Sant Pau - Institut de Recerca

Main lines of research

Acute Respiratory Failure and Artificial Ventilation

Non-invasive ventilation.
New ventilation modes: proportional-assist ventilation and NAVA.
Prone decubitus in acute respiratory dysfunction syndrome (ARDS).
Artificial ventilation withdrawal.
Expert ventilation systems.
Sleep and artificial ventilation.
Early and active mobilization of the critical patient.
Extracorporeal CO2 removal in ARDS patients.
High-flow oxygen administration by nasal cannula in postextubation phase.
Prevalence of drug interactions in critical care unit.

Study of the Usefulness of New Biomarkers in Critically Ill Patients

BNP in weaning from mechanical ventilation.
Use of the NGAL protein in the renal prognosis of critically ill patients.
Strict control of blood glucose in critically ill patients.
Prophylaxis of acute gastric mucosal injury in critically ill patients.
Study of the haemodynamic effects of different antipyretic drugs in critically ill patients.
Influence of position change to supine decubitus position in intra-abdominal pressure.

Challenges

Consolidate clinical and physiological research into ventilation in critically ill patients through multicentre and multinational networking.
Create a stable and well-trained group of researchers in this discipline.

Group coordination

Subirà Cuyas, Carles FGS
csubira@santpau.cat

Members

Alvarez Viloria, Andrea Valeska FGS
Baldira Martinez De Irujo, Jaume FGS
Belles Casas, Ariadna FGS
Betbese Roig, Antoni Jordi FGS
Cordon Abalde, Alejandra FGS
Diaz Tormo, Carmen FGS
Flores Orella, Matias Nicolas FGS
Gomila Sintes, Carme FGS
Izura Gomez, Marta FGS
Mas Serra, Arantxa FGS
Nievas, Maria Veronica FGS
Rodriguez Farre, Nuria FGS
Santos Rodriguez, Jose Alberto FGS
Serrano Garcia, Maria Angeles FGS
Suarez Montero, Juan Carlos FGS
Subira Cuyas, Carles FGS
Torrens Sonet, Maria FGS
Vera Artazcoz, Paula FGS
Zapata Fenor, Luis FGS

Publications 2023

(JIF 2022)

-Baldirà J, Ruiz JC, Ruiz A, Chiscano L, Cortes A, Sistac DÁ, Ferrer R, Comas I, Villena Y, Larrosa MN, González JJ, Ferrer R. Use of Biomarkers to Improve 28-Day Mortality Stratification in Patients with Sepsis and SOFA = 6. Biomedicines. 2023; 11(8):2149. DOI:10.3390/biomedicines11082149. PMID:37626646. IF:4,700 (Q1/3D). Document type: Article.

-Bosma KJ, Martin CM, Burns K, Mancebo J, Suárez JC, Skrobik Y, Thorpe KE, Amaral A, Arabi Y, Basmaji J, Beduneau G, Beloncle F, Carteaux G, Charbonney E, Demoule A, Dres M, Fanelli V, Geagea A, Goligher E, Lellouche F, Maraffi T, Mercat A, Rodriguez PO, Shahin J, Sibley S, Spadaro S, Vaporidi K, Wilcox ME, Brochard L, Canadian Critical Care Trials G, REVA N. Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study. Trials. 2023; 24(1). DOI:10.1186/s13063-023-07163-w. PMID:36973743. IF:2,500 (Q3/8D). Document type: Article.

-Ceccato A, Camprubi M, Bos LDJ, Povoa P, Martin I, Forne C, Areny A, Campaña E, Morales L, Quero S, Ramirez P, Esperatti M, Torres A, Blanch L, Artigas A. Evaluation of the Kinetics of Pancreatic Stone Protein as a Predictor of Ventilator-Associated Pneumonia. Biomedicines. 2023; 11(10):2676. DOI:10.3390/biomedicines11102676. PMID:37893050. IF:4,700 (Q1/3D). Document type: Article.

-De La Vega A, Pérez AN, Pérez M, Sonet MT, Buendia YD, Ballujera PO, López MR, Riera JS, Olmo A, Torra EV, García MA, Villamayor MI, Ibars RMC, Zelaya IO, Chica JP, Anglès CR, Tomasa TM, Serra AB, Casanova EJ, González De Molina FJ. “Acute kidney injury in critically ill patients with COVID-19: The AKICOV multicenter study in Catalonia”. PLoS One. 2023; 18(4):e0284248. DOI:10.1371/journal.pone.0284248. PMID:37058544. IF:3,700 (Q2/4D). Document type: Article.

-Lopez JC, Grau T, Mor E, Bordeje ML, Portugal E, Lorencio C, Vera P, Macaya L, Llorente B, Iglesias R, Monge D, Martinez JF, Sanchez L, Sanchez A, Crespo M, Leon C, Flordelis JL, Servia L, ENPIC GRP. Parenteral Nutrition: Current Use, Complications, and Nutrition Delivery in Critically Ill Patients. Nutrients. 2023; 15(21):4665. DOI:10.3390/nu15214665. PMID:37960318. IF:5,900 (Q1/2D). Document type: Article.

-Lopez JC, Servia L, Grau T, Bordeje L, Portugal E, Lorencio C, Vera P, Macaya L, Martinez JF, Marin J, Flordelís JL, Seron C, Alcazar MLN, Navas E, Aldunate S, Nieto B, Martinez de Lagran I. Factors associated with the need of parenteral nutrition in critically ill patients after the initiation of enteral nutrition therapy. Frontiers in Nutrition. 2023; 10:1250305. DOI:10.3389/fnut.2023.1250305. PMID:37693244. IF:5,000 (Q2/4D). Document type: Article.

-Martin L, Martinez M, Diaz JF, Zapata L. Cardiogenic shock code 2023, towards a quality multidisciplinary organization. Medicina Intensiva. 2023; 47(7). DOI:10.1016/j.medin.2023.03.006. PMID:37173216. IF:3,000 (Q3/7D). Document type: Editorial Material.

-Martin M, Aseginolaza M, Boronat P, Asensio MJ, Alaman G, Alvarez F, Roa D, Socias L, Vera P, Ramirez P, Trabajo Infec Sepsis GTEIS GRP&, Soc Espanola Med I. Severe community-acquired Streptococcus pneumoniae bacterial meningitis: clinical and prognostic picture from the intensive care unit. CRITICAL CARE. 2023; 27(1):72. DOI:10.1186/s13054-023-04347-3. PMID:36823625. IF:15,100 (Q1/2D). Document type: Article.

-Martínez M, Hernández FJ, Uribarri A, Martín L, Zapata L, Alonso JJ, Amat IJ, Ariza A, Barrabés JA, Barrio JM, Canteli Á, Alonso M, Corbí MJ, Díaz D, Crespo MG, de la Torre JM, Ferrera C, García MJ, García J, García L, García A, Jorge P, González JR, López de Sá E, Sánchez PL, Monteagudo M, Palomo N, Reyes G, Rosell F, Solla MA, Segovia J, Sionis A, Stepanenko A, Iglesias D, Viana A, Voces R, Fuset MP, Gimeno JR, Díaz J, Fernández F. Cardiogenic shock code 2023. Expert document for a multidisciplinary organization that allows quality care. REVISTA ESPANOLA DE CARDIOLOGIA. 2023; 76(4). DOI:10.1016/j.recesp.2022.10.010. PMID:36565750. IF:7,050 (Q1/3D). Document type: Article.

-Mateos A, Roig A, Rodriguez J, Guix EM. Change in prefilter pressure as a key determinant in the decision to return blood in continuous renal replacement therapy: An observational study. Nursing in Critical Care. 2023; DOI:10.1111/nicc.12933. PMID:37277948. IF:3,000 (Q1/2D). Document type: Article.

-Mateos A, Roig A, Rodríguez J, Guix EM. Comparison of diluted vs concentrated regional citrate anticoagulation in continuous renal replacement therapy: A quasi-experimental study. Nursing in Critical Care. 2023; DOI:10.1111/nicc.12991. PMID:37897131. IF:3,000 (Q1/2D). Document type: Article.

-Morales L, Scala R, Silva JM, Leidi A, Leszek A, Vazquez R, Pascual S, Serpa A, Artigas A, Schultz MJ. Associations of Awake Prone Positioning-Induced Changes in Physiology with Intubation: An International Prospective Observational Study in Patients with Acute Hypoxemic Respiratory Failure Related to COVID-19. Pulmonary Therapy. 2023; 9(4). DOI:10.1007/s41030-023-00242-y. PMID:37917322. Document type: Article.

-Mulet M, Osuna R, Zamora C, Artesero I, Arús M, Vera P, Cordón A, Vilalta N, San P, Abril A, Moliné A, Morán I, López J, Vidal S. Dysregulated neutrophil extracellular traps formation in sepsis. IMMUNOLOGY. 2023; 170(3). DOI:10.1111/imm.13676. PMID:37381594. IF:6,400 (Q2/3D). Document type: Article.

-Ochagavía A, Fraile V, Zapata L. Introduction to the update series: update in intensive care medicine: ultrasound in the critically ill patient. Clinical applications. Medicina Intensiva. 2023; 47(9). DOI:10.1016/j.medine.2023.08.001. PMID:37634919. Document type: Article.

-Ochagavía A, Fraile V, Zapata L. Introduction to the Update series: Update in intensive care medicine: ultrasound in the critically ill patient. Clinical applications. Medicina Intensiva. 2023; 47(9). DOI:10.1016/j.medin.2023.08.001. IF:3,000 (Q3/7D). Document type: Article.

-Suarez JC, Cordon A, Torrego A. An unusual foreign body aspiration. Medicina Intensiva. 2023; 47(3). DOI:10.1016/j.medin.2021.01.005. PMID:33674124. Document type: Article.

-Weiss R, von T, Ostermann M, Lumlertgul N, Weerapolchai K, Garcia M, Cano JMM, del Corral BD, Broch MJ, Carrasco MP, Sanchez AD, Sousa E, Catarino A, Roig A, de Irujo JBM, de Rosa S, de la Pena MGM, Tomasa T, Brivio M, De Molina FJG, Gerss J, Kellum JA, Wempe C, Leidereiter A, Meersch M, Zarbock A. The Role of Cell Cycle Arrest Biomarkers for Predicting Acute Kidney Injury in Critically Ill COVID-19 Patients: A Multicenter, Observational Study. CRITICAL CARE MEDICINE. 2023; 51(8). DOI:10.1097/CCM.0000000000005853. PMID:36975308. IF:8,800 (Q1/2D). Document type: Article.

-Zapata L, Blancas R, Conejo I, García M. Role of ultrasound in acute respiratory failure and in the weaning of mechanical ventilation. Medicina Intensiva. 2023; 47(9). DOI:10.1016/j.medine.2023.03.018. PMID:37419839. Document type: Article.

-Zapata L, Blancas R, Conejo I, García M. Role of ultrasound in acute respiratory failure and in the weaning of mechanical ventilation. Medicina Intensiva. 2023; 47(9). DOI:10.1016/j.medin.2023.03.009. IF:3,000 (Q3/7D). Document type: Article.

-Zapata L, Guía C, Gómez R, García T, Colinas L, Portugal E, Rodado I, Leache I, Fernández A, Hermosilla IA, Roche F, ICA G. Clinical presentation and outcomes of acute heart failure in the critically ill patient: A prospective, observational, multicentre study. Medicina Intensiva. 2023; 47(4). DOI:10.1016/j.medin.2022.03.009. PMID:36272910. IF:3,000 (Q3/7D). Document type: Article.

-Zapata L, Suarez JC, López PA. Association between diastolic dysfunction and fluid balance in critically ill patients during weaning from mechanical ventilation. Medicina Intensiva. 2023; 47(12). DOI:10.1016/j.medine.2023.05.012. PMID:37380508. Document type: Article.

Publications 2022

(JIF 2022)

Amado L, Rodríguez R, Bellani G, Pham T, Fan E, Madotto F, Laffey JG, Pesenti A, Brochard L, Esteban A, Gattinoni L, van F, Ranieri M, Rubenfeld G, Taylor B, Slutsky AS, Rios F, Van F, Sottiaux T, Lora FS, Azevedo LC, Bugedo G, Gonzalez M, Silesky J, Cerny V, Jibaja M, Wrigge H, Matamis D, Ranero JL, Amin P, Hashemian SM, Clarkson K, Kurahashi K, Villagomez A, et al. [Mancebo J]. Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study. Journal of Intensive Care. 2022; 10(1):55. DOI:10.1186/s40560-022-00648-x. IF:7,1 (Q1/3D). Document type: Article.
Baldirà J, Morán I, Marruecos L. Banisteriopsis caapi/Psychotria viridis. In: Toxic Plants. Reports, studies and research 2022. Ministry of Health. Publications Center, 2022; 49-52. https://cpage.mpr.gob.es NIPO en linea: 133-22-020-8. Document type: Book chapter.
Baldirà J, Morán I, Marruecos L. Coriaria myrtifolia. Roldón. In: Toxic Plants. Reports, studies and research 2022. Ministry of Health. Publications Center, 2022; 85-87. https://cpage.mpr.gob.es. NIPO en linea: 133-22-020-8. Document type: Book chapter.
Baldirà J, Morán I, Marruecos L. Hydrangea macrophylla. In: Toxic Plants. Reports, studies and research 2022. Ministry of Health. Publications Center, 2022; 124-126. https://cpage.mpr.gob.es NIPO en linea: 133-22-020-8. Document type: Book chapter.
Baldirà J, Morán I, Marruecos L. Narcissus spp. I: Toxic Plants. Reports, studies and research 2022. Ministry of Health. Publications Center, 2022; 172-174. https://cpage.mpr.gob.es. NIPO en linea: 133-22-020-8. Document type: Book chapter.
Baldirà J, Morán I, Marruecos L. Oenanthe crocata. Nabo del diablo. In: Toxic Plants. Reports, studies and research 2022. Ministry of Health. Publications Center, 2022; 184-187. https://cpage.mpr.gob.es. NIPO en linea: 133-22-020-8. Document type: Book chapter.
Baldirà J, Morán I, Marruecos L. Senecio jacobea. Hierba de Santiago. In: Toxic Plants. Reports, studies and research 2022. Ministry of Health. Publications Center, 2022; 222-224. https://cpage.mpr.gob.es. NIPO en linea: 133-22-020-8. Document type: Book chapter.
Belvís R, Morollón N, Cortés E, Morán I. Tabún, sarín, somán, VX y novichoks: agentes neurotóxicos organofosforados con finalidad bélica o criminal. 2022; 17(2). DOI:10.24875/KRANION.M22000030. Document type: Review.
Brault C, Mancebo J, Montero JCS, Bentall T, Burns K, Piraino T, Lellouche F, Bouchard PA, Charbonney E, Carteaux G, Maraffi T, Beduneau G, Mercat A, Skrobik Y, Zuo F, Lafreniere M, Thorpe K, Brochard L, Bosma KJ. The PROMIZING trial enrollment algorithm for early identification of patients ready for unassisted breathing. CRITICAL CARE. 2022; 26(1):188. DOI:10.1186/s13054-022-04063-4. PMID:35739553. IF:15,1 (Q1/1D). Document type: Article.
Chastre J, François B, Bourgeois M, Komnos A, Ferrer R, Rahav G, De Schryver N, Lepape A, Koksal I, Luyt C-E, Sánchez M, Torres A, Eggimann P, Koulenti D, Holland TL, Ali O, Shoemaker K, Ren P, Sauser J, Ruzin A, Tabor DE, Akhgar A, Wu Y, Jiang Y, DiGiandomenico A, Colbert S, Vandamme D, Coenjaerts F, Malhotra S, Timbermont L, Oliver A, Barraud O, et al. [Vera P]. Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial. CRITICAL CARE. 2022; 26(1):355. DOI:10.1186/s13054-022-04204-9. PMID:36380312. IF:15,1 (Q1/1D). Document type: Article.
Co-author of the Book: Algorithms of nutritional intervention in the critically ill Publishing House: Health and Editions, S.L. Edition: Second. ISBN: 978‑84‑18351‑74‑7 Publication date: 01/06/2022. List of authors in alphabetical order, page 6 (Paula Vera). Book pages: 1-94. Document type: Book.
Frutos F, Peñuelas O, Muriel A, Mancebo J, García A, de Pablo R, Valledor M, Ferrer M, León M, Quiroga JM, Temprano S, Vallverdú I, Fernández R, Gordo F, Anzueto A, Esteban A. Mechanical ventilation in Spain, 1998-2016: changes in the disconnection of mechanical ventilation. Medicina Intensiva. 2022; 46(7). DOI:10.1016/j.medin.2021.04.005. PMID:34092422. IF:3 (Q3/7D). Document type: Article.
Gomila Sintes C, Bernal S, Rojas E, Flores Orella MN, Leoz P, Betbesé Roig AJ. Favism in the elderly. Archives of Clinical and Medical Case Reports. 2022;6(4):582-585. DOI: 10.26502/acmcr.96550521. Document type: Article.
Lopez JC, Grau T, Trujillano J, Garcia C, Mor E, Bordeje ML, Portugal E, Lorencio C, Vera P, Macaya L, Martinez JF, Mateu L, Gero M, Gastaldo R, Vila B, Flordelis JL, Montejo JC, Servia L, ENPIC GRP. The Effect of Enteral Immunonutrition in the Intensive Care Unit: Does It Impact on Outcomes?. 2022; 14(9):1904. DOI:10.3390/nu14091904. PMID:35565870. IF:5,9 (Q1/2D). Document type: Article.
Maddali MV, Churpek M, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P, Rios F, Van F, Sottiaux T, Lora FS, Azevedo LC, Fan E, Bugedo G, Qiu H, Gonzalez M, Silesky J, Cerny V, et al. [Mancebo J]. Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. Lancet Respiratory Medicine. 2022; 10(4). DOI:10.1016/S2213-2600(21)00461-6. PMID:35026177. IF:76,2 (Q1/1D). Document type: Article.
Maggiore SM, Jaber S, Grieco DL, Mancebo J, Zakynthinos S, Demoule A, Ricard J-D, Navalesi P, Vaschetto R, Hraiech S, Klouche K, Frat J-P, Lemiale V, Fanelli V, Chanques G, Natalini D, Ischaki E, Reuter D, Morán I, Combe BL, Longhini F, De Gaetano A, Ranieri VM, Brochard LJ, Antonelli M, RINO Trial Study G. High-Flow Versus VenturiMask Oxygen Therapy to Prevent Reintubation in Hypoxemic Patients after Extubation: A Multicenter Randomized Clinical Trial. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022; 206(12). DOI:10.1164/rccm.202201-0065OC. PMID:35849787. IF:24,7 (Q1/1D). Document type: Article.
Mateos A, Betbesé AJ, Guix EM. Fundamental concepts for the management of continuous replacement therapies. Enfermeria Intensiva. 2022; 33. DOI:10.1016/j.enfi.2021.06.003. Document type: Review.
Morales L, Mancebo J, Del Sorbo L. Hypercapnia and extracorporeal carbon dioxide removal (ECCO2R) in the acute respiratory distress syndrome. Signa Vitae. 2022; 18(5). DOI:10.22514/sv.2022.046. IF:1,1 (Q4/9D). Document type: Review.
Munshi L, Mancebo J, Brochard LJ. Noninvasive Respiratory Support for Adults with Acute Respiratory Failure. NEW ENGLAND JOURNAL OF MEDICINE. 2022; 387(18). DOI:10.1056/NEJMra2204556. PMID:36322846. IF:158,5 (Q1/1D). Document type: Review.
Nasa P, Azoulay E, Chakrabarti A, Divatia JV, Jain R, Rodrigues C, Rosenthal VD, Alhazzani W, Arabi YM, Bakker J, Bassetti M, De Waele J, Dimopoulos G, Du B, Einav S, Evans L, Finfer S, Guerin C, Hammond NE, Jaber S, Kleinpell RM, Koh Y, Kollef M, Levy MM, Machado FR, Mancebo J, Martin I, Mer M, Niederman MS, Pelosi P, Perner A, Peter JV, Phua J, Piquilloud L, Pletz MW, Rhodes A, Schultz MJ, Singer M, Timsit JF, Venkatesh B, Vincent JL, Welte T, Myatra S. Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method. LANCET INFECTIOUS DISEASES. 2022; 22(3):e74-e87. DOI:10.1016/S1473-3099(21)00626-5. PMID:34774188. IF:56,3 (Q1/1D). Document type: Review.
Pisani L, Algera AG, Neto AS, Azevedo LC, Paulus F, de Abreu MG, Pelosi P, Dondorp AM, Bellani G, Laffey JG, Schultz MJ, Martinez A, Leal L, Jorge A, de Oliveira M, Neto JA, Piras C, Moreira CL, Braga P, Dalcomune DM, Ribeiro de Carvalho AG, Gondim LAR, Castelo Branco Reis LM, da Cunha Ribeiro D, de Assis L, Campos RS, Fernandez Versiani dos Anjos JC, Bruzzi F, et al. [Mancebo J]. Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies. Lancet Global Health. 2022; 10(2). DOI:10.1016/S2214-109X(21)00485-X. PMID:34914899. IF:34,3 (Q1/1D). Document type: Article.
Riera P, Sole N, Suarez JC, Lopez PA, Fonts N, Rodriguez N, de Gamarra EF, Moran I. Drug-drug interactions in an intensive care unit and comparison of updates in two databases. Farmacia Hospitalaria. 2022; 46(5). DOI:10.7399/fh.13180. PMID:36183229. Document type: Article.
Sassoon CS, Mancebo J. The Double-edged Sword of Reverse Triggering: Impact on the Diaphragm. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022; 205(6). DOI:10.1164/rccm.202201-0099ED. PMID:35139008. IF:24,7 (Q1/1D). Document type: Editorial material.
Servia L, Lopez JC, Grau T, Trujillano J, Bordeje ML, Mor E, Portugal E, Lorencio C, Montejo JC, Vera P, Macaya L, Martinez JF, Iglesias R, Monge D, Flordelis JL, Llorente B, Menor EM, de Lagran IM, Yebenes JC. Evaluation of Nutritional Practices in the Critical Care patient (The ENPIC study): Does nutrition really affect ICU mortality?. Clinical Nutrition Espen. 2022; 47. DOI:10.1016/j.clnesp.2021.11.018. PMID:35063222. Document type: Article.
Suárez JC, Caballero AC, Martín L, Mancebo J. Immune effector cell-associated neurotoxicity syndrome: A therapeutic approach in the critically ill. Medicina Intensiva. 2022; 46(4). DOI:10.1016/j.medin.2020.06.014. PMID:32873409. IF:3 (Q3/7D). Document type: Article.
Torrego A, Muñoz AM, Lucena CM, Castro P, López L, Badía JR, Betbesé A, Ramirez J, Andreo F, Fernández M-T, Fabra M, Pajares V, Agustí C. Safety and Feasibility of Transbronchial Cryobiopsy in Mechanically Ventilated Patients. ARCHIVOS DE BRONCONEUMOLOGIA. 2022; 58(8). DOI:10.1016/j.arbres.2021.11.005. PMID:35312520. IF:8 (Q1/2D). Document type: Letter.
Vidal P, Díaz E, Aguilar E, Amezaga R, Ballesteros MÁ, Bodí MA, Bordejé ML, Garnacho J, García M, López M, Martín I, Ochagavía A, Ramírez P, Alcántara S, Andaluz D, Badallo O, Barrasa H, Borges M, Castellanos Á, Estella Á, Ferrer R, Fraile V, Fuset M, Giménez C, González C, Hernández A, Igeño JC, Iglesias D, Jiménez JJ, Llanos C, Llompart JA, López V, et al. [Zapata L]. Recommendations for the management of critically ill patients with COVID-19 in Intensive Care Units. Medicina Intensiva. 2022; 46(2). DOI:10.1016/j.medin.2021.08.011. PMID:34545260. IF:3 (Q3/7D). Document type: Article.
Vidal P, Díaz E, Aguilar E, Amezaga R, Ballesteros MÁ, Bodí MA, Bordejé ML, Garnacho J, García M, López M, Martín I, Ochagavía A, Ramírez P, Alcántara S, Andaluz D, Badallo O, Barrasa H, Borges M, Castellanos Á, Estella Á, Ferrer R, Fraile V, Fuset M, Giménez C, González C, Hernández A, Igeño JC, Iglesias D, Jiménez JJ, Llanos C, Llompart JA, López V, et al. [Zapata L]. Recommendations for the management of critically ill patients with COVID-19 in Intensive Care Units. Medicina Intensiva. 2022; 46(2). DOI:10.1016/j.medine.2021.11.019. PMID:34903475. IF:3 (Q3/7D). Document type: Article/Practice guideline.
Wendel PD, Mas A, Gonzalez C, Ferrer R, Manez R, Masclans JR, Sandoval E, Vera P, Trenado J, Fernandez R, Sirvent JM, Martinez M, Ibarz M, Garro P, Lopera JL, Bodi M, Yebenes JC, Triginer C, Vallverdu I, Baro A, Bodi F, Saludes P, Valencia M, Roche F, Huerta A, Cambra FJ, Barbera C, Echevarria J, Penuelas O, Mancebo J, UCIsCAT GRP. Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study. CRITICAL CARE. 2022; 26(1):37. DOI:10.1186/s13054-022-03905-5. PMID:35135588. IF:15,1 (Q1/1D). Document type: Article.
Zapata L, Suarez JC, Flores MN, Morales EM, Segarra A, Santos JA. Acute cor pulmonale in patients with acute respiratory distress syndrome due to COVID-19. Medicina Intensiva. 2022; 46(11). DOI:10.1016/j.medin.2021.12.016. PMID:35079192. IF:3 (Q3/7D). Document type: Letter.

Publications 2021

Albaiceta GM, Brochard L, Santos CCD, Fernandez R, Georgopoulos D, Girard T, Jubran A, Lopez J, Mancebo J, Pelosi P, Skrobik Y, Thille AW, Wilcox ME, Blanch L. The central nervous system during lung injury and mechanical ventilation: a narrative review. BRITISH JOURNAL OF ANAESTHESIA. 2021; 127(4). DOI:10.1016/j.bja.2021.05.038. PMID:34340836. IF:11,719.
Astigarraga P, Lerma FA, Zambrano CB, Costa RG, Vidal FG, Navarro RD, Suarez CR, Pallas TA, Montero JG, Vera P, Alemparte E. Epidemiology and prognosis of patients with a history of cancer admitted to intensive care. A multicenter observational study. Medicina Intensiva. 2021; 45(6). DOI:10.1016/j.medin.2020.01.013. PMID:32307264. IF:2,799.
Berenguer J, Borobia AM, Ryan P, Rodriguez J, Bellon JM, Jarrin I, Carratala J, Pachon J, Carcas AJ, Yllescas M, Arribas JR, López J, Pascual P, Pomar V, Rabella N, Benito N, Domingo P, Bonfill X, Mancebo J, MARTIN A. Development and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: the COVID-19 SEIMC score. THORAX. 2021; 76(9). DOI:10.1136/thoraxjnl-2020-216001. PMID:33632764. IF:9,102.
Grieco DL, Maggiore SM, Roca O, Spinelli E, Patel BK, Thille AW, Barbas CSV, De Acilu MG, Cutuli SL, Bongiovanni F, Amato M, Frat JP, Mauri T, Kress JP, Mancebo J, Antonelli M. Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS. INTENSIVE CARE MEDICINE. 2021; 47(8). DOI:10.1007/s00134-021-06459-2. PMID:34232336. IF:41,787.
Gutierrez B, del Toro MD, Borobia AM, Carcas A, Jarrin I, Yllescas M, Ryan P, Pachon J, Carratala J, Berenguer J, Arribas JR, Rodriguez J, López J, Pascual P, Pomar V, Rabella N, Benito N, Domingo P, Bonfill X, Puig M, Mancebo J, Martinez G. Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study. LANCET INFECTIOUS DISEASES. 2021; 21(6). DOI:10.1016/S1473-3099(21)00019-0. PMID:33636145. IF:71,421.
Johnstone J, Meade M, Lauzier F, Marshall J, Duan E, Dionne J, Arabi YM, Heels D, Thabane L, Lamarche D, Surette M, Zytaruk N, Mehta S, Dodek P, McIntyre L, English S, Rochwerg B, Karachi T, Henderson W, Wood G, Ovakim D, Herridge M, Granton J, Wilcox ME, Goffi A, Stelfox HT, Niven D, Muscedere J, Lamontagne F, D’Aragon F, St C, Ball I, et al. [Mancebo J]. Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2021; 326(11). DOI:10.1001/jama.2021.13355. PMID:34546300. IF:157,335.
Lomeli M, Cenzano LD, Torres L, Chavarria U, Poblano M, Tendillo F, Blanch L, Mancebo J. Aggressive alveolar recruitment in ARDS: more shadows than lights. Medicina Intensiva. 2021; 45(7). DOI:10.1016/j.medin.202.0.03.008. IF:2,799.
Madotto F, McNicholas B, Rezoagli E, Pham T, Laffey JG, Bellani G, Mancebo J, Pesenti A. Death in hospital following ICU discharge: insights from the LUNG SAFE study. CRITICAL CARE. 2021; 25(1):144. DOI:10.1186/s13054-021-03465-0. PMID:33849625. IF:19,334.
Mauri T, Foti G, Fornari C, Grasselli G, Pinciroli R, Lovisari F, Tubiolo D, Volta CA, Spadaro S, Rona R, Rondelli E, Navalesi P, Garofalo E, Knafelj R, Gorjup V, Colombo R, Cortegiani A, Zhou JX, D’Andrea R, Calamai I, Gonzalez AV, Roca O, Grieco DL, Jovaisa T, Bampalis D, Becher T, Battaglini D, Ge HQ, Luz M, Constantin JM, Ranieri M, Guerin C, Mancebo J, et al. Sigh in Patients With Acute Hypoxemic Respiratory Failure and ARDS The PROTECTION Pilot Randomized Clinical Trial. CHEST. 2021; 159(4). DOI:10.1016/j.chest.2020.10.079. PMID:33197403. IF:10,262.
Nasa P, Azoulay E, Khanna AK, Jain R, Gupta S, Javeri Y, Juneja D, Rangappa P, Sundararajan K, Alhazzani W, Antonelli M, Arabi YM, Bakker J, Brochard LJ, Deane AM, Du B, Einav S, Esteban A, Gajic O, Galvagno SM, Guerin C, Jaber S, Khilnani GC, Koh Y, Lascarrou JB, Machado FR, Malbrain MLNG, Mancebo J, McCurdy MT, McGrath BA, Mehta S, et al. Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method. CRITICAL CARE. 2021; 25(1):106. DOI:10.1186/s13054-021-03491-y. PMID:33726819. IF:19,334.
Penuelas O, del Campo L, de Aledo A, Anon JM, Rodriguez C, Mancebo J, Vera P, Ballesteros D, Jimenez J, Maseda E, Figueira JC, Franco N, Algaba A, Aviles JP, Diaz R, Abad B, Canabal A, Abella A, Gordo F, Garcia J, Suarez JG, Cedeno J, Martinez B, Manteiga E, Martinez O, Blancas R, Bardi T, Pestana D, Lorente JA, Muriel A, Esteban A, Frutos F. Long-term survival of mechanically ventilated patients with severe COVID-19: an observational cohort study. Annals of Intensive Care. 2021; 11(1):143. DOI:10.1186/s13613-021-00929-y. PMID:34601646. IF:10,318.
Peñuelas O, Frutos-Vivar F, Muriel A, Mancebo J, García-Jiménez A, de Pablo R, Valledor M, Ferrer M, León M, Quiroga JM, Temprano S, Vallverdú I, Fernández R, Gordo F, Anzueto A, Esteban A. Mechanical ventilation in Spain, 1998-2016: Epidemiology and outcomes. Medicina Intensiva (Engl Ed). 2021;45(1):3-13. English, Spanish. DOI:10.1016/j.medin.2020.04.024. PMID: 32723483. IF:2,799.
Pham T, Montanya J, Telias I, Piraino T, Magrans R, Coudroy R, Damiani LF, Artigas RM, Madorno M, Blanch L, Brochard L, Mancebo J, Papazian L. Automated detection and quantification of reverse triggering effort under mechanical ventilation. CRITICAL CARE. 2021; 25(1):60. DOI:10.1186/s13054-020-03387-3. PMID:33588912. IF:19,334.
Pham T, Pesenti A, Bellani G, Rubenfeld G, Fan E, Bugedo G, Lorente JA, Fernandes AD, Van F, Bruhn A, Rios F, Esteban A, Gattinoni L, Larsson A, McAuley DF, Ranieri M, Thompson BT, Wrigge H, Brochard LJ, Laffey JG, Mancebo J, Schomer AM. Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study. EUROPEAN RESPIRATORY JOURNAL. 2021; 57(6):2003317. DOI:10.1183/13993003.03317-2020. PMID:33334944. IF:33,795.
Robba C, Citerio G, Taccone FS, Galimberti S, Rebora P, Vargiolu A, Pelosi P, Mancebo J, Laffey J. Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol. BMJ Open. 2021; 11(8):e047100. DOI:10.1136/bmjopen-2020-047100. PMID:34380722. IF:3,006.
Tomasa TM, Sabater J, Pérez M, Ortiz P, Díaz Y, Navas A, Betbesé A, Rodríguez M, Ibarz M, Olmo A, Oliva I, Rovira C, Cano S, Vendrell E, Catalan RM, Miralbés M, González de Molina J, Xirgu J, Marcos P. Augmented renal clearance. An unnoticed relevant event. SCIENCE PROGRESS. 2021; 104(2):368504211018580. DOI:10.1177/00368504211018580. PMID:34078190. IF:1,512.

Introduction

Main lines of research

Acute Respiratory Failure and Artificial Ventilation

Non-invasive ventilation.
New ventilation modes: proportional-assist ventilation and NAVA.
Prone decubitus in acute respiratory dysfunction syndrome (ARDS).
Artificial ventilation withdrawal.
Expert ventilation systems.
Sleep and artificial ventilation.
Early and active mobilization of the critical patient.
Extracorporeal CO2 removal in ARDS patients.
High-flow oxygen administration by nasal cannula in postextubation phase.
Prevalence of drug interactions in critical care unit.

Study of the Usefulness of New Biomarkers in Critically Ill Patients

BNP in weaning from mechanical ventilation.
Use of the NGAL protein in the renal prognosis of critically ill patients.
Strict control of blood glucose in critically ill patients.
Prophylaxis of acute gastric mucosal injury in critically ill patients.
Study of the haemodynamic effects of different antipyretic drugs in critically ill patients.
Influence of position change to supine decubitus position in intra-abdominal pressure.

Challenges

Consolidate clinical and physiological research into ventilation in critically ill patients through multicentre and multinational networking.
Create a stable and well-trained group of researchers in this discipline.

Team

Group coordination

Subirà Cuyas, Carles FGS
csubira@santpau.cat

Members

Scientific output

Publications 2023

(JIF 2022)

-Suarez JC, Cordon A, Torrego A. An unusual foreign body aspiration. Medicina Intensiva. 2023; 47(3). DOI:10.1016/j.medin.2021.01.005. PMID:33674124. Document type: Article.

-Zapata L, Blancas R, Conejo I, García M. Role of ultrasound in acute respiratory failure and in the weaning of mechanical ventilation. Medicina Intensiva. 2023; 47(9). DOI:10.1016/j.medin.2023.03.009. IF:3,000 (Q3/7D). Document type: Article.

Publications 2022

(JIF 2022)

Amado L, Rodríguez R, Bellani G, Pham T, Fan E, Madotto F, Laffey JG, Pesenti A, Brochard L, Esteban A, Gattinoni L, van F, Ranieri M, Rubenfeld G, Taylor B, Slutsky AS, Rios F, Van F, Sottiaux T, Lora FS, Azevedo LC, Bugedo G, Gonzalez M, Silesky J, Cerny V, Jibaja M, Wrigge H, Matamis D, Ranero JL, Amin P, Hashemian SM, Clarkson K, Kurahashi K, Villagomez A, et al. [Mancebo J]. Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study. Journal of Intensive Care. 2022; 10(1):55. DOI:10.1186/s40560-022-00648-x. IF:7,1 (Q1/3D). Document type: Article.
Baldirà J, Morán I, Marruecos L. Banisteriopsis caapi/Psychotria viridis. In: Toxic Plants. Reports, studies and research 2022. Ministry of Health. Publications Center, 2022; 49-52. https://cpage.mpr.gob.es NIPO en linea: 133-22-020-8. Document type: Book chapter.
Baldirà J, Morán I, Marruecos L. Coriaria myrtifolia. Roldón. In: Toxic Plants. Reports, studies and research 2022. Ministry of Health. Publications Center, 2022; 85-87. https://cpage.mpr.gob.es. NIPO en linea: 133-22-020-8. Document type: Book chapter.
Baldirà J, Morán I, Marruecos L. Hydrangea macrophylla. In: Toxic Plants. Reports, studies and research 2022. Ministry of Health. Publications Center, 2022; 124-126. https://cpage.mpr.gob.es NIPO en linea: 133-22-020-8. Document type: Book chapter.
Baldirà J, Morán I, Marruecos L. Narcissus spp. I: Toxic Plants. Reports, studies and research 2022. Ministry of Health. Publications Center, 2022; 172-174. https://cpage.mpr.gob.es. NIPO en linea: 133-22-020-8. Document type: Book chapter.
Baldirà J, Morán I, Marruecos L. Oenanthe crocata. Nabo del diablo. In: Toxic Plants. Reports, studies and research 2022. Ministry of Health. Publications Center, 2022; 184-187. https://cpage.mpr.gob.es. NIPO en linea: 133-22-020-8. Document type: Book chapter.
Baldirà J, Morán I, Marruecos L. Senecio jacobea. Hierba de Santiago. In: Toxic Plants. Reports, studies and research 2022. Ministry of Health. Publications Center, 2022; 222-224. https://cpage.mpr.gob.es. NIPO en linea: 133-22-020-8. Document type: Book chapter.
Belvís R, Morollón N, Cortés E, Morán I. Tabún, sarín, somán, VX y novichoks: agentes neurotóxicos organofosforados con finalidad bélica o criminal. 2022; 17(2). DOI:10.24875/KRANION.M22000030. Document type: Review.
Brault C, Mancebo J, Montero JCS, Bentall T, Burns K, Piraino T, Lellouche F, Bouchard PA, Charbonney E, Carteaux G, Maraffi T, Beduneau G, Mercat A, Skrobik Y, Zuo F, Lafreniere M, Thorpe K, Brochard L, Bosma KJ. The PROMIZING trial enrollment algorithm for early identification of patients ready for unassisted breathing. CRITICAL CARE. 2022; 26(1):188. DOI:10.1186/s13054-022-04063-4. PMID:35739553. IF:15,1 (Q1/1D). Document type: Article.
Chastre J, François B, Bourgeois M, Komnos A, Ferrer R, Rahav G, De Schryver N, Lepape A, Koksal I, Luyt C-E, Sánchez M, Torres A, Eggimann P, Koulenti D, Holland TL, Ali O, Shoemaker K, Ren P, Sauser J, Ruzin A, Tabor DE, Akhgar A, Wu Y, Jiang Y, DiGiandomenico A, Colbert S, Vandamme D, Coenjaerts F, Malhotra S, Timbermont L, Oliver A, Barraud O, et al. [Vera P]. Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial. CRITICAL CARE. 2022; 26(1):355. DOI:10.1186/s13054-022-04204-9. PMID:36380312. IF:15,1 (Q1/1D). Document type: Article.
Co-author of the Book: Algorithms of nutritional intervention in the critically ill Publishing House: Health and Editions, S.L. Edition: Second. ISBN: 978‑84‑18351‑74‑7 Publication date: 01/06/2022. List of authors in alphabetical order, page 6 (Paula Vera). Book pages: 1-94. Document type: Book.
Frutos F, Peñuelas O, Muriel A, Mancebo J, García A, de Pablo R, Valledor M, Ferrer M, León M, Quiroga JM, Temprano S, Vallverdú I, Fernández R, Gordo F, Anzueto A, Esteban A. Mechanical ventilation in Spain, 1998-2016: changes in the disconnection of mechanical ventilation. Medicina Intensiva. 2022; 46(7). DOI:10.1016/j.medin.2021.04.005. PMID:34092422. IF:3 (Q3/7D). Document type: Article.
Gomila Sintes C, Bernal S, Rojas E, Flores Orella MN, Leoz P, Betbesé Roig AJ. Favism in the elderly. Archives of Clinical and Medical Case Reports. 2022;6(4):582-585. DOI: 10.26502/acmcr.96550521. Document type: Article.
Lopez JC, Grau T, Trujillano J, Garcia C, Mor E, Bordeje ML, Portugal E, Lorencio C, Vera P, Macaya L, Martinez JF, Mateu L, Gero M, Gastaldo R, Vila B, Flordelis JL, Montejo JC, Servia L, ENPIC GRP. The Effect of Enteral Immunonutrition in the Intensive Care Unit: Does It Impact on Outcomes?. 2022; 14(9):1904. DOI:10.3390/nu14091904. PMID:35565870. IF:5,9 (Q1/2D). Document type: Article.
Maddali MV, Churpek M, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P, Rios F, Van F, Sottiaux T, Lora FS, Azevedo LC, Fan E, Bugedo G, Qiu H, Gonzalez M, Silesky J, Cerny V, et al. [Mancebo J]. Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. Lancet Respiratory Medicine. 2022; 10(4). DOI:10.1016/S2213-2600(21)00461-6. PMID:35026177. IF:76,2 (Q1/1D). Document type: Article.
Maggiore SM, Jaber S, Grieco DL, Mancebo J, Zakynthinos S, Demoule A, Ricard J-D, Navalesi P, Vaschetto R, Hraiech S, Klouche K, Frat J-P, Lemiale V, Fanelli V, Chanques G, Natalini D, Ischaki E, Reuter D, Morán I, Combe BL, Longhini F, De Gaetano A, Ranieri VM, Brochard LJ, Antonelli M, RINO Trial Study G. High-Flow Versus VenturiMask Oxygen Therapy to Prevent Reintubation in Hypoxemic Patients after Extubation: A Multicenter Randomized Clinical Trial. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022; 206(12). DOI:10.1164/rccm.202201-0065OC. PMID:35849787. IF:24,7 (Q1/1D). Document type: Article.
Mateos A, Betbesé AJ, Guix EM. Fundamental concepts for the management of continuous replacement therapies. Enfermeria Intensiva. 2022; 33. DOI:10.1016/j.enfi.2021.06.003. Document type: Review.
Morales L, Mancebo J, Del Sorbo L. Hypercapnia and extracorporeal carbon dioxide removal (ECCO2R) in the acute respiratory distress syndrome. Signa Vitae. 2022; 18(5). DOI:10.22514/sv.2022.046. IF:1,1 (Q4/9D). Document type: Review.
Munshi L, Mancebo J, Brochard LJ. Noninvasive Respiratory Support for Adults with Acute Respiratory Failure. NEW ENGLAND JOURNAL OF MEDICINE. 2022; 387(18). DOI:10.1056/NEJMra2204556. PMID:36322846. IF:158,5 (Q1/1D). Document type: Review.
Nasa P, Azoulay E, Chakrabarti A, Divatia JV, Jain R, Rodrigues C, Rosenthal VD, Alhazzani W, Arabi YM, Bakker J, Bassetti M, De Waele J, Dimopoulos G, Du B, Einav S, Evans L, Finfer S, Guerin C, Hammond NE, Jaber S, Kleinpell RM, Koh Y, Kollef M, Levy MM, Machado FR, Mancebo J, Martin I, Mer M, Niederman MS, Pelosi P, Perner A, Peter JV, Phua J, Piquilloud L, Pletz MW, Rhodes A, Schultz MJ, Singer M, Timsit JF, Venkatesh B, Vincent JL, Welte T, Myatra S. Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method. LANCET INFECTIOUS DISEASES. 2022; 22(3):e74-e87. DOI:10.1016/S1473-3099(21)00626-5. PMID:34774188. IF:56,3 (Q1/1D). Document type: Review.
Pisani L, Algera AG, Neto AS, Azevedo LC, Paulus F, de Abreu MG, Pelosi P, Dondorp AM, Bellani G, Laffey JG, Schultz MJ, Martinez A, Leal L, Jorge A, de Oliveira M, Neto JA, Piras C, Moreira CL, Braga P, Dalcomune DM, Ribeiro de Carvalho AG, Gondim LAR, Castelo Branco Reis LM, da Cunha Ribeiro D, de Assis L, Campos RS, Fernandez Versiani dos Anjos JC, Bruzzi F, et al. [Mancebo J]. Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies. Lancet Global Health. 2022; 10(2). DOI:10.1016/S2214-109X(21)00485-X. PMID:34914899. IF:34,3 (Q1/1D). Document type: Article.
Riera P, Sole N, Suarez JC, Lopez PA, Fonts N, Rodriguez N, de Gamarra EF, Moran I. Drug-drug interactions in an intensive care unit and comparison of updates in two databases. Farmacia Hospitalaria. 2022; 46(5). DOI:10.7399/fh.13180. PMID:36183229. Document type: Article.
Sassoon CS, Mancebo J. The Double-edged Sword of Reverse Triggering: Impact on the Diaphragm. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022; 205(6). DOI:10.1164/rccm.202201-0099ED. PMID:35139008. IF:24,7 (Q1/1D). Document type: Editorial material.
Servia L, Lopez JC, Grau T, Trujillano J, Bordeje ML, Mor E, Portugal E, Lorencio C, Montejo JC, Vera P, Macaya L, Martinez JF, Iglesias R, Monge D, Flordelis JL, Llorente B, Menor EM, de Lagran IM, Yebenes JC. Evaluation of Nutritional Practices in the Critical Care patient (The ENPIC study): Does nutrition really affect ICU mortality?. Clinical Nutrition Espen. 2022; 47. DOI:10.1016/j.clnesp.2021.11.018. PMID:35063222. Document type: Article.
Suárez JC, Caballero AC, Martín L, Mancebo J. Immune effector cell-associated neurotoxicity syndrome: A therapeutic approach in the critically ill. Medicina Intensiva. 2022; 46(4). DOI:10.1016/j.medin.2020.06.014. PMID:32873409. IF:3 (Q3/7D). Document type: Article.
Torrego A, Muñoz AM, Lucena CM, Castro P, López L, Badía JR, Betbesé A, Ramirez J, Andreo F, Fernández M-T, Fabra M, Pajares V, Agustí C. Safety and Feasibility of Transbronchial Cryobiopsy in Mechanically Ventilated Patients. ARCHIVOS DE BRONCONEUMOLOGIA. 2022; 58(8). DOI:10.1016/j.arbres.2021.11.005. PMID:35312520. IF:8 (Q1/2D). Document type: Letter.
Vidal P, Díaz E, Aguilar E, Amezaga R, Ballesteros MÁ, Bodí MA, Bordejé ML, Garnacho J, García M, López M, Martín I, Ochagavía A, Ramírez P, Alcántara S, Andaluz D, Badallo O, Barrasa H, Borges M, Castellanos Á, Estella Á, Ferrer R, Fraile V, Fuset M, Giménez C, González C, Hernández A, Igeño JC, Iglesias D, Jiménez JJ, Llanos C, Llompart JA, López V, et al. [Zapata L]. Recommendations for the management of critically ill patients with COVID-19 in Intensive Care Units. Medicina Intensiva. 2022; 46(2). DOI:10.1016/j.medin.2021.08.011. PMID:34545260. IF:3 (Q3/7D). Document type: Article.
Vidal P, Díaz E, Aguilar E, Amezaga R, Ballesteros MÁ, Bodí MA, Bordejé ML, Garnacho J, García M, López M, Martín I, Ochagavía A, Ramírez P, Alcántara S, Andaluz D, Badallo O, Barrasa H, Borges M, Castellanos Á, Estella Á, Ferrer R, Fraile V, Fuset M, Giménez C, González C, Hernández A, Igeño JC, Iglesias D, Jiménez JJ, Llanos C, Llompart JA, López V, et al. [Zapata L]. Recommendations for the management of critically ill patients with COVID-19 in Intensive Care Units. Medicina Intensiva. 2022; 46(2). DOI:10.1016/j.medine.2021.11.019. PMID:34903475. IF:3 (Q3/7D). Document type: Article/Practice guideline.
Wendel PD, Mas A, Gonzalez C, Ferrer R, Manez R, Masclans JR, Sandoval E, Vera P, Trenado J, Fernandez R, Sirvent JM, Martinez M, Ibarz M, Garro P, Lopera JL, Bodi M, Yebenes JC, Triginer C, Vallverdu I, Baro A, Bodi F, Saludes P, Valencia M, Roche F, Huerta A, Cambra FJ, Barbera C, Echevarria J, Penuelas O, Mancebo J, UCIsCAT GRP. Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study. CRITICAL CARE. 2022; 26(1):37. DOI:10.1186/s13054-022-03905-5. PMID:35135588. IF:15,1 (Q1/1D). Document type: Article.
Zapata L, Suarez JC, Flores MN, Morales EM, Segarra A, Santos JA. Acute cor pulmonale in patients with acute respiratory distress syndrome due to COVID-19. Medicina Intensiva. 2022; 46(11). DOI:10.1016/j.medin.2021.12.016. PMID:35079192. IF:3 (Q3/7D). Document type: Letter.

Publications 2021

Albaiceta GM, Brochard L, Santos CCD, Fernandez R, Georgopoulos D, Girard T, Jubran A, Lopez J, Mancebo J, Pelosi P, Skrobik Y, Thille AW, Wilcox ME, Blanch L. The central nervous system during lung injury and mechanical ventilation: a narrative review. BRITISH JOURNAL OF ANAESTHESIA. 2021; 127(4). DOI:10.1016/j.bja.2021.05.038. PMID:34340836. IF:11,719.
Astigarraga P, Lerma FA, Zambrano CB, Costa RG, Vidal FG, Navarro RD, Suarez CR, Pallas TA, Montero JG, Vera P, Alemparte E. Epidemiology and prognosis of patients with a history of cancer admitted to intensive care. A multicenter observational study. Medicina Intensiva. 2021; 45(6). DOI:10.1016/j.medin.2020.01.013. PMID:32307264. IF:2,799.
Berenguer J, Borobia AM, Ryan P, Rodriguez J, Bellon JM, Jarrin I, Carratala J, Pachon J, Carcas AJ, Yllescas M, Arribas JR, López J, Pascual P, Pomar V, Rabella N, Benito N, Domingo P, Bonfill X, Mancebo J, MARTIN A. Development and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: the COVID-19 SEIMC score. THORAX. 2021; 76(9). DOI:10.1136/thoraxjnl-2020-216001. PMID:33632764. IF:9,102.
Grieco DL, Maggiore SM, Roca O, Spinelli E, Patel BK, Thille AW, Barbas CSV, De Acilu MG, Cutuli SL, Bongiovanni F, Amato M, Frat JP, Mauri T, Kress JP, Mancebo J, Antonelli M. Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS. INTENSIVE CARE MEDICINE. 2021; 47(8). DOI:10.1007/s00134-021-06459-2. PMID:34232336. IF:41,787.
Gutierrez B, del Toro MD, Borobia AM, Carcas A, Jarrin I, Yllescas M, Ryan P, Pachon J, Carratala J, Berenguer J, Arribas JR, Rodriguez J, López J, Pascual P, Pomar V, Rabella N, Benito N, Domingo P, Bonfill X, Puig M, Mancebo J, Martinez G. Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study. LANCET INFECTIOUS DISEASES. 2021; 21(6). DOI:10.1016/S1473-3099(21)00019-0. PMID:33636145. IF:71,421.
Johnstone J, Meade M, Lauzier F, Marshall J, Duan E, Dionne J, Arabi YM, Heels D, Thabane L, Lamarche D, Surette M, Zytaruk N, Mehta S, Dodek P, McIntyre L, English S, Rochwerg B, Karachi T, Henderson W, Wood G, Ovakim D, Herridge M, Granton J, Wilcox ME, Goffi A, Stelfox HT, Niven D, Muscedere J, Lamontagne F, D’Aragon F, St C, Ball I, et al. [Mancebo J]. Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2021; 326(11). DOI:10.1001/jama.2021.13355. PMID:34546300. IF:157,335.
Lomeli M, Cenzano LD, Torres L, Chavarria U, Poblano M, Tendillo F, Blanch L, Mancebo J. Aggressive alveolar recruitment in ARDS: more shadows than lights. Medicina Intensiva. 2021; 45(7). DOI:10.1016/j.medin.202.0.03.008. IF:2,799.
Madotto F, McNicholas B, Rezoagli E, Pham T, Laffey JG, Bellani G, Mancebo J, Pesenti A. Death in hospital following ICU discharge: insights from the LUNG SAFE study. CRITICAL CARE. 2021; 25(1):144. DOI:10.1186/s13054-021-03465-0. PMID:33849625. IF:19,334.
Mauri T, Foti G, Fornari C, Grasselli G, Pinciroli R, Lovisari F, Tubiolo D, Volta CA, Spadaro S, Rona R, Rondelli E, Navalesi P, Garofalo E, Knafelj R, Gorjup V, Colombo R, Cortegiani A, Zhou JX, D’Andrea R, Calamai I, Gonzalez AV, Roca O, Grieco DL, Jovaisa T, Bampalis D, Becher T, Battaglini D, Ge HQ, Luz M, Constantin JM, Ranieri M, Guerin C, Mancebo J, et al. Sigh in Patients With Acute Hypoxemic Respiratory Failure and ARDS The PROTECTION Pilot Randomized Clinical Trial. CHEST. 2021; 159(4). DOI:10.1016/j.chest.2020.10.079. PMID:33197403. IF:10,262.
Nasa P, Azoulay E, Khanna AK, Jain R, Gupta S, Javeri Y, Juneja D, Rangappa P, Sundararajan K, Alhazzani W, Antonelli M, Arabi YM, Bakker J, Brochard LJ, Deane AM, Du B, Einav S, Esteban A, Gajic O, Galvagno SM, Guerin C, Jaber S, Khilnani GC, Koh Y, Lascarrou JB, Machado FR, Malbrain MLNG, Mancebo J, McCurdy MT, McGrath BA, Mehta S, et al. Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method. CRITICAL CARE. 2021; 25(1):106. DOI:10.1186/s13054-021-03491-y. PMID:33726819. IF:19,334.
Penuelas O, del Campo L, de Aledo A, Anon JM, Rodriguez C, Mancebo J, Vera P, Ballesteros D, Jimenez J, Maseda E, Figueira JC, Franco N, Algaba A, Aviles JP, Diaz R, Abad B, Canabal A, Abella A, Gordo F, Garcia J, Suarez JG, Cedeno J, Martinez B, Manteiga E, Martinez O, Blancas R, Bardi T, Pestana D, Lorente JA, Muriel A, Esteban A, Frutos F. Long-term survival of mechanically ventilated patients with severe COVID-19: an observational cohort study. Annals of Intensive Care. 2021; 11(1):143. DOI:10.1186/s13613-021-00929-y. PMID:34601646. IF:10,318.
Peñuelas O, Frutos-Vivar F, Muriel A, Mancebo J, García-Jiménez A, de Pablo R, Valledor M, Ferrer M, León M, Quiroga JM, Temprano S, Vallverdú I, Fernández R, Gordo F, Anzueto A, Esteban A. Mechanical ventilation in Spain, 1998-2016: Epidemiology and outcomes. Medicina Intensiva (Engl Ed). 2021;45(1):3-13. English, Spanish. DOI:10.1016/j.medin.2020.04.024. PMID: 32723483. IF:2,799.
Pham T, Montanya J, Telias I, Piraino T, Magrans R, Coudroy R, Damiani LF, Artigas RM, Madorno M, Blanch L, Brochard L, Mancebo J, Papazian L. Automated detection and quantification of reverse triggering effort under mechanical ventilation. CRITICAL CARE. 2021; 25(1):60. DOI:10.1186/s13054-020-03387-3. PMID:33588912. IF:19,334.
Pham T, Pesenti A, Bellani G, Rubenfeld G, Fan E, Bugedo G, Lorente JA, Fernandes AD, Van F, Bruhn A, Rios F, Esteban A, Gattinoni L, Larsson A, McAuley DF, Ranieri M, Thompson BT, Wrigge H, Brochard LJ, Laffey JG, Mancebo J, Schomer AM. Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study. EUROPEAN RESPIRATORY JOURNAL. 2021; 57(6):2003317. DOI:10.1183/13993003.03317-2020. PMID:33334944. IF:33,795.
Robba C, Citerio G, Taccone FS, Galimberti S, Rebora P, Vargiolu A, Pelosi P, Mancebo J, Laffey J. Multicentre observational study on practice of ventilation in brain injured patients: the VENTIBRAIN study protocol. BMJ Open. 2021; 11(8):e047100. DOI:10.1136/bmjopen-2020-047100. PMID:34380722. IF:3,006.
Tomasa TM, Sabater J, Pérez M, Ortiz P, Díaz Y, Navas A, Betbesé A, Rodríguez M, Ibarz M, Olmo A, Oliva I, Rovira C, Cano S, Vendrell E, Catalan RM, Miralbés M, González de Molina J, Xirgu J, Marcos P. Augmented renal clearance. An unnoticed relevant event. SCIENCE PROGRESS. 2021; 104(2):368504211018580. DOI:10.1177/00368504211018580. PMID:34078190. IF:1,512.

TRANSLATIONAL MEDICINE

Intensive Medicine

Main lines of research

Acute Respiratory Failure and Artificial Ventilation

Study of the Usefulness of New Biomarkers in Critically Ill Patients

Challenges

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Main lines of research

Acute Respiratory Failure and Artificial Ventilation

Study of the Usefulness of New Biomarkers in Critically Ill Patients

Challenges

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau