Sant Pau - Institut de Recerca

Main lines of research

Application of imaging techniques to intraoperative studies of perforators with the aim to improve the design of flaps, evaluate the suitable and viability of perfusion avoiding secondary postoperative
complications and vascular complications.
Anatomical studies of the variability of perforators in the following regions: internal mammary artery, inferior epigastric system and internal superficial circumflex system.
Study of the perioperative and postoperative factors that influence on the viability of the microsurgical free flaps.
Research by indocyanine green angiography of the concept of post-vascular balance post diseccional of perforator flap.
Research by indocyanine green angiography of the relationship between the different anatomical patterns of lymphatic vessels in the upper extremity and its readiness to develop lymphedema in the affected breast cancer patients.
Feasibility of the research in animal models of major surgical and nonsurgical techniques existing today to treat secondary lymphatic insufficiency: fat transplant autologous stem cells, stem cell transplantation autologous bone marrow, lymphatic-venous anastomosys flap free vascularised autologous lymph node.

Challenges

Consolidate and optimize preoperative management techniques for locating perforating vessels suitable for each microsurgical flap.
Minimize intra- and postoperative complications in perforator flaps using new imaging techniques to visualize intraoperatively patterns of vascularisation of the flaps and vascular dominance.
Lymphedema prevention in those patients with mastectomy in which we perform searching procedures of sentinel node and / or axillaries lymph node dissections using new techniques of surgical treatment for this disease (lymphatic venous anastomosys, transfer of vascularised nodes.
Identification by indocyanine green angiography for those patients affected with breast cancer with a major risk of developing secondary lymphedema.

Group coordination

MASIA AYALA, JAUME FGS
jmasia@santpau.cat

Members

Condrea, Silvia FGS
Guerrero Lojano, Andrea Elisabeth FGS
Leoveanu, Floriana Irina FGS
Lopez Fernandez, Susana FGS
Lusetti, Irene Laura FGS
Mohedano Puig, Elena IR
Olivares Dominguez, Maria De Leyre FGS
Perez Sempere, Maria FGS
Pons Playa, Gemma FGS
Vega Garcia, Maria del Carmen FGS
Vela Lasagabaster, Arturo FGS
Zamora Alarcon, Paul David FGS

Publications 2023

(JIF 2022)

-Abdelfattah U, Pons G, Masia J. Evaluating the Impact of Immediate Lymphatic Reconstruction for the Surgical Prevention of Lymphedema. PLASTIC AND RECONSTRUCTIVE SURGERY. 2023; 151(3):522e-523e. DOI:10.1097/PRS.0000000000009942. PMID:36730128. IF:3,600 (Q1/2D). Document type: Letter.

-Al AM, Bonfill X, Ardiles S, Bendersky J, Sola I, Masia J. Risk-of-bias assessment of the randomized clinical trials and systematic reviews on surgical treatments for breast cancer-related lymphedema: A mapping review. Journal of Plastic Reconstructive and Aesthetic Surgery. 2023; 84DOI:10.1016/j.bjps.2023.05.002. PMID:37329747. IF:2,700 (Q2/4D). Document type: Review.

-Casanovas A, Sebio R, Ciendones M, Cuartero J, Estanyol B, Padrós J, García B, Barnadas A, Masia J. Prehabilitation in Patients With Breast Cancer Receiving Neoadjuvant Therapy to Minimize Musculoskeletal Postoperative Complications and Enhance Recovery (PREOPtimize): A Protocol for a Randomized Controlled Trial. PHYSICAL THERAPY. 2023; 103(9):pzad062. DOI:10.1093/ptj/pzad062. PMID:37318267. IF:3,200 (Q1/3D). Document type: Article.

-Fernández M, Torrano L, González J, Masia J, Sisternas L, D’Guilio G, Zamora P. To bulge or not to bulge: Rectus abdominis functional reconstruction after soft tissue sarcoma resection. Journal of Plastic Reconstructive and Aesthetic Surgery. 2023; 78DOI:10.1016/j.bjps.2022.11.051. PMID:36736105. IF:2,700 (Q2/4D). Document type: Letter.

-Martínez P, Linares PF, Masià J, Jané P, Monforte C. Temporal validation of a risk prediction model for breast cancer-related lymphoedema in European population: A retrospective study. JOURNAL OF ADVANCED NURSING. 2023; 79(12). DOI:10.1111/jan.15727. PMID:37269083. IF:3,800 (Q1/1D). Document type: Article.

-Torrano L, Zamora P, Ibarra A, Masiá J, Sisternas L, Fernández M. Chimeric SCIP flap with iliac bone for reconstruction of foot first ray in a radiated surgical bed: A case report. MICROSURGERY. 2023; 43(4). DOI:10.1002/micr.31019. PMID:36748171. IF:2,100 (Q2/5D). Document type: Article.

Publications 2022

(JIF 2022)

Al-Sakkaf AM, Masia J, Auladell A, Shamardal AI, Vasconcello L, Sola I, Bonfill X. Evidence Mapping of the Treatments for Breast Cancer-related Lymphedema. Plastic And Reconstructive Surgery-Global Open. 2022; 10(1):e4045. DOI:10.1097/GOX.0000000000004045. PMID:35070599. Document type: Article.
Amat V, Yelamos O, Agut E, Dalmau J, Mozos A, Lopez S, Roe E. Spitzoid proliferative nodules arising in a congenital melanocytic naevus: A case report with clinical, dermoscopic and histologic correlation. AUSTRALASIAN JOURNAL OF DERMATOLOGY. 2022; 63(3). DOI:10.1111/ajd.13861. PMID:35510363. IF:2 (Q3/7D). Document type: Article.
Berner JE,Chan JK-K,Gardiner MD,Navia A,Tejos R,Ortiz M,Ortega A et al. International Lower Limb Collaborative (INTELLECT) study: a multicentre, international retrospective audit of lower extremity open fractures. NJ USA:WILEY, 2022. pp. 792-795. Document type: Conference paper.
Campos JL, Pons G, Rodriguez E, Al AM, Vela FJ, Pires L, Jara MJ, Sánchez FM, Abellán E, Masiá J. Popliteal Vascular Lymph Node Resection in the Rabbit Hindlimb for Secondary Lymphedema Induction. Jove-Journal of Visualized Experiments. 2022; 2022(189):e64576. DOI:10.3791/64576. PMID:36533826. IF:1,2 (Q3/8D). Document type: Article.
Dip F, Alexandru N, Amore M, Becker C, Belgrado J-P, Bourgeois P, Chang EI-F, Koshima I, Liberale G, Masia J, Mortimer P, Neligan P, Batista BN, Olszewski W, Salvia SA, Suami H, Vankerckhove S, Yamamoto T, Lo Menzo E, White KP, Rosenthal RJ. Use of fluorescence imaging during lymphatic surgery: A Delphi survey of experts worldwide. SURGERY. 2022; 172(6). DOI:10.1016/j.surg.2022.08.026. PMID:36427924. IF:3,8 (Q1/2D). Document type: Article.
Fernandez E, Suarez X, Carrasco A, Pinol P, Lopez S, Pons G, Serra JJB, de la Torre C, De Luna N, Gallardo E, Diaz J. RhoA/ROCK2 signalling is enhanced by PDGF-AA in fibro-adipogenic progenitor cells: implications for Duchenne muscular dystrophy. Journal of Cachexia Sarcopenia and Muscle. 2022; 13(2). DOI:10.1002/jcsm.12923. PMID:35132805. IF:8,9 (Q1/1D). Document type: Article.
Fernandez M, Nunez T, Zamora P, Masia J, Leon X. The extended SCIP flap: An anatomical and clinical study of a new SCIP flap design. Journal of Plastic Reconstructive and Aesthetic Surgery. 2022; 75(9). DOI:10.1016/j.bjps.2022.06.021. PMID:35961925. IF:2,7 (Q2/4D). Document type: Article.
Kobialka P, Sabata H, Vilalta O, Gouveia L, Angulo A, Muixi L, Zanoncello J, Munoz O, Olaciregui NG, Fanlo L, Esteve A, Lavarino C, Javierre BM, Celis V, Rovira C, Lopez S, Baselga E, Mora J, Castillo SD, Graupera M. The onset of PI3K-related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib. EMBO Molecular Medicine. 2022; 14(7):e15619. DOI:10.15252/emmm.202115619. PMID:35695059. IF:11,1 (Q1/1D). Document type: Article.
Lopez JG, Hernandez LS, Fernandez SL, Garrido MF. Abdominal Wall Reconstruction Using Unique Composite Anterolateral and Fascia Lata Perforator Free Flap After Failed Attempts. Indian Journal of Surgery. 2022; 84(5). DOI:10.1007/s12262-021-03196-0. IF:0,4 (Q4/10D). Document type: Article.
Manrique A, Salazar J, Arranz MJ, Bague S, Orellana R, Lopez A, Cerda P, Gracia I, Majercakova K, Peiro A, Trullols L, Fernandez M, Valverde S, Quintana MJ, Bell O, Artigas A, Sebio A. Pharmacogenetic Profiling in High-Risk Soft Tissue Sarcomas Treated with Neoadjuvant Chemotherapy. Journal of Personalized Medicine. 2022; 12(4):618. DOI:10.3390/jpm12040618. PMID:35455734. Document type: Article.
Martinez P, Linares PF, Piller N, Masia J, Yamamoto T, Lopez L, Monforte C. Multidisciplinary preventive intervention for breast cancer-related lymphedema: An international consensus. EUROPEAN JOURNAL OF CANCER CARE. 2022; 31(6):e13704. DOI:10.1111/ecc.13704. PMID:36113999. IF:2,1 (Q2/5D). Document type: Article.
Martinez P, Verdu MA, Forero CG, Salazar SA, Linares PF, Monforte C, Masia J. Breast cancer-related lymphoedema: Risk factors and prediction model. JOURNAL OF ADVANCED NURSING. 2022; 78(3). DOI:10.1111/jan.15005. PMID:34363640. IF:3,8 (Q1/1D). Document type: Article.
Nunez T, Zamora P, Masia J, Fernandez M. Ankle joint salvage surgery with an ipsilateral mid-fibula osteocutaneous free flap and contralateral anterolateral thigh free flap: A case report and literature review. 2022; 42(5). DOI:10.1002/micr.30864. PMID:35083775. IF:2,1 (Q2/5D). Document type: Review.
Schols RM, Dip F, Lo Menzo E, Haddock NT, Landin L, Lee BT, Malagón P, Masia J, Mathes DW, Nahabedian MY, Neligan PC, Newman MI, Phillips BT, Pons G, Pruimboom T, Qiu SS, Ritschl LM, Rozen WM, Saint M, Song SY, van der Hulst RRWJ, Venturi ML, Wongkietkachorn A, Yamamoto T, White KP, Rosenthal RJ. Delphi survey of intercontinental experts to identify areas of consensus on the use of indocyanine green angiography for tissue perfusion assessment during plastic and reconstructive surgery. 2022; 172(6):S46-S53. DOI:10.1016/j.surg.2022.04.015. PMID:36427930. IF:3,8 (Q1/2D). Document type: Article.

Publications 2021

Angrigiani C, Rancati AO, Masia J, Farhadi J, Khouri K, Acquaviva J, Rancati A. Modified anterior intercostal artery perforator flap (AICAP) for autologous breast volume restoration after explantation. Journal of Plastic Reconstructive and Aesthetic Surgery. 2021; 74(11). DOI:10.1016/j.bjps.2021.03.123. PMID:34020904. IF:3,022.
Chang DW, Dayan J, Greene AK, MacDonald JK, Masia J, Mehrara B, Neligan PC, Nguyen D. Surgical Treatment of Lymphedema: A Systematic Review and Meta-Analysis of Controlled Trials. Results of a Consensus Conference. PLASTIC AND RECONSTRUCTIVE SURGERY. 2021; 147(4). DOI:10.1097/PRS.0000000000007783. PMID:33761519. IF:5,169.
Gil LSP, Vintro XL, Fernandez SL, Garcia CV, Playa GP, Garrido MF, Ayala JM. The Effect of Perioperative Blood Transfusions on Microvascular Anastomoses. Journal of Clinical Medicine. 2021; 10(6):1333. DOI:10.3390/jcm10061333. PMID:33807085. IF:4,964.
Pons G, Abdelfattah U, Sarria J, Duch J, Masia J. Reverse Lymph Node Mapping Using Indocyanine Green Lymphography: A Step Forward in Minimizing Donor-Site Morbidity in Vascularized Lymph Node Transfer. PLASTIC AND RECONSTRUCTIVE SURGERY. 2021; 147(2). DOI:10.1097/PRS.0000000000007585. PMID:33565822. IF:5,169.
Suarez X, Fernandez E, Pinol P, Alonso J, Carrasco A, Lleixa C, Lopez S, Pons G, Soria L, Bigot A, Mouly V, Illa I, Gallardo E, Jaiswal JK, Diaz J. Isolation of human fibroadipogenic progenitors and satellite cells from frozen muscle biopsies. FASEB JOURNAL. 2021; 35(9):e21819. DOI:10.1096/fj.202100588R. PMID:34405910. IF:5,834.
Zhang YX, Xiao WT, Ng S, Zhou HH, Min PR, Xi WJ, Masia J, Blondeel P, Feng SQ. Infrared thermography-guided designing and harvesting of pre-expanded pedicled flap for head and neck reconstruction. Journal of Plastic Reconstructive and Aesthetic Surgery. 2021; 74(9). DOI:10.1016/j.bjps.2020.12.102. PMID:33551358. IF:3,022.

Introduction

Main lines of research

Application of imaging techniques to intraoperative studies of perforators with the aim to improve the design of flaps, evaluate the suitable and viability of perfusion avoiding secondary postoperative
complications and vascular complications.
Anatomical studies of the variability of perforators in the following regions: internal mammary artery, inferior epigastric system and internal superficial circumflex system.
Study of the perioperative and postoperative factors that influence on the viability of the microsurgical free flaps.
Research by indocyanine green angiography of the concept of post-vascular balance post diseccional of perforator flap.
Research by indocyanine green angiography of the relationship between the different anatomical patterns of lymphatic vessels in the upper extremity and its readiness to develop lymphedema in the affected breast cancer patients.
Feasibility of the research in animal models of major surgical and nonsurgical techniques existing today to treat secondary lymphatic insufficiency: fat transplant autologous stem cells, stem cell transplantation autologous bone marrow, lymphatic-venous anastomosys flap free vascularised autologous lymph node.

Challenges

Consolidate and optimize preoperative management techniques for locating perforating vessels suitable for each microsurgical flap.
Minimize intra- and postoperative complications in perforator flaps using new imaging techniques to visualize intraoperatively patterns of vascularisation of the flaps and vascular dominance.
Lymphedema prevention in those patients with mastectomy in which we perform searching procedures of sentinel node and / or axillaries lymph node dissections using new techniques of surgical treatment for this disease (lymphatic venous anastomosys, transfer of vascularised nodes.
Identification by indocyanine green angiography for those patients affected with breast cancer with a major risk of developing secondary lymphedema.

Team

Group coordination

MASIA AYALA, JAUME FGS
jmasia@santpau.cat

Members

Scientific output

Publications 2023

(JIF 2022)

Publications 2022

(JIF 2022)

Al-Sakkaf AM, Masia J, Auladell A, Shamardal AI, Vasconcello L, Sola I, Bonfill X. Evidence Mapping of the Treatments for Breast Cancer-related Lymphedema. Plastic And Reconstructive Surgery-Global Open. 2022; 10(1):e4045. DOI:10.1097/GOX.0000000000004045. PMID:35070599. Document type: Article.
Amat V, Yelamos O, Agut E, Dalmau J, Mozos A, Lopez S, Roe E. Spitzoid proliferative nodules arising in a congenital melanocytic naevus: A case report with clinical, dermoscopic and histologic correlation. AUSTRALASIAN JOURNAL OF DERMATOLOGY. 2022; 63(3). DOI:10.1111/ajd.13861. PMID:35510363. IF:2 (Q3/7D). Document type: Article.
Berner JE,Chan JK-K,Gardiner MD,Navia A,Tejos R,Ortiz M,Ortega A et al. International Lower Limb Collaborative (INTELLECT) study: a multicentre, international retrospective audit of lower extremity open fractures. NJ USA:WILEY, 2022. pp. 792-795. Document type: Conference paper.
Campos JL, Pons G, Rodriguez E, Al AM, Vela FJ, Pires L, Jara MJ, Sánchez FM, Abellán E, Masiá J. Popliteal Vascular Lymph Node Resection in the Rabbit Hindlimb for Secondary Lymphedema Induction. Jove-Journal of Visualized Experiments. 2022; 2022(189):e64576. DOI:10.3791/64576. PMID:36533826. IF:1,2 (Q3/8D). Document type: Article.
Dip F, Alexandru N, Amore M, Becker C, Belgrado J-P, Bourgeois P, Chang EI-F, Koshima I, Liberale G, Masia J, Mortimer P, Neligan P, Batista BN, Olszewski W, Salvia SA, Suami H, Vankerckhove S, Yamamoto T, Lo Menzo E, White KP, Rosenthal RJ. Use of fluorescence imaging during lymphatic surgery: A Delphi survey of experts worldwide. SURGERY. 2022; 172(6). DOI:10.1016/j.surg.2022.08.026. PMID:36427924. IF:3,8 (Q1/2D). Document type: Article.
Fernandez E, Suarez X, Carrasco A, Pinol P, Lopez S, Pons G, Serra JJB, de la Torre C, De Luna N, Gallardo E, Diaz J. RhoA/ROCK2 signalling is enhanced by PDGF-AA in fibro-adipogenic progenitor cells: implications for Duchenne muscular dystrophy. Journal of Cachexia Sarcopenia and Muscle. 2022; 13(2). DOI:10.1002/jcsm.12923. PMID:35132805. IF:8,9 (Q1/1D). Document type: Article.
Fernandez M, Nunez T, Zamora P, Masia J, Leon X. The extended SCIP flap: An anatomical and clinical study of a new SCIP flap design. Journal of Plastic Reconstructive and Aesthetic Surgery. 2022; 75(9). DOI:10.1016/j.bjps.2022.06.021. PMID:35961925. IF:2,7 (Q2/4D). Document type: Article.
Kobialka P, Sabata H, Vilalta O, Gouveia L, Angulo A, Muixi L, Zanoncello J, Munoz O, Olaciregui NG, Fanlo L, Esteve A, Lavarino C, Javierre BM, Celis V, Rovira C, Lopez S, Baselga E, Mora J, Castillo SD, Graupera M. The onset of PI3K-related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib. EMBO Molecular Medicine. 2022; 14(7):e15619. DOI:10.15252/emmm.202115619. PMID:35695059. IF:11,1 (Q1/1D). Document type: Article.
Lopez JG, Hernandez LS, Fernandez SL, Garrido MF. Abdominal Wall Reconstruction Using Unique Composite Anterolateral and Fascia Lata Perforator Free Flap After Failed Attempts. Indian Journal of Surgery. 2022; 84(5). DOI:10.1007/s12262-021-03196-0. IF:0,4 (Q4/10D). Document type: Article.
Manrique A, Salazar J, Arranz MJ, Bague S, Orellana R, Lopez A, Cerda P, Gracia I, Majercakova K, Peiro A, Trullols L, Fernandez M, Valverde S, Quintana MJ, Bell O, Artigas A, Sebio A. Pharmacogenetic Profiling in High-Risk Soft Tissue Sarcomas Treated with Neoadjuvant Chemotherapy. Journal of Personalized Medicine. 2022; 12(4):618. DOI:10.3390/jpm12040618. PMID:35455734. Document type: Article.
Martinez P, Linares PF, Piller N, Masia J, Yamamoto T, Lopez L, Monforte C. Multidisciplinary preventive intervention for breast cancer-related lymphedema: An international consensus. EUROPEAN JOURNAL OF CANCER CARE. 2022; 31(6):e13704. DOI:10.1111/ecc.13704. PMID:36113999. IF:2,1 (Q2/5D). Document type: Article.
Martinez P, Verdu MA, Forero CG, Salazar SA, Linares PF, Monforte C, Masia J. Breast cancer-related lymphoedema: Risk factors and prediction model. JOURNAL OF ADVANCED NURSING. 2022; 78(3). DOI:10.1111/jan.15005. PMID:34363640. IF:3,8 (Q1/1D). Document type: Article.
Nunez T, Zamora P, Masia J, Fernandez M. Ankle joint salvage surgery with an ipsilateral mid-fibula osteocutaneous free flap and contralateral anterolateral thigh free flap: A case report and literature review. 2022; 42(5). DOI:10.1002/micr.30864. PMID:35083775. IF:2,1 (Q2/5D). Document type: Review.
Schols RM, Dip F, Lo Menzo E, Haddock NT, Landin L, Lee BT, Malagón P, Masia J, Mathes DW, Nahabedian MY, Neligan PC, Newman MI, Phillips BT, Pons G, Pruimboom T, Qiu SS, Ritschl LM, Rozen WM, Saint M, Song SY, van der Hulst RRWJ, Venturi ML, Wongkietkachorn A, Yamamoto T, White KP, Rosenthal RJ. Delphi survey of intercontinental experts to identify areas of consensus on the use of indocyanine green angiography for tissue perfusion assessment during plastic and reconstructive surgery. 2022; 172(6):S46-S53. DOI:10.1016/j.surg.2022.04.015. PMID:36427930. IF:3,8 (Q1/2D). Document type: Article.

Publications 2021

Angrigiani C, Rancati AO, Masia J, Farhadi J, Khouri K, Acquaviva J, Rancati A. Modified anterior intercostal artery perforator flap (AICAP) for autologous breast volume restoration after explantation. Journal of Plastic Reconstructive and Aesthetic Surgery. 2021; 74(11). DOI:10.1016/j.bjps.2021.03.123. PMID:34020904. IF:3,022.
Chang DW, Dayan J, Greene AK, MacDonald JK, Masia J, Mehrara B, Neligan PC, Nguyen D. Surgical Treatment of Lymphedema: A Systematic Review and Meta-Analysis of Controlled Trials. Results of a Consensus Conference. PLASTIC AND RECONSTRUCTIVE SURGERY. 2021; 147(4). DOI:10.1097/PRS.0000000000007783. PMID:33761519. IF:5,169.
Gil LSP, Vintro XL, Fernandez SL, Garcia CV, Playa GP, Garrido MF, Ayala JM. The Effect of Perioperative Blood Transfusions on Microvascular Anastomoses. Journal of Clinical Medicine. 2021; 10(6):1333. DOI:10.3390/jcm10061333. PMID:33807085. IF:4,964.
Pons G, Abdelfattah U, Sarria J, Duch J, Masia J. Reverse Lymph Node Mapping Using Indocyanine Green Lymphography: A Step Forward in Minimizing Donor-Site Morbidity in Vascularized Lymph Node Transfer. PLASTIC AND RECONSTRUCTIVE SURGERY. 2021; 147(2). DOI:10.1097/PRS.0000000000007585. PMID:33565822. IF:5,169.
Suarez X, Fernandez E, Pinol P, Alonso J, Carrasco A, Lleixa C, Lopez S, Pons G, Soria L, Bigot A, Mouly V, Illa I, Gallardo E, Jaiswal JK, Diaz J. Isolation of human fibroadipogenic progenitors and satellite cells from frozen muscle biopsies. FASEB JOURNAL. 2021; 35(9):e21819. DOI:10.1096/fj.202100588R. PMID:34405910. IF:5,834.
Zhang YX, Xiao WT, Ng S, Zhou HH, Min PR, Xi WJ, Masia J, Blondeel P, Feng SQ. Infrared thermography-guided designing and harvesting of pre-expanded pedicled flap for head and neck reconstruction. Journal of Plastic Reconstructive and Aesthetic Surgery. 2021; 74(9). DOI:10.1016/j.bjps.2020.12.102. PMID:33551358. IF:3,022.

ASSOCIATED GROUPS

Plastic Surgery

Main lines of research

Challenges

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Main lines of research

Challenges

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau