del grupo

CASTELLS SALA CRISTINA BST
ccastells@bst.cat

Miembros

Baptista Piteira, Ana Rita BST
Bermudo Gascon, Raquel BST
Cabrera Perez, Raquel BST
Fariñas Barbera, Oscar BST
Rodriguez Martinez, Jose Ignacio BST
Ruiz Ponsell, Laia BST
Savio Lopez, Andres BST
Tabera Fernandez, Jaime BST
Vilarrodona Serrat, Anna BST

Publicaciones 2023

(JIF 2022)

-Castells C, Pérez ML, Agustí E, Aiti A, Tarragona E, Navarro A, Tabera J, Farinas O, Pomar JL, Vilarrodona A. Last twenty-years activity of cardiovascular tissue banking in Barcelona. CELL AND TISSUE BANKING. 2023; DOI:10.1007/s10561-022-10059-9. PMID:36849631. IF:1,500 (Q4/9D). Document type: Article.

-Castells C, Perez ML, Lopez P, Lopez L, Martinez J, Ruiz L, Aiti A, Madariaga SE, Sastre S, Farinas O, Vilarrodona A. Development of a full-thickness acellular dermal graft from human skin: Case report of first patient rotator cuff patch augmentation repair. TRANSPLANT IMMUNOLOGY. 2023; 78:101825. DOI:10.1016/j.trim.2023.101825. PMID:36934900. IF:1,500 (Q4/8D). Document type: Article.

-Contreras E, Traserra S, Bolívar S, Nieto N, Jaramillo J, Forés J, Jose E, Moll X, García F, Delgado I, Fariñas O, López P, Vilarrodona A, Udina E, Navarro X. Decellularized Graft for Repairing Severe Peripheral Nerve Injuries in Sheep. Neurosurgery. 2023; 93(6). DOI:10.1227/neu.0000000000002572. PMID:37319401. IF:4,800 (Q1/1D). Document type: Article.

-Corcoll F, Perez D, Karbysheva S, Trampuz A, Farinas O, Monllau JC. Are Hamstring Grafts a Predisposing Factor to Infection in R-ACL Surgery? A Comparative In Vitro Study. Pathogens. 2023; 12(6):761. DOI:10.3390/pathogens12060761. PMID:37375451. IF:3,700 (Q2/5D). Document type: Article.

-Lopez P, Perez ML, Castells C, Piteria RA, Farinas O, Tabera J, Vilarrodona A. Quality by Design: Development of Safe and Efficacious Full-Thickness Acellular Dermal Matrix Based on EuroGTPII Methodologies. Therapeutics and Clinical Risk Management. 2023; 19. DOI:10.2147/TCRM.S410574. PMID:37425344. IF:2,800 (Q3/6D). Document type: Article.

-Sabater N, Figueras M, Martinez EM, Vilarrodona A, Casaroli RP. Pterygium surgery with lyophilized versus cryopreserved amniotic membrane graft. JOURNAL FRANCAIS D OPHTALMOLOGIE. 2023; 46(3). DOI:10.1016/j.jfo.2022.08.014. PMID:36792470. IF:1,200 (Q4/10D). Document type: Article.

-Schwab N, Jordana X, Soler J, Garrido X, Brillas P, Savio A, Lavín S, Ortega M, Galtés I. Can Synbone® cylinders and deer femurs reproduce ballistic fracture patterns observed in human long bones?. JOURNAL OF MATERIALS SCIENCE. 2023; 58(11). DOI:10.1007/s10853-023-08333-6. IF:4,500 (Q2/4D). Document type: Article.

Publicaciones 2022

(JIF 2022)

Contreras E, Bolivar S, Nieto N, Farinas O, Lopez P, Navarro X, Udina E. A novel decellularized nerve graft for repairing peripheral nerve long gap injury in the rat. CELL AND TISSUE RESEARCH. 2022; 390(3). DOI:10.1007/s00441-022-03682-1. PMID:36114915. IF:3,6 (Q3/7D). Document type: Article.
Gelber PE, Ramirez E, Farinas O. Early Postoperative CT Scan Provides Prognostic Data on Clinical Outcomes of Fresh Osteochondral Transplantation of the Knee. AMERICAN JOURNAL OF SPORTS MEDICINE. 2022; 50(14). DOI:10.1177/03635465221129601. PMID:36322380. IF:4,8 (Q1/1D). Document type: Article.
Gelber PE, Ramirez E, Grau A, Gonzalez A, Farinas O. Computerized tomography scan evaluation after fresh osteochondral allograft transplantation of the knee correlates with clinical outcomes. INTERNATIONAL ORTHOPAEDICS. 2022; 46(7). DOI:10.1007/s00264-022-05373-6. PMID:35411436. IF:2,7 (Q2/4D). Document type: Article.
Lopez P, Riba T, Farinas O, Gelber PE, Casaroli RP, Vilarrodona A. A Comparative Study Using Fluorescent Confocal Microscopy and Flow Cytometry to Evaluate Chondrocyte Viability in Human Osteochondral Allografts. Bioengineering-Basel. 2022; 9(10):515. DOI:10.3390/bioengineering9100515. PMID:36290483. IF:4,6 (Q2/4D). Document type: Article.
Nieto N, Lopez P, Torrico C, Bolivar S, Contreras E, Udina E, Navarro X, Casaroli RP, Farinas O, Vilarrodona A. «Off-the-Shelf» Nerve Matrix Preservation. Biopreservation and Biobanking. 2022; 20(1). DOI:10.1089/bio.2020.0158. PMID:34542324. IF:1,6 (Q3/6D). Document type: Article.
Perez ML, Barreales S, Sabater N, Martinez EM, Vilarrodona A, Casaroli RP. Amniotic membrane extract eye drops: a new approach to severe ocular surface pathologies. CELL AND TISSUE BANKING. 2022; 23(3). DOI:10.1007/s10561-021-09962-4. PMID:34549352. IF:1,5 (Q4/9D). Document type: Article.
Pero M, Castells C, Alserawan L, Casani L, Juan JO, Jorba I, Pérez ML, Moga E, Otero J, López P, Badimon L, Vilarrodona A, Porta O. Comparison of a human acellular dermal matrix and a polypropylene mesh for pelvic floor reconstruction: a randomized trial study in a rabbit model. Scientific Reports. 2022; 12(1):20698. DOI:10.1038/s41598-022-22190-4. PMID:36450745. IF:4,6 (Q2/3D). Document type: Article.
Sabater N, Martinez E, Vilarrodona A, Casaroli RP. Lyophilized amniotic membrane graft for primary pterygium surgery: preliminary results. CELL AND TISSUE BANKING. 2022; 23(2). DOI:10.1007/s10561-021-09955-3. PMID:34628551. IF:1,5 (Q4/9D). Document type: Article.

Publicaciones 2021

Canut MI, Villa O, Kudsieh B, Mattlin H, Banchs I, Gonzalez JR, Armengol L, Casaroli RP. MLIP genotype as a predictor of pharmacological response in primary open-angle glaucoma and ocular hypertension. Scientific Reports. 2021; 11(1):1583. DOI:10.1038/s41598-020-80954-2. PMID:33452295. IF:4,996.
Duarri A, Rodríguez E, Martínez G, Biarnés M, García M, Ferraro LL, Kuebler B, Aran B, Izquierdo E, Aguilera E, Casaroli RP, Trias E, Fernandez E, Raya Á, Veiga A, Monés J. Transplantation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in a Swine Model of Geographic Atrophy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(19):10497. DOI:10.3390/ijms221910497. PMID:34638840. IF:6,208.
Figueras-Roca M, Parrado-Carrillo A, Nguyen V, Casaroli-Marano RP, Moll-Udina A, Gillies MC, Barthelmes D, Zarranz-Ventura J. Treat-and-extend versus fixed bimonthly treatment regimens for treatment-naive neovascular age-related macular degeneration: real world data from the Fight Retinal Blindness registry. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2021;259(6):1463-1470. DOI:10.1007/s00417-020-05016-9. PMID: 33219442. IF:3,535.
Garcia-Lopez J, Delgadillo J, Vilarrodona A, Querol S, Ovejo J, Coll R, Millan A, Madrigal A, Soria G, Vidal F, Vives J, Herrero MJ, Lopez I, Sauleda S, Contreras E, Grifols JR, Guasch R, Tahull E, Puig L, Masip A, Argelagués E, Muñiz-Diaz E. SARS-CoV-2/COVID-19 pandemic: first wave, impact, response and lessons learnt in a fully integrated Regional Blood and Tissue Bank. A narrative report. Blood Transfusion. 2021;19(2):158-167. DOI:10.2450/2021.0259-20. PMID: 33539280. IF:5,752.
Gelber PE, Ramirez E, Grau A, Gonzalez A, Llauger J, Farinas O. A new computed tomography scoring system to assess osteochondral allograft transplantation for the knee: inter-observer and intra-observer agreement. INTERNATIONAL ORTHOPAEDICS. 2021; 45(5). DOI:10.1007/s00264-020-04927-w. PMID:33416905. IF:3,479.
Nieto N, Lopez P, Farinas O, Bolivar S, Udina E, Navarro X, Casaroli RP, Vilarrodona A. Effective decellularization of human nerve matrix for regenerative medicine with a novel protocol. CELL AND TISSUE RESEARCH. 2021; 384(1). DOI:10.1007/s00441-020-03317-3. PMID:33471198. IF:4,051.
Nieto N, Martinez EM, Fuentes S, Arnalich F, Garcia I, De Miguel MP, Casaroli RP. Priming human adipose-derived mesenchymal stem cells for corneal surface regeneration. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2021; 25(11). DOI:10.1111/jcmm.16501. PMID:33951289. IF:5,295.
Perez ML, Castells C, Lopez P, Nieto N, Aiti A, Farinas O, Casaroli RP, Porta O, Vilarrodona A. Fast protocol for the processing of split-thickness skin into decellularized human dermal matrix. TISSUE & CELL. 2021; 72:101572. DOI:10.1016/j.tice.2021.101572. PMID:34119882. IF:2,586.
Pero M, Casani L, Castells C, Perez ML, Naranjo EM, Juan O, De Lamo LA, Lopez P, Serrat AV, Badimon L, Roda OP. Rabbit as an animal model for the study of biological grafts in pelvic floor dysfunctions. Scientific Reports. 2021; 11(1):10545. DOI:10.1038/s41598-021-89698-z. PMID:34006889. IF:4,996.
Piteira AR, Bofill AM, Farinas O, Tabera J, Vilarrodona A. Lessons Learned From SARS-CoV-2 Pandemic in Donation and Tissue Banking Activities: Key Takeaways. TRANSPLANTATION. 2021; 105(7). DOI:10.1097/TP.0000000000003716. PMID:34019361. IF:5,385.
Sabater N, Figueras M, Ferran M, Agusti E, Martinez EM, Perez ML, Vilarrodona A, Casaroli RP. Amniotic membrane extract eye drops for ocular surface diseases: use and clinical outcome in real-world practice. INTERNATIONAL OPHTHALMOLOGY. 2021; 41(9). DOI:10.1007/s10792-021-01856-4. PMID:33864578. IF:2,029.
Sabater N, Figueras M, Padro L, Tort J, Casaroli RP. Corneal transplantation activity in Catalonia, Spain, from 2011 to 2018: Evolution of indications and surgical techniques. PLoS One. 2021; 16(4):e0249946. DOI:10.1371/journal.pone.0249946. PMID:33831081. IF:3,752.
Sabater N, Otero N, Dotti M, Rios J, Gris O, Guell JL, Vilarrodona A, Casaroli RP. Eye bank and theatre factors for positive microbiological culture of corneoscleral rim and cornea storage medium in the real-world. EYE. 2021; 35(11). DOI:10.1038/s41433-020-01342-8. PMID:33469128. IF:4,456.
Samarkanova D, Cox S, Hernandez D, Rodriguez L, Perez ML, Madrigal A, Vilarrodona A, Querol S, Casaroli RP. Cord blood and amniotic membrane extract eye drop preparations display immune-suppressive and regenerative properties. Scientific Reports. 2021; 11(1):13754. DOI:10.1038/s41598-021-93150-7. PMID:34215804. IF:4,996.
Samarkanova D, Martin S, Bisbe L, Puig J, Calatayud M, Rodriguez L, Azqueta C, Coll R, Casaroli R, Madrigal A, Rebulla P, Querol S, Barcelona Cbed Study GRP. Clinical evaluation of allogeneic eye drops from cord blood platelet lysate. Blood Transfusion. 2021; 19(4). DOI:10.2450/2020.0130-20. PMID:33085593. IF:5,752.

Presentación

Tissue procurement, clinical application, ethics and regulation.

Tissue decellularization approaches for clinical applications.
Cell-based therapy for ocular diseases.
3D bioimpression and biocompatible substrates.
Ex-vivo cell expansion for regenerative purposes.

Challenges

Optimization and improvement of technical procedures related to the donor and tissues. Advances in the elaboration of criteria, regulation and ethics for donor and tissues.
Technical excellence related to the processing cells, tissues and advanced therapies medical products (ATMP).
The development of new approaches and ATMPs for regenerative medicine.

Equipo

Coordinación del grupo

CASTELLS SALA CRISTINA BST
ccastells@bst.cat

Miembros

Producción científica

Publicaciones 2023

(JIF 2022)

Publicaciones 2022

(JIF 2022)

Contreras E, Bolivar S, Nieto N, Farinas O, Lopez P, Navarro X, Udina E. A novel decellularized nerve graft for repairing peripheral nerve long gap injury in the rat. CELL AND TISSUE RESEARCH. 2022; 390(3). DOI:10.1007/s00441-022-03682-1. PMID:36114915. IF:3,6 (Q3/7D). Document type: Article.
Gelber PE, Ramirez E, Farinas O. Early Postoperative CT Scan Provides Prognostic Data on Clinical Outcomes of Fresh Osteochondral Transplantation of the Knee. AMERICAN JOURNAL OF SPORTS MEDICINE. 2022; 50(14). DOI:10.1177/03635465221129601. PMID:36322380. IF:4,8 (Q1/1D). Document type: Article.
Gelber PE, Ramirez E, Grau A, Gonzalez A, Farinas O. Computerized tomography scan evaluation after fresh osteochondral allograft transplantation of the knee correlates with clinical outcomes. INTERNATIONAL ORTHOPAEDICS. 2022; 46(7). DOI:10.1007/s00264-022-05373-6. PMID:35411436. IF:2,7 (Q2/4D). Document type: Article.
Lopez P, Riba T, Farinas O, Gelber PE, Casaroli RP, Vilarrodona A. A Comparative Study Using Fluorescent Confocal Microscopy and Flow Cytometry to Evaluate Chondrocyte Viability in Human Osteochondral Allografts. Bioengineering-Basel. 2022; 9(10):515. DOI:10.3390/bioengineering9100515. PMID:36290483. IF:4,6 (Q2/4D). Document type: Article.
Nieto N, Lopez P, Torrico C, Bolivar S, Contreras E, Udina E, Navarro X, Casaroli RP, Farinas O, Vilarrodona A. «Off-the-Shelf» Nerve Matrix Preservation. Biopreservation and Biobanking. 2022; 20(1). DOI:10.1089/bio.2020.0158. PMID:34542324. IF:1,6 (Q3/6D). Document type: Article.
Perez ML, Barreales S, Sabater N, Martinez EM, Vilarrodona A, Casaroli RP. Amniotic membrane extract eye drops: a new approach to severe ocular surface pathologies. CELL AND TISSUE BANKING. 2022; 23(3). DOI:10.1007/s10561-021-09962-4. PMID:34549352. IF:1,5 (Q4/9D). Document type: Article.
Pero M, Castells C, Alserawan L, Casani L, Juan JO, Jorba I, Pérez ML, Moga E, Otero J, López P, Badimon L, Vilarrodona A, Porta O. Comparison of a human acellular dermal matrix and a polypropylene mesh for pelvic floor reconstruction: a randomized trial study in a rabbit model. Scientific Reports. 2022; 12(1):20698. DOI:10.1038/s41598-022-22190-4. PMID:36450745. IF:4,6 (Q2/3D). Document type: Article.
Sabater N, Martinez E, Vilarrodona A, Casaroli RP. Lyophilized amniotic membrane graft for primary pterygium surgery: preliminary results. CELL AND TISSUE BANKING. 2022; 23(2). DOI:10.1007/s10561-021-09955-3. PMID:34628551. IF:1,5 (Q4/9D). Document type: Article.

Publicaciones 2021

Canut MI, Villa O, Kudsieh B, Mattlin H, Banchs I, Gonzalez JR, Armengol L, Casaroli RP. MLIP genotype as a predictor of pharmacological response in primary open-angle glaucoma and ocular hypertension. Scientific Reports. 2021; 11(1):1583. DOI:10.1038/s41598-020-80954-2. PMID:33452295. IF:4,996.
Duarri A, Rodríguez E, Martínez G, Biarnés M, García M, Ferraro LL, Kuebler B, Aran B, Izquierdo E, Aguilera E, Casaroli RP, Trias E, Fernandez E, Raya Á, Veiga A, Monés J. Transplantation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in a Swine Model of Geographic Atrophy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(19):10497. DOI:10.3390/ijms221910497. PMID:34638840. IF:6,208.
Figueras-Roca M, Parrado-Carrillo A, Nguyen V, Casaroli-Marano RP, Moll-Udina A, Gillies MC, Barthelmes D, Zarranz-Ventura J. Treat-and-extend versus fixed bimonthly treatment regimens for treatment-naive neovascular age-related macular degeneration: real world data from the Fight Retinal Blindness registry. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2021;259(6):1463-1470. DOI:10.1007/s00417-020-05016-9. PMID: 33219442. IF:3,535.
Garcia-Lopez J, Delgadillo J, Vilarrodona A, Querol S, Ovejo J, Coll R, Millan A, Madrigal A, Soria G, Vidal F, Vives J, Herrero MJ, Lopez I, Sauleda S, Contreras E, Grifols JR, Guasch R, Tahull E, Puig L, Masip A, Argelagués E, Muñiz-Diaz E. SARS-CoV-2/COVID-19 pandemic: first wave, impact, response and lessons learnt in a fully integrated Regional Blood and Tissue Bank. A narrative report. Blood Transfusion. 2021;19(2):158-167. DOI:10.2450/2021.0259-20. PMID: 33539280. IF:5,752.
Gelber PE, Ramirez E, Grau A, Gonzalez A, Llauger J, Farinas O. A new computed tomography scoring system to assess osteochondral allograft transplantation for the knee: inter-observer and intra-observer agreement. INTERNATIONAL ORTHOPAEDICS. 2021; 45(5). DOI:10.1007/s00264-020-04927-w. PMID:33416905. IF:3,479.
Nieto N, Lopez P, Farinas O, Bolivar S, Udina E, Navarro X, Casaroli RP, Vilarrodona A. Effective decellularization of human nerve matrix for regenerative medicine with a novel protocol. CELL AND TISSUE RESEARCH. 2021; 384(1). DOI:10.1007/s00441-020-03317-3. PMID:33471198. IF:4,051.
Nieto N, Martinez EM, Fuentes S, Arnalich F, Garcia I, De Miguel MP, Casaroli RP. Priming human adipose-derived mesenchymal stem cells for corneal surface regeneration. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2021; 25(11). DOI:10.1111/jcmm.16501. PMID:33951289. IF:5,295.
Perez ML, Castells C, Lopez P, Nieto N, Aiti A, Farinas O, Casaroli RP, Porta O, Vilarrodona A. Fast protocol for the processing of split-thickness skin into decellularized human dermal matrix. TISSUE & CELL. 2021; 72:101572. DOI:10.1016/j.tice.2021.101572. PMID:34119882. IF:2,586.
Pero M, Casani L, Castells C, Perez ML, Naranjo EM, Juan O, De Lamo LA, Lopez P, Serrat AV, Badimon L, Roda OP. Rabbit as an animal model for the study of biological grafts in pelvic floor dysfunctions. Scientific Reports. 2021; 11(1):10545. DOI:10.1038/s41598-021-89698-z. PMID:34006889. IF:4,996.
Piteira AR, Bofill AM, Farinas O, Tabera J, Vilarrodona A. Lessons Learned From SARS-CoV-2 Pandemic in Donation and Tissue Banking Activities: Key Takeaways. TRANSPLANTATION. 2021; 105(7). DOI:10.1097/TP.0000000000003716. PMID:34019361. IF:5,385.
Sabater N, Figueras M, Ferran M, Agusti E, Martinez EM, Perez ML, Vilarrodona A, Casaroli RP. Amniotic membrane extract eye drops for ocular surface diseases: use and clinical outcome in real-world practice. INTERNATIONAL OPHTHALMOLOGY. 2021; 41(9). DOI:10.1007/s10792-021-01856-4. PMID:33864578. IF:2,029.
Sabater N, Figueras M, Padro L, Tort J, Casaroli RP. Corneal transplantation activity in Catalonia, Spain, from 2011 to 2018: Evolution of indications and surgical techniques. PLoS One. 2021; 16(4):e0249946. DOI:10.1371/journal.pone.0249946. PMID:33831081. IF:3,752.
Sabater N, Otero N, Dotti M, Rios J, Gris O, Guell JL, Vilarrodona A, Casaroli RP. Eye bank and theatre factors for positive microbiological culture of corneoscleral rim and cornea storage medium in the real-world. EYE. 2021; 35(11). DOI:10.1038/s41433-020-01342-8. PMID:33469128. IF:4,456.
Samarkanova D, Cox S, Hernandez D, Rodriguez L, Perez ML, Madrigal A, Vilarrodona A, Querol S, Casaroli RP. Cord blood and amniotic membrane extract eye drop preparations display immune-suppressive and regenerative properties. Scientific Reports. 2021; 11(1):13754. DOI:10.1038/s41598-021-93150-7. PMID:34215804. IF:4,996.
Samarkanova D, Martin S, Bisbe L, Puig J, Calatayud M, Rodriguez L, Azqueta C, Coll R, Casaroli R, Madrigal A, Rebulla P, Querol S, Barcelona Cbed Study GRP. Clinical evaluation of allogeneic eye drops from cord blood platelet lysate. Blood Transfusion. 2021; 19(4). DOI:10.2450/2020.0130-20. PMID:33085593. IF:5,752.

MEDICINA TRANSLACIONAL

Medicina regenerativa y bioingeniería de los tejidos

Tissue procurement, clinical application, ethics and regulation.

Challenges

Coordinación del grupo

Miembros

Publicaciones 2023

Publicaciones 2022

Publicaciones 2021

Tissue procurement, clinical application, ethics and regulation.

Challenges

Coordinación del grupo

Miembros

Publicaciones 2023

Publicaciones 2022

Publicaciones 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau