Acute myeloid leukemia is a very heterogeneous disease, the usual treatment is very aggressive and with severe side effects. In the investigation of a new, more effective drug, researchers led by the Oncogenesis and Antitumoral Research Group of the Sant Pau Hospital Research Institute – IIB Sant Pau (Ramon Mangues, Isolda Casanova and Víctor Pallarès) attached to the CIBER-BBN, have demonstrated the efficacy of the self-created nanoparticle that blocks the spread of leukemia cells in animal models of acute myeloid leukemia and directly attacks tumor cells without damaging healthy ones, minimizing adverse effects.

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Patricia Cancelo, sculptor, painter and journalist, has donated a collection of sculptures and paintings, valued at 10,000 euros, to the Sant Pau, in order to start two research projects in the field of pregnancy, childbirth and postpartum in women affected by Covid-19. These two studies are part of the more than 30 works initiated by the Sant Pau Research Institute in the field of Covid-19.

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The Berlin State Senate, at the proposal of the Mayor of this city and the Senator for Science and Research, Michael Müller, recently appointed Lina Badimon, director of the “ICCC Cardiovascular Program” of the Sant Pau-IIB Sant Pau Research Institute and group leader of the CIBERCV, as a new Member of the Supervisory Board of the Berlin Health Institute (BIH Supervisory Board).

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One of the world’s leading medical journals, The Lancet, published the article ‘Clinical and biomarker changes of Alzheimer’s disease in adults with Down syndrome: a cross-sectional study’, led by the Alzheimer-Down Unit of Hospital de la Santa Creu i Sant Pau and the Fundación Catalana Síndrome de Down, in collaboration with researchers of the University of Cambridge, United Kingdom, promoted by Fundació “la Caixa”.

Link to the article

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Researchers in the research group on the Metabolic Basis of Cardiovascular Risk at the Sant Pau Research Institute, attached to CIBERDEM, led by Juan Carlos Escolà-Gil and Francisco Blanco-Vaca, have identified a new metabolic pathway that allows HDLs to transport cholesterol from macrophages in the artery wall and transfer it to LDLs for its subsequent elimination from the body through the liver. The work carried out in collaboration with other Spanish and Finnish researchers has been published in Circulation Research.

More information

Next Saturday 27th June at 6 p.m., the first regulated race in the new normality will take place at the Sant Pau Modernist complex, organised by the Hospital de Sant Pau and Champion, with the support of the Fundació Privada Hospital de la Santa Creu i Sant Pau. The entire proceeds will be used for the Sant Pau investigation against Covid-19.

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The 2020 edition of La Marató of TV3 and Catalunya Radio por Covid-19 will be exceptional and one of the first novelties is the dissemination and awareness campaign, which usually starts in October and, in this edition, starts with a first phase in June with the graphic image, the slogan of the campaign, a new solidarity product and the possibility of already making donations.

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Researchers from the Research Group on Lipids and Cardiovascular Pathology at IR Sant Pau and IIBB-CSIC, led by Dr. Vicenta Llorente, have published an article in Theranostics. In the article “Immunization with the Gly1127-Cys1140 amino acid sequence of the LRP1 receptor reduces atherosclerosis in rabbits. Molecular, immunohistochemical and nuclear imaging studies ”have also collaborated researchers from the Autonomous University of Barcelona and the Hospital Vall d’Hebron in the context of different CIBER groups.

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The building of the Research Institute of the Hospital de la Santa Creu i Sant Pau has obtained the LEED GOLD certification from the U.S. Green Building Council, which identifies the building as an example of energy efficiency and sustainability both in its construction and in its useful life and demonstrates the leadership of the awarded Institution in favour of energy rationality and the transformation towards a more sustainable building.

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La Fura dels Baus has presented at the Sant Pau Modernist enclosure the charity show NN (New Normality). The proposal, which will pay tribute to the health sector and to all those who are fighting to overcome the Covid-19, will allocate the money collected from their performances at the site to the Covid-19 micro-patronage campaign of the Hospital de Sant Pau.

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The Sant Pau Institute for Biomedical Research (IIB Sant Pau) has initiated more than 30 research projects to combat and learn more about the new coronavirus and Covid-19 disease. The projects are developed in different research areas in order to have a global vision of the disease.

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A new study by Sant Pau researchers attached to CIBERDEM and CIBERCV establishes that patients with severe/advanced abdominal aortic aneurysm (AAA) present a significant reduction in the main cardioprotective function of HDLs, their ability to prevent the accumulation of cholesterol in the macrophages of the arterial wall.

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The Alliance of Institutes for Health Research and Innovation in Catalonia (IRISCAT) is organizing its first joint scientific dissemination action: a series of webinars that will address different topics related to biomedical research and COVID-19. These online research seminars will be held every two weeks and the first one, led by Dr. Manuel Puig, from the Germans Trias i Pujol Hospital and Research Institute, will take place on 27 May at 4 pm.

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A higher degree of adherence to the Mediterranean Diet is associated with better quality of life in patients with type 1 diabetes. This is demonstrated by a multicentre study published in Nutrients and promoted by the CIBER group on diabetes and metabolic diseases (CIBERDEM) at the Sant Pau Biomedical Research Institute (IIB Sant Pau), led by Dr. Dídac Mauricio, head of the Endocrinology, Diabetes and Nutrition Research Group at the Sant Pau Research Institute and director of the Endocrinology and Nutrition Service at Sant Pau Hospital.

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The Pneumology and Intensive Care Medicine Services of Sant Pau have collaborated in the writing of a scientific article, which has recently been published in the prestigious American Journal of Respiratory and Critical Care Medicine.

The paper describes the experience of Sant Pau in performing bronchoscopies in severe patients with COVID-19, respiratory failure and invasive mechanical ventilation. The data were collected during the first three weeks of the epidemic outbreak and it is the first published worldwide series of these characteristics. In addition to the description of technical aspects, the work shows that the performance of bronchoscopies in these patients has contributed favorably to the management of bronchial secretions and infectious complications.

Article link

Researchers from the CIBER on Cardiovascular Diseases (CIBERCV) have analysed the contribution of a protein (the NOR-1 nuclear receptor) to the progression of hypertensive cardiac hypertrophy, thanks to the creation of a transgenic mouse model. In this way, they open a new way to discover new therapies to face this disease, which is the main cause of heart failure, one of the most important health problems of our society.

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Dr. Israel Fernández Cadenas, from the Pharmacogenomics and Neurovascular Genetics Research Group at the Sant Pau Research Institute, is one of the 25 speakers who today presented their work at the Research Symposium on Coronavirus organized by the Catalan Society of Biology.

In his participation, Dr. Fenández Cadenas has presented the INMUNGEN-CoV2 Project that his group has initiated in the Institute of Research of Sant Pau together with Dr. Anna Planas Principal Investigator and member of the IIB-CSIC and with Dr. Jordi Pérez Tur of the IBV-CSIC with financing of the CSIC.

A Sant Paul’s study of the factors that determine aortic diameter in families at high risk for abdominal aortic aneurysm (AAA) reveals two new candidate genes. The article was recently published in the Journal of Clinical Mecicine: https://www.mdpi.com/2077-0383/9/4/1242

The Complex Diseases Genomics Group of the Sant Pau Hospital Research Institute – IIB Sant Pau, led by Dr. José Manuel Soria, demonstrates, for the first time, which epigenetic mechanisms are involved in the risk of suffering a thrombotic condition. This work, which will be published in the May issue of the prestigious scientific journal ATVB (Arteriosclerosis, Thrombosis and Vascular Biology), recognizes the group of Sant Pau scientists as world pioneers in establishing an epigenetic profile of thrombosis.

Link to the article

The study has specifically analysed microRNAs, elements responsible for regulating the expression of our genes under certain specific circumstances, and has made it possible to establish a profile of microRNA expression (biomarkers) as a risk factor for thrombosis. This allows us to establish a pattern that detects the genetic predisposition of a patient to develop thrombotic conditions.

The results of the work will improve the diagnosis, prevention and treatment of thrombosis, changing clinical practice, and therefore will have a high impact on the health of the population.

Only in Europe, every minute, a person dies from a thrombotic event

Currently, the Complex Disease Genomics research group is analyzing the impact that this microRNA profile has on the risk of thrombosis in cancer patients, since thromboembolic disease is the leading cause of death among cancer patients (about 20% of cancer patients will suffer a thrombotic event, depending on the type of tumor).

This microRNA profile will also play an important role in the project that the Sant Pau Research Group is designing to assess the risk of thrombosis in the COVID patient, who develops coagulation and thrombosis disorders, which is a serious clinical complication with a high mortality rate.

The team of scientists has developed the study at the Hospital de Sant Pau Research Institute – IIB Sant Pau, and it is led by the head of the Complex Diseases Genomics Group of the same institute, Dr. José Manuel Soria, who has coordinated Drs. Alba Rodríguez-Ríos, Sonia López, Angel Martínez-Pérez and Dr. Juan Carlos Souto, research member of the Hospital de la Santa Creu i Sant Pau and consultant to the Haemostasis Unit of the Haematology Service.

Association “ACTIVA’TT against thrombosis”

Doctors Soria and Souto are founding members of the association “ACTIVA’TT against thrombosis”, which works with the Sant Pau Research Institute and the Hospital de Sant Pau, to improve the diagnosis, prevention, treatment and social education towards these important pathologies.

www.activatt.com

Dr. Eduard Gallardo has been appointed group leader of the U762 CIBERER (Centre for Research on Rare Disease Networks) in Sant Pau, replacing Dr. Isabel Illa. This research group specializes in neuromuscular diseases.

Since 1993, Dr. Gallardo has been working in the field of desinmune neuropathies, myasthenia, inflammatory myopathies and muscular dystrophies, specifically in dysferlinopathies. He has published over 100 articles in scientific journals in the field of neuromuscular diseases and has been a principal investigator in 12 research projects.

The research carried out by this research group at CIBERER de Sant Pau is clearly translational, which has led to the development of multiple diagnostic techniques that have been incorporated into the Hospital de Sant Pau’s laboratory test portfolio.

The goals achieved in the laboratory, together with the work of excellence in the clinic of the Neuromuscular Diseases Unit of the Hospital de Sant Pau, led by Dr. Isabel Illa, have led the group to be highlighted as a unit of excellence in Spain (CSUR) – http://www.santpau.cat/web/public/csur– and in Europe (ERN).