Sant Pau - Institut de Recerca

Main lines of researchThe Group of “Regulatory mechanisms of cardiovascular remodeling” investigates key aspects of vascular biology, atherothrombosis and myocardial pathophysiology geared towards the characterization of the cellular and molecular mechanisms involved in the onset, progression and complication of ischemic heart disease, abdominal aortic aneurysm (AAA) and cardiac hypertrophy. The ultimate goal of the group is to identify novel therapeutic targets and biomarkers to better manage these highly prevalent cardiovascular diseases.

Main lines of research

Extracellular matrix remodeling in cardiovascular diseases.
Nuclear receptors in ischemic heart disease, vascular biology and cardiac hypertrophy.
Novel therapeutic targets in hypertensive disease

Objectives:
To analyze the molecular basis of abdominal aortic aneurysm and to identify novel therapeutic targets.
To study the pathophysiological and molecular mechanisms underlying the development of thoracic aortic aneurysm in syndromic patients.
To identify novel biomarkers and therapeutic targets for peripheral artery disease and vascular dysfunction.
To analyze the molecular mechanisms that involve nuclear receptors in the regulation of vascular calcification.
To identify and validate novel pharmacological tools in cardiovascular diseases.
To develop new animal models in cardiovascular disease.

Group coordination

RODRIGUEZ SINOVAS, MARIA CRISTINA IR
crodriguezs@santpau.cat

Members

Aguilo Nuñez, Silvia IR
Almendra Peguero, Rafael Antonio IR
Alonso Nieto, Judith CIBERCV
Ballester Servera, Carme CSIC
Blanco Casoliva, Laia CSIC
Martinez Gonzalez, Jose CSIC
Vazquez Sufuentes, Paula CSIC

Publications 2023

(JIF 2022)

-Ballester C, Alonso J, Cañes L, Vázquez P, Puertas L, Fernández A, Taurón M, Rodríguez A, López N, Rodríguez C, Martínez J. Lysyl oxidase-dependent extracellular matrix crosslinking modulates calcification in atherosclerosis and aortic valve disease. BIOMEDICINE & PHARMACOTHERAPY. 2023; 167:115469. DOI:10.1016/j.biopha.2023.115469. PMID:37729730. IF:7,500 (Q1/1D). Document type: Article.

-Bonilla DA, Daga R, Gamero A, Pérez A, Pérez E, Pérez P, Petermann F, Lozano M, García MR, Kouiti M, Carrillo E, Fernández T, Apolinar E, Nava EJ, Benítez N, Almendra R. Applications of artificial intelligence in nutrition and dietetics: Beyond virtual assistants. Revista Espanola De Nutricion Humana Y Dietetica. 2023; 27(4). DOI:10.14306/renhyd.27.4.2054. Document type: Editorial Material

-Consegal M, Barba I, del Blanco BG, Otaegui I, Rodriguez JF, Marti G, Serra B, Bellera N, Ojeda M, Valente F, Carmona MA, Miro E, Sambola A, Lidon RM, Baneras J, Barrabes JA, Rodriguez C, Benito B, Ruiz M, Inserte J, Ferreira I, Rodriguez A. Spontaneous reperfusion enhances succinate concentration in peripheral blood from stemi patients but its levels does not correlate with myocardial infarct size or area at risk. Scientific Reports. 2023; 13(1):6907. DOI:10.1038/s41598-023-34196-7. PMID:37106099. IF:4,600 (Q2/4D). Document type: Article.

-del Campo LSD, García AB, Rodríguez C, Zaragoza C, Duro S, Palmas F, De Benito A, Socuéllamos PG, Peraza DA, Rodrigues R, Valenzuela C, Dalli J, Salaices M, Briones AM. Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension. HYPERTENSION. 2023; 80(1). DOI:10.1161/HYPERTENSIONAHA.122.19448. PMID:36337053. IF:8,300 (Q1/2D). Document type: Article.

-Kelly L, Sharp MM, Thomas I, Brown C, Schrag M, Antunes LV, Solopova E, Martinez J, Rodríguez C, Carare RO. Targeting lysyl-oxidase (LOX) may facilitate intramural periarterial drainage for the treatment of Alzheimer’s disease. Cerebral Circulation – Cognition And Behavior. 2023; 5:100171. DOI:10.1016/j.cccb.2023.100171. PMID:37457664. Document type: Article.

-Munoz E, Pérez A, Apolinar E, Fernández T, Brito NB, Petermann F, Gamero A, Pérez P, Lozano M, Bonilla DA, Pérez É, Nava EJ, Troncoso C, Almendra R. Balance of the year 2022 and new Strategic Plan 2023-2026 of the Spanish Journal of Human Nutrition and Dietetics. Revista Espanola De Nutricion Humana Y Dietetica. 2023; 27(1). DOI:10.14306/renhyd.27.1.1903. Document type: Editorial Material.

-Nava EJ, Apolinar E, Bénitez N, Pérez P, Pérez A, Troncoso C, Bonilla DA, Fernández T, Petermann F, Gamero A, Pérez É, Navarrete EM, Lozano M, Almendra R. Formación del dietista-nutricionista clínico en Latinoamérica: un espejo donde debe mirarse España. Revista Espanola De Nutricion Humana Y Dietetica. 2023; 27(2). DOI:10.14306/renhyd.27.2.1957. Document type: Editorial Material.

-Navas M, Almendra R, Puertas L, Jimenez F, Julve J, Perez B, Consegal M, Kassan M, Martinez J, Rodriguez C, Galan M. Targeting mitochondrial stress with Szeto-Schiller 31 prevents experimental abdominal aortic aneurysm: Crosstalk with endoplasmic reticulum stress. BRITISH JOURNAL OF PHARMACOLOGY. 2023; 180(17). DOI:10.1111/bph.16077. PMID:36964990. IF:7,300 (Q1/1D). Document type: Article.

-Pérez A, Fernández T, Lozano M, Pérez P, García MR, Pérez E, Gamero A, Petermann F, Apolinar E, Nava EJ, Almendra R. Pros and cons of open science from the Spanish Journal of Human Nutrition and Dietetics. Revista Espanola De Nutricion Humana Y Dietetica. 2023; 27(4). DOI:10.14306/renhyd.27.4.2055. Document type: Editorial Material.

-Puertas L, Almendra R, Jimenez F, Sirvent M, Galan M, Martinez J, Rodriguez C. Novel pharmacological approaches in abdominal aortic aneurysm. CLINICAL SCIENCE. 2023; 137(15). DOI:10.1042/CS20220795. PMID:37559446. IF:6,000 (Q1/3D). Document typer: Review.

-Puertas L, Alonso J, Hove L, Martínez J, Rodríguez C. PDE4 Phosphodiesterases in Cardiovascular Diseases: Key Pathophysiological Players and Potential Therapeutic Targets. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023; 24(23):17017. DOI:10.3390/ijms242317017. PMID:38069339. IF:5,600 (Q1/3D). Document type: Review.

-Puertas L, Varona S, Ballester C, Alonso J, Aguiló S, Orriols M, Martínez E, Rodríguez A, Martínez J, Rodríguez C. Activation of Wnt/ß-catenin signaling in abdominal aortic aneurysm: A potential therapeutic opportunity?. Genes And Diseases. 2023; 10(3). DOI:10.1016/j.gendis.2022.05.017. PMID:37396504. IF:6,800 (Q1/2D). Document type: Article.

-Reyes AI, Bernabeu J, Rodriguez C, Santamaria A, de Castellar R, Martinez J. Post-Pandemic Feeding Patterns and Mediterranean Diet Adherence in Spanish Toddlers. -Nutrients. 2023; 15(9):2049. DOI:10.3390/nu15092049. PMID:37432177. IF:5,900 (Q1/2D). Document type: Article

-Zagmutt S, Mera P, Gonzalez I, Ibeas K, Romero MD, Obri A, Martin B, Esteve A, Soler MC, Bastias M, Canes L, Auge E, Pelegri C, Vilaplana J, Ariza X, Garcia J, Martinez J, Casals N, Lopez M, Palmiter R, Sanz E, Quintana A, Herrero L, Serra D. CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst. Biology of Sex Differences. 2023; 14(1):14. DOI:10.1186/s13293-023-00498-8. PMID:36966335. IF:7,900 (Q1/1D). Document type: Article.

Publications 2022

(JIF 2022)

Ballester C, Canes L, Alonso J, Puertas L, Tauron M, Rodriguez C, Martinez J. Nuclear receptor NOR-1 (Neuron-derived Orphan Receptor-1) in pathological vascular remodelling and vascular remodelling. Clinica E Investigacion En Arteriosclerosis. 2022; 34(4). DOI:10.1016/j.arteri.2022.03.002. PMID:35581107. Document type: Review.
Ballesteros C, Rodrigues R, Beltran LM, Moreno R, Martinez E, Gonzalez M, Martinez J, Rodriguez C, Cachofeiro V, Salaices M, Briones AM. Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity. BRITISH JOURNAL OF PHARMACOLOGY. 2022; 179(11). DOI:10.1111/bph.15776. PMID:34877656. IF:7,3 (Q1/1D). Document type: Article. Document type: Article.
Blanco R, de la Fuente H, Rodriguez C, Martin L, Sanchez R, Jimenez R, Rodriguez I, Curtabbi A, Garcia MM, Vera A, Rivero F, Cuesta J, Jimenez LJ, Cecconi A, Duran A, Tauron M, Alonso J, Bueno H, Villalba M, Enriquez JA, Robson SC, Alfonso F, Sanchez F, Martinez J, Martin P. CD69 expression on regulatory T cells protects from immune damage after myocardial infarction. JOURNAL OF CLINICAL INVESTIGATION. 2022; 132(21):e152418. DOI:10.1172/JCI152418. PMID:36066993. IF: 15,9 (Q1/1D). Document type: Article.
González M, García AB, Jorge I, Zalba G, Becares M, Ruiz MJ, Rodríguez C, Bermeo H, Rodrigues R, Rios FJ, Montezano AC, Martínez J, Vázquez J, Redondo JM, Touyz RM, Guerra S, Salaices M, Briones AM. Interferon stimulated gene 15 pathway is a novel mediator of endothelial dysfunction and aneurysms development in angiotensin II infused mice through increased oxidative stress. CARDIOVASCULAR RESEARCH. 2022; 118(16). DOI:10.1093/cvr/cvab321. PMID:34672341. IF:10,8 (Q1/1D). Document type: Article.
Jimenez F, Marzi J, Galan M, Dantas AP, Ortega M, Rojas S, Egea G, Schenke K, Jimenez E, Planas AM. Arachnoid membrane as a source of sphingosine-1-phosphate that regulates mouse middle cerebral artery tone. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2022; 42(1):0271678X211033362. DOI:10.1177/0271678X211033362. PMID:34474613. IF:6,3 (Q1/2D). Document type: Article.
Jimenez M, Rodriguez C, Canes L, Ballester C, Vara A, Requena S, de la Fuente H, Martinez J, Sanchez F. CD69-oxLDL ligand engagement induces Programmed Cell Death 1 (PD-1) expression in human CD4+T lymphocytes. CELLULAR AND MOLECULAR LIFE SCIENCES. 2022; 79(8):468. DOI:10.1007/s00018-022-04481-1. PMID:35930205. IF:8 (Q1/2D). Document type: Article.
Lehmann GL, Ginsberg M, Nolan DJ, Rodriguez C, Martinez J, Zeng SM, Voigt AP, Mullins RF, Rafii S, Rodriguez E, Benedicto I. Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells. Cells. 2022; 11(19):2975. DOI:10.3390/cells11192975. PMID:36230937. IF:6 (Q2/4D). Document type: Article.
Troncoso C, Petermann F, Lozano M, Perez A, Almendra R, Fernandez T, Nava EJ, Gamero A, Camacho S, Bonillal DA, Perez E, Navarrete EM. A qualitative look at the research in the Spanish Journal of Human Nutrition and Dietetics. Revista Espanola De Nutricion Humana Y Dietetica. 2022; 26(3). DOI:10.14306/renhyd.26.3.1723. Document type: Editorial material.
Valls L, Puertas L, Varona S, Martinez J, Rodriguez C, Rodriguez A. Human Lysyl Oxidase Over-Expression Enhances Baseline Cardiac Oxidative Stress but Does Not Aggravate ROS Generation or Infarct Size Following Myocardial Ischemia-Reperfusion. Antioxidants. 2022; 11(1):75. DOI:10.3390/antiox11010075. PMID:35052579. IF:7 (Q1/1D). Document type: Article.
Vila A, Ramirez C, Apolinar E, Rojas P, Valera D, Almendra R, Navarrete EM. Factors Associated with Dietary Restriction and Emotional and Uncontrolled Eating in Adults from Spanish-Speaking Countries during the COVID-19 Confinement: Results of the CoV-Eat Project. Nutrients. 2022; 14(22):4866. DOI:10.3390/nu14224866. PMID:36432551. IF:5,9 (Q1/2D). Document type: Article.

Publications 2021

Canes L, Alonso J, Ballester C, Varona S, Escudero JR, Andres V, Rodriguez C, Martinez J. Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm Impact on Inflammation, Oxidative Stress, and Vascular Remodeling. HYPERTENSION. 2021; 78(3). DOI:10.1161/HYPERTENSIONAHA.121.17517. PMID:34304581. IF:9,897.
Canes L, Marti I, Ballester C, Alonso J, ELENA C, Briones AM, Rodriguez C, Martinez J. High NOR-1 (Neuron-Derived Orphan Receptor 1) Expression Strengthens the Vascular Wall Response to Angiotensin II Leading to Aneurysm Formation in Mice. HYPERTENSION. 2021; 77(2). DOI:10.1161/HYPERTENSIONAHA.120.16078. PMID:33356402. IF:9,897.
Jimenez T, Ballester C, Quetglas M, Morell D, Torres N, Bautista AM, Serra N, Girona E. Cryopreservation of platelets treated with riboflavin and UV light and stored at-80 degrees C for 1 year. TRANSFUSION. 2021; 61(4). DOI:10.1111/trf.16324. PMID:33694171. IF:3,337.
Martinez J, Canes L, Alonso J, Ballester C, Rodriguez A, Corrales I, Rodriguez C. NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(21):11371. DOI:10.3390/ijms222111371. PMID:34768801. IF:6,208.
Muntsant A, Jimenez F, Puertas L, Jimenez E, Vila E, Gimenez L. Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging. Biomedicines. 2021; 9(2):111. DOI:10.3390/biomedicines9020111. PMID:33498895. IF:4,757.
Sanchez D, Nus M, Navas M, Fite J, Perez B, Barros AJ, Soto B, Martinez J, Camacho M, Rodriguez C, Mallat Z, Galan M. Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm. Antioxidants. 2021; 10(4):602. DOI:10.3390/antiox10040602. PMID:33919749. IF:7,675.
Souza FV, Jimenez S, Delgado B, Jurado R, Genty M, Romero A, Rodriguez C, Nieto ML, Martinez E, Cachofeiro V. The Interplay of Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress in Cardiovascular Fibrosis in Obese Rats. Antioxidants. 2021; 10(8):1274. DOI:10.3390/antiox10081274. PMID:34439522. IF:7,675.
Varona S, Puertas L, Galan M, Orriols M, Canes L, Aguilo S, Camacho M, Sirvent M, Andres V, Martinez J, Rodriguez C. Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA. Antioxidants. 2021; 10(3):460. DOI:10.3390/antiox10030460. PMID:33809405. IF:7,675.

Introduction

Main lines of research

Extracellular matrix remodeling in cardiovascular diseases.
Nuclear receptors in ischemic heart disease, vascular biology and cardiac hypertrophy.
Novel therapeutic targets in hypertensive disease

Objectives:
To analyze the molecular basis of abdominal aortic aneurysm and to identify novel therapeutic targets.
To study the pathophysiological and molecular mechanisms underlying the development of thoracic aortic aneurysm in syndromic patients.
To identify novel biomarkers and therapeutic targets for peripheral artery disease and vascular dysfunction.
To analyze the molecular mechanisms that involve nuclear receptors in the regulation of vascular calcification.
To identify and validate novel pharmacological tools in cardiovascular diseases.
To develop new animal models in cardiovascular disease.

Team

Group coordination

RODRIGUEZ SINOVAS, MARIA CRISTINA IR
crodriguezs@santpau.cat

Members

Scientific output

Publications 2023

(JIF 2022)

Publications 2022

(JIF 2022)

Ballester C, Canes L, Alonso J, Puertas L, Tauron M, Rodriguez C, Martinez J. Nuclear receptor NOR-1 (Neuron-derived Orphan Receptor-1) in pathological vascular remodelling and vascular remodelling. Clinica E Investigacion En Arteriosclerosis. 2022; 34(4). DOI:10.1016/j.arteri.2022.03.002. PMID:35581107. Document type: Review.
Ballesteros C, Rodrigues R, Beltran LM, Moreno R, Martinez E, Gonzalez M, Martinez J, Rodriguez C, Cachofeiro V, Salaices M, Briones AM. Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity. BRITISH JOURNAL OF PHARMACOLOGY. 2022; 179(11). DOI:10.1111/bph.15776. PMID:34877656. IF:7,3 (Q1/1D). Document type: Article. Document type: Article.
Blanco R, de la Fuente H, Rodriguez C, Martin L, Sanchez R, Jimenez R, Rodriguez I, Curtabbi A, Garcia MM, Vera A, Rivero F, Cuesta J, Jimenez LJ, Cecconi A, Duran A, Tauron M, Alonso J, Bueno H, Villalba M, Enriquez JA, Robson SC, Alfonso F, Sanchez F, Martinez J, Martin P. CD69 expression on regulatory T cells protects from immune damage after myocardial infarction. JOURNAL OF CLINICAL INVESTIGATION. 2022; 132(21):e152418. DOI:10.1172/JCI152418. PMID:36066993. IF: 15,9 (Q1/1D). Document type: Article.
González M, García AB, Jorge I, Zalba G, Becares M, Ruiz MJ, Rodríguez C, Bermeo H, Rodrigues R, Rios FJ, Montezano AC, Martínez J, Vázquez J, Redondo JM, Touyz RM, Guerra S, Salaices M, Briones AM. Interferon stimulated gene 15 pathway is a novel mediator of endothelial dysfunction and aneurysms development in angiotensin II infused mice through increased oxidative stress. CARDIOVASCULAR RESEARCH. 2022; 118(16). DOI:10.1093/cvr/cvab321. PMID:34672341. IF:10,8 (Q1/1D). Document type: Article.
Jimenez F, Marzi J, Galan M, Dantas AP, Ortega M, Rojas S, Egea G, Schenke K, Jimenez E, Planas AM. Arachnoid membrane as a source of sphingosine-1-phosphate that regulates mouse middle cerebral artery tone. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2022; 42(1):0271678X211033362. DOI:10.1177/0271678X211033362. PMID:34474613. IF:6,3 (Q1/2D). Document type: Article.
Jimenez M, Rodriguez C, Canes L, Ballester C, Vara A, Requena S, de la Fuente H, Martinez J, Sanchez F. CD69-oxLDL ligand engagement induces Programmed Cell Death 1 (PD-1) expression in human CD4+T lymphocytes. CELLULAR AND MOLECULAR LIFE SCIENCES. 2022; 79(8):468. DOI:10.1007/s00018-022-04481-1. PMID:35930205. IF:8 (Q1/2D). Document type: Article.
Lehmann GL, Ginsberg M, Nolan DJ, Rodriguez C, Martinez J, Zeng SM, Voigt AP, Mullins RF, Rafii S, Rodriguez E, Benedicto I. Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells. Cells. 2022; 11(19):2975. DOI:10.3390/cells11192975. PMID:36230937. IF:6 (Q2/4D). Document type: Article.
Troncoso C, Petermann F, Lozano M, Perez A, Almendra R, Fernandez T, Nava EJ, Gamero A, Camacho S, Bonillal DA, Perez E, Navarrete EM. A qualitative look at the research in the Spanish Journal of Human Nutrition and Dietetics. Revista Espanola De Nutricion Humana Y Dietetica. 2022; 26(3). DOI:10.14306/renhyd.26.3.1723. Document type: Editorial material.
Valls L, Puertas L, Varona S, Martinez J, Rodriguez C, Rodriguez A. Human Lysyl Oxidase Over-Expression Enhances Baseline Cardiac Oxidative Stress but Does Not Aggravate ROS Generation or Infarct Size Following Myocardial Ischemia-Reperfusion. Antioxidants. 2022; 11(1):75. DOI:10.3390/antiox11010075. PMID:35052579. IF:7 (Q1/1D). Document type: Article.
Vila A, Ramirez C, Apolinar E, Rojas P, Valera D, Almendra R, Navarrete EM. Factors Associated with Dietary Restriction and Emotional and Uncontrolled Eating in Adults from Spanish-Speaking Countries during the COVID-19 Confinement: Results of the CoV-Eat Project. Nutrients. 2022; 14(22):4866. DOI:10.3390/nu14224866. PMID:36432551. IF:5,9 (Q1/2D). Document type: Article.

Publications 2021

Canes L, Alonso J, Ballester C, Varona S, Escudero JR, Andres V, Rodriguez C, Martinez J. Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm Impact on Inflammation, Oxidative Stress, and Vascular Remodeling. HYPERTENSION. 2021; 78(3). DOI:10.1161/HYPERTENSIONAHA.121.17517. PMID:34304581. IF:9,897.
Canes L, Marti I, Ballester C, Alonso J, ELENA C, Briones AM, Rodriguez C, Martinez J. High NOR-1 (Neuron-Derived Orphan Receptor 1) Expression Strengthens the Vascular Wall Response to Angiotensin II Leading to Aneurysm Formation in Mice. HYPERTENSION. 2021; 77(2). DOI:10.1161/HYPERTENSIONAHA.120.16078. PMID:33356402. IF:9,897.
Jimenez T, Ballester C, Quetglas M, Morell D, Torres N, Bautista AM, Serra N, Girona E. Cryopreservation of platelets treated with riboflavin and UV light and stored at-80 degrees C for 1 year. TRANSFUSION. 2021; 61(4). DOI:10.1111/trf.16324. PMID:33694171. IF:3,337.
Martinez J, Canes L, Alonso J, Ballester C, Rodriguez A, Corrales I, Rodriguez C. NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021; 22(21):11371. DOI:10.3390/ijms222111371. PMID:34768801. IF:6,208.
Muntsant A, Jimenez F, Puertas L, Jimenez E, Vila E, Gimenez L. Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging. Biomedicines. 2021; 9(2):111. DOI:10.3390/biomedicines9020111. PMID:33498895. IF:4,757.
Sanchez D, Nus M, Navas M, Fite J, Perez B, Barros AJ, Soto B, Martinez J, Camacho M, Rodriguez C, Mallat Z, Galan M. Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm. Antioxidants. 2021; 10(4):602. DOI:10.3390/antiox10040602. PMID:33919749. IF:7,675.
Souza FV, Jimenez S, Delgado B, Jurado R, Genty M, Romero A, Rodriguez C, Nieto ML, Martinez E, Cachofeiro V. The Interplay of Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress in Cardiovascular Fibrosis in Obese Rats. Antioxidants. 2021; 10(8):1274. DOI:10.3390/antiox10081274. PMID:34439522. IF:7,675.
Varona S, Puertas L, Galan M, Orriols M, Canes L, Aguilo S, Camacho M, Sirvent M, Andres V, Martinez J, Rodriguez C. Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA. Antioxidants. 2021; 10(3):460. DOI:10.3390/antiox10030460. PMID:33809405. IF:7,675.

CARDIOVASCULAR DISEASES

Regulatory Mechanisms of Cardiovascular Remodelling

Main lines of research

Objectives:

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Main lines of research

Objectives:

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau