Sant Pau - Institut de Recerca

Main lines of research

Physiopathological role of LRP family proteins
in chronic diseases.
Identification and characterization of transcription factors and genetic targets. Role of lipids and inflammation.
Vascular impact of ischaemia and angiogenesis in heart disease. Cell therapy.
Research into new targets to inhibit the transformation of silent atherosclerosis into ischaemic syndromes: tissue-factormediated angiogenic switch.

Challenges

Broaden the experimental focus to include transgenic animal models with/without cardiovascular risk factors in order to proceed to in-depth analysis of molecules involved in the modulation of new proteins identified by post-genomic technologies and systems biology approaches.
Maintain present scientific networks and establish new multidisciplinary collaborations.
Increase international funding for the extension of new and established platforms in order to implement proposed activities.

Group coordination

VILAHUR GARCIA, GEMMA IR
gvilahur@santpau.cat

Members

Alcover Rullan, Sebastian IR
Borrell Pages, Maria Montserrat IR
Canovas Noe, Maria Angeles IR
Catalina Garcia, Pablo IR
Escate Chavez, Oscar Rafael CIBERCV
Giron Martinez, Gabriela O. IR
Grau Ruiz, Gerard IR
Huertas Segarra, Sonia IR
Lopez Bernal, Sergio IR
Lopez Yerena, Anallely IR
Luquero Gomez, Aureli IR
Muñoz Garcia, Natalia IR
Otero Rodriguez, Sergi IR
Pescador Romero, Monica IR
Pimentel Mayordomo, Noelia IR
Ramos Regalado, Lisaidy IR
Simon Ramon, Clara IR
Suades Soler, Rosa IR

Publications 2023

(JIF 2023)

-Andreotti F, Geisler T, Collet JP, Gigante B, Gorog DA, Halvorsen S, Lip GYH, Morais J, Navarese EP, Patrono C, Rocca B, Rubboli A, Sibbing D, Storey RF, Verheugt F, Vilahur G. Acute, periprocedural and longterm antithrombotic therapy in older adults 2022 Update by the ESC Working Group on Thrombosis. EUROPEAN HEART JOURNAL. 2023; 44(4). DOI:10.1093/eurheartj/ehac515. PMID:36477po865. IF:38,100 (Q1/1D). Document type: Review.

-Arderiu G, Civit A, Badimon L. Adipose-Derived Stem Cells to Treat Ischemic Diseases: The Case of Peripheral Artery Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(23):16752. DOI:10.3390/ijms242316752. PMID:38069074. IF:4,900 (Q1/3D). Document type: Review.

-Arderiu G, Mendieta G, Gallinat A, Lambert C, Díez A, Ballesta C, Badimon L. Type 2 Diabetes in Obesity: A Systems Biology Study on Serum and Adipose Tissue Proteomic Profiles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(1):827. DOI:10.3390/ijms24010827. PMID:36614270. IF:4,900 (Q1/3D). Document type: Article.

-Badimon L, Arderiu G. Atherosclerotic Plaque VASA Vasorum in Diabetic Macroangiopathy: WHEN IS Important, but also HOW IS Needed. THROMBOSIS AND HAEMOSTASIS. 2023; 123(10). DOI:10.1055/a-2116-7261. PMID:37353212. IF:5,000 (Q1/2D). Document type: Editorial Material.

-Badimon L, Mendieta G, Vilahur G. Statins revisited: therapeutic applications beyond lipid lowering?. EUROPEAN HEART JOURNAL. 2023; 44(25). DOI:10.1093/eurheartj/ehad324. PMID:37316965. IF:38,100 (Q1/1D). Document type: Editorial Material.

-Badimon L, Vilahur G, Padro T, Mendieta G. Cardiovascular residual risk: aetiology, lipids and inflammation. Revista Espanola De Cardiologia Suplementos. 2023; 23. DOI:10.1016/S1131-3587(23)00008-0. Document type: Article.

-Badimon L, Padro T, Vilahur G. Chapter 27: Moving from reactive to preventive medicine. Aging. 2023; 663-681. DOI: 10.1016/B978-0-12-823761-8.00003-3. Document type: Book Chapter.

-Badimon L, Vilahur G. Chapter 1: Arterial thrombosis: pathophysiological background. The ESC Textbook of Thrombosis. The European Society of Cardiology Series. Oxford Academic. 2023; C1-C1P114. DOI:10.1093/med/9780192869227.003.0001. Document type: Book Chapter.

-Benincasa G, Suades R, Padrò T, Badimon L, Napoli C. Bioinformatic platforms for clinical stratification of natural history of atherosclerotic cardiovascular diseases. European Heart Journal-Cardiovascular Pharmacotherapy. 2023; 9(8). DOI:10.1093/ehjcvp/pvad059. PMID:37562936. IF:5,400 (Q1/1D). Document type: Article.

-Bergami M, Manfrini O, Nava S, Caramori G, Yoon J, Badimon L, Cenko E, David A, Demiri I, Dorobantu M, Fabin N, Gheorghe O, Jankovic R, Kedev S, Ladjevic N, Lasica R, Loncar G, Mancuso G, Mendieta G, Milicic D, Mjehovic P, Pasalic M, Petrovic M, Poposka L, Scarpone M, Stefanovic M, van der Schaar M, Vasiljevic Z, Vavlukis M, Pittao MLV, Vukomanovic V, Zdravkovic M, Bugiardini R. Relationship Between Azithromycin and Cardiovascular Outcomes in Unvaccinated Patients With COVID-19 and Preexisting Cardiovascular Disease. Journal of the American Heart Association. 2023; 12(14):e028939. DOI:10.1161/JAHA.122.028939. PMID:37449568. IF:5,000 (Q1/2D). Document type: Article.

-Bonfrate L, Di A, Khalil M, Farella I, Chirico R, Vilahur G, Portincasa P. Gender-dependent impact of COVID-19 lockdown on metabolic and psychological aspects. Internal and Emergency Medicine. 2023; 18(2). DOI:10.1007/s11739-022-03173-9. PMID:36703077. IF:3,200 (Q1/2D). Document type: Article.

-Borrell M, Luquero A, Vilahur G, Padró T, Badimon L. Canonical Wnt pathway and the LDL receptor superfamily in neuronal cholesterol homeostasis and function. CARDIOVASCULAR RESEARCH. 2023; DOI:10.1093/cvr/cvad159. PMID:37882606. IF:10,400 (Q1/1D). Document type: Article.

-Bugiardini R, Nava S, Caramori G, Yoon J, Badimon L, Bergami M, Cenko E, David A, Demiri I, Dorobantu M, Fronea O, Jankovic R, Kedev S, Ladjevic N, Lasica R, Loncar G, Mancuso G, Mendieta G, Milicic D, Mjehovic P, Pasalic M, Petrovic M, Poposka L, Scarpone M, Stefanovic M, van der Schaar M, Vasiljevic Z, Vavlukis M, Pittao MLV, Vukomanovic V, Zdravkovic M, Manfrini O. Sex differences and disparities in cardiovascular outcomes of COVID-19. CARDIOVASCULAR RESEARCH. 2023; 119(5). DOI:10.1093/cvr/cvad011. PMID:36651866. IF:10,400 (Q1/1D). Document type: Article.

-Charalampous P, Haagsma JA, Jakobsen LS, Gorasso V, Noguer I, Padron A, Sarmiento R, Santos JV, Mcdonald SA, Plass D, Wyper GMA, Assunção R, Von Der Lippe E, Ádám B, Alkerwi A, Arabloo J, Baltazar AL, Bikbov B, Borrell M, Brus I, Burazeri G, Chaintoutis SC, Chen J, Chkhaberidze N, Cilovic S, Corso B, Cuschieri S, Di C, Dopelt K, Economou M, Emeto TI, Fantke P, Fischer F, Freitas A, García JM, Gazzelloni F, Gissler M, Gkitakou A, Gulmez H, Gunes S, Haller S, Haneef R, Hincapié CA, Hynds P, Idavain J, Ilic M, Ilic I, Isola G, Kabir Z, Kamusheva M, Kolkhir P, Konar NM, Kostoulas P, Kulimbet M, La Vecchia C, Lauriola P, Levi M, Majer M, Mechili EA, Monasta L, Mondello S, Muñoz J, Nena E, Ng ESW, Nguewa P, Niranjan V, Nola IA, O’caoimh R, Obradovic M, Pallari E, Peyroteo M, Pinheiro V, Pranjic N, Reina M, Riva S, Santoso CMA, Santric M, Schmitt T, Speybroeck N, Sprügel M, Steiropoulos P, Stevanovic A, Thygesen LC, Tozija F, Unim B, Bektas H, Varga O, Vasic M, Vieira RJ, Yigit V, Devleesschauwer B, Pires SM. Burden of infectious disease studies in Europe and the United Kingdom: a review of methodological design choices. EPIDEMIOLOGY AND INFECTION. 2023; 151:e19. DOI:10.1017/S0950268823000031. PMID:36621004. IF:2,500 (Q2/4D). Document type: Review.

-Cordero A, Fernández R, Badimon L, Santos CG, Castellano JM, Fácila L, Rodriguez M, Bonanad C, Vilahur G, Escribano D, Badimon JJ, González JR. The efficacy of intensive lipid-lowering therapies on the reduction of LDLc and of major cardiovascular events. Journal of Clinical Lipidology. 2023; 17(5). DOI:10.1016/j.jacl.2023.08.006. PMID:37775463. IF:3,600 (Q2/3D). Document type: Article.

-Cordero A, Munoz N, Padro T, Vilahur G, Bertomeu V, Escribano D, Flores E, Zuazola P, Badimon L. HDL Function and Size in Patients with On-Target LDL Plasma Levels and a First-Onset ACS. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(6):5391. DOI:10.3390/ijms24065391. PMID:36982465. IF:4,900 (Q1/3D). Document type: Article.

-Davidson SM, Boulanger CM, Aikawa E, Badimon L, Barile L, Binder CJ, Brisson A, Buzas E, Emanueli C, Jansen F, Katsur M, Lacroix R, Lim SK, Mackman N, Mayr M, Menasché P, Nieuwland R, Sahoo S, Takov K, Thum T, Vader P, Wauben MHM, Witwer K, Sluijter JPG. Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles. CARDIOVASCULAR RESEARCH. 2023; 119(1). DOI:10.1093/cvr/cvac031. PMID:35325061. IF:10,400 (Q1/1D). Document type: Review.

-Doehner W, Böhm M, Boriani G, Christersson C, Coats A, Haeusler KG, Jones ID, Lip GYH, Metra M, Ntaios G, Savarese G, Shantsila E, Vilahur G, Rosano G. Interaction of heart failure and stroke: A clinical consensus statement of the ESC Council on Stroke, the Heart Failure Association (HFA) and the ESC Working Group on Thrombosis. EUROPEAN JOURNAL OF HEART FAILURE. 2023; 25(12). DOI:10.1002/ejhf.3071. PMID:37905380. IF:16,900 (Q1/1D). Document type: Article.

-Encinas LF, Lluch N, Wu A, Kaski JC, Badimon L, Cubedo J. A Novel ELISA for the Quantification of Serum Levels of 2 Glycosylated Variants of Apolipoprotein J: Biomarkers for Myocardial Ischemia. Journal Of Applied Laboratory Medicine. 2023; 8(5). DOI:10.1093/jalm/jfad034. PMID:37473435. IF:1,800 (Q3/6D). Document type: Article.

-Gallinat A, Vilahur G, Padro T, Badimon L. Effects of Antioxidants in Fermented Beverages in Tissue Transcriptomics: Effect of Beer Intake on Myocardial Tissue after Oxidative Injury. Antioxidants. 2023; 12(5):1096. DOI:10.3390/antiox12051096. PMID:37237963. IF:6,000 (Q1/2D). Document type: Article.

-Garcia MC, Padro T, Munoz N, Bianchi M, Alvarez L, Badimon L, Corbella E, Pinto X. Dysfunctional antioxidant capacity of high-density lipoprotein in rheumatoid arthritis. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2023; 53(8):e13999. DOI:10.1111/eci.13999. PMID:36994808. IF:4,400 (Q1/2D). Document type: Article.

-Gigante B, Levy JH, van E, Bartoloni A, Bochaton ML, Back M, ten H, Christersson C, Ferreiro JL, Geisler T, Lutgens E, Schulman S, Storey RF, Thachil J, Vilahur G, Liaw PC, Rocca B. Management of patients on antithrombotic therapy with severe infections: a joint clinical consensus statement of the ESC Working Group on Thrombosis, the ESC Working Group on Atherosclerosis and Vascular Biology, and the International Society on Thrombosis and Haemostasis. EUROPEAN HEART JOURNAL. 2023; 44(32). DOI:10.1093/eurheartj/ehad388. PMID:37439553. IF:38,100 (Q1/1D). Document type: Article.

-Kaski JC, Lluch N, Lopez JL, Gorog DA, Antorrena I, Avanzas P, Herrero P, Sionis A, González JR, Íñiguez A, Cordero A, Ako E, Fernández F, Atienza F, Recio A, Wu A, Crea F, Storey R, Badimon L, Cubedo J. Changes in circulating ApoJ-Glyc levels in patients with suspected acute coronary syndrome: The EDICA trial. INTERNATIONAL JOURNAL OF CARDIOLOGY. 2023; 391:131291. DOI:10.1016/j.ijcard.2023.131291. PMID:37619880. IF:3,200 (Q2/3D). Document type: Article.

-Lezoualc’h F, Badimon L, Baker H, Bernard M, Czibik G, De Boer RA, D’Humieres T, Kergoat M, Kowala M, Rieusset J, Vilahur G, Detrait M, Watson C, Derumeaux GA. Diabetic cardiomyopathy: the need for adjusting experimental models to meet clinical reality. CARDIOVASCULAR RESEARCH. 2023; 119(5). DOI:10.1093/cvr/cvac152. PMID:36082907. IF:10,400 (Q1/1D). Document type: Review.

-López A, Padro T, Villaplana VD, Muñoz N, Pérez A, Vilahur G, Badimon L. Vascular and Platelet Effects of Tomato Soffritto Intake in Overweight and Obese Subjects. Nutrients. 2023; 15(24):5084. DOI:10.3390/nu15245084. PMID:38140343. IF:4,800 (Q1/2D). Document type: Article.

-Padro T, López A, Pérez A, Vilahur G, Badimon L. Dietary ?3 Fatty Acids and Phytosterols in the Modulation of the HDL Lipidome: A Longitudinal Crossover Clinical Study. Nutrients. 2023; 15(16):3637. DOI:10.3390/nu15163637. PMID:37630826. IF:4,800 (Q1/2D). Document type: Article.

-Radike M, Ben-Aicha S, Gutiérrez M, Hidalgo A, Badimón L, Vilahur G. Comparison of two cardiac magnetic resonance imaging postprocessing software tools in a pig model of myocardial infarction. Rev Esp Cardiol (Engl Ed). 2023; 76(2):123-126. DOI: 10.1016/j.rec.2022.06.009. PMID: 35809893. IF:7,200 (Q1/2D). Document type: Editorial Material.

-Radike M, Sutelman P, Ben S, Gutiérrez M, Mendieta G, Alcover S, Casaní L, Arderiu G, Borrell M, Padró T, Badimon L, Vilahur G. A comprehensive and longitudinal cardiac magnetic resonance imaging study of the impact of coronary ischemia duration on myocardial damage in a highly translatable animal model. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2023; 53(1):e13860. DOI:10.1111/eci.13860. PMID:35986736. IF:4,400 (Q1/2D). Document type: Article.

-Roth L, Dogan S, Tuna BG, Aranyi T, Benitez S, Borrell M, Bozaykut P, De Meyer GRY, Duca L, Durmus N, Fonseca D, Fraenkel E, Gillery P, Giudici A, Jaisson S, Johansson M, Julve J, Lucas AK, Martinet W, Maurice P, McDonnell BJ, Ozbek EN, Pucci G, Pugh C, Rochfort KD, Roks A, Rotllan N, Shadiow J, Sohrabi Y, Spronck B, Szeri F, Terentes D, Aydin ET, Tura O, Ucar E, Yetik G. Pharmacological modulation of vascular ageing: A review from VascAgeNet. AGEING RESEARCH REVIEWS. 2023; 92:102122. DOI:10.1016/j.arr.2023.102122. PMID:37956927. IF:12,500 (Q1/1D). Document type: Review.

-Rubboli A, Gorog DA, Vilahur G. The European Society of Cardiology Working Group on Thrombosis. EUROPEAN HEART JOURNAL. 2023; 44(25). DOI:10.1093/eurheartj/ehad063. PMID:36814406. IF:38,100 (Q1/1D). Document type: Article.

-Sanchez F, Avendano C, Badimon L, Bueren JA, Canals JM, Delgadillo J, Delgado J, Eguizabal C, Fernandez ME, Garcia D, Gonzalez G, Juan M, Martin F, Mata R, Montserrat N, Perez A, Perez JA, Prosper F, Urbano A, Zapata AG, Sureda A, Moraleda JM. Role of Hospital Exemption in Europe: position paper from the Spanish Advanced Therapy Network (TERAV). BONE MARROW TRANSPLANTATION. 2023; 58(6)DOI:10.1038/s41409-023-01962-0. PMID:36966215. IF:4,500 (Q1/2D). Document type: Letter.

-Schoch L, Alcover S, Padró T, Ben S, Mendieta G, Badimon L, Vilahur G. Update of HDL in atherosclerotic cardiovascular disease. Clinica E Investigacion En Arteriosclerosis. 2023; 35(6). DOI:10.1016/j.arteri.2023.10.002. PMID:37940388. IF:1,900 (Q3/6D). Document type: Review.

-Schoch L, Sutelman P, Suades R, Badimon L, Moreno I, Vilahur G. The gut microbiome dysbiosis is recovered by restoring a normal diet in hypercholesterolemic pigs. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2023; 53(4):e13927. DOI:10.1111/eci.13927. PMID:36453873. IF:4,400 (Q1/2D). Document type: Article.

-Suades R, Vilella A, Padro T, Mirabet S, Badimon L. Red Blood Cells and Endothelium Derived Circulating Extracellular Vesicles in Health and Chronic Heart Failure: A Focus on Phosphatidylserine Dynamics in Vesiculation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(14):11824. DOI:10.3390/ijms241411824. PMID:37511585. IF:4,900 (Q1/3D). Document type: Article.

-van der Vorst E, Badimon L. The unknown functions of a known protein: the case of coagulation factor XI. CARDIOVASCULAR RESEARCH. 2023; 119(7):cvad066. DOI:10.1093/cvr/cvad066. PMID:37141257. IF:10,400 (Q1/1D). Document type: Editorial Material.

-van J, Tokgozoglu LS, Badimon L, Dumanski SM, Gulati M, Hess CN, Holven KB, Kavousi M, Kayikcioglu M, Lutgens E, Michos ED, Prescott E, Stock JK, Tybjaerg A, Wermer MJH, Benn M. Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society. EUROPEAN HEART JOURNAL. 2023; 44(39):ehad472. DOI:10.1093/eurheartj/ehad472. PMID:37611089. IF:38,100 (Q1/1D). Document type: Article.

-Vilahur G. A primordial obstacle in cardioprotection: the answer resides in our genes. CARDIOVASCULAR RESEARCH. 2023; 119(3):e122-e124. DOI:10.1093/cvr/cvad034. PMID:36919864. IF:10,400 (Q1/1D). Document type: Editorial Material.

-Vilella A, Cordero A, Mirabet S, Munoz N, Suades R, Padro T, Badimon L. Platelet-Released Extracellular Vesicle Characteristics Differ in Chronic and in Acute Heart Disease. THROMBOSIS AND HAEMOSTASIS. 2023; 123(9). DOI:10.1055/s-0043-57017. PMID:37075787. IF:5,000 (Q1/2D). Document type: Article.

Publications 2022

(JIF 2022)

Alonso J, Carrasco A, Borrell M, Fernandez E, Pinol P, Badimon L, Wollin L, Lleixa C, Gallardo E, Olive M, Diaz J, Suarez X. Nintedanib Reduces Muscle Fibrosis and Improves Muscle Function of the Alpha-Sarcoglycan-Deficient Mice. Biomedicines. 2022; 10(10):2629. DOI:10.3390/biomedicines10102629. PMID:36289891. IF:4,7 (Q1/3D). Document type: Article.
Arderiu G, Pena E, Badimon L. Ischaemic tissue released microvesicles induce monocyte reprogramming and increase tissue repair by a tissue factor-dependent mechanism. CARDIOVASCULAR RESEARCH. 2022; 118(10). DOI:10.1093/cvr/cvab266. PMID:34406379. IF:10,8 (Q1/1D). Document type: Article.
Arderiu G, Pena E, Civit A, Badimon L. Endothelium-Released Microvesicles Transport miR-126 That Induces Proangiogenic Reprogramming in Monocytes. Frontiers in Immunology. 2022; 13:836662. DOI:10.3389/fimmu.2022.836662. PMID:35251029. IF:7,3 (Q1/3D). Document type: Article.
Badimon L, Padro T, Arderiu G, Vilahur G, Borrell M, Suades R. Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets. IMMUNOLOGICAL REVIEWS. 2022; 312(1). DOI:10.1111/imr.13127. PMID:35996799. IF:8,7 (Q1/2D). Document type: Review.
Badimon L, Padro T, Vilahur G. Moving from reactive to preventive medicine. En:Aging: From Fundamental Biology To Societal Impact. Elsevier. 2022. p. 663-681. Document type: Book chapter.
Barriuso I, Worner F, Vilahur G. Novel Antithrombotic Agents in Ischemic Cardiovascular Disease: Progress in the Search for the Optimal Treatment. Journal of Cardiovascular Development and Disease. 2022; 9(11):397. DOI:10.3390/jcdd9110397. PMID:36421932. IF:2,4 (Q3/7D). Document type: Review.
Bell RM, Basalay M, Botker HE, Kalkhoran SB, Carr RD, Cunningham J, Davidson SM, England TJ, Giesz S, Ghosh AK, Golforoush P, Gourine AV, Hausenloy DJ, Heusch G, Ibanez B, Kleinbongard P, Lecour S, Lukhna K, Ntsekhe M, Ovize M, Salama AD, Vilahur G, Walker JM, Yellon DM. Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop. BASIC RESEARCH IN CARDIOLOGY. 2022; 117(1):39. DOI:10.1007/s00395-022-00947-2. PMID:35970954. IF:9,5 (Q1/2D). Document type: Article.
Bergami M, Cenko E, Yoon J, Mendieta G, Kedev S, Zdravkovic M, Vasiljevic Z, Milicic D, Manfrini O, van der Schaar M, Gale CP, Badimon L, Bugiardini R. Statins for primary prevention among elderly men and women. CARDIOVASCULAR RESEARCH. 2022; 118(14). DOI:10.1093/cvr/cvab348. PMID:34864917. IF:10,8 (Q1/1D). Document type: Article.
Bugiardini R, Cenko E, Yoon J, van der Schaar M, Kedev S, Gale CP, Vasiljevic Z, Bergami M, Milicic D, Zdravkovic M, Krljanac G, Badimon L, Manfrini O. Concerns about the use of digoxin in acute coronary syndromes. European Heart Journal-Cardiovascular Pharmacotherapy. 2022; 8(5). DOI:10.1093/ehjcvp/pvab055. PMID:34251454. IF:7,1 (Q1/1D). Document type: Article.
Bugiardini R, Yoon J, Mendieta G, Kedev S, Zdravkovic M, Vasiljevic Z, Milicic D, Manfrini O, van der Schaar M, Gale CP, Bergami M, Badimon L, Cenko E. Reduced Heart Failure and Mortality in Patients Receiving Statin Therapy Before Initial Acute Coronary Syndrome. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2022; 79(20). DOI:10.1016/j.jacc.2022.03.354. PMID:35589164. IF:24 (Q1/1D). Document type: Article.
Crea F, Badimon L, Berry C, De Caterina R, Elliott PM, Hatala R, Libby P, Linde C, Tybjaerg A, EHJ B. The European Heart Journal: fulfilling the mission. EUROPEAN HEART JOURNAL. 2022; 43(23). DOI:10.1093/eurheartj/ehac171. PMID:35512309. IF:39,3 (Q1/1D). Document type: Article.
Cubedo J, Padro T, Vilahur G, Crea F, Storey RF, Sendon JLL, Kaski JC, Sionis A, Sans J, Fernandez E, Gallinat A, Badimon L. Glycosylated apolipoprotein J in cardiac ischaemia: molecular processing and circulating levels in patients with acute ischaemic events. EUROPEAN HEART JOURNAL. 2022; 43(2)DOI:10.1093/eurheartj/ehab691. PMID:34580705. IF:39,3 (Q1/1D). Document type: Article.
Delgado J, Alcala JF, Torres JD, Quintana GM, Fuentes F, Garcia A, Ortiz AM, Perez AI, Yubero EM, Rangel OA, Camargo A, Rodriguez F, Lopez F, Badimon L, Ordovas JM, Perez F, Perez P, Lopez J, Almaden Y, Aranda E, Arenas de Larriva AP, Badimon JJ, Blanco A, Blanco R, Bolivar J, Caballero J, Chica J, Corina A, Criado J, Cruz C, Daponte A, de Teresa E, Delgado N, Estruch R, et al. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV) a randomised controlled trial. LANCET. 2022; 399(10338). DOI:10.1016/S0140-6736(22)00122-2. PMID:35525255. IF:168,9 (Q1/1D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Urinary Proteomic Signature in Acute Decompensated Heart Failure: Advances into Molecular Pathophysiology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(4):2344. DOI:10.3390/ijms23042344. PMID:35216460. IF:5,6 (Q1/3D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Vitamin D Binding Protein and Renal Injury in Acute Decompensated Heart Failure. Frontiers in Cardiovascular Medicine. 2022; 9:829490. DOI:10.3389/fcvm.2022.829490. PMID:35757319. IF:3,6 (Q2/5D). Document type: Article.
Esteve MA, Rivera JM, Ruiz M, Muniz J, Roldan I, Otero D, Lopez R, Cequier A, Bertomeu V, Badimon L, Anguita M, Lip GYH, Marin F, FANTASIIA I. A comparison of front-line oral anticoagulants for the treatment of non-valvular atrial fibrillation: effectiveness and safety of direct oral anticoagulants in the FANTASIIA registry. EXPERT OPINION ON PHARMACOTHERAPY. 2022; 23(12). DOI:10.1080/14656566.2022.2109961. PMID:35924672. IF:3,2 (Q3/6D). Document type: Article.
Esteve MA, Ruiz M, Muniz J, Roldan I, Otero D, Cequier A, Bertomeu V, Badimon L, Anguita M, Lip GYH, Marin F, FANTASIIA I. Impact of Integrated Care Management on Clinical Outcomes in Atrial Fibrillation Patients: A Report From the FANTASIIA Registry. Frontiers in Cardiovascular Medicine. 2022; 9:856222. DOI:10.3389/fcvm.2022.856222. PMID:35586656. IF:3,6 (Q2/5D). Document type: Article.
Evans PC, Davidson SM, Wojta J, Back M, Bollini S, Brittan M, Catapano AL, Chaudhry B, Cluitmans M, Gnecchi M, Guzik TJ, Hoefer I, Madonna R, Monteiro JP, Morawietz H, Osto E, Padro T, Sluimer JC, Tocchetti CG, Van der Heiden K, Vilahur G, Waltenberger J, Weber C. From novel discovery tools and biomarkers to precision medicine-basic cardiovascular science highlights of 2021/22. CARDIOVASCULAR RESEARCH. 2022; 118(13). DOI:10.1093/cvr/cvac114. PMID:35899362. IF:10,8 (Q1/1D). Document type: Review.
Gallinat A, Badimon L. DJ-1 interacts with the ectopic ATP-synthase in endothelial cells during acute ischemia and reperfusion. Scientific Reports. 2022; 12(1):12753. DOI:10.1038/s41598-022-16998-3. PMID:35882968. IF:4,6 (Q2/3D). Document type: Article.
Gallinat A, Mendieta G, Vilahur G, Padro T, Badimon L. DJ-1 administration exerts cardioprotection in a mouse model of acute myocardial infarction. Frontiers in Pharmacology. 2022; 13:1002755. DOI:10.3389/fphar.2022.1002755. PMID:36210822. IF:5,6 (Q1/2D). Document type: Article.
Gallinat A, Rakovic A, Klein C, Badimon L. DJ-1 regulates mitochondrial gene expression during ischemia and reperfusion. FREE RADICAL BIOLOGY AND MEDICINE. 2022; 193. DOI:10.1016/j.freeradbiomed.2022.10.315. PMID:36341940. IF:7,4 (Q1/2D). Document type: Article.
Gallinat A, Vilahur G, Padro T, Badimon L. Network-Assisted Systems Biology Analysis of the Mitochondrial Proteome in a Pre-Clinical Model of Ischemia, Revascularization and Post-Conditioning. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(4):2087. DOI:10.3390/ijms23042087. PMID:35216205. IF:5,6 (Q1/3D). Document type: Article.
Gorog DA, Gue YX, Chao TF, Fauchier L, Ferreiro JL, Huber K, Konstantinidis SV, Lane DA, Marin F, Oldgren J, Potpara T, Roldan V, Rubboli A, Sibbing D, Tse HF, Vilahur G, Lip GYH. Assessment and Mitigation of Bleeding Risk in Atrial Fibrillation and Venous Thromboembolism: Executive Summary of a European and Asia-Pacific Expert Consensus Paper. THROMBOSIS AND HAEMOSTASIS. 2022; 122(10). DOI:10.1055/s-0042-1750385. PMID:35793691. IF:6,7 (Q1/2D). Document type: Review.
Gorog DA, Gue YX, Chao TF, Fauchier L, Ferreiro JL, Huber K, Konstantinidis SV, Lane DA, Marin F, Oldgren J, Potpara T, Roldan V, Rubboli A, Sibbing D, Tse HF, Vilahur G, Lip GYH. Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: A Position Paper from the ESC Working Group on Thrombosis, in collaboration with the European Heart Rhythm Association, the Association for Acute CardioVascular Care and the Asia-Pacific Heart Rhythm Society. 2022; 24(11). DOI:10.1093/europace/euac020. PMID:35323922. IF:6,1 (Q1/3D). Document type: Article.
Gorog DA, Storey RF, Gurbel PA, Tantry US, Berger JS, Chan MY, Duerschmied D, Smyth SS, Parker W, Ajjan RA, Vilahur G, Badimon L, ten JM, ten H, Peyvandi F, Wang TT, Becker RC. Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium. Nature Reviews Cardiology. 2022; 19(7). DOI:10.1038/s41569-021-00665-7. PMID:35027697. IF:49,6 (Q1/1D). Document type: Article.
Koller A, Laughlin MH, Cenko E, de Wit C, Toth K, Bugiardini R, Trifunovits D, Vavlukis M, Manfrini O, Lelbach A, Dornyei G, Padro T, Badimon L, Tousoulis D, Gielen S, Duncker DJ. Functional and structural adaptations of the coronary macro- and microvasculature to regular aerobic exercise by activation of physiological, cellular, and molecular mechanisms: ESC Working Group on Coronary Pathophysiology and Microcirculation position paper. CARDIOVASCULAR RESEARCH. 2022; 118(2). DOI:10.1093/cvr/cvab246. PMID:34358290. IF:10,8 (Q1/1D). Document type: Review.
Lee GA, Aktaa S, Baker E, Gale CP, Yaseen IF, Gulati G, Asteggiano R, Szmit S, Cohen A, Abdin A, Jurczak W, Garrido P, Sverdlov AL, Tocchetti CG, Barac A, Parrini I, Zamorano P, Iakobishvili Z, Pudil R, Badimon L, Kirby AM, Blaes AH, Farmakis D, Curigliano G, Stephens R, Lyon AR, Lopez T. European Society of Cardiology quality indicators for the prevention and management of cancer therapy-related cardiovascular toxicity in cancer treatment. European Heart Journal-Quality of Care and Clinical Outcomes. 2022; 9(1). DOI:10.1093/ehjqcco/qcac070. PMID:36316010. IF:5,2 (Q2/3D). Document type: Review.
Liberale L, Badimon L, Montecucco F, Luscher TF, Libby P, Camici GG. Inflammation, Aging, and Cardiovascular Disease JACC Review Topic of the Week. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2022; 79(8). DOI:10.1016/j.jacc.2021.12.017. PMID:35210039. IF:24 (Q1/1D). Document type: Review.
Luquero A, Vilahur G, Casani L, Badimon L, Borrell M. Differential cholesterol uptake in liver cells: A role for PCSK9. FASEB JOURNAL. 2022; 36(5):e22291. DOI:10.1096/fj.202101660RR. PMID:35344222. IF:4,8 (Q1/2D). Document type: Article.
Maestro A, Asmarats L, Li CHP, Mirabet S. Percutaneous tricuspid valve repair after orthotopic heart transplantation. Rec: Cardioclinics. 2022; 57(2). DOI:10.1016/j.rccl.2021.12.002. Document type: Article.
Maestro A, Rivas M, Fernandez J, Lopez L, Sole E, Brossa V, Mirabet S, Roig E, Cinca J, Alvarez J, Sionis A. Incremental prognostic value of lung ultrasound on contemporary heart failure risk scores. Frontiers in Physiology. 2022; 13:1006589. DOI:10.3389/fphys.2022.1006589. PMID:36187763. IF:4 (Q2/3D). Document type: Article.
Maestro A, Vela P, de Frutos F, Mora N, Pomares A, Gonzalez E, Briceno A, Cabrera E, Cobo M, Dominguez F, Gonzalez E, Segovia J, Lara E, Garcia P. Frequency of hereditary transthyretin amyloidosis among elderly patients with transthyretin cardiomyopathy. EUROPEAN JOURNAL OF HEART FAILURE. 2022; 24(12)DOI:10.1002/ejhf.2658. PMID:35999650. IF:18,2 (Q1/1D). Document type: Article.
Pavao TP, Chemello D, Ferigollo A, Saffi M, Moresco RN, Stein CD, Emanuelli T, Somacal S, Moriguchi EH, Badimon L, Chagas P. Acute effect of coffee on arterial stiffness and endothelial function in overweight and obese individuals: A randomized clinical trial. Clinical Nutrition Espen. 2022; 50. DOI:10.1016/j.clnesp.2022.05.003. PMID:35871944. Document type: Article.
Pérez de Isla L, Alonso R, Argüeso R, Muñiz O, Álvarez P, Badimón L, Watts GF, Mata P, SAFEHEART I. Predicting resilience in heterozygous familial hypercholesterolaemia: A cohort study of octogenarian patients. Journal of Clinical Lipidology. 2022; 16(5). DOI:10.1016/j.jacl.2022.07.007. PMID:35906178. IF:4,4 (Q2/3D). Document type: Article.
Pérez de Isla L, Watts GF, Muñiz O, Díaz JL, Alonso R, Zambón D, Fuentes F, Mauri M, Padró T, Vidal JI, Barba MA, Ruiz E, Michán A, Mediavilla JD, Hernandez AM, Romero MJ, Badimon L, Mata P. A resilient type of familial hypercholesterolaemia: case-control follow-up of genetically characterized older patients in the SAFEHEART cohort. European Journal of Preventive Cardiology. 2022; 29(5). DOI:10.1093/eurjpc/zwab185. PMID:34864959. IF:8,3 (Q1/2D). Document type: Article.
Pero M, Castells C, Alserawan L, Casani L, Juan JO, Jorba I, Pérez ML, Moga E, Otero J, López P, Badimon L, Vilarrodona A, Porta O. Comparison of a human acellular dermal matrix and a polypropylene mesh for pelvic floor reconstruction: a randomized trial study in a rabbit model. Scientific Reports. 2022; 12(1):20698. DOI:10.1038/s41598-022-22190-4. PMID:36450745. IF:4,6 (Q2/3D). Document type: Article.
Radike M, Ben S, Gutiérrez M, Hidalgo A, Badimón L, Vilahur G. Comparación de dos programas de posprocesamiento de imágenes de cardiorresonancia magnética en un modelo porcino de infarto de miocardio. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 76(2). DOI:10.1016/j.recesp.2022.06.007. PMID:35809893. IF:5,9 (Q1/3D). Document type: Article.
Rivera JM, Badimón L, Ferreira I, Gómez JJ, Roca I, Lekuona I, Jimenez J, Rodríguez L, González C, Calvo R, Fácila L, Ruiz M, Anguita M, Marín F. Variables affecting the quality of anticoagulation in atrial fibrillation patients newly initiating vitamin K antagonists: Insights from the national and multicentre SULTAN registry. EUROPACE. 2022; 24(1). DOI:10.1093/europace/euab131. PMID:34115857. IF:6,1 (Q1/3D). Document type: Article.
Schoch L, Sutelman P, Suades R, Casani L, Padro T, Badimon L, Vilahur G. Hypercholesterolemia-Induced HDL Dysfunction Can Be Reversed: The Impact of Diet and Statin Treatment in a Preclinical Animal Model. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(15):8596. DOI:10.3390/ijms23158596. PMID:35955730. IF:5,6 (Q1/3D). Document type: Article.
Suades R, Greco MF, Padro T, Badimon L. Extracellular Vesicles as Drivers of Immunoinflammation in Atherothrombosis. 2022; 11(11):1845. DOI:10.3390/cells11111845. PMID:35681540. IF:6 (Q2/4D). Document type: Review.
Suades R, Padro T, Vilahur G, Badimon L. Platelet-released extracellular vesicles: the effects of thrombin activation. CELLULAR AND MOLECULAR LIFE SCIENCES. 2022; 79(3):190. DOI:10.1007/s00018-022-04222-4. PMID:35288766. IF:8 (Q1/2D). Document type: Article.
Sutelman P, Vilahur G. An obscure myocardial blood flow may illuminate post-acute sequelae of COVID-19 cardiovascular syndrome. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2022; 52(12):e13884. DOI:10.1111/eci.13884. PMID:36197894. IF:5,5 (Q1/3D). Document type: Editorial material.
Vavlukis A, Vavlukis M, Mladenovska K, Dimovski A, Munoz N, de Santisteban V, Padro T, Badimon L. Antioxidative Effects of Rosuvastatin in Low-to-Moderate Cardiovascular Risk Subjects. Prilozi (makedonska Akademija Na Naukite I Umetnostite. Oddelenie Za Medicinski Nauki). 2022; 43(1). DOI:10.2478/prilozi-2022-0007. Document type: Article.
Vilahur G, Nguyen PH, Badimon L. Impact of Diabetes Mellitus on the Potential of Autologous Stem Cells and Stem Cell-Derived Microvesicles to Repair the Ischemic Heart. CARDIOVASCULAR DRUGS AND THERAPY. 2022; 36(5). DOI:10.1007/s10557-021-07208-9. PMID:34251593. IF:3,4 (Q2/5D). Document type: Review.
Vilahur G, Sutelman P, Ben S, Mendieta G, Radike M, Schoch L, Casani L, Borrell M, Padro T, Badimon L. Supplementation With Spirulina Reduces Infarct Size and Ameliorates Cardiac Function in a Pig Model of STEMI. Frontiers in Pharmacology. 2022; 13:891801. DOI:10.3389/fphar.2022.891801. PMID:35592428. IF:5,6 (Q1/2D). Document type: Article.
Vilella A, Gallinat A, Escate R, Mirabet S, Padró T, Badimon L. Systems Biology in Chronic Heart Failure—Identification of Potential miRNA Regulators. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(23):15226. DOI:10.3390/ijms232315226. PMID:36499552. IF:5,6 (Q1/3D). Document type: Article.
Vilella A, Padro T, Roig E, Mirabet S, Badimon L. New factors in heart failure pathophysiology: Immunity cells release of extracellular vesicles. Frontiers in Cardiovascular Medicine. 2022; 9:939625. DOI:10.3389/fcvm.2022.939625. PMID:36407432. IF:3,6 (Q2/5D). Document type: Article.
Vogel RF, Delewi R, Badimon L, Angiolillo DJ, Vlachojannis GJ. Current Status and Future Direction of Antithrombotic Therapy for Patients with STEMI Undergoing Primary PCI. Reviews in Cardiovascular Medicine. 2022; 23(9):297. DOI:10.31083/j.rcm2309297. IF:2,7 (Q3/6D). Document type: Review.

Publications 2021

Ajjan RA, Kietsiriroje N, Badimon L, Vilahur G, Gorog DA, Angiolillo DJ, Russell DA, Rocca B, Storey RF. Antithrombotic therapy in diabetes: which, when, and for how long?. EUROPEAN HEART JOURNAL. 2021; 42(23). DOI:10.1093/eurheartj/ehab128. PMID:33764414. IF:35,855.
Alexander Y, Osto E, Schmidt A, Shechter M, Trifunovic D, Duncker DJ, Aboyans V, Back M, Badimon L, Cosentino F, De Carlo M, Dorobantu M, Harrison DG, Guzik TJ, Hoefer I, Morris PD, Norata GD, Suades R, Taddei S, Vilahur G, Waltenberger J, Weber C, Wilkinson F, Bochaton ML, Evans PC. Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardioloy working Groups on Artherosclerosis and Vascular Biology, Aorta and Perirpheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis. CARDIOVASCULAR RESEARCH. 2021; 117(1). DOI:10.1093/cvr/cvaa085. PMID:32282914. IF:13,081.
Arauna D, Chiva-Blanch G, Padro T, Fuentes E, Palomo I, Badimon L. Frail older adults show a distinct plasma microvesicle profile suggesting a prothrombotic and proinflammatory phenotype. JOURNAL OF CELLULAR PHYSIOLOGY. 2021; 236(3):2099-2108. DOI: 10.1002/jcp.29996. PMID: 32749745. IF:6,513.
Badimon L, Luquero A, Crespo J, Pena E, Borrell M. PCSK9 and LRP5 in macrophage lipid internalization and inflammation. CARDIOVASCULAR RESEARCH. 2021; 117(9). DOI:10.1093/cvr/cvaa254. PMID:32991689. IF:13,081.
Badimon L, Robinson EL, Jusic A, Carpusca I, DeWindt LJ, Emanueli C, Ferdinandy P, Gu W, Gyongyosi M, Hackl M, Karaduzovic K, Lustrek M, Martelli F, Nham E, Potocnjak I, Satagopam V, Schneider R, Thum T, Devaux Y. Cardiovascular RNA markers and artificial intelligence may improve COVID-19 outcome: a position paper from the EU-CardioRNA COST Action CA17129. CARDIOVASCULAR RESEARCH. 2021; 117(8). DOI:10.1093/cvr/cvab094. PMID:33839767. IF:13,081.
Badimon L, Vilahur G, Rocca B, Patrono C. The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis. CARDIOVASCULAR RESEARCH. 2021; 117(9). DOI:10.1093/cvr/cvab003. PMID:33484117. IF:13,081.
Bertomeu-Gonzalez V, Moreno-Arribas J, Esteve-Pastor MA, Roldan-Rabadan I, Muniz J, Otero Garcia D, Ruiz-Ortiz M, Cequier A, Bertomeu-Martinez V, Badimon L, Anguita M, Lip GYH, Marin F. Peripheral artery disease and clinical outcomes in patients with atrial fibrillation: A report from the FANTASIIA registry. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2021; 51(4): e13431. DOI: 10.1111/eci.13431. PMID: 33065765. IF:5,722.
Cenko E, Badimon L, Bugiardini R, Claeys MJ, De Luca G, de Wit C, Derumeaux G, Dorobantu M, Duncker DJ, Eringa EC, Gorog DA, Hassager C, Heinzel FR, Huber K, Manfrini O, Milicic D, Oikonomou E, Padro T, Trifunovic D, Vasiljevic Z, Vavlukis M, Vilahur G, Tousoulis D. Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA). CARDIOVASCULAR RESEARCH. 2021; 117(14). DOI:10.1093/cvr/cvab298. PMID:34528075. IF:13,081.
Chiva G, Bratseth V, Laake K, Arnesen H, Solheim S, Schmidt EB, Badimon L, Seljeflot I. One year of omega 3 polyunsaturated fatty acid supplementation does not reduce circulating prothrombotic microvesicles in elderly subjects after suffering a myocardial infarction. CLINICAL NUTRITION. 2021; 40(12). DOI:10.1016/j.clnu.2021.10.007. PMID:34742136. IF:7,643.
Chiva G, Pena E, Cubedo J, Garcia M, Pane A, Gil PA, Perez A, Ortega E, Padro T, Badimon L. Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2 alpha and platelet aggregation in diabetic and normal platelets. Translational Research. 2021; 235. DOI:10.1016/j.trsl.2021.04.003. PMID:33887528. IF:10,171.
Chiva G, Vilella A, Padro T, Formiga F, Ferrer A, Badimon L. Functional and Cognitive Decline Is Associated With Increased Endothelial Cell Inflammation and Platelet Activation: Liquid Biopsy of Microvesicles in Community- Dwelling Octogenarians. Frontiers in Cell and Developmental Biology. 2021; 9:716435. DOI:10.3389/fcell.2021.716435. IF:6,081.
Davidson SM, Padro T, Bollini S, Vilahur G, Duncker DJ, Evans PC, Guzik T, Hoefer IE, Waltenberger J, Wojta J, Weber C. Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart. CARDIOVASCULAR RESEARCH. 2021; 117(10). DOI:10.1093/cvr/cvab200. PMID:34114614. IF:13,081.
Escate R, Padro T, Suades R, Camino S, Muniz O, Diaz JL, Sionis A, Mata P, Badimon L. High miR-133a levels in the circulation anticipates presentation of clinical events in familial hypercholesterolaemia patients. CARDIOVASCULAR RESEARCH. 2021; 117(1). DOI:10.1093/cvr/cvaa039. PMID:32061123. IF:13,081.
Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T, Badimon L, Weber C, Council Basic Cardiovasc S. The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics. CARDIOVASCULAR RESEARCH. 2021; 117(8). DOI:10.1093/cvr/cvab105. PMID:33744925. IF:13,081.
Flores EJ, Ortega L, Cepas PL, Giacchi G, Padro T, Badimon L, Sabate M, Brugaletta S. Endothelial Progenitor Cell Function in Patients With Coronary Chronic Total Occlusion and its Relationship With Collateral Circulation. JOURNAL OF INVASIVE CARDIOLOGY. 2021; 33(10). PMID:34544035. IF:1,711.
Garcia M, Diaz E, Pena E, Escate R, Juan O, Mata P, Badimon L, Padro T. Alternative C3 Complement System: Lipids and Atherosclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(10):5122. DOI:10.3390/ijms22105122. PMID:34066088. IF:6,208.
Giro O, Jimenez A, Pane A, Badimon L, Ortega E, Chiva G. Extracellular vesicles in atherothrombosis and cardiovascular disease: Friends and foes. ATHEROSCLEROSIS. 2021; 330. DOI:10.1016/j.atherosclerosis.2021.07.002. PMID:34256307. IF:6,847.
Grigorian L, Sanz R, Climent A, Badimon L, Barile L, Bolli R, Chamuleau S, Grobbee DE, Janssens S, Kastrup J, Kragten L, Madonna R, Mathur A, Menasche P, Pompilio G, Prosper F, Sena E, Smart N, Zimmermann WH, Fernandez F. Insights into therapeutic products, preclinical research models, and clinical trials in cardiac regenerative and reparative medicine: where are we now and the way ahead. Current opinion paper of the ESC Working Group on Cardiovascular Regenerative and Reparative Medicine. CARDIOVASCULAR RESEARCH. 2021; 117(6). DOI:10.1093/cvr/cvaa337. PMID:33258961. IF:13,081.
Krychtiuk KA, Speidl WS, Giannitsis E, Gigante B, Gorog DA, Jaffe AS, Mair J, Mockel M, Mueller C, Storey RF, Vilahur G, Wojta J, Huber K, Halvorsen S, Geisler T, Morais J, Lindahl B, Thygesen K. Biomarkers of coagulation and fibrinolysis in acute myocardial infarction: a joint position paper of the Association for Acute Cardio Vascular Care and the European Society of Cardiology Working Group on Thrombosis. European Heart Journal-Acute Cardiovascular Care. 2021; 10(3). DOI:10.1093/ehjacc/zuaa025. PMID:33620437. IF:4,766.
Kunadian V, Chieffo A, Camici PG, Berry C, Escaned J, Maas A, Prescott E, Karam N, Appelman Y, Fraccaro C, Buchanan GL, Manzo S, Al R, Regar E, Lansky A, Abbott JD, Badimon L, Duncker DJ, Mehran R, Capodanno D, Baumbach A. An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group. EuroIntervention. 2021; 16(13). DOI:10.4244/EIJY20M07_01. PMID:32624456. IF:7,728.
Luquero A, Badimon L, Borrell M. PCSK9 Functions in Atherosclerosis Are Not Limited to Plasmatic LDL-Cholesterol Regulation. Frontiers in Cardiovascular Medicine. 2021; 8:639727. DOI:10.3389/fcvm.2021.639727. PMID:33834043. IF:5,846.
Luquero A, Vilahur G, Crespo J, Badimon L, Borrell M. Microvesicles carrying LRP5 induce macrophage polarization to an anti-inflammatory phenotype. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2021; 25(16). DOI:10.1111/jcmm.16723. PMID:34288375. IF:5,295.
Mata P, Alonso R, de Isla LP, Badimon L. Dyslipidemia and aortic valve disease. CURRENT OPINION IN LIPIDOLOGY. 2021; 32(6). DOI:10.1097/MOL.0000000000000794. PMID:34629429. IF:4,616.
Munoz N, Escate R, Badimon L, Padro T. Moderate Beer Intake Downregulates Inflammasome Pathway Gene Expression in Human Macrophages. Biology-Basel. 2021; 10(11):1159. DOI:10.3390/biology10111159. PMID:34827151. IF:5,168.
Padro T, Munoz N, Pena E, Badimon L. Sex Differences and Emerging New Risk Factors for Atherosclerosis and Its Throm-botic Complications. CURRENT PHARMACEUTICAL DESIGN. 2021; 27(29). DOI:10.2174/1381612826666201118094209. PMID:33213315. IF:3,310.
Pero M, Casani L, Castells C, Perez ML, Naranjo EM, Juan O, De Lamo LA, Lopez P, Serrat AV, Badimon L, Roda OP. Rabbit as an animal model for the study of biological grafts in pelvic floor dysfunctions. Scientific Reports. 2021; 11(1):10545. DOI:10.1038/s41598-021-89698-z. PMID:34006889. IF:4,996.
Povsic TJ, Sanz R, Climent AM, Bolli R, Taylor DA, Gersh BJ, Menasche P, Perin EC, Pompilio G, Atsma DE, Badimon L, DeMaria AN, Hare JM, Henry TD, Janssens S, Kastrup J, Torella D, Traverse JH, Willerson JT, Fernandez F. Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies. ESC Heart Failure. 2021; 8(3). DOI:10.1002/ehf2.13256. PMID:33652498. IF:3,612.
Proietti M, Esteve MA, Rivera JM, Roldan V, Rabadan IR, Muniz J, Cequier A, Bertomeu V, Badimon L, Anguita M, Lip GYH, Marin F, FANTASIIA I. Relationship between multimorbidity and outcomes in atrial fibrillation. EXPERIMENTAL GERONTOLOGY. 2021; 153:111482. DOI:10.1016/j.exger.2021.111482. PMID:34303775. IF:4,253.
Rodriguez L, Badimon L, Mendez D, Padro T, Vilahur G, Pena E, Carrasco B, Vogel H, Palomo I, Fuentes E. Antiplatelet Activity of Isorhamnetin via Mitochondrial Regulation. Antioxidants. 2021; 10(5):666. DOI:10.3390/antiox10050666. PMID:33922903. IF:7,675.
Schoch L, Badimon L, Vilahur G. Unraveling the Complexity of HDL Remodeling: On the Hunt to Restore HDL Quality. Biomedicines. 2021; 9(7):805. DOI:10.3390/biomedicines9070805. PMID:34356869. IF:4,757.
Vasiljevic Z, Scarpone M, Bergami M, Yoon J, van der Schaar M, Krljanac G, Asanin M, Davidovic G, Simovic S, Manfrini O, Mickovski N, Badimon L, Cenko E, Bugiardini R. Smoking and sex differences in first manifestation of cardiovascular disease. ATHEROSCLEROSIS. 2021; 330. DOI:10.1016/j.atherosclerosis.2021.06.909. PMID:34233252. IF:6,847.
Vilahur G, Sutelman P, Mendieta G, Ben S, Borrell M, Pena E, Crespo J, Casani L, Badimon L. Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum. ATHEROSCLEROSIS. 2021; 324. DOI:10.1016/j.atherosclerosis.2021.03.014. PMID:33857761. IF:6,847.

2017 Scientific Report -Molecular Pathology

Introduction

Main lines of research

Physiopathological role of LRP family proteins
in chronic diseases.
Identification and characterization of transcription factors and genetic targets. Role of lipids and inflammation.
Vascular impact of ischaemia and angiogenesis in heart disease. Cell therapy.
Research into new targets to inhibit the transformation of silent atherosclerosis into ischaemic syndromes: tissue-factormediated angiogenic switch.

Challenges

Broaden the experimental focus to include transgenic animal models with/without cardiovascular risk factors in order to proceed to in-depth analysis of molecules involved in the modulation of new proteins identified by post-genomic technologies and systems biology approaches.
Maintain present scientific networks and establish new multidisciplinary collaborations.
Increase international funding for the extension of new and established platforms in order to implement proposed activities.

Team

Group coordination

VILAHUR GARCIA, GEMMA IR
gvilahur@santpau.cat

Members

Scientific output

Publications 2023

(JIF 2023)

-Badimon L, Padro T, Vilahur G. Chapter 27: Moving from reactive to preventive medicine. Aging. 2023; 663-681. DOI: 10.1016/B978-0-12-823761-8.00003-3. Document type: Book Chapter.

Publications 2022

(JIF 2022)

Alonso J, Carrasco A, Borrell M, Fernandez E, Pinol P, Badimon L, Wollin L, Lleixa C, Gallardo E, Olive M, Diaz J, Suarez X. Nintedanib Reduces Muscle Fibrosis and Improves Muscle Function of the Alpha-Sarcoglycan-Deficient Mice. Biomedicines. 2022; 10(10):2629. DOI:10.3390/biomedicines10102629. PMID:36289891. IF:4,7 (Q1/3D). Document type: Article.
Arderiu G, Pena E, Badimon L. Ischaemic tissue released microvesicles induce monocyte reprogramming and increase tissue repair by a tissue factor-dependent mechanism. CARDIOVASCULAR RESEARCH. 2022; 118(10). DOI:10.1093/cvr/cvab266. PMID:34406379. IF:10,8 (Q1/1D). Document type: Article.
Arderiu G, Pena E, Civit A, Badimon L. Endothelium-Released Microvesicles Transport miR-126 That Induces Proangiogenic Reprogramming in Monocytes. Frontiers in Immunology. 2022; 13:836662. DOI:10.3389/fimmu.2022.836662. PMID:35251029. IF:7,3 (Q1/3D). Document type: Article.
Badimon L, Padro T, Arderiu G, Vilahur G, Borrell M, Suades R. Extracellular vesicles in atherothrombosis: From biomarkers and precision medicine to therapeutic targets. IMMUNOLOGICAL REVIEWS. 2022; 312(1). DOI:10.1111/imr.13127. PMID:35996799. IF:8,7 (Q1/2D). Document type: Review.
Badimon L, Padro T, Vilahur G. Moving from reactive to preventive medicine. En:Aging: From Fundamental Biology To Societal Impact. Elsevier. 2022. p. 663-681. Document type: Book chapter.
Barriuso I, Worner F, Vilahur G. Novel Antithrombotic Agents in Ischemic Cardiovascular Disease: Progress in the Search for the Optimal Treatment. Journal of Cardiovascular Development and Disease. 2022; 9(11):397. DOI:10.3390/jcdd9110397. PMID:36421932. IF:2,4 (Q3/7D). Document type: Review.
Bell RM, Basalay M, Botker HE, Kalkhoran SB, Carr RD, Cunningham J, Davidson SM, England TJ, Giesz S, Ghosh AK, Golforoush P, Gourine AV, Hausenloy DJ, Heusch G, Ibanez B, Kleinbongard P, Lecour S, Lukhna K, Ntsekhe M, Ovize M, Salama AD, Vilahur G, Walker JM, Yellon DM. Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop. BASIC RESEARCH IN CARDIOLOGY. 2022; 117(1):39. DOI:10.1007/s00395-022-00947-2. PMID:35970954. IF:9,5 (Q1/2D). Document type: Article.
Bergami M, Cenko E, Yoon J, Mendieta G, Kedev S, Zdravkovic M, Vasiljevic Z, Milicic D, Manfrini O, van der Schaar M, Gale CP, Badimon L, Bugiardini R. Statins for primary prevention among elderly men and women. CARDIOVASCULAR RESEARCH. 2022; 118(14). DOI:10.1093/cvr/cvab348. PMID:34864917. IF:10,8 (Q1/1D). Document type: Article.
Bugiardini R, Cenko E, Yoon J, van der Schaar M, Kedev S, Gale CP, Vasiljevic Z, Bergami M, Milicic D, Zdravkovic M, Krljanac G, Badimon L, Manfrini O. Concerns about the use of digoxin in acute coronary syndromes. European Heart Journal-Cardiovascular Pharmacotherapy. 2022; 8(5). DOI:10.1093/ehjcvp/pvab055. PMID:34251454. IF:7,1 (Q1/1D). Document type: Article.
Bugiardini R, Yoon J, Mendieta G, Kedev S, Zdravkovic M, Vasiljevic Z, Milicic D, Manfrini O, van der Schaar M, Gale CP, Bergami M, Badimon L, Cenko E. Reduced Heart Failure and Mortality in Patients Receiving Statin Therapy Before Initial Acute Coronary Syndrome. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2022; 79(20). DOI:10.1016/j.jacc.2022.03.354. PMID:35589164. IF:24 (Q1/1D). Document type: Article.
Crea F, Badimon L, Berry C, De Caterina R, Elliott PM, Hatala R, Libby P, Linde C, Tybjaerg A, EHJ B. The European Heart Journal: fulfilling the mission. EUROPEAN HEART JOURNAL. 2022; 43(23). DOI:10.1093/eurheartj/ehac171. PMID:35512309. IF:39,3 (Q1/1D). Document type: Article.
Cubedo J, Padro T, Vilahur G, Crea F, Storey RF, Sendon JLL, Kaski JC, Sionis A, Sans J, Fernandez E, Gallinat A, Badimon L. Glycosylated apolipoprotein J in cardiac ischaemia: molecular processing and circulating levels in patients with acute ischaemic events. EUROPEAN HEART JOURNAL. 2022; 43(2)DOI:10.1093/eurheartj/ehab691. PMID:34580705. IF:39,3 (Q1/1D). Document type: Article.
Delgado J, Alcala JF, Torres JD, Quintana GM, Fuentes F, Garcia A, Ortiz AM, Perez AI, Yubero EM, Rangel OA, Camargo A, Rodriguez F, Lopez F, Badimon L, Ordovas JM, Perez F, Perez P, Lopez J, Almaden Y, Aranda E, Arenas de Larriva AP, Badimon JJ, Blanco A, Blanco R, Bolivar J, Caballero J, Chica J, Corina A, Criado J, Cruz C, Daponte A, de Teresa E, Delgado N, Estruch R, et al. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV) a randomised controlled trial. LANCET. 2022; 399(10338). DOI:10.1016/S0140-6736(22)00122-2. PMID:35525255. IF:168,9 (Q1/1D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Urinary Proteomic Signature in Acute Decompensated Heart Failure: Advances into Molecular Pathophysiology. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(4):2344. DOI:10.3390/ijms23042344. PMID:35216460. IF:5,6 (Q1/3D). Document type: Article.
Diaz E, Garcia M, Lopez L, Garcia X, Badimon L, Padro T. Vitamin D Binding Protein and Renal Injury in Acute Decompensated Heart Failure. Frontiers in Cardiovascular Medicine. 2022; 9:829490. DOI:10.3389/fcvm.2022.829490. PMID:35757319. IF:3,6 (Q2/5D). Document type: Article.
Esteve MA, Rivera JM, Ruiz M, Muniz J, Roldan I, Otero D, Lopez R, Cequier A, Bertomeu V, Badimon L, Anguita M, Lip GYH, Marin F, FANTASIIA I. A comparison of front-line oral anticoagulants for the treatment of non-valvular atrial fibrillation: effectiveness and safety of direct oral anticoagulants in the FANTASIIA registry. EXPERT OPINION ON PHARMACOTHERAPY. 2022; 23(12). DOI:10.1080/14656566.2022.2109961. PMID:35924672. IF:3,2 (Q3/6D). Document type: Article.
Esteve MA, Ruiz M, Muniz J, Roldan I, Otero D, Cequier A, Bertomeu V, Badimon L, Anguita M, Lip GYH, Marin F, FANTASIIA I. Impact of Integrated Care Management on Clinical Outcomes in Atrial Fibrillation Patients: A Report From the FANTASIIA Registry. Frontiers in Cardiovascular Medicine. 2022; 9:856222. DOI:10.3389/fcvm.2022.856222. PMID:35586656. IF:3,6 (Q2/5D). Document type: Article.
Evans PC, Davidson SM, Wojta J, Back M, Bollini S, Brittan M, Catapano AL, Chaudhry B, Cluitmans M, Gnecchi M, Guzik TJ, Hoefer I, Madonna R, Monteiro JP, Morawietz H, Osto E, Padro T, Sluimer JC, Tocchetti CG, Van der Heiden K, Vilahur G, Waltenberger J, Weber C. From novel discovery tools and biomarkers to precision medicine-basic cardiovascular science highlights of 2021/22. CARDIOVASCULAR RESEARCH. 2022; 118(13). DOI:10.1093/cvr/cvac114. PMID:35899362. IF:10,8 (Q1/1D). Document type: Review.
Gallinat A, Badimon L. DJ-1 interacts with the ectopic ATP-synthase in endothelial cells during acute ischemia and reperfusion. Scientific Reports. 2022; 12(1):12753. DOI:10.1038/s41598-022-16998-3. PMID:35882968. IF:4,6 (Q2/3D). Document type: Article.
Gallinat A, Mendieta G, Vilahur G, Padro T, Badimon L. DJ-1 administration exerts cardioprotection in a mouse model of acute myocardial infarction. Frontiers in Pharmacology. 2022; 13:1002755. DOI:10.3389/fphar.2022.1002755. PMID:36210822. IF:5,6 (Q1/2D). Document type: Article.
Gallinat A, Rakovic A, Klein C, Badimon L. DJ-1 regulates mitochondrial gene expression during ischemia and reperfusion. FREE RADICAL BIOLOGY AND MEDICINE. 2022; 193. DOI:10.1016/j.freeradbiomed.2022.10.315. PMID:36341940. IF:7,4 (Q1/2D). Document type: Article.
Gallinat A, Vilahur G, Padro T, Badimon L. Network-Assisted Systems Biology Analysis of the Mitochondrial Proteome in a Pre-Clinical Model of Ischemia, Revascularization and Post-Conditioning. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(4):2087. DOI:10.3390/ijms23042087. PMID:35216205. IF:5,6 (Q1/3D). Document type: Article.
Gorog DA, Gue YX, Chao TF, Fauchier L, Ferreiro JL, Huber K, Konstantinidis SV, Lane DA, Marin F, Oldgren J, Potpara T, Roldan V, Rubboli A, Sibbing D, Tse HF, Vilahur G, Lip GYH. Assessment and Mitigation of Bleeding Risk in Atrial Fibrillation and Venous Thromboembolism: Executive Summary of a European and Asia-Pacific Expert Consensus Paper. THROMBOSIS AND HAEMOSTASIS. 2022; 122(10). DOI:10.1055/s-0042-1750385. PMID:35793691. IF:6,7 (Q1/2D). Document type: Review.
Gorog DA, Gue YX, Chao TF, Fauchier L, Ferreiro JL, Huber K, Konstantinidis SV, Lane DA, Marin F, Oldgren J, Potpara T, Roldan V, Rubboli A, Sibbing D, Tse HF, Vilahur G, Lip GYH. Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: A Position Paper from the ESC Working Group on Thrombosis, in collaboration with the European Heart Rhythm Association, the Association for Acute CardioVascular Care and the Asia-Pacific Heart Rhythm Society. 2022; 24(11). DOI:10.1093/europace/euac020. PMID:35323922. IF:6,1 (Q1/3D). Document type: Article.
Gorog DA, Storey RF, Gurbel PA, Tantry US, Berger JS, Chan MY, Duerschmied D, Smyth SS, Parker W, Ajjan RA, Vilahur G, Badimon L, ten JM, ten H, Peyvandi F, Wang TT, Becker RC. Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium. Nature Reviews Cardiology. 2022; 19(7). DOI:10.1038/s41569-021-00665-7. PMID:35027697. IF:49,6 (Q1/1D). Document type: Article.
Koller A, Laughlin MH, Cenko E, de Wit C, Toth K, Bugiardini R, Trifunovits D, Vavlukis M, Manfrini O, Lelbach A, Dornyei G, Padro T, Badimon L, Tousoulis D, Gielen S, Duncker DJ. Functional and structural adaptations of the coronary macro- and microvasculature to regular aerobic exercise by activation of physiological, cellular, and molecular mechanisms: ESC Working Group on Coronary Pathophysiology and Microcirculation position paper. CARDIOVASCULAR RESEARCH. 2022; 118(2). DOI:10.1093/cvr/cvab246. PMID:34358290. IF:10,8 (Q1/1D). Document type: Review.
Lee GA, Aktaa S, Baker E, Gale CP, Yaseen IF, Gulati G, Asteggiano R, Szmit S, Cohen A, Abdin A, Jurczak W, Garrido P, Sverdlov AL, Tocchetti CG, Barac A, Parrini I, Zamorano P, Iakobishvili Z, Pudil R, Badimon L, Kirby AM, Blaes AH, Farmakis D, Curigliano G, Stephens R, Lyon AR, Lopez T. European Society of Cardiology quality indicators for the prevention and management of cancer therapy-related cardiovascular toxicity in cancer treatment. European Heart Journal-Quality of Care and Clinical Outcomes. 2022; 9(1). DOI:10.1093/ehjqcco/qcac070. PMID:36316010. IF:5,2 (Q2/3D). Document type: Review.
Liberale L, Badimon L, Montecucco F, Luscher TF, Libby P, Camici GG. Inflammation, Aging, and Cardiovascular Disease JACC Review Topic of the Week. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2022; 79(8). DOI:10.1016/j.jacc.2021.12.017. PMID:35210039. IF:24 (Q1/1D). Document type: Review.
Luquero A, Vilahur G, Casani L, Badimon L, Borrell M. Differential cholesterol uptake in liver cells: A role for PCSK9. FASEB JOURNAL. 2022; 36(5):e22291. DOI:10.1096/fj.202101660RR. PMID:35344222. IF:4,8 (Q1/2D). Document type: Article.
Maestro A, Asmarats L, Li CHP, Mirabet S. Percutaneous tricuspid valve repair after orthotopic heart transplantation. Rec: Cardioclinics. 2022; 57(2). DOI:10.1016/j.rccl.2021.12.002. Document type: Article.
Maestro A, Rivas M, Fernandez J, Lopez L, Sole E, Brossa V, Mirabet S, Roig E, Cinca J, Alvarez J, Sionis A. Incremental prognostic value of lung ultrasound on contemporary heart failure risk scores. Frontiers in Physiology. 2022; 13:1006589. DOI:10.3389/fphys.2022.1006589. PMID:36187763. IF:4 (Q2/3D). Document type: Article.
Maestro A, Vela P, de Frutos F, Mora N, Pomares A, Gonzalez E, Briceno A, Cabrera E, Cobo M, Dominguez F, Gonzalez E, Segovia J, Lara E, Garcia P. Frequency of hereditary transthyretin amyloidosis among elderly patients with transthyretin cardiomyopathy. EUROPEAN JOURNAL OF HEART FAILURE. 2022; 24(12)DOI:10.1002/ejhf.2658. PMID:35999650. IF:18,2 (Q1/1D). Document type: Article.
Pavao TP, Chemello D, Ferigollo A, Saffi M, Moresco RN, Stein CD, Emanuelli T, Somacal S, Moriguchi EH, Badimon L, Chagas P. Acute effect of coffee on arterial stiffness and endothelial function in overweight and obese individuals: A randomized clinical trial. Clinical Nutrition Espen. 2022; 50. DOI:10.1016/j.clnesp.2022.05.003. PMID:35871944. Document type: Article.
Pérez de Isla L, Alonso R, Argüeso R, Muñiz O, Álvarez P, Badimón L, Watts GF, Mata P, SAFEHEART I. Predicting resilience in heterozygous familial hypercholesterolaemia: A cohort study of octogenarian patients. Journal of Clinical Lipidology. 2022; 16(5). DOI:10.1016/j.jacl.2022.07.007. PMID:35906178. IF:4,4 (Q2/3D). Document type: Article.
Pérez de Isla L, Watts GF, Muñiz O, Díaz JL, Alonso R, Zambón D, Fuentes F, Mauri M, Padró T, Vidal JI, Barba MA, Ruiz E, Michán A, Mediavilla JD, Hernandez AM, Romero MJ, Badimon L, Mata P. A resilient type of familial hypercholesterolaemia: case-control follow-up of genetically characterized older patients in the SAFEHEART cohort. European Journal of Preventive Cardiology. 2022; 29(5). DOI:10.1093/eurjpc/zwab185. PMID:34864959. IF:8,3 (Q1/2D). Document type: Article.
Pero M, Castells C, Alserawan L, Casani L, Juan JO, Jorba I, Pérez ML, Moga E, Otero J, López P, Badimon L, Vilarrodona A, Porta O. Comparison of a human acellular dermal matrix and a polypropylene mesh for pelvic floor reconstruction: a randomized trial study in a rabbit model. Scientific Reports. 2022; 12(1):20698. DOI:10.1038/s41598-022-22190-4. PMID:36450745. IF:4,6 (Q2/3D). Document type: Article.
Radike M, Ben S, Gutiérrez M, Hidalgo A, Badimón L, Vilahur G. Comparación de dos programas de posprocesamiento de imágenes de cardiorresonancia magnética en un modelo porcino de infarto de miocardio. REVISTA ESPANOLA DE CARDIOLOGIA. 2022; 76(2). DOI:10.1016/j.recesp.2022.06.007. PMID:35809893. IF:5,9 (Q1/3D). Document type: Article.
Rivera JM, Badimón L, Ferreira I, Gómez JJ, Roca I, Lekuona I, Jimenez J, Rodríguez L, González C, Calvo R, Fácila L, Ruiz M, Anguita M, Marín F. Variables affecting the quality of anticoagulation in atrial fibrillation patients newly initiating vitamin K antagonists: Insights from the national and multicentre SULTAN registry. EUROPACE. 2022; 24(1). DOI:10.1093/europace/euab131. PMID:34115857. IF:6,1 (Q1/3D). Document type: Article.
Schoch L, Sutelman P, Suades R, Casani L, Padro T, Badimon L, Vilahur G. Hypercholesterolemia-Induced HDL Dysfunction Can Be Reversed: The Impact of Diet and Statin Treatment in a Preclinical Animal Model. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(15):8596. DOI:10.3390/ijms23158596. PMID:35955730. IF:5,6 (Q1/3D). Document type: Article.
Suades R, Greco MF, Padro T, Badimon L. Extracellular Vesicles as Drivers of Immunoinflammation in Atherothrombosis. 2022; 11(11):1845. DOI:10.3390/cells11111845. PMID:35681540. IF:6 (Q2/4D). Document type: Review.
Suades R, Padro T, Vilahur G, Badimon L. Platelet-released extracellular vesicles: the effects of thrombin activation. CELLULAR AND MOLECULAR LIFE SCIENCES. 2022; 79(3):190. DOI:10.1007/s00018-022-04222-4. PMID:35288766. IF:8 (Q1/2D). Document type: Article.
Sutelman P, Vilahur G. An obscure myocardial blood flow may illuminate post-acute sequelae of COVID-19 cardiovascular syndrome. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2022; 52(12):e13884. DOI:10.1111/eci.13884. PMID:36197894. IF:5,5 (Q1/3D). Document type: Editorial material.
Vavlukis A, Vavlukis M, Mladenovska K, Dimovski A, Munoz N, de Santisteban V, Padro T, Badimon L. Antioxidative Effects of Rosuvastatin in Low-to-Moderate Cardiovascular Risk Subjects. Prilozi (makedonska Akademija Na Naukite I Umetnostite. Oddelenie Za Medicinski Nauki). 2022; 43(1). DOI:10.2478/prilozi-2022-0007. Document type: Article.
Vilahur G, Nguyen PH, Badimon L. Impact of Diabetes Mellitus on the Potential of Autologous Stem Cells and Stem Cell-Derived Microvesicles to Repair the Ischemic Heart. CARDIOVASCULAR DRUGS AND THERAPY. 2022; 36(5). DOI:10.1007/s10557-021-07208-9. PMID:34251593. IF:3,4 (Q2/5D). Document type: Review.
Vilahur G, Sutelman P, Ben S, Mendieta G, Radike M, Schoch L, Casani L, Borrell M, Padro T, Badimon L. Supplementation With Spirulina Reduces Infarct Size and Ameliorates Cardiac Function in a Pig Model of STEMI. Frontiers in Pharmacology. 2022; 13:891801. DOI:10.3389/fphar.2022.891801. PMID:35592428. IF:5,6 (Q1/2D). Document type: Article.
Vilella A, Gallinat A, Escate R, Mirabet S, Padró T, Badimon L. Systems Biology in Chronic Heart Failure—Identification of Potential miRNA Regulators. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022; 23(23):15226. DOI:10.3390/ijms232315226. PMID:36499552. IF:5,6 (Q1/3D). Document type: Article.
Vilella A, Padro T, Roig E, Mirabet S, Badimon L. New factors in heart failure pathophysiology: Immunity cells release of extracellular vesicles. Frontiers in Cardiovascular Medicine. 2022; 9:939625. DOI:10.3389/fcvm.2022.939625. PMID:36407432. IF:3,6 (Q2/5D). Document type: Article.
Vogel RF, Delewi R, Badimon L, Angiolillo DJ, Vlachojannis GJ. Current Status and Future Direction of Antithrombotic Therapy for Patients with STEMI Undergoing Primary PCI. Reviews in Cardiovascular Medicine. 2022; 23(9):297. DOI:10.31083/j.rcm2309297. IF:2,7 (Q3/6D). Document type: Review.

Publications 2021

Ajjan RA, Kietsiriroje N, Badimon L, Vilahur G, Gorog DA, Angiolillo DJ, Russell DA, Rocca B, Storey RF. Antithrombotic therapy in diabetes: which, when, and for how long?. EUROPEAN HEART JOURNAL. 2021; 42(23). DOI:10.1093/eurheartj/ehab128. PMID:33764414. IF:35,855.
Alexander Y, Osto E, Schmidt A, Shechter M, Trifunovic D, Duncker DJ, Aboyans V, Back M, Badimon L, Cosentino F, De Carlo M, Dorobantu M, Harrison DG, Guzik TJ, Hoefer I, Morris PD, Norata GD, Suades R, Taddei S, Vilahur G, Waltenberger J, Weber C, Wilkinson F, Bochaton ML, Evans PC. Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardioloy working Groups on Artherosclerosis and Vascular Biology, Aorta and Perirpheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis. CARDIOVASCULAR RESEARCH. 2021; 117(1). DOI:10.1093/cvr/cvaa085. PMID:32282914. IF:13,081.
Arauna D, Chiva-Blanch G, Padro T, Fuentes E, Palomo I, Badimon L. Frail older adults show a distinct plasma microvesicle profile suggesting a prothrombotic and proinflammatory phenotype. JOURNAL OF CELLULAR PHYSIOLOGY. 2021; 236(3):2099-2108. DOI: 10.1002/jcp.29996. PMID: 32749745. IF:6,513.
Badimon L, Luquero A, Crespo J, Pena E, Borrell M. PCSK9 and LRP5 in macrophage lipid internalization and inflammation. CARDIOVASCULAR RESEARCH. 2021; 117(9). DOI:10.1093/cvr/cvaa254. PMID:32991689. IF:13,081.
Badimon L, Robinson EL, Jusic A, Carpusca I, DeWindt LJ, Emanueli C, Ferdinandy P, Gu W, Gyongyosi M, Hackl M, Karaduzovic K, Lustrek M, Martelli F, Nham E, Potocnjak I, Satagopam V, Schneider R, Thum T, Devaux Y. Cardiovascular RNA markers and artificial intelligence may improve COVID-19 outcome: a position paper from the EU-CardioRNA COST Action CA17129. CARDIOVASCULAR RESEARCH. 2021; 117(8). DOI:10.1093/cvr/cvab094. PMID:33839767. IF:13,081.
Badimon L, Vilahur G, Rocca B, Patrono C. The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis. CARDIOVASCULAR RESEARCH. 2021; 117(9). DOI:10.1093/cvr/cvab003. PMID:33484117. IF:13,081.
Bertomeu-Gonzalez V, Moreno-Arribas J, Esteve-Pastor MA, Roldan-Rabadan I, Muniz J, Otero Garcia D, Ruiz-Ortiz M, Cequier A, Bertomeu-Martinez V, Badimon L, Anguita M, Lip GYH, Marin F. Peripheral artery disease and clinical outcomes in patients with atrial fibrillation: A report from the FANTASIIA registry. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2021; 51(4): e13431. DOI: 10.1111/eci.13431. PMID: 33065765. IF:5,722.
Cenko E, Badimon L, Bugiardini R, Claeys MJ, De Luca G, de Wit C, Derumeaux G, Dorobantu M, Duncker DJ, Eringa EC, Gorog DA, Hassager C, Heinzel FR, Huber K, Manfrini O, Milicic D, Oikonomou E, Padro T, Trifunovic D, Vasiljevic Z, Vavlukis M, Vilahur G, Tousoulis D. Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA). CARDIOVASCULAR RESEARCH. 2021; 117(14). DOI:10.1093/cvr/cvab298. PMID:34528075. IF:13,081.
Chiva G, Bratseth V, Laake K, Arnesen H, Solheim S, Schmidt EB, Badimon L, Seljeflot I. One year of omega 3 polyunsaturated fatty acid supplementation does not reduce circulating prothrombotic microvesicles in elderly subjects after suffering a myocardial infarction. CLINICAL NUTRITION. 2021; 40(12). DOI:10.1016/j.clnu.2021.10.007. PMID:34742136. IF:7,643.
Chiva G, Pena E, Cubedo J, Garcia M, Pane A, Gil PA, Perez A, Ortega E, Padro T, Badimon L. Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2 alpha and platelet aggregation in diabetic and normal platelets. Translational Research. 2021; 235. DOI:10.1016/j.trsl.2021.04.003. PMID:33887528. IF:10,171.
Chiva G, Vilella A, Padro T, Formiga F, Ferrer A, Badimon L. Functional and Cognitive Decline Is Associated With Increased Endothelial Cell Inflammation and Platelet Activation: Liquid Biopsy of Microvesicles in Community- Dwelling Octogenarians. Frontiers in Cell and Developmental Biology. 2021; 9:716435. DOI:10.3389/fcell.2021.716435. IF:6,081.
Davidson SM, Padro T, Bollini S, Vilahur G, Duncker DJ, Evans PC, Guzik T, Hoefer IE, Waltenberger J, Wojta J, Weber C. Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart. CARDIOVASCULAR RESEARCH. 2021; 117(10). DOI:10.1093/cvr/cvab200. PMID:34114614. IF:13,081.
Escate R, Padro T, Suades R, Camino S, Muniz O, Diaz JL, Sionis A, Mata P, Badimon L. High miR-133a levels in the circulation anticipates presentation of clinical events in familial hypercholesterolaemia patients. CARDIOVASCULAR RESEARCH. 2021; 117(1). DOI:10.1093/cvr/cvaa039. PMID:32061123. IF:13,081.
Evans P, Wojta J, Hoefer IE, Waltenberger J, Guzik T, Badimon L, Weber C, Council Basic Cardiovasc S. The year in basic vascular biology research: from mechanoreceptors and neutrophil extracellular traps to smartphone data and omics. CARDIOVASCULAR RESEARCH. 2021; 117(8). DOI:10.1093/cvr/cvab105. PMID:33744925. IF:13,081.
Flores EJ, Ortega L, Cepas PL, Giacchi G, Padro T, Badimon L, Sabate M, Brugaletta S. Endothelial Progenitor Cell Function in Patients With Coronary Chronic Total Occlusion and its Relationship With Collateral Circulation. JOURNAL OF INVASIVE CARDIOLOGY. 2021; 33(10). PMID:34544035. IF:1,711.
Garcia M, Diaz E, Pena E, Escate R, Juan O, Mata P, Badimon L, Padro T. Alternative C3 Complement System: Lipids and Atherosclerosis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(10):5122. DOI:10.3390/ijms22105122. PMID:34066088. IF:6,208.
Giro O, Jimenez A, Pane A, Badimon L, Ortega E, Chiva G. Extracellular vesicles in atherothrombosis and cardiovascular disease: Friends and foes. ATHEROSCLEROSIS. 2021; 330. DOI:10.1016/j.atherosclerosis.2021.07.002. PMID:34256307. IF:6,847.
Grigorian L, Sanz R, Climent A, Badimon L, Barile L, Bolli R, Chamuleau S, Grobbee DE, Janssens S, Kastrup J, Kragten L, Madonna R, Mathur A, Menasche P, Pompilio G, Prosper F, Sena E, Smart N, Zimmermann WH, Fernandez F. Insights into therapeutic products, preclinical research models, and clinical trials in cardiac regenerative and reparative medicine: where are we now and the way ahead. Current opinion paper of the ESC Working Group on Cardiovascular Regenerative and Reparative Medicine. CARDIOVASCULAR RESEARCH. 2021; 117(6). DOI:10.1093/cvr/cvaa337. PMID:33258961. IF:13,081.
Krychtiuk KA, Speidl WS, Giannitsis E, Gigante B, Gorog DA, Jaffe AS, Mair J, Mockel M, Mueller C, Storey RF, Vilahur G, Wojta J, Huber K, Halvorsen S, Geisler T, Morais J, Lindahl B, Thygesen K. Biomarkers of coagulation and fibrinolysis in acute myocardial infarction: a joint position paper of the Association for Acute Cardio Vascular Care and the European Society of Cardiology Working Group on Thrombosis. European Heart Journal-Acute Cardiovascular Care. 2021; 10(3). DOI:10.1093/ehjacc/zuaa025. PMID:33620437. IF:4,766.
Kunadian V, Chieffo A, Camici PG, Berry C, Escaned J, Maas A, Prescott E, Karam N, Appelman Y, Fraccaro C, Buchanan GL, Manzo S, Al R, Regar E, Lansky A, Abbott JD, Badimon L, Duncker DJ, Mehran R, Capodanno D, Baumbach A. An EAPCI Expert Consensus Document on Ischaemia with Non-Obstructive Coronary Arteries in Collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group. EuroIntervention. 2021; 16(13). DOI:10.4244/EIJY20M07_01. PMID:32624456. IF:7,728.
Luquero A, Badimon L, Borrell M. PCSK9 Functions in Atherosclerosis Are Not Limited to Plasmatic LDL-Cholesterol Regulation. Frontiers in Cardiovascular Medicine. 2021; 8:639727. DOI:10.3389/fcvm.2021.639727. PMID:33834043. IF:5,846.
Luquero A, Vilahur G, Crespo J, Badimon L, Borrell M. Microvesicles carrying LRP5 induce macrophage polarization to an anti-inflammatory phenotype. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2021; 25(16). DOI:10.1111/jcmm.16723. PMID:34288375. IF:5,295.
Mata P, Alonso R, de Isla LP, Badimon L. Dyslipidemia and aortic valve disease. CURRENT OPINION IN LIPIDOLOGY. 2021; 32(6). DOI:10.1097/MOL.0000000000000794. PMID:34629429. IF:4,616.
Munoz N, Escate R, Badimon L, Padro T. Moderate Beer Intake Downregulates Inflammasome Pathway Gene Expression in Human Macrophages. Biology-Basel. 2021; 10(11):1159. DOI:10.3390/biology10111159. PMID:34827151. IF:5,168.
Padro T, Munoz N, Pena E, Badimon L. Sex Differences and Emerging New Risk Factors for Atherosclerosis and Its Throm-botic Complications. CURRENT PHARMACEUTICAL DESIGN. 2021; 27(29). DOI:10.2174/1381612826666201118094209. PMID:33213315. IF:3,310.
Pero M, Casani L, Castells C, Perez ML, Naranjo EM, Juan O, De Lamo LA, Lopez P, Serrat AV, Badimon L, Roda OP. Rabbit as an animal model for the study of biological grafts in pelvic floor dysfunctions. Scientific Reports. 2021; 11(1):10545. DOI:10.1038/s41598-021-89698-z. PMID:34006889. IF:4,996.
Povsic TJ, Sanz R, Climent AM, Bolli R, Taylor DA, Gersh BJ, Menasche P, Perin EC, Pompilio G, Atsma DE, Badimon L, DeMaria AN, Hare JM, Henry TD, Janssens S, Kastrup J, Torella D, Traverse JH, Willerson JT, Fernandez F. Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies. ESC Heart Failure. 2021; 8(3). DOI:10.1002/ehf2.13256. PMID:33652498. IF:3,612.
Proietti M, Esteve MA, Rivera JM, Roldan V, Rabadan IR, Muniz J, Cequier A, Bertomeu V, Badimon L, Anguita M, Lip GYH, Marin F, FANTASIIA I. Relationship between multimorbidity and outcomes in atrial fibrillation. EXPERIMENTAL GERONTOLOGY. 2021; 153:111482. DOI:10.1016/j.exger.2021.111482. PMID:34303775. IF:4,253.
Rodriguez L, Badimon L, Mendez D, Padro T, Vilahur G, Pena E, Carrasco B, Vogel H, Palomo I, Fuentes E. Antiplatelet Activity of Isorhamnetin via Mitochondrial Regulation. Antioxidants. 2021; 10(5):666. DOI:10.3390/antiox10050666. PMID:33922903. IF:7,675.
Schoch L, Badimon L, Vilahur G. Unraveling the Complexity of HDL Remodeling: On the Hunt to Restore HDL Quality. Biomedicines. 2021; 9(7):805. DOI:10.3390/biomedicines9070805. PMID:34356869. IF:4,757.
Vasiljevic Z, Scarpone M, Bergami M, Yoon J, van der Schaar M, Krljanac G, Asanin M, Davidovic G, Simovic S, Manfrini O, Mickovski N, Badimon L, Cenko E, Bugiardini R. Smoking and sex differences in first manifestation of cardiovascular disease. ATHEROSCLEROSIS. 2021; 330. DOI:10.1016/j.atherosclerosis.2021.06.909. PMID:34233252. IF:6,847.
Vilahur G, Sutelman P, Mendieta G, Ben S, Borrell M, Pena E, Crespo J, Casani L, Badimon L. Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum. ATHEROSCLEROSIS. 2021; 324. DOI:10.1016/j.atherosclerosis.2021.03.014. PMID:33857761. IF:6,847.

CARDIOVASCULAR DISEASES

Molecular Pathology and Therapeutic of Ischaemic and Atherothrombotic Diseases

Main lines of research

Challenges

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Main lines of research

Challenges

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau