Sant Pau - Institut de Recerca

Main lines of research

Critical analysis of new clinical technologies

Anaconda-inhaled sedation in patients undergoing postoperative mechanical ventilation.
New monitoring systems for anaesthesia depth and cerebral oxygen status.

Perioperative medicine

Epidemiological study of perioperative morbidity and mortality

Rationalization of perioperative fluid therapy and blood products

Institutional protocolization of massive transfusions.
Monitoring of critical perioperative coagulopathy.
Identification and recovery from preoperative anaemia.
Study of the Prevalence of perioperative transfusions.
Monitoring of perioperative fluid therapy.

New health service delivery systems

Professional team preoperative evaluations.
Zero preoperative stay.

Physiology, pharmacology and anaesthetic techniques

Intraoperative respiratory physiology.
Peripheral nerve blocking for postoperative analgesia in CMA.
Lipid Rescue due systemic complications after ALR.

Challenges

Critical analysis of new clinical technologies.
Patient blood management.
Perioperative medicine.
Development of new health service systems.
Clinical and preclinical research into physiology, pharmacology and anaesthetic/ analgesic techniques.

Group coordination

PANIAGUA IGLESIAS, PILAR FGS
ppaniagua@santpau.cat

Members

Argilaga Nogues, Marta FGS
Azparren Cabezon, Gonzalo FGS
Bainac Albadalejo, Albert Lluis FGS
Barbero Espinosa, Silvia FGS
Batalla Gonzalez, Astrid Maria FGS
Bericat Melero, Paula FGS
Bueno Izquierdo, Ana FGS
Cegarra Sanmartin, Virginia FGS
Cueva Castro, Luisa Fernanda FGS
De la Torre Weinreiter, Mariano Raul FGS
Felipe Correoso, Maria Mar FGS
Fonseca Pinto, Teresa FGS
Font Gual, Adria FGS
Garcia Alvarez, Maria Mercedes FGS
Garcia Rodriguez, Alejandro FGS
Gil Sanchez, Jose Maria FGS
Gine Serven, Marta FGS
Gomez Caro, Ana Maria FGS
Gonzalez Fernandez, Joaquin FGS
Gracia Tomas, Roger FGS
Guadalupe Fernandez, Nerea FGS
Gutierrez Marques, Alejandro FGS
Hermenegildo Chavez, Gisela Myrella FGS
Herranz Perez, Gracia FGS
Hinojal Blanco, Ignacio FGS
India Aldana, Inmaculada FGS
Koller, Tobias Bernhard FGS
Maestre Hittinger, Maria Luz FGS
Martin Navarro, Manuel FGS
Martinez Garcia, Clara FGS
Merten, Alfredo R. FGS
Millan Moreo, Irina FGS
Miralles Bagan, Jordi FGS
Moreno Bueno, Marisa FGS
Mur Irizar, Marta FGS
Nuñez Sacristan, Sergio FGS
Pardo Pinzon, Laura Andrea FGS
Parrilla Quiles, Laura FGS
Paz Martin, Adriano FGS
Perez Garcia, Sergio FGS
Rivilla Lizano, Maria Teresa FGS
Rodriguez Prieto, Mireia FGS
Sabate Tenas, Sergi FGS
Sneyers Closa, Marijke FGS
Solans Duran, Jose Ramon FGS
Toral Fernandez, Diego FGS
Villamizar Avendaño, Angelica FGS

Publications 2023

(JIF 2023)

-Álvarez J, Popova E, Vives M, de Nadal M, Ordonez J, Rivas M, Moustafa A-H, Solé E, Paniagua P, Garcia X, Viladés D, Leta R, Oristrell G, Zamora J, Ferreira I, Alonso P, Carreras F. Myocardial injury after major non-cardiac surgery evaluated with advanced cardiac imaging: a pilot study. BMC Cardiovascular Disorders. 2023; 23(1):78. DOI:10.1186/s12872-023-03065-6. PMID:36765313. IF:2,000 (Q3/6D). Document type: Article.

-Beltran de Heredia S, Mases A, Recasens L, SabatT S, Nunez M, Bosch L, Roman L, Rueda M, Alonso E, Gallart L. Mortality and incidence of cardiovascular events in patients treated with aspirin and statins at one year after myocardial injury in noncardiac surgery: a prospective observational study. Minerva Anestesiologica. 2023; 89(5). DOI:10.23736/S0375-9393.22.16807-0. PMID:36287395. IF:2,900 (Q1/3D). Document type: Article.

-Castellarnau S, Gaya JM, Espinosa J, Sierra P, Huguet J, Palou J, Hernando D, Sabate S, Breda A. Clinical impact of the suspension of the ERAS protocol on patients undergoing radical cystectomy during the COVID-19 pandemic. Actas Urologicas Espanolas. 2023; 47(6). DOI:10.1016/j.acuro.2023.01.005. PMID:36776227. IF:1,200 (Q3/8D). Document type: Article.

-Jiménez E, Asmarats L, Roqué M, Millán X, Li CHP, Fernández E, Sánchez J, Massó van Roessel A, Maestre ML, Paniagua P, Arzamendi D. Impact of Baseline Anemia in Patients Undergoing Transcatheter Aortic Valve Replacement: A Prognostic Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2023; 12(18):6025. DOI:10.3390/jcm12186025. PMID:37762965. IF:3,000 (Q1/2D). Document type: Review.

-Llau JV, Aldecoa C, Guasch E, Marco P, Marcos P, Paniagua P, Páramo JA, Quintana M, Rodríguez FJ, Serrano A. Multidisciplinary consensus document on the management of massive haemorrhage. First update 2023 (document HEMOMAS-II). Revista Espanola De Anestesiologia Y Reanimacion. 2023; 70(7). DOI:10.1016/j.redare.2023.08.001. PMID:37640281. IF:0,900 (Q3/7D). Document type: Article.

-Llau JV, Aldecoa C, Guasch E, Marco P, Marcos P, Paniagua P, Páramo JA, Quintana M, Rodríguez FJ, Serrano A. Multidisciplinary consensus document on the management of massive haemorrhage. First update 2023 (document HEMOMAS-II). Medicina Intensiva. 2023; 47(8). DOI:10.1016/j.medin.2023.03.007. IF:2,700 (Q2/5D). Document type: Article.

-Marcucci M, Painter TW, Conen D, Lomivorotov V, Sessler DI, Chan MTV, Borges FK, Leslie K, Duceppe E, Martinez MJ, Wang CY, Xavier D, Ofori SN, Wang MK, Efremov S, Landoni G, Kleinlugtenbelt YV, Szczeklik W, Schmartz D, Garg AX, Short TG, Wittmann M, Meyhoff CS, Amir M, Torres D, Patel A, Ruetzler K, Parlow JL, Tandon V, Fleischmann E, Polanczyk CA, Lamy A, Jayaram R, Astrakov SV, Wu WKK, Cheong CC, Ayad S, Kirov M, de Nadal M, Likhvantsev VV, Paniagua P, Aguado HJ, Maheshwari K, Whitlock RP, McGillion MH, Vincent J, Copland I, Balasubramanian K, Biccard BM, Srinathan S, Ismoilov S, Pettit S, Stillo D, Kurz A, Belley EP, Spence J, McIntyre WF, Bangdiwala SI, Guyatt G, Yusuf S, Devereaux PJ, POISE Trial Investigators Study 3. Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery An International Randomized Controlled Trial. ANNALS OF INTERNAL MEDICINE. 2023; 176(5). DOI:10.7326/M22-3157. PMID:37094336. IF:19,600 (Q1/1D). Document type: Article.

-Mases A, Beltrán de Heredia S, Gallart L, Román L, Bosch L, Núñez M, Rueda M, Recasens L, Sabaté S. Prediction of Acute Myocardial Injury in Noncardiac Surgery in Patients at Risk for Major Adverse Cardiovascular and Cerebrovascular Events: A Multivariable Risk Model. ANESTHESIA AND ANALGESIA. 2023; 137(6). DOI:10.1213/ANE.0000000000006469. PMID:37043386. IF:4,600 (Q1/2D). Document type: Article.

-Merchán A, Anaya R, Rodriguez M, Llorca J, Castejón M, Gil JM, Millan A, Estepa V, Cardona E, Garcia Y, Ruiz A, Martinez MJ, AFFEcT G. Quality of Life and Post-Surgical Complications in Patients on Chronic Antiplatelet Therapy with Proximal Femur Fracture: 12-Month Follow-Up after Implementing a Strategy to Shorten the Time to Surgery. Journal of Clinical Medicine. 2023; 12(3):1130. DOI:10.3390/jcm12031130. PMID:36769778. IF:3,000 (Q1/2D). Document type: Article.

-Popova E, Alonso P, Álvarez J, Paniagua P, Rué M, Vives M, Font A, Gich I, Martínez C, Ordóñez J, Carles M. Cost-effectiveness of a high-sensitivity cardiac troponin T systematic screening strategy compared with usual care to identify patients with peri-operative myocardial injury after major noncardiac surgery. EUROPEAN JOURNAL OF ANAESTHESIOLOGY. 2023; 40(3). DOI:10.1097/EJA.0000000000001793. PMID:36722187. IF:4,200 (Q1/2D). Document type: Article.

-Popova E, Paniagua P, Álvarez J, Vives M, González A, García Á, Rivas M, Hermenegildo G, Diaz R, Azparren G, Barceló M, Moustafa A-H, Aguilar R, Ordonez J, Alonso P. The Relevance of Implementing the Systematic Screening of Perioperative Myocardial Injury in Noncardiac Surgery Patients. Journal of Clinical Medicine. 2023; 12(16):5371. DOI:10.3390/jcm12165371. PMID:37629413. IF:3,000 (Q1/2D). Document type: Article.

-Rincón MD, Felipe MM, Candela Á. Assessment of the degree of knowledge of the massive transfusion protocol in four Spanish hospitals. MEDICINA CLINICA. 2023; 161(7). DOI:10.1016/j.medcli.2023.05.010. PMID:37380548. IF:2,600 (Q1/3D). Document type: Article.

-Zarbock A, Weiss R, Albert F, Rutledge K, Kellum JA, Bellomo R, Grigoryev E, Candela AM, Demir ZA, Legros V, Rosenberger P, Menendez PG, Alvarez MG, Peng K, Leger M, Khalel W, Orhan M, Meersch M, Epis I. Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study. INTENSIVE CARE MEDICINE. 2023; DOI:10.1007/s00134-023-07169-7. PMID:37505258. IF:29,600 (Q1/1D). Document type: Article.

Publications 2022

(JIF 2022)

Campos NS, Bluth T, Hemmes SNT, Librero J, Pozo N, Ferrando C, Ball L, Mazzinari G, Pelosi P, Gama de Abreu M, Schultz MJ, Serpa A; REPEAT; investigators for the PROVHILO study; iPROVE study; PROBESE study investigators; PROVE Network [Unzueta C, Moral MV, Sabate S, Cegarra V]. Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials. BRITISH JOURNAL OF ANAESTHESIA. 2022; 128(6). DOI:10.1016/j.bja.2022.02.039. PMID:35431038. IF:9,8 (Q1/1D). Document type: Article.
Devereaux PJ, Lamy A, Chan MTV, Allard RV, Lomivorotov VV, Landoni G, Zheng H, Paparella D, McGillion MH, Belley EP, Parlow JL, Underwood MJ, Wang CY, Dvirnik N, Abubakirov M, Fominskiy E, Choi S, Fremes S, Monaco F, Urrutia G, Maestre M, Hajjar LA, Hillis GS, Mills NL, Margari V, Mills JD, Billing JS, Methangkool E, Polanczyk CA, Sant’Anna R, Shukevich D, Conen D, Kavsak PA, McQueen MJ, Brady K, Spence J, Le Y, Mian R, Lee SF, Bangdiwala SI, Hussain S, Borges FK, Pettit S, Vincent J, Guyatt GH, Yusuf S, Alpert JS, White HD, Whitlock RP, VISION Cardiac Surg I. High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality. NEW ENGLAND JOURNAL OF MEDICINE. 2022; 386(9). DOI:10.1056/NEJMoa2000803. PMID:35235725. IF:158,5 (Q1/1D). Document type: Article.
Devereaux PJ, Marcucci M, Painter TW, Conen D, Lomivorotov V, Sessler DI, Chan MTV, Borges FK, Martinez MJ, Wang CY, Xavier D, Ofori SN, Wang MK, Efremov S, Landoni G, Kleinlugtenbelt YV, Szczeklik W, Schmartz D, Garg AX, Short TG, Wittmann M, Meyhoff CS, Amir M, Torres D, Patel A, Duceppe E, Ruetzler K, Parlow JL, Tandon V, Fleischmann E, Polanczyk CA, Lamy A, Astrakov SV, Rao M, Wu WKK, Bhatt K, de Nadal M, Likhvantsev VV, Paniagua P, Aguado HJ, Whitlock RP, McGillion MH, Prystajecky M, Vincent J, Eikelboom J, Copland I, Balasubramanian K, Turan A, Bangdiwala SI, Stillo D, Gross PL, Cafaro T, Alfonsi P, Roshanov PS, Belley EP, Spence J, Richards T, VanHelder T, McIntyre W, Guyatt G, Yusuf S, Leslie K, POISE I. Tranexamic Acid in Patients Undergoing Noncardiac Surgery. NEW ENGLAND JOURNAL OF MEDICINE. 2022; 386(21). DOI:10.1056/NEJMoa2201171. PMID:35363452. IF:158,5 (Q1/1D). Document type: Article.
Drudis R, Colomina J, Torra M, Sabate S, Villalba P, Marco G, Triquell X, Del Pozo D, Palliso F, Montero A. Adductor canal block performed 20 hours after total knee arthroplasty to improve postoperative analgesia and functional recovery: a double-blind randomized controlled clinical trial. Minerva Anestesiologica. 2022; 88(4). DOI:10.23736/S0375-9393.21.15838-9. PMID:34709013. IF:3,2 (Q2/5D). Document type: Article.
Galan J, Mateo E, Carmona P, Gajate L, Mazer CD, Martinez MJ. Restrictive or liberal transfusion for cardiac surgery: Spanish results of a randomized multicenter international parallel open-label clinical trial. Medicina Intensiva. 2022; 46(1). DOI:10.1016/j.medin.2020.07.011; DOI (English Edition):10.1016/j.medine.2020.07.003. PMID:34991874. IF:3 (Q3/7D). Document type: Letter.
Garg AX, Cuerden M, Aguado H, Amir M, Belley EP, Bhatt K, Biccard BM, Borges FK, Chan M, Conen D, Duceppe E, Efremov S, Eikelboom J, Fleischmann E, Giovanni L, Gross P, Jayaram R, Kirov M, Kleinlugtenbelt Y, Kurz A, Lamy A, Leslie K, Likhvantsev V, Lomivorotov V, Marcucci M, Martinez MJ, McGillion M, McIntyre W, Meyhoff C, Ofori S, Painter T, Paniagua P, Parikh C, Parlow J, Patel A, Polanczyk C, Richards T, Roshanov P, Schmartz D, Sessler D, Short T, Sontrop JM, Spence J, Srinathan S, Stillo D, Szczeklik W, Tandon V, Torres D, Van T, Vincent J, Wang CY, Wang M, Whitlock R, Wittmann M, Xavier D, Devereaux PJ. Effect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury: A Clinical Research Protocol for a Substudy of the POISE-3 Randomized Clinical Trial. Canadian Journal Of Kidney Health And Disease. 2022; 9:20543581211069225. DOI:10.1177/20543581211069225. PMID:35024154. Document type: Article.
Li C-H, González V, Bertolí E, Viladés D, Descalzo M, Carreras F, Leta R, Cinca J, Capellades H, Cueva L, Paniagua P. Propofol sedation administered by cardiologists in echocardiography studies. Rec: Cardioclinics. 2022; 57(1). DOI:10.1016/j.rccl.2021.02.007. Document type: Article.
Li CHP, Asmarats L, Maestre ML, Fernandez E, Serra A, Arzamendi D. New PASCAL Ace implant system in complex percutaneous mitral valve repair. Rec-Interventional Cardiology. 2022; 4(1). DOI:10.24875/RECICE.M21000201. Document type: Letter.
Marcucci M, Painter TW, Conen D, Leslie K, Lomivorotov VV, Sessler D, Chan MTV, Borges FK, Martínez-Zapata MJ, Wang CY, Xavier D, Ofori SN, Landoni G, Efremov S, Kleinlugtenbelt YV, Szczeklik W, Schmartz D, Garg AX, Short TG, Wittmann M, Meyhoff CS, Amir M, Torres D, Patel A, Duceppe E, Ruetzler K, Parlow JL, Tandon V, Wang MK, Fleischmann E, Polanczyk CA, Jayaram R, et al. [Paniagua P]. Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery. 2022; 23(1):101. DOI:10.1186/s13063-021-05992-1. PMID:35101083. IF:2,5 (Q3/8D). Document type: Article.
Osuna AG, Rojas LF, Lamas C, Roig XA, Pla F, Videla S, Martinez MJ, Valle M, Font A, Fernández JA, Rodriguez M, Banos V. Population Pharmacokinetics of Intra-articular and Intravenous Administration of Tranexamic Acid in Patients Undergoing Total Knee Replacement. CLINICAL PHARMACOKINETICS. 2022; 61(1). DOI:10.1007/s40262-021-01043-9. PMID:34255299. IF:4,5 (Q2/3D). Document type: Article.
Ripollés J, Sánchez R, Abad A, Gimeno AM, Díez Y, Jove P, Aragó P, Ortiz S, Sánchez R, Ramírez JM, Trullenque R, Valentí V, Ramiro Á, Correa OC, Batalla A, Gimeno C, Sanahuja JM, González FM, Galán P, Díez MJ, Vilallonga R, Zorrilla A, Pascual AM, Martínez J, Carrascosa T, Ruiz A, Martín E, Suárez A, Bausili M, Palacios Á, Olvera MM, Meza JA, Sánchez A, Abad A, Ferrando C, Martín B, Torres JR, Aguado S, Sánchez F, García JA, Aldecoa C, POWER Study Investigators Group 3. Higher Adherence to ERAS Society® Recommendations is Associated with Shorter Hospital Stay Without an Increase in Postoperative Complications or Readmissions in Bariatric Surgery: the Association Between Use of Enhanced Recovery After Surgery Protocols and Postoperative Complications after Bariatric Surgery (POWER 3) Multicenter Observational Study. OBESITY SURGERY. 2022; 32(4). DOI:10.1007/s11695-022-05949-6. PMID:35143011. IF:2,9 (Q2/3D). Document type: Article.
Sabaté S (2022). Valoración preoperatoria: Escala de valoración y riesgos anestésicos de los pacientes. In: ‘Máster Semipresencial en Enfermería de Anestesia, Reanimación y Tratamiento del Dolor que imparten la Escuela Universitaria de Enfermería y la Facultad de Medicina de la Universitat de Barcelona’. ISBN:978-84-19282-13-2. DL: B10923-2022. Document type: Book chapter.
Veliziotis I, Benítez A, Ramos I, Larrañaga L, Nuñez M, Adalid I, Ferrando C, Arruti E, Minini A, Bassas E, Taccone FS, Peluso L, Abad A, Abad A, Acevedo IA, Adalia R, Adalid I, Aguilar G, Aguilera L, Agulló AJ, Agustí M, Albala MI, Alberdi A, Albericio B, Alcon A, Alday E, Aldecoa C, Algar B, Aliaga J, Almuedo A, Alonso JR, Alonso P, Alonso M, Alonso O, Álvarez A, Álvarez JC, et al. [Bainac A, Moral MV, Paniagua P, Pérez-García S]. Early procalcitonin to predict mortality in critically ill COVID-19 patients: a multicentric cohort study. Minerva Anestesiologica. 2022; 88(4). DOI:10.23736/s0375-9393.22.15942-0. PMID:35072432. IF:3,2 (Q2/5D). Document type: Article.

Publications 2021

Anaya R, Rodriguez M, Gil JM, Vilalta N, Merchan A, Moral V, Mateo J, Martinez MJ. Correlation between PlateletWorks(R) and PFA-100(R) for Measuring Platelet Function before Urgent Surgery in Patients with Chronic Antiplatelet Therapy. Journal of Clinical Medicine. 2021; 10(2):255. DOI:10.3390/jcm10020255. PMID:33445597. IF:4,964.
Anaya R, Rodriguez M, Millan A, Reguant F, Llorca J, Guilabert P, Ruiz A, Pantoja PE, Gil JM, Moral V, Merchan A, Martinez MJ. Early Surgery with Neuraxial Anaesthesia in Patients on Chronic Antiplatelet Therapy with a Proximal Femur Fracture: Multicentric Randomised Clinical Trial. Journal of Clinical Medicine. 2021; 10(22):5371. DOI:10.3390/jcm10225371. PMID:34830654. IF:4,964.
Khan JS, Sessler DI, Chan MTV, Wang CY, Garutti I, Szczeklik W, Turan A, Busse JW, Buckley DN, Paul J, McGillion M, Fernandez C, Srinathan SK, Shanthanna H, Gilron I, Jacka M, Jackson P, Hankinson J, Paniagua P, Pettit S, Devereaux PJ. Persistent Incisional Pain after Noncardiac Surgery: An International Prospective Cohort Study. ANESTHESIOLOGY. 2021; 135(4). DOI:10.1097/ALN.0000000000003951. PMID:34499129. IF:8,986.
Koller T, Kinast N, Castellanos AG, Garcia SP, Iglesias PP, Vintro XL, Arranz JM, Seto NV, Garcia MVM, Moreno AB, Aznar J, Albaladejo GE, Diaz M. Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry. Scandinavian Journal of Trauma Resuscitation & Emergency Medicine. 2021; 29(1):57. DOI:10.1186/s13049-021-00867-5. PMID:33836790. IF:3,803.
Koller T, Ruiz AP, Diaz M, Caro A. Role of fibrinogen concentrates for treatment of critical perioperative hemorrhage. DRUGS OF TODAY. 2021; 57(3). DOI:10.1358/dot.2021.57.3.3250287. PMID:33729219. IF:2,436.
Osuna AG, Rojas LF, Lamas C, Roig XA, Pla F, Videla S, Martinez MJ, Valle M, Font A, Fernández JA, Rodriguez M, Banos V. Population Pharmacokinetics of Intra-articular and Intravenous Administration of Tranexamic Acid in Patients Undergoing Total Knee Replacement. CLINICAL PHARMACOKINETICS. 2022; 61(1). DOI:10.1007/s40262-021-01043-9. PMID:34255299. IF:5,577.
Serrano AB, Diaz O, Melchor J, Abad A, Ramirez JM, Martinez J, Sanchez M, Rodriguez R, Jorda L, Gil S, Cabellos M, Bordonaba D, Aldecoa C, Azparren G, Bastitta M, Batalla A, Cueva L, Gine M, Gómez AM, India I, POWER GRP. Neuromuscular blockade management and postoperative outcomes in enhanced recovery colorectal surgery: secondary analysis of POWER trial. Minerva Anestesiologica. 2021; 87(1). DOI:10.23736/S0375-9393.20.14589-9. PMID:33538417. IF:3,396.
Weiss R, Saadat-Gilani K, Kerschke L, Wempe C, Meersch M, Zarbock A; EPIS-AKI Investigators [Batalla A]. EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): study protocol for a multicentre, observational trial. BMJ Open. 2021;11(12):e055705. DOI:10.1136/bmjopen-2021-055705. PMID: 35588372. IF:3,006.
Zarbock A, Kullmar M, Ostermann M, Lucchese G, Baig K, Cennamo A, Rajani R, McCorkell S, Arndt C, Wulf H, Irqsusi M, Monaco F, Di AL, Alvarez MG, Italiano S, Bagan JM, Kunst G, Nair S, L’Acqua C, Hoste E, Vandenberghe W, Honore PM, Kellum JA, Forni LG, Grieshaber P, Massoth C, Weiss R, Gerss J, Wempe C, Meersch M. Prevention of Cardiac Surgery-Associated Acute Kidney Injury by Implementing the KDIGO Guidelines in High-Risk Patients Identified by Biomarkers: The PrevAKI-Multicenter Randomized Controlled Trial. ANESTHESIA AND ANALGESIA. 2021; 133(2). DOI:10.1213/ANE.0000000000005458. PMID:33684086. IF:6,627.
Zorrilla A, Stone AB, Ripolles J, Abad A, Ramirez JM, Galan P, Mena GE, Grant MC, Batalla A, Azparren G, Bastitta M, Felipe M, Cueva L, Gine M, Gómez AM, India I, Piñol S, Renedo P. Institutional factors associated with adherence to enhanced recovery protocols for colorectal surgery: Secondary analysis of a multicenter study. JOURNAL OF CLINICAL ANESTHESIA. 2021; 74:110378. DOI:10.1016/j.jclinane.2021.110378. PMID:34144497. IF:9,375.

Introduction

Main lines of research

Critical analysis of new clinical technologies

Anaconda-inhaled sedation in patients undergoing postoperative mechanical ventilation.
New monitoring systems for anaesthesia depth and cerebral oxygen status.

Perioperative medicine

Epidemiological study of perioperative morbidity and mortality

Rationalization of perioperative fluid therapy and blood products

Institutional protocolization of massive transfusions.
Monitoring of critical perioperative coagulopathy.
Identification and recovery from preoperative anaemia.
Study of the Prevalence of perioperative transfusions.
Monitoring of perioperative fluid therapy.

New health service delivery systems

Professional team preoperative evaluations.
Zero preoperative stay.

Physiology, pharmacology and anaesthetic techniques

Intraoperative respiratory physiology.
Peripheral nerve blocking for postoperative analgesia in CMA.
Lipid Rescue due systemic complications after ALR.

Challenges

Critical analysis of new clinical technologies.
Patient blood management.
Perioperative medicine.
Development of new health service systems.
Clinical and preclinical research into physiology, pharmacology and anaesthetic/ analgesic techniques.

Team

Group coordination

PANIAGUA IGLESIAS, PILAR FGS
ppaniagua@santpau.cat

Members

Scientific output

Publications 2023

(JIF 2023)

-Llau JV, Aldecoa C, Guasch E, Marco P, Marcos P, Paniagua P, Páramo JA, Quintana M, Rodríguez FJ, Serrano A. Multidisciplinary consensus document on the management of massive haemorrhage. First update 2023 (document HEMOMAS-II). Medicina Intensiva. 2023; 47(8). DOI:10.1016/j.medin.2023.03.007. IF:2,700 (Q2/5D). Document type: Article.

Publications 2022

(JIF 2022)

Campos NS, Bluth T, Hemmes SNT, Librero J, Pozo N, Ferrando C, Ball L, Mazzinari G, Pelosi P, Gama de Abreu M, Schultz MJ, Serpa A; REPEAT; investigators for the PROVHILO study; iPROVE study; PROBESE study investigators; PROVE Network [Unzueta C, Moral MV, Sabate S, Cegarra V]. Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials. BRITISH JOURNAL OF ANAESTHESIA. 2022; 128(6). DOI:10.1016/j.bja.2022.02.039. PMID:35431038. IF:9,8 (Q1/1D). Document type: Article.
Devereaux PJ, Lamy A, Chan MTV, Allard RV, Lomivorotov VV, Landoni G, Zheng H, Paparella D, McGillion MH, Belley EP, Parlow JL, Underwood MJ, Wang CY, Dvirnik N, Abubakirov M, Fominskiy E, Choi S, Fremes S, Monaco F, Urrutia G, Maestre M, Hajjar LA, Hillis GS, Mills NL, Margari V, Mills JD, Billing JS, Methangkool E, Polanczyk CA, Sant’Anna R, Shukevich D, Conen D, Kavsak PA, McQueen MJ, Brady K, Spence J, Le Y, Mian R, Lee SF, Bangdiwala SI, Hussain S, Borges FK, Pettit S, Vincent J, Guyatt GH, Yusuf S, Alpert JS, White HD, Whitlock RP, VISION Cardiac Surg I. High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality. NEW ENGLAND JOURNAL OF MEDICINE. 2022; 386(9). DOI:10.1056/NEJMoa2000803. PMID:35235725. IF:158,5 (Q1/1D). Document type: Article.
Devereaux PJ, Marcucci M, Painter TW, Conen D, Lomivorotov V, Sessler DI, Chan MTV, Borges FK, Martinez MJ, Wang CY, Xavier D, Ofori SN, Wang MK, Efremov S, Landoni G, Kleinlugtenbelt YV, Szczeklik W, Schmartz D, Garg AX, Short TG, Wittmann M, Meyhoff CS, Amir M, Torres D, Patel A, Duceppe E, Ruetzler K, Parlow JL, Tandon V, Fleischmann E, Polanczyk CA, Lamy A, Astrakov SV, Rao M, Wu WKK, Bhatt K, de Nadal M, Likhvantsev VV, Paniagua P, Aguado HJ, Whitlock RP, McGillion MH, Prystajecky M, Vincent J, Eikelboom J, Copland I, Balasubramanian K, Turan A, Bangdiwala SI, Stillo D, Gross PL, Cafaro T, Alfonsi P, Roshanov PS, Belley EP, Spence J, Richards T, VanHelder T, McIntyre W, Guyatt G, Yusuf S, Leslie K, POISE I. Tranexamic Acid in Patients Undergoing Noncardiac Surgery. NEW ENGLAND JOURNAL OF MEDICINE. 2022; 386(21). DOI:10.1056/NEJMoa2201171. PMID:35363452. IF:158,5 (Q1/1D). Document type: Article.
Drudis R, Colomina J, Torra M, Sabate S, Villalba P, Marco G, Triquell X, Del Pozo D, Palliso F, Montero A. Adductor canal block performed 20 hours after total knee arthroplasty to improve postoperative analgesia and functional recovery: a double-blind randomized controlled clinical trial. Minerva Anestesiologica. 2022; 88(4). DOI:10.23736/S0375-9393.21.15838-9. PMID:34709013. IF:3,2 (Q2/5D). Document type: Article.
Galan J, Mateo E, Carmona P, Gajate L, Mazer CD, Martinez MJ. Restrictive or liberal transfusion for cardiac surgery: Spanish results of a randomized multicenter international parallel open-label clinical trial. Medicina Intensiva. 2022; 46(1). DOI:10.1016/j.medin.2020.07.011; DOI (English Edition):10.1016/j.medine.2020.07.003. PMID:34991874. IF:3 (Q3/7D). Document type: Letter.
Garg AX, Cuerden M, Aguado H, Amir M, Belley EP, Bhatt K, Biccard BM, Borges FK, Chan M, Conen D, Duceppe E, Efremov S, Eikelboom J, Fleischmann E, Giovanni L, Gross P, Jayaram R, Kirov M, Kleinlugtenbelt Y, Kurz A, Lamy A, Leslie K, Likhvantsev V, Lomivorotov V, Marcucci M, Martinez MJ, McGillion M, McIntyre W, Meyhoff C, Ofori S, Painter T, Paniagua P, Parikh C, Parlow J, Patel A, Polanczyk C, Richards T, Roshanov P, Schmartz D, Sessler D, Short T, Sontrop JM, Spence J, Srinathan S, Stillo D, Szczeklik W, Tandon V, Torres D, Van T, Vincent J, Wang CY, Wang M, Whitlock R, Wittmann M, Xavier D, Devereaux PJ. Effect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury: A Clinical Research Protocol for a Substudy of the POISE-3 Randomized Clinical Trial. Canadian Journal Of Kidney Health And Disease. 2022; 9:20543581211069225. DOI:10.1177/20543581211069225. PMID:35024154. Document type: Article.
Li C-H, González V, Bertolí E, Viladés D, Descalzo M, Carreras F, Leta R, Cinca J, Capellades H, Cueva L, Paniagua P. Propofol sedation administered by cardiologists in echocardiography studies. Rec: Cardioclinics. 2022; 57(1). DOI:10.1016/j.rccl.2021.02.007. Document type: Article.
Li CHP, Asmarats L, Maestre ML, Fernandez E, Serra A, Arzamendi D. New PASCAL Ace implant system in complex percutaneous mitral valve repair. Rec-Interventional Cardiology. 2022; 4(1). DOI:10.24875/RECICE.M21000201. Document type: Letter.
Marcucci M, Painter TW, Conen D, Leslie K, Lomivorotov VV, Sessler D, Chan MTV, Borges FK, Martínez-Zapata MJ, Wang CY, Xavier D, Ofori SN, Landoni G, Efremov S, Kleinlugtenbelt YV, Szczeklik W, Schmartz D, Garg AX, Short TG, Wittmann M, Meyhoff CS, Amir M, Torres D, Patel A, Duceppe E, Ruetzler K, Parlow JL, Tandon V, Wang MK, Fleischmann E, Polanczyk CA, Jayaram R, et al. [Paniagua P]. Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery. 2022; 23(1):101. DOI:10.1186/s13063-021-05992-1. PMID:35101083. IF:2,5 (Q3/8D). Document type: Article.
Osuna AG, Rojas LF, Lamas C, Roig XA, Pla F, Videla S, Martinez MJ, Valle M, Font A, Fernández JA, Rodriguez M, Banos V. Population Pharmacokinetics of Intra-articular and Intravenous Administration of Tranexamic Acid in Patients Undergoing Total Knee Replacement. CLINICAL PHARMACOKINETICS. 2022; 61(1). DOI:10.1007/s40262-021-01043-9. PMID:34255299. IF:4,5 (Q2/3D). Document type: Article.
Ripollés J, Sánchez R, Abad A, Gimeno AM, Díez Y, Jove P, Aragó P, Ortiz S, Sánchez R, Ramírez JM, Trullenque R, Valentí V, Ramiro Á, Correa OC, Batalla A, Gimeno C, Sanahuja JM, González FM, Galán P, Díez MJ, Vilallonga R, Zorrilla A, Pascual AM, Martínez J, Carrascosa T, Ruiz A, Martín E, Suárez A, Bausili M, Palacios Á, Olvera MM, Meza JA, Sánchez A, Abad A, Ferrando C, Martín B, Torres JR, Aguado S, Sánchez F, García JA, Aldecoa C, POWER Study Investigators Group 3. Higher Adherence to ERAS Society® Recommendations is Associated with Shorter Hospital Stay Without an Increase in Postoperative Complications or Readmissions in Bariatric Surgery: the Association Between Use of Enhanced Recovery After Surgery Protocols and Postoperative Complications after Bariatric Surgery (POWER 3) Multicenter Observational Study. OBESITY SURGERY. 2022; 32(4). DOI:10.1007/s11695-022-05949-6. PMID:35143011. IF:2,9 (Q2/3D). Document type: Article.
Sabaté S (2022). Valoración preoperatoria: Escala de valoración y riesgos anestésicos de los pacientes. In: ‘Máster Semipresencial en Enfermería de Anestesia, Reanimación y Tratamiento del Dolor que imparten la Escuela Universitaria de Enfermería y la Facultad de Medicina de la Universitat de Barcelona’. ISBN:978-84-19282-13-2. DL: B10923-2022. Document type: Book chapter.
Veliziotis I, Benítez A, Ramos I, Larrañaga L, Nuñez M, Adalid I, Ferrando C, Arruti E, Minini A, Bassas E, Taccone FS, Peluso L, Abad A, Abad A, Acevedo IA, Adalia R, Adalid I, Aguilar G, Aguilera L, Agulló AJ, Agustí M, Albala MI, Alberdi A, Albericio B, Alcon A, Alday E, Aldecoa C, Algar B, Aliaga J, Almuedo A, Alonso JR, Alonso P, Alonso M, Alonso O, Álvarez A, Álvarez JC, et al. [Bainac A, Moral MV, Paniagua P, Pérez-García S]. Early procalcitonin to predict mortality in critically ill COVID-19 patients: a multicentric cohort study. Minerva Anestesiologica. 2022; 88(4). DOI:10.23736/s0375-9393.22.15942-0. PMID:35072432. IF:3,2 (Q2/5D). Document type: Article.

Publications 2021

Anaya R, Rodriguez M, Gil JM, Vilalta N, Merchan A, Moral V, Mateo J, Martinez MJ. Correlation between PlateletWorks(R) and PFA-100(R) for Measuring Platelet Function before Urgent Surgery in Patients with Chronic Antiplatelet Therapy. Journal of Clinical Medicine. 2021; 10(2):255. DOI:10.3390/jcm10020255. PMID:33445597. IF:4,964.
Anaya R, Rodriguez M, Millan A, Reguant F, Llorca J, Guilabert P, Ruiz A, Pantoja PE, Gil JM, Moral V, Merchan A, Martinez MJ. Early Surgery with Neuraxial Anaesthesia in Patients on Chronic Antiplatelet Therapy with a Proximal Femur Fracture: Multicentric Randomised Clinical Trial. Journal of Clinical Medicine. 2021; 10(22):5371. DOI:10.3390/jcm10225371. PMID:34830654. IF:4,964.
Khan JS, Sessler DI, Chan MTV, Wang CY, Garutti I, Szczeklik W, Turan A, Busse JW, Buckley DN, Paul J, McGillion M, Fernandez C, Srinathan SK, Shanthanna H, Gilron I, Jacka M, Jackson P, Hankinson J, Paniagua P, Pettit S, Devereaux PJ. Persistent Incisional Pain after Noncardiac Surgery: An International Prospective Cohort Study. ANESTHESIOLOGY. 2021; 135(4). DOI:10.1097/ALN.0000000000003951. PMID:34499129. IF:8,986.
Koller T, Kinast N, Castellanos AG, Garcia SP, Iglesias PP, Vintro XL, Arranz JM, Seto NV, Garcia MVM, Moreno AB, Aznar J, Albaladejo GE, Diaz M. Normalization of blood clotting characteristics using prothrombin complex concentrate, fibrinogen and FXIII in an albumin based fluid: experimental studies in thromboelastometry. Scandinavian Journal of Trauma Resuscitation & Emergency Medicine. 2021; 29(1):57. DOI:10.1186/s13049-021-00867-5. PMID:33836790. IF:3,803.
Koller T, Ruiz AP, Diaz M, Caro A. Role of fibrinogen concentrates for treatment of critical perioperative hemorrhage. DRUGS OF TODAY. 2021; 57(3). DOI:10.1358/dot.2021.57.3.3250287. PMID:33729219. IF:2,436.
Osuna AG, Rojas LF, Lamas C, Roig XA, Pla F, Videla S, Martinez MJ, Valle M, Font A, Fernández JA, Rodriguez M, Banos V. Population Pharmacokinetics of Intra-articular and Intravenous Administration of Tranexamic Acid in Patients Undergoing Total Knee Replacement. CLINICAL PHARMACOKINETICS. 2022; 61(1). DOI:10.1007/s40262-021-01043-9. PMID:34255299. IF:5,577.
Serrano AB, Diaz O, Melchor J, Abad A, Ramirez JM, Martinez J, Sanchez M, Rodriguez R, Jorda L, Gil S, Cabellos M, Bordonaba D, Aldecoa C, Azparren G, Bastitta M, Batalla A, Cueva L, Gine M, Gómez AM, India I, POWER GRP. Neuromuscular blockade management and postoperative outcomes in enhanced recovery colorectal surgery: secondary analysis of POWER trial. Minerva Anestesiologica. 2021; 87(1). DOI:10.23736/S0375-9393.20.14589-9. PMID:33538417. IF:3,396.
Weiss R, Saadat-Gilani K, Kerschke L, Wempe C, Meersch M, Zarbock A; EPIS-AKI Investigators [Batalla A]. EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): study protocol for a multicentre, observational trial. BMJ Open. 2021;11(12):e055705. DOI:10.1136/bmjopen-2021-055705. PMID: 35588372. IF:3,006.
Zarbock A, Kullmar M, Ostermann M, Lucchese G, Baig K, Cennamo A, Rajani R, McCorkell S, Arndt C, Wulf H, Irqsusi M, Monaco F, Di AL, Alvarez MG, Italiano S, Bagan JM, Kunst G, Nair S, L’Acqua C, Hoste E, Vandenberghe W, Honore PM, Kellum JA, Forni LG, Grieshaber P, Massoth C, Weiss R, Gerss J, Wempe C, Meersch M. Prevention of Cardiac Surgery-Associated Acute Kidney Injury by Implementing the KDIGO Guidelines in High-Risk Patients Identified by Biomarkers: The PrevAKI-Multicenter Randomized Controlled Trial. ANESTHESIA AND ANALGESIA. 2021; 133(2). DOI:10.1213/ANE.0000000000005458. PMID:33684086. IF:6,627.
Zorrilla A, Stone AB, Ripolles J, Abad A, Ramirez JM, Galan P, Mena GE, Grant MC, Batalla A, Azparren G, Bastitta M, Felipe M, Cueva L, Gine M, Gómez AM, India I, Piñol S, Renedo P. Institutional factors associated with adherence to enhanced recovery protocols for colorectal surgery: Secondary analysis of a multicenter study. JOURNAL OF CLINICAL ANESTHESIA. 2021; 74:110378. DOI:10.1016/j.jclinane.2021.110378. PMID:34144497. IF:9,375.

ASSOCIATED GROUPS

Anaesthesiology

Main lines of research

Critical analysis of new clinical technologies

Perioperative medicine

Rationalization of perioperative fluid therapy and blood products

New health service delivery systems

Physiology, pharmacology and anaesthetic techniques

Challenges

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Main lines of research

Critical analysis of new clinical technologies

Perioperative medicine

Rationalization of perioperative fluid therapy and blood products

New health service delivery systems

Physiology, pharmacology and anaesthetic techniques

Challenges

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau