The incorporation of new technologies that facilitate molecular profiling and gene regulation has led to innovative research into heart and other cardiovascular diseases including arrhythmias, aorta aneurism, vascular diseases, thrombosis, etc. The great diversity of groups in this area gives varied perspectives to on-going research, whether in developing or testing the effectiveness of new biomarkers (as in the investigation of the metabolic and genetic bases of cardiovascular diseases) or therapeutic applications in the short term. Before final translation to humans, many of the advances in this area can be validated in animal models including small and large mammals including pigs.