Dr. José Julve, from the IIB Sant Pau and Dr. Francisco Blanco Vaca, director of the Biochemistry Service of Sant Pau and PI of the Grupo de Bases metabólicos del riesgo cardiovascular del IIB, is the main author of an article published in Translational Research, The Journal of Laboratory and Clinical Medicine.
The article demonstrates an important alteration in fecal cholesterol excretion in a model of rodents of the Muridae family of diabetes and extreme obesity, due to an alteration of signaling that regulates this excretion and is controlled by an adjustable transcriptional factor for binders called LXR alpha that controls the entero-hepatic cholesterol transporters ABCG5/G8.
Although this finding corresponds to a specific animal model, bariatric surgery of patients with morbid obesity improved the liver expression of alpha LXR and ABCG5/G8 suggesting that these alterations in cholesterol traffic, which are known to favor the development of cardiovascular diseases, are observed in patients with morbid obesity and diabetes.
You can view the article in pdf in the attached file.
