The Pharmacogenomics and Neurovascular Genetics reserch group composed of seven members and led by Dr. Israel Fernández, focuses his research on genetic and epigenetic studies of stroke. The group also studies the intestinal microbiota to determine the role of the gut microbiota in stroke occurrence. The objective of the group is to perform a translational research using these genomic tools, bioinformatic analyses and functional studies in vitro and in vivo.
The Group participates in several international consortia as members of the executive and scientific committees of these consortia. Currently, the group collaborates actively in four of these organizations that have their research focus on stroke genetics and / or associated diseases (IGSC, MEGASTROKE, CADISP and ICPC). The research group is currently coordinating the Spanish Stroke Genetics Consortium (Genestroke consortium) a consortium that is composed by 15 hospitals and research centers in Spain.
L1 Genetic factors associated with stroke risk.
L2 Genetic and epigenetic factors associated with post-stroke neurological deterioration.
L3 Genetic and epigenetic factors associated with post-stroke disability.
L4 CADASIL and small vessel diseases.
L5 Microbioma and stroke.
We highlight the following publications:
Fernández-Cadenas I, et al. GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke. Stroke. 2017;48:1147-1153. IF:5.7
Soriano-Tárraga C, et al. Biological age is better than chronological as predictor of 3-month outcome in ischemic stroke. Neurology. 2017 Aug 22;89(8):830-836. IF:8
Muiño E, et al. Systematic Review of Cysteine-Sparing NOTCH3 Missense Mutations in Patients with Clinical Suspicion of CADASIL. Int J Mol Sci. 2017 Sep 13;18(9). IF:2.3
Rannikmäe K, et al. COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls. Neurology. 2017 Sep 27. IF:8
Phuah CL, et al. Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke. Brain. 2017;140(10):2663-2672. IF: 10.2
Díaz-Maroto Cicuéndez I, et al. The UCP2-866G/A Polymorphism Could be Considered as a Genetic Marker of Different Functional Prognosis in Ischemic Stroke After Recanalization. Neuromolecular Med. 2017 Dec;19(4):571-578. IF: 3.2
FERNANDEZ CADENAS, ISRAEL
ifernandezc@santpau.cat
Boldo Cobo, Paula IR
Carcel Marquez, Jara IR
Fernandez Vidal, Joan Miquel FGS
Gallego Fabrega, Cristina IR
Marine Llorente, Laia IR
Martin Campos, Jesus Maria IR
Muiño Acuña, Elena FGS
Villatoro Gonzalez, Paula IR
The Pharmacogenomics and Neurovascular Genetics reserch group composed of seven members and led by Dr. Israel Fernández, focuses his research on genetic and epigenetic studies of stroke. The group also studies the intestinal microbiota to determine the role of the gut microbiota in stroke occurrence. The objective of the group is to perform a translational research using these genomic tools, bioinformatic analyses and functional studies in vitro and in vivo.
The Group participates in several international consortia as members of the executive and scientific committees of these consortia. Currently, the group collaborates actively in four of these organizations that have their research focus on stroke genetics and / or associated diseases (IGSC, MEGASTROKE, CADISP and ICPC). The research group is currently coordinating the Spanish Stroke Genetics Consortium (Genestroke consortium) a consortium that is composed by 15 hospitals and research centers in Spain.
L1 Genetic factors associated with stroke risk.
L2 Genetic and epigenetic factors associated with post-stroke neurological deterioration.
L3 Genetic and epigenetic factors associated with post-stroke disability.
L4 CADASIL and small vessel diseases.
L5 Microbioma and stroke.
We highlight the following publications:
Fernández-Cadenas I, et al. GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke. Stroke. 2017;48:1147-1153. IF:5.7
Soriano-Tárraga C, et al. Biological age is better than chronological as predictor of 3-month outcome in ischemic stroke. Neurology. 2017 Aug 22;89(8):830-836. IF:8
Muiño E, et al. Systematic Review of Cysteine-Sparing NOTCH3 Missense Mutations in Patients with Clinical Suspicion of CADASIL. Int J Mol Sci. 2017 Sep 13;18(9). IF:2.3
Rannikmäe K, et al. COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls. Neurology. 2017 Sep 27. IF:8
Phuah CL, et al. Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke. Brain. 2017;140(10):2663-2672. IF: 10.2
Díaz-Maroto Cicuéndez I, et al. The UCP2-866G/A Polymorphism Could be Considered as a Genetic Marker of Different Functional Prognosis in Ischemic Stroke After Recanalization. Neuromolecular Med. 2017 Dec;19(4):571-578. IF: 3.2
FERNANDEZ CADENAS, ISRAEL
ifernandezc@santpau.cat
Boldo Cobo, Paula IR
Carcel Marquez, Jara IR
Fernandez Vidal, Joan Miquel FGS
Gallego Fabrega, Cristina IR
Marine Llorente, Laia IR
Martin Campos, Jesus Maria IR
Muiño Acuña, Elena FGS
Villatoro Gonzalez, Paula IR
(JIF 2023)
-Duperron MG, Knol MJ, Le Q, Evans TE, Mishra A, Tsuchida A, Roshchupkin G, Konuma T, Tregouet DA, Romero JR, Frenzel S, Luciano M, Hofer E, Bourgey M, Dueker ND, Delgado P, Hilal S, Tankard RM, Dubost F, Shin J, Saba Y, Armstrong NJ, Bordes C, Bastin ME, Beiser A, Brodaty H, Bulow R, Carrera C, Chen CSP, Cheng CY, Deary IJ, Gampawar PG, Himali JJ, Jiang JY, Kawaguchi T, Li S, Macalli M, Marquis P, Morris Z, Maniega SM, Miyamoto S, Okawa M, Paradise M, Parva P, Rundek T, Sargurupremraj M, Schilling S, Setoh K, Soukarieh O, Tabara Y, Teumer A, Thalamuthu A, Trollor JN, Hernandez MCV, Vernooij MW, Volker U, Wittfeld K, Wong TY, Wright MJ, Zhang JY, Zhao WT, Zhu YC, Schmidt H, Sachdev PS, Wen W, Yoshida K, Joutel A, Satizabal CL, Sacco RL, Bourque G, Lathrop M, Paus T, Fernandez I, Yang Q, Mazoyer B, Boutinaud P, Okada Y, Grabe HJ, Mather KA, Schmidt R, Joliot M, Ikram MA, Matsuda F, Tzourio C, Wardlaw JM, Seshadri S, Adams HHH, Debette S, CHARGE C. Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease. NATURE MEDICINE. 2023; 29(4). DOI:10.1038/s41591-023-02268-w. PMID:37069360. IF:58,700 (Q1/1D). Document type: Article.
-Heald A, Qin R, Williams R, Warner J, Narayanan RP, Fernandez I, Peng Y, Gibson JM, McCay K, Anderson SG, Ollier W. A Longitudinal Clinical Trajectory Analysis Examining the Accumulation of Co-morbidity in People with Type 2 Diabetes (T2D) Compared with Non-T2D Individuals. Diabetes Therapy. 2023; 14(11). DOI:10.1007/s13300-023-01463-9. PMID:37707702. IF:2,800 (Q3/6D). Document type: Article.
-Lledós M, Prats L, Llucià L, Cárcel J, Muino E, Cullell N, Gallego C, Martín JM, Aguilera A, Guasch M, Guisado D, Ramos A, Martínez A, Izquierdo A, Marín R, Camps P, Martí J, Fernández I. Ischaemic stroke patients present sex differences in gut microbiota. EUROPEAN JOURNAL OF NEUROLOGY. 2023; 30(11). DOI:10.1111/ene.15931. PMID:37329328. IF:4,500 (Q1/2D). Document type: Article.
-Llucià L, Muiño E, Cullell N, Cárcel J, Lledós M, Gallego C, Martin J, Martí J, Aguilera A, Planas AM, DeDiego ML, de Felipe A, Masjuan J, García S, Segura T, González E, Serrano G, Domínguez A, Menéndez P, Montaner J, Migeotte I, Rahmouni S, Darcis G, Bernardo D, Rojo S, Schulte EC, Protzer U, Fricke L, Winter C, Niemi M, Cordioli M, Delgado P, Fernández I. Genetic Architecture of Ischaemic Strokes after COVID-19 Shows Similarities with Large Vessel Strokes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(17):13452. DOI:10.3390/ijms241713452. PMID:37686257IF:4,900 (Q1/3D). Document type: Article.
-Marti J, Camps P, Best JG, Ramos A, Guasch M, Martinez A, Guisado D, Gomez BM, Ambler G, Wilson D, Lee KJ, Lim JS, Bae HJ, Shiozawa M, Koga M, Toyoda K, Hennerici MG, Chabriat H, Jouvent E, Wong DYK, Mak H, Lau KK, Kim YD, Song TJ, Heo JH, Eppinger S, Gattringer T, Uysal E, Demirelli DS, Bornstein N, Ben E, Hallevi H, Molad JA, Nishihara M, Tanaka J, Hara H, Yakushiji Y, Coutts SB, Smith E, Polymeris AA, Wagner B, Seiffge D, Lyrer PA, Peters N, Engelter ST, Salman RA, Jager HR, Lip GYH, Goeldlin M, Panos L, Karayiannis CC, Phan TG, Srikanth VK, Christ N, Gunkel S, Fluri F, Leung TW, Soo Y, Chu WN, Abrigo J, Barbato C, Browning S, Simister R, Mendyk AM, Bordet R, Hilal S, Gyanwali B, Chen CSP, Jung SM, Orken DN, Werring D, Prats L, Microbleeds Int Collaborative N. Stroke Risk and Antithrombotic Treatment During Follow-up of Patients With Ischemic Stroke and Cortical Superficial Siderosis. NEUROLOGY. 2023; 100(12):e1267-e1281. DOI:10.1212/WNL.0000000000201723. PMID:36535778. IF:8,400 (Q1/1D). Document type: Article.
-Martín JM, Cárcel J, Llucià L, Lledós M, Cullell N, Muino E, Gallego C, Fernández I. Causal role of lipid metabolome on the risk of ischemic stroke, its etiological subtypes, and long-term outcome: A Mendelian randomization study. ATHEROSCLEROSIS. 2023; 386:117382. DOI:10.1016/j.atherosclerosis.2023.117382. PMID:38006695. IF:4,900 (Q1/2D). Document type: Article.
-Pinosanu LR, Capitanescu B, Glavan D, Godeanu S, Cadenas IF, Doeppner TR, Hermann DM, Balseanu A-T, Bogdan C, Popa A. Neuroglia Cells Transcriptomic in Brain Development, Aging and Neurodegenerative Diseases. Aging and Disease. 2023; 14(1). DOI:10.14336/AD.2022.0621. PMID:36818562. IF:7,000 (Q1/1D). Document type: Review.
-Surugiu R, Burdusel D, Ruscu MA, Cercel A, Hermann DM, Cadenas IF, Popa A. Clinical Ageing. Sub-Cellular Biochemistry. 2023; 103. DOI:10.1007/978-3-031-26576-1_16. PMID:37120476. Document type: Article.
(JIF 2022)
