Sant Pau - Institut de Recerca

Main Lines of Research

Malignant Haemopathologies

ADiagnostic activities: morphological, immunophenotyping, cytogenetic and molecular characterization (particularly of acute leukaemias).
Biological characteristics responding to therapy.
New treatments using cell line models aimed at molecular targets.
Genomic (microarrays) and proteomic platforms for diagnosis.
Murine models development.

Noncancerous Haemopathologies

Diagnosis and characterization of thrombocytopenias, thrombocytopathies and other platelet pathologies, especially complex pathologies (of genetic, mixed or unknown origin) and including unusual presentations of common diseases.
In the framework of the GAIT-2 (genetic analysis of idiopathic thrombophilia, phase 2) project, to seek new phenotypes that favour the development of thrombosis, specifically related to the structure and function of platelets and other blood cells.

Challenges

Consolidate characterization of haematological tumours and complex, rare and genetic noncancerous haematopathologies.
Include the results of mass-analysis genomic and proteomic platforms in diagnostic algorithms and establish prognostic factors for haematological disorders, preferably complex or genetic neoplasms and noncancerous pathologies.
Develop functional cell culture and animal (murine) models.
Consolidate cooperation with the GAIT-2 project, especially regarding platelet and other blood cell participation in thrombosis generation.
Promote interaction and stable links with internal groups (clinical haematology, pathology, gastrointestinal, haemostasis and thrombosis, complex disease genomics areas) and with other groups in Spain and abroad, especially those with complementary technologies.

Group coordination

NOMDEDEU GUINOT, JOSEP FRANCESC FGS
jnomdedeu@santpau.cat

Members

Blanco, Maria Laura FGS
Brell Martinez, Albert FGS
Bussaglia Petrillo, Elena Mart FGS
Carricondo Morcillo, Maite FGS
Espadaler Pare, Montserrat FGS
Fernandez Rosales, Maria Nieves FGS
Fuentes Hernandez, Francisca FGS
Gine Vilalta, Anna IR
Martinez Sanchez, Elisabeth FGS
Martinez Valverde, Clara Maria FGS
Ortin Quilez, Rosa FGS
Pratcorona Canela, Marta FGS
Ramil Lopez, Guillermo IR
Remacha Sevilla, Angel Francisco FGS
Sanchez Garcia, Jana FGS
Serra Ferrer, Marta FGS
Ubeda Rodenas, Jose FGS

Publications 2023

(JIF 2022)

-Arguello M, Albiol N, Jara P, Garcia I, Redondo S, Esquirol A, Novelli S, Saavedra S, Martino R, Nomdedeu J, Sierra J, Mora A, Moreno C. Evolution in the frontline treatment of patients with chronic lymphocytic leukemia: experience from one European center. LEUKEMIA & LYMPHOMA. 2023; 64(10). DOI:10.1080/10428194.2023.2232489. PMID:37452739. IF:2,600 (Q3/7D). Document type: Article.

-Castillo MI, Ribate VE, Muñoz CM, Santillana SG, Taboada SE, Casterá ME, Abinzano CMJ, Barranco IA, Nieto CR, Pampliega VM, Blanco ML, de Andrés ÁS, de Oteyza PJ, del Castillo BT, Font GI, Cayuela JA, Díez M, Sánchez AR, Vercet SC, Díaz TM, Grupo Espanol de Sindromes Mielodisplasicos (Incidence and prognostic impact of U2AF1 mutations and other gene alterations in myelodysplastic neoplasms with isolated 20q deletion. Cancer Medicine. 2023; 12(16)DOI:10.1002/cam4.6300. PMID:37403747. IF:4,000 (Q2/4D). Document type: Article.

-Marin O, Romero D, Rodriguez J, Distefano M, Lessi F, Aretini P, Liquori A, Castaño J, Kozyra E, Kotmayer L, Bueno C, Cervera J, Rodriguez JC, Nomdedeu JF, Murillo L, De Heredia CD, Pérez A, López F, Martínez C, Dorado N, Marco FM, Prósper F, Menendez P, Valcárcel D, Ballestar E, Bödör C, Bigas A, Catalá A, Wlodarski MW, Giorgetti A. Epigenome profiling reveals aberrant DNA methylation signature in GATA2 deficiency. HAEMATOLOGICA. 2023; 108(9)DOI:10.3324/haematol.2022.282305. PMID:36815365. IF:10,100 (Q1/2D). Document type: Letter.

-Mosquera A, Perez M, Hernandez A, Gonzalez T, Arellano E, Martinez J, Villaverde A, Raya JM, Ayala R, Ferrer F, Fox ML, Velez P, Mora E, Xicoy B, Mata MI, Garcia M, Angona A, Cuevas B, Senin MA, Ramirez A, Ramirez MJ, Perez R, de Villambrosia SG, Martinez C, Gomez MT, Garcia C, Gasior M, Bellosillo B, Steegmann JL, Alvarez A, Hernandez JM, Hernandez JC, Spanish MPNGRP. Machine Learning Improves Risk Stratification in Myelofibrosis: An Analysis of the Spanish Registry of Myelofibrosis. Hemasphere. 2023; 7(1):e818. DOI:10.1097/HS9.0000000000000818. PMID:36570691. IF:6,600 (Q1/3D). Document type: Article.

– Mulet M, Osuna-Gómez R, Zamora C, Artesero I, Arús M, Vera-Artazcoz P, Cordón A, Vilalta N, San-José P, Abril A, Moliné A, Morán I, López-Contreras J, Vidal S. Dysregulated neutrophil extracellular traps formation in sepsis. Immunology. 2023; 170(3):374-387. DOI: 10.1111/imm.13676. PMID: 37381594. IF: 6,400 (Q2/3D). Document type: Article.

-Onate G, Pratcorona M, Garrido A, Artigas A, Bataller A, Tormo M, Arnan M, Vives S, Coll R, Salamero O, Vall F, Sampol A, Garcia A, Cervera M, Avila SG, Bargay J, Ortín X, Nomdedéu JF, Esteve J, Sierra J, Spanish Cooperative Study GRP. Survival improvement of patients with FLT3 mutated acute myeloid leukemia: results from a prospective 9 years cohort. Blood Cancer Journal. 2023; 13(1):69. DOI:10.1038/s41408-023-00839-1. PMID:37147301. IF:12,800 (Q1/1D). Document type: Article.

-Orgueira AM, Encinas MMP, Varela N, Mora E, Díaz M, Montoro MJ, Pomares H, Ramos F, Tormo M, Jerez A, Nomdedeu JF, Sanchez CD, Leonor A, Cárcel P, Romero MTC, Xicoy B, Rivero E, Barreto R, Diez M, Benlloch LE, Crucitti D, Valcárcel D. Machine Learning Improves Risk Stratification in Myelodysplastic Neoplasms: An Analysis of the Spanish Group of Myelodysplastic Syndromes. Hemasphere. 2023; 7(10):e961. DOI:10.1097/HS9.0000000000000961. PMID:37841754. IF:6,600 (Q1/3D).Document type: Article.

Publications 2022

(JIF 2022)

Alvarez A, Garrote M, Ferrer F, Perez M, Mata MI, Bellosillo B, Arellano E, Gomez M, Garcia R, Garcia V, Gasior M, Cuevas B, Angona A, Gomez MT, Martinez CM, Magro E, Ayala R, del Orbe R, Perez R, Fox ML, Raya JM, Guerrero L, Garcia C, Caballero G, Murillo I, Xicoy B, Ramirez MJ, Carreno G, Hernandez JC, Pereira A, Spanish MPNGRP, Grupo Espanol Enfermedades M. Real-world analysis of main clinical outcomes in patients with polycythemia vera treated with ruxolitinib or best available therapy after developing resistance/intolerance to hydroxyurea. CANCER. 2022; 128(13). DOI:10.1002/cncr.34195. PMID:35417564. IF:6,2 (Q1/3D). Document type: Article.
Bataller A, Garrido A, Guijarro F, Onate G, Diaz M, Arnan M, Tormo M, Vives S, de Llano MPQ, Coll R, Gallardo D, Vall F, Escoda L, Garcia A, Salamero O, Sampol A, Merchan BM, Bargay J, Castano S, Esteban D, Oliver A, Rivero A, Mozas P, Lopez M, Pratcorona M, Zamora L, Costa D, Rozman M, Nomdedeu JF, Colomer D, Brunet S, Sierra J, Esteve J. European LeukemiaNet 2017 risk stratification for acute myeloid leukemia: validation in a risk-adapted protocol. Blood Advances. 2022; 6(4). DOI:10.1182/bloodadvances.2021005585. PMID:34911079. IF:7,5 (Q1/2D). Document type: Article.
Diaz J, Rodriguez R, Coll R, Osca G, Pratcorona M, Gonzalez M, Garrido A, Angona A, Talarn C, Tormo M, Arnan M, Vives S, Salamero O, Tuset E, Lloveras N, Diez I, Zamora L, Bargay J, Sampol A, Cruz D, Vila J, Sitges M, Garcia A, Vall F, Esteve J, Sierra J, Gallardo D, Cooperativo Estudio Tratamient GRP. 5 ‘-nucleotidase, cytosolic II genotype, and clinical outcome in patients with acute myeloid leukemia with intermediate-risk cytogenetics. EUROPEAN JOURNAL OF HAEMATOLOGY. 2022; 109(6). DOI:10.1111/ejh.13862. PMID:36063368. IF:3,1 (Q3/6D). Document type: Article.
Dunn WG, Gu MXS, Fabre MA, Cooper J, Nomdedeu JF, Koumas L, Nicolaou K, Chi JX, Costeas P, Vassiliou GS. The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients. ANNALS OF HEMATOLOGY. 2022; 101(2). DOI:10.1007/s00277-021-04472-5. PMID:33650061. IF:3,5 (Q2/5D). Document type: Letter.
Hernandez JC, Pastor I, Arellano E, Raya JM, Perez M, Ayala R, Ferrer F, Velez P, Mora E, Fox ML, Hernandez JM, Xicoy B, Mata MI, Garcia M, Perez R, Angona A, Cuevas B, Senin A, Ramirez MJ, Ramirez A, Gomez MT, Martinez C, Magro E, Steegmann JL, Duran MA, Garcia C, Gasior M, de Villambrosia SG, Alvarez A, Pereira A, Spanish MPNGRP. Predictors of thrombosis and bleeding in 1613 myelofibrosis patients from the Spanish Registry of Myelofibrosis. BRITISH JOURNAL OF HAEMATOLOGY. 2022; 199(4). DOI:10.1111/bjh.18440. PMID:36089912. IF:6,5 (Q1/3D). Document type: Article.
Onate G, Bataller A, Garrido A, Hoyos M, Arnan M, Vives S, Coll R, Tormo M, Sampol A, Escoda L, Salamero O, Garcia A, Bargay J, Aljarilla A, Nomdedeu JF, Esteve J, Sierra J, Pratcorona M. Prognostic impact of DNMT3A mutation in acute myeloid leukemia with mutated NPM1. Blood Advances. 2022; 6(3). DOI:10.1182/bloodadvances.2020004136. PMID:34516636. IF:7,5 (Q1/2D). Document type: Article.
Ramos M, Trincado JL, Blanco J, Bueno C, Rodriguez VC, Bataller A, Lopez B, Schwab C, Ortega M, Velasco P, Blanco ML, Nomdedeu J, Ramirez M, Minguela A, Fuster JL, Cuatrecasas E, Camos M, Ballerini P, Escherich G, Boer J, DenBoer M, Hernandez JM, Calasanz MJ, Cazzaniga G, Harrison CJ, Menendez P, Molina O. Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high-hyperdiploid B-cell acute lymphoblastic leukemia. Molecular Oncology. 2022; 16(16). DOI:10.1002/1878-0261.13276. PMID:35726693. IF:6,6 (Q1/3D). Document type: Article.
Ramos S, Puiggros A, Bea S, Bougeon S, Larrayoz MJ, Costa D, Parker H, Rigolin GM, Ortega M, Blanco ML, Collado R, Salgado R, Baumann T, Gimeno E, Moreno C, Bosch F, Calvo X, Calasanz MJ, Cuneo A, Strefford JC, Nguyen F, Oscier D, Haferlach C, Schoumans J, Espinet B. Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients. HAEMATOLOGICA. 2022; 107(3). DOI:10.3324/haematol.2020.274456. PMID:33691382. IF:10,1 (Q1/2D). Document type: Article.
Ramos S, Puiggros A, Kamaso J, Bea S, Bougeon S, Larrayoz MJ, Costa D, Parker H, Rigolin GM, Blanco ML, Collado R, Ancin I, Salgado R, Moro MA, Baumann T, Gimeno E, Moreno C, Salido M, Calvo X, Calasanz MJ, Cuneo A, Nguyen F, Oscier D, Haferlach C, Strefford JC, Schoumans J, Espinet B. TP53 Abnormalities Are Underlying the Poor Outcome Associated with Chromothripsis in Chronic Lymphocytic Leukemia Patients with Complex Karyotype. 2022; 14(15):3715. DOI:10.3390/cancers14153715. PMID:35954380. IF:5,2 (Q2/3D). Document type: Article.
Soria JM, Mojal S, Martinez A, Acosta FR, López S, Miqueleiz S, Rodriguez D, Quijada MA, Cardenas A, Vidal F, Remacha A, Antonijoan RM, Souto JC. A validated clinical-genetic score for assessing the risk of thrombosis in patients with COVID-19 receiving thromboprophylaxis. HAEMATOLOGICA. 2022; 107(9). DOI:10.3324/haematol.2022.281068. PMID:35545920. IF:10,1 (Q1/2D). Document type: Article.
Triguero A, Pedraza A, Perez M, Mata MI, Velez P, Fox L, Gomez M, Garcia R, Gasior M, Ferrer F, Garcia V, Angona A, Gomez MT, Cuevas B, Martinez C, Perez R, Raya JM, Guerrero L, Murillo I, Bellosillo B, Hernandez JC, Sanz C, Alvarez A, Spanish MPNGRP. Low-risk polycythemia vera treated with phlebotomies: clinical characteristics, hematologic control and complications in 453 patients from the Spanish Registry of Polycythemia Vera. ANNALS OF HEMATOLOGY. 2022; 101(10). DOI:10.1007/s00277-022-04963-z. PMID:36042023. IF:3,5 (Q2/5D). Document type: Article.
Vives JL, Krishnevskaya E, Hernandez I, Payan S, Sevilla A, Badell I. Red cell ektacytometry in two patients with chronic hemolytic anemia and three new alpha-spectrin variants. ANNALS OF HEMATOLOGY. 2022; 101(3). DOI:10.1007/s00277-021-04723-5. PMID:34845540. IF:3,5 (Q2/5D). Document type: Article.

Publications 2021

de la Guardia RD, Velasco T, Gutierrez F, Roca H, Molina O, Nombela C, Bataller A, Fuster JL, Anguita E, Vives S, Zamora L, Nomdedeu J, Gomez MT, Ramirez M, Lapillonne H, Ramos V, Rodriguez JC, Bueno C, Lopez B, Menendez P. Engraftment characterization of risk-stratified AML in NSGS mice. Blood Advances. 2021; 5(23). DOI:10.1182/bloodadvances.2020003958. PMID:34470043. IF:7,637.
Martin I, Villamon E, Abellan R, Calasanz MJ, Irigoyen A, Sanz G, Such E, Mora E, Gutierrez M, Collado R, Garcia R, Vara M, Blanco ML, Oiartzabal I, Alvarez S, Bernal T, Granada I, Xicoy B, Jerez A, Calabuig M, Diez R, Gil A, Diez M, Solano C, Tormo M. Myelodysplastic syndromes with 20q deletion: incidence, prognostic value and impact on response to azacitidine of ASXL1 chromosomal deletion and genetic mutations. BRITISH JOURNAL OF HAEMATOLOGY. 2021; 194(4). DOI:10.1111/bjh.17675. PMID:34296432. IF:8,615.
Payan S, Llobet AR, Sevilla A, Egido J, Castan J, Moreno JA. Sickle cell nephropathy. Clinical manifestations and new mechanisms involved in kidney injury. NEFROLOGIA. 2021; 41(4). DOI:10.1016/j.nefro.2020.10.012. PMID:33714630. IF:3,084.
Payan S, Perez LG, Sevilla A, Gil JS, Canales SN. Absolute Lymphocytes, Ferritin, C-Reactive Protein, and Lactate Dehydrogenase Predict Early Invasive Ventilation in Patients With COVID-19. LABORATORY MEDICINE. 2021; 52(2). DOI:10.1093/labmed/lmaa105. PMID:33336243. IF:1,865.
Pich O, Cortes A, Muinos F, Pratcorona M, Gonzalez A, Lopez N. The evolution of hematopoietic cells under cancer therapy. Nature Communications. 2021; 12(1):4803. DOI:10.1038/s41467-021-24858-3. PMID:34376657. IF:17,694.
Vega N, Perez S, Esperanza E, Vicente C, Torrebadell M, Jimenez A, Ortega M, Llop M, Abad L, Vagace JM, Minguela A, Pratcorona M, Sanchez J, Garcia CB, Gomez MT, Martin E, Escudero A, Martinez MR, Munoz L, Velasco MR, Garcia M, Catala A, Pascual A, Velasco P, Fernandez JM, Lassaletta A, Fuster JL, Badell I, Molinos A, Molines A, Guerra P, et al. Measurable Residual Disease Assessed by Flow-Cytometry Is a Stable Prognostic Factor for Pediatric T-Cell Acute Lymphoblastic Leukemia in Consecutive SEHOP Protocols Whereas the Impact of Oncogenetics Depends on Treatment. Frontiers in Pediatrics. 2021; 8:614521. DOI:10.3389/fped.2020.614521. PMID:33614543. IF:3,569.

2017 Scientific Report – Haematological diagnosis

Introduction

Main Lines of Research

Malignant Haemopathologies

ADiagnostic activities: morphological, immunophenotyping, cytogenetic and molecular characterization (particularly of acute leukaemias).
Biological characteristics responding to therapy.
New treatments using cell line models aimed at molecular targets.
Genomic (microarrays) and proteomic platforms for diagnosis.
Murine models development.

Noncancerous Haemopathologies

Diagnosis and characterization of thrombocytopenias, thrombocytopathies and other platelet pathologies, especially complex pathologies (of genetic, mixed or unknown origin) and including unusual presentations of common diseases.
In the framework of the GAIT-2 (genetic analysis of idiopathic thrombophilia, phase 2) project, to seek new phenotypes that favour the development of thrombosis, specifically related to the structure and function of platelets and other blood cells.

Challenges

Consolidate characterization of haematological tumours and complex, rare and genetic noncancerous haematopathologies.
Include the results of mass-analysis genomic and proteomic platforms in diagnostic algorithms and establish prognostic factors for haematological disorders, preferably complex or genetic neoplasms and noncancerous pathologies.
Develop functional cell culture and animal (murine) models.
Consolidate cooperation with the GAIT-2 project, especially regarding platelet and other blood cell participation in thrombosis generation.
Promote interaction and stable links with internal groups (clinical haematology, pathology, gastrointestinal, haemostasis and thrombosis, complex disease genomics areas) and with other groups in Spain and abroad, especially those with complementary technologies.

Team

Group coordination

NOMDEDEU GUINOT, JOSEP FRANCESC FGS
jnomdedeu@santpau.cat

Members

Scientific output

Publications 2023

(JIF 2022)

Publications 2022

(JIF 2022)

Alvarez A, Garrote M, Ferrer F, Perez M, Mata MI, Bellosillo B, Arellano E, Gomez M, Garcia R, Garcia V, Gasior M, Cuevas B, Angona A, Gomez MT, Martinez CM, Magro E, Ayala R, del Orbe R, Perez R, Fox ML, Raya JM, Guerrero L, Garcia C, Caballero G, Murillo I, Xicoy B, Ramirez MJ, Carreno G, Hernandez JC, Pereira A, Spanish MPNGRP, Grupo Espanol Enfermedades M. Real-world analysis of main clinical outcomes in patients with polycythemia vera treated with ruxolitinib or best available therapy after developing resistance/intolerance to hydroxyurea. CANCER. 2022; 128(13). DOI:10.1002/cncr.34195. PMID:35417564. IF:6,2 (Q1/3D). Document type: Article.
Bataller A, Garrido A, Guijarro F, Onate G, Diaz M, Arnan M, Tormo M, Vives S, de Llano MPQ, Coll R, Gallardo D, Vall F, Escoda L, Garcia A, Salamero O, Sampol A, Merchan BM, Bargay J, Castano S, Esteban D, Oliver A, Rivero A, Mozas P, Lopez M, Pratcorona M, Zamora L, Costa D, Rozman M, Nomdedeu JF, Colomer D, Brunet S, Sierra J, Esteve J. European LeukemiaNet 2017 risk stratification for acute myeloid leukemia: validation in a risk-adapted protocol. Blood Advances. 2022; 6(4). DOI:10.1182/bloodadvances.2021005585. PMID:34911079. IF:7,5 (Q1/2D). Document type: Article.
Diaz J, Rodriguez R, Coll R, Osca G, Pratcorona M, Gonzalez M, Garrido A, Angona A, Talarn C, Tormo M, Arnan M, Vives S, Salamero O, Tuset E, Lloveras N, Diez I, Zamora L, Bargay J, Sampol A, Cruz D, Vila J, Sitges M, Garcia A, Vall F, Esteve J, Sierra J, Gallardo D, Cooperativo Estudio Tratamient GRP. 5 ‘-nucleotidase, cytosolic II genotype, and clinical outcome in patients with acute myeloid leukemia with intermediate-risk cytogenetics. EUROPEAN JOURNAL OF HAEMATOLOGY. 2022; 109(6). DOI:10.1111/ejh.13862. PMID:36063368. IF:3,1 (Q3/6D). Document type: Article.
Dunn WG, Gu MXS, Fabre MA, Cooper J, Nomdedeu JF, Koumas L, Nicolaou K, Chi JX, Costeas P, Vassiliou GS. The PML-RARA fusion is not detectable in historical blood samples of acute promyelocytic leukaemia patients. ANNALS OF HEMATOLOGY. 2022; 101(2). DOI:10.1007/s00277-021-04472-5. PMID:33650061. IF:3,5 (Q2/5D). Document type: Letter.
Hernandez JC, Pastor I, Arellano E, Raya JM, Perez M, Ayala R, Ferrer F, Velez P, Mora E, Fox ML, Hernandez JM, Xicoy B, Mata MI, Garcia M, Perez R, Angona A, Cuevas B, Senin A, Ramirez MJ, Ramirez A, Gomez MT, Martinez C, Magro E, Steegmann JL, Duran MA, Garcia C, Gasior M, de Villambrosia SG, Alvarez A, Pereira A, Spanish MPNGRP. Predictors of thrombosis and bleeding in 1613 myelofibrosis patients from the Spanish Registry of Myelofibrosis. BRITISH JOURNAL OF HAEMATOLOGY. 2022; 199(4). DOI:10.1111/bjh.18440. PMID:36089912. IF:6,5 (Q1/3D). Document type: Article.
Onate G, Bataller A, Garrido A, Hoyos M, Arnan M, Vives S, Coll R, Tormo M, Sampol A, Escoda L, Salamero O, Garcia A, Bargay J, Aljarilla A, Nomdedeu JF, Esteve J, Sierra J, Pratcorona M. Prognostic impact of DNMT3A mutation in acute myeloid leukemia with mutated NPM1. Blood Advances. 2022; 6(3). DOI:10.1182/bloodadvances.2020004136. PMID:34516636. IF:7,5 (Q1/2D). Document type: Article.
Ramos M, Trincado JL, Blanco J, Bueno C, Rodriguez VC, Bataller A, Lopez B, Schwab C, Ortega M, Velasco P, Blanco ML, Nomdedeu J, Ramirez M, Minguela A, Fuster JL, Cuatrecasas E, Camos M, Ballerini P, Escherich G, Boer J, DenBoer M, Hernandez JM, Calasanz MJ, Cazzaniga G, Harrison CJ, Menendez P, Molina O. Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high-hyperdiploid B-cell acute lymphoblastic leukemia. Molecular Oncology. 2022; 16(16). DOI:10.1002/1878-0261.13276. PMID:35726693. IF:6,6 (Q1/3D). Document type: Article.
Ramos S, Puiggros A, Bea S, Bougeon S, Larrayoz MJ, Costa D, Parker H, Rigolin GM, Ortega M, Blanco ML, Collado R, Salgado R, Baumann T, Gimeno E, Moreno C, Bosch F, Calvo X, Calasanz MJ, Cuneo A, Strefford JC, Nguyen F, Oscier D, Haferlach C, Schoumans J, Espinet B. Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients. HAEMATOLOGICA. 2022; 107(3). DOI:10.3324/haematol.2020.274456. PMID:33691382. IF:10,1 (Q1/2D). Document type: Article.
Ramos S, Puiggros A, Kamaso J, Bea S, Bougeon S, Larrayoz MJ, Costa D, Parker H, Rigolin GM, Blanco ML, Collado R, Ancin I, Salgado R, Moro MA, Baumann T, Gimeno E, Moreno C, Salido M, Calvo X, Calasanz MJ, Cuneo A, Nguyen F, Oscier D, Haferlach C, Strefford JC, Schoumans J, Espinet B. TP53 Abnormalities Are Underlying the Poor Outcome Associated with Chromothripsis in Chronic Lymphocytic Leukemia Patients with Complex Karyotype. 2022; 14(15):3715. DOI:10.3390/cancers14153715. PMID:35954380. IF:5,2 (Q2/3D). Document type: Article.
Soria JM, Mojal S, Martinez A, Acosta FR, López S, Miqueleiz S, Rodriguez D, Quijada MA, Cardenas A, Vidal F, Remacha A, Antonijoan RM, Souto JC. A validated clinical-genetic score for assessing the risk of thrombosis in patients with COVID-19 receiving thromboprophylaxis. HAEMATOLOGICA. 2022; 107(9). DOI:10.3324/haematol.2022.281068. PMID:35545920. IF:10,1 (Q1/2D). Document type: Article.
Triguero A, Pedraza A, Perez M, Mata MI, Velez P, Fox L, Gomez M, Garcia R, Gasior M, Ferrer F, Garcia V, Angona A, Gomez MT, Cuevas B, Martinez C, Perez R, Raya JM, Guerrero L, Murillo I, Bellosillo B, Hernandez JC, Sanz C, Alvarez A, Spanish MPNGRP. Low-risk polycythemia vera treated with phlebotomies: clinical characteristics, hematologic control and complications in 453 patients from the Spanish Registry of Polycythemia Vera. ANNALS OF HEMATOLOGY. 2022; 101(10). DOI:10.1007/s00277-022-04963-z. PMID:36042023. IF:3,5 (Q2/5D). Document type: Article.
Vives JL, Krishnevskaya E, Hernandez I, Payan S, Sevilla A, Badell I. Red cell ektacytometry in two patients with chronic hemolytic anemia and three new alpha-spectrin variants. ANNALS OF HEMATOLOGY. 2022; 101(3). DOI:10.1007/s00277-021-04723-5. PMID:34845540. IF:3,5 (Q2/5D). Document type: Article.

Publications 2021

de la Guardia RD, Velasco T, Gutierrez F, Roca H, Molina O, Nombela C, Bataller A, Fuster JL, Anguita E, Vives S, Zamora L, Nomdedeu J, Gomez MT, Ramirez M, Lapillonne H, Ramos V, Rodriguez JC, Bueno C, Lopez B, Menendez P. Engraftment characterization of risk-stratified AML in NSGS mice. Blood Advances. 2021; 5(23). DOI:10.1182/bloodadvances.2020003958. PMID:34470043. IF:7,637.
Martin I, Villamon E, Abellan R, Calasanz MJ, Irigoyen A, Sanz G, Such E, Mora E, Gutierrez M, Collado R, Garcia R, Vara M, Blanco ML, Oiartzabal I, Alvarez S, Bernal T, Granada I, Xicoy B, Jerez A, Calabuig M, Diez R, Gil A, Diez M, Solano C, Tormo M. Myelodysplastic syndromes with 20q deletion: incidence, prognostic value and impact on response to azacitidine of ASXL1 chromosomal deletion and genetic mutations. BRITISH JOURNAL OF HAEMATOLOGY. 2021; 194(4). DOI:10.1111/bjh.17675. PMID:34296432. IF:8,615.
Payan S, Llobet AR, Sevilla A, Egido J, Castan J, Moreno JA. Sickle cell nephropathy. Clinical manifestations and new mechanisms involved in kidney injury. NEFROLOGIA. 2021; 41(4). DOI:10.1016/j.nefro.2020.10.012. PMID:33714630. IF:3,084.
Payan S, Perez LG, Sevilla A, Gil JS, Canales SN. Absolute Lymphocytes, Ferritin, C-Reactive Protein, and Lactate Dehydrogenase Predict Early Invasive Ventilation in Patients With COVID-19. LABORATORY MEDICINE. 2021; 52(2). DOI:10.1093/labmed/lmaa105. PMID:33336243. IF:1,865.
Pich O, Cortes A, Muinos F, Pratcorona M, Gonzalez A, Lopez N. The evolution of hematopoietic cells under cancer therapy. Nature Communications. 2021; 12(1):4803. DOI:10.1038/s41467-021-24858-3. PMID:34376657. IF:17,694.
Vega N, Perez S, Esperanza E, Vicente C, Torrebadell M, Jimenez A, Ortega M, Llop M, Abad L, Vagace JM, Minguela A, Pratcorona M, Sanchez J, Garcia CB, Gomez MT, Martin E, Escudero A, Martinez MR, Munoz L, Velasco MR, Garcia M, Catala A, Pascual A, Velasco P, Fernandez JM, Lassaletta A, Fuster JL, Badell I, Molinos A, Molines A, Guerra P, et al. Measurable Residual Disease Assessed by Flow-Cytometry Is a Stable Prognostic Factor for Pediatric T-Cell Acute Lymphoblastic Leukemia in Consecutive SEHOP Protocols Whereas the Impact of Oncogenetics Depends on Treatment. Frontiers in Pediatrics. 2021; 8:614521. DOI:10.3389/fped.2020.614521. PMID:33614543. IF:3,569.

ONCOHEMATOLOGIC DISEASES

Haematological Diagnosis

Main Lines of Research

Malignant Haemopathologies

Noncancerous Haemopathologies

Challenges

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Main Lines of Research

Malignant Haemopathologies

Noncancerous Haemopathologies

Challenges

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau