Sant Pau - Institut de Recerca

Main lines of research

Morbimortality, low-grade inflammation and cardiovascular risk in patients with acromegaly or Cushing syndrome.
ERCUSYN: European Registry on Cushing syndrome. Initiated with funding from SANCO, EU Public Health Programme.
Neuroradiological, neuropsychological and clinical study of endogenous hypercortisolism: comparison of Cushing syndrome and chronic major depressive disorder.
Validation of psychological properties of specific questionnaires to evaluate health-related quality of life (HRQoL) in Cushing syndrome and acromegaly.
Study of signal transduction of GH in muscle by gene expression in a C2C12 cell line stimulated with GH.
Aetiology of cardiopathy in acromegaly and its relation to body composition.
Role of telomeres in endocrine diseases.

Challenges

Investigate the neuropsychological, neuroradiological and clinical correlation of patients with endogenous hypercortisolism (due to Cushing syndrome or chronic major depressive disorder) or exogenous exposure to low-dose glucocorticoids (due to treatment of adrenal insufficiency or rheumatoid arthritis). Similar studies for acromegaly.
Study gene expression in cultured muscle cells after exposure to GH using microarrays.
Correlate neuropsychological status and circadian rhythm of cortisol in patients with hypercortisolism (Cushing syndrome) and without hypercortisolism (non-functioning pituitary adenomas) compared to normal controls.
Evaluate long-term morbidity and mortality in patients who have had Cushing syndrome or acromegaly in the last 25 years.
Analyse and update the European database of patients with Cushing syndrome (ERCUSYN), which at the end of 2013 included over 1100 patients from 57 centres in 36 countries.
Conduct in vitro molecular analysis of operated pituitary adenomas within the REMAH (Molecular Registry of Pituitary Adenomas) study, sponsored by the Spanish Endocrinology and Nutrition Society.
Investigate correlations of telomere length and different clinical and biochemical parameters in patients with Cushing syndrome.

2017 Scientific Report – Pituitary Gland Disorders

Group coordination

WEBB YOUDALE, SUSANA UAB
swebb@santpau.cat

Members

Asla Roca, Queralt FGS
Aulinas Maso, Anna FGS
Gil Ortega, Joan CIBERER
Mateu Salat, Manuel IR
Santos Vives, Alicia IR

Publications 2023

(JIF 2022)

-Amodru V, Ferriere A, Tabarin A, Castinetti F, Tsagarakis S, Toth M, Feelders RA, Webb SM, Reincke M, Netea R, Kastelan D, Elenkova A, Maiter D, Ragnarsson O, Santos A, Valass E, ERCUSYN GRP. Cushing’s syndrome in the elderly: data from the European Registry on Cushing’s syndrome. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2023; 188(4). DOI:10.1093/ejendo/lvad008. PMID:36749009. IF:5,800 (Q1/3D). Document type: Article.

-Asla Q, Sarda H, Segui N, de Pinillos GM, Mazarico I, Capel I, Rives J, Suarez J, avila V, Torres MM, Saigi I, Palacios N, Urgell E, Webb SM, Fernandez M, Oriola J, Mora M, Tondo M, Aulinas A. Clinical and outcome comparison of genetically positive vs. negative patients in a large cohort of suspected familial hypocalciuric hypercalcemia. ENDOCRINE. 2023; DOI:10.1007/s12020-023-03560-y. PMID:38214877. IF:3,700 (Q3/6D). Document type: Article.

-Aulinas A, Muhammed M, Becker KR, Asanza E, Hauser K, Stern C, Gydus J, Holmes T, Murray HB, Breithaupt L, Micali N, Misra M, Eddy KT, Thomas JJ, Lawson EA. Oxytocin response to food intake in avoidant/restrictive food intake disorder. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2023; 189(2). DOI:10.1093/ejendo/lvad087. PMID:37474111. IF:5,800 (Q1/3D). Document type: Article.

-Biagetti B, Iglesias P, Villar R, Moure MD, Paja M, Araujo M, Ares J, Alvarez C, Vicente A, Guivernau EA, Novoa I, Perez FG, Camara R, Lecumberri B, Gomez CG, Bernabeu I, Manjon L, Gaztambide S, Cordido F, Webb SM, Menendez EL, Diez JJ, Simo R, Puig M. Mortality in Acromegaly Diagnosed in Older Individuals in Spain Is Higher in Women Compared to the General Spanish Population. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2023; 108(9). DOI:10.1210/clinem/dgad141. PMID:36916151. IF:5,800 (Q1/3D). Document type: Article.

-Gil J, Marques M, Valassi E, Serra G, Salinas I, Xifra G, Casano P, Carrato C, Biagetti B, Sesmilo G, Marcos J, Rodriguez H, Rueda A, Aulinas A, Blanco A, Hostalot C, Simó A, Munoz F, Rico M, Ibanez J, Cordero E, Webb SM, Jordà M, Puig M. Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors. Frontiers in Endocrinology. 2023; 14:1129213. DOI:10.3389/fendo.2023.1129213. PMID:37033229. IF:5,200 (Q1/3D). Document type: Article.

-Marques M, Gil J, Jordà M, Puig M. Predictors of Response to Treatment with First-Generation Somatostatin Receptor Ligands in Patients with Acromegaly. ARCHIVES OF MEDICAL RESEARCH. 2023; 54(8):102924. DOI:10.1016/j.arcmed.2023.102924. PMID:38042683. IF:7,700 (Q1/2D). Document type: Article.

-Marques M, Gil J, Valassi E, Hernández M, Biagetti B, Giménez O, Martínez S, Carrato C, Pons L, Villar R, Araujo M, Blanco C, Simón I, Simó A, Xifra G, Vázquez F, Pavón I, García R, Zavala R, Hanzu FA, Mora M, Aulinas A, Vilarrasa N, Librizzi S, Calatayud M, de Miguel P, Alvarez C, Picó A, Sampedro M, Salinas I, Fajardo C, Cámara R, Bernabéu I, Jordà M, Webb SM, Marazuela M, Puig M. Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly. Frontiers in Endocrinology. 2023; 14:1269787. DOI:10.3389/fendo.2023.1269787. PMID:38027102. IF:5,200 (Q1/3D). Document type: Article.

-O’Toole D, Kunz PL, Webb SM, Goldstein G, Khawaja S, McDonnell M, Boiziau S, Gueguen D, Houchard A, Jr A, Prebtani A. PRESTO 2: An International Survey to Evaluate Patients’ Injection Experiences with the Latest Devices/Formulations of Long-Acting Somatostatin Analog Therapies for Neuroendocrine Tumors or Acromegaly. ADVANCES IN THERAPY. 2023; 40(2). DOI:10.1007/s12325-022-02360-6. PMID:36502449. IF:3,800 (Q2/4D). Document type: Article.

-Santos A, Nalin C, Bortolotti G, Dominguez E, Daniela G, Cortesi L, Pagani M, Momblan M, Gich I, Webb SM, Trevisan R, Resmini E. The effect of mindfulness therapy in acromegaly, a pilot study. CLINICAL ENDOCRINOLOGY. 2023; 98(3). DOI:10.1111/cen.14844. PMID:36342059. IF:3,200 (Q3/7D). Document type: Article.

-Valassi E, Manichanh C, Amodru V, Fernández PG, Gaztambide S, Yanez F, Martel L, Puig M, Webb SM. Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk. Frontiers in Endocrinology. 2023; 14:1074757. DOI:10.3389/fendo.2023.1074757. PMID:37342265. IF:5,200 (Q1/3D). Document type: Article.

-Webb SM, Valassi E. Quality of life in pituitary diseases. Endocrinologia Diabetes y Nutricion. 2023; 70(7). DOI:10.1016/j.endien.2023.03.021. PMID:37516611. IF:1,900 (Q4/9D). Document type: Editorial Material.

Publications 2022

(JIF 2022)

Aibar JA, Oladotun M, Asencio C, Valassi E, Webb S, Gras JR, Monserrat J, Ribo PT, Munoz F. Complication Rates after Endoscopic Transsphenoidal Surgery for ACTH-Secreting Pituitary Adenomas: A Comparative Analysis with GH and Nonfunctioning Adenomas. Journal of Neurological Surgery Part B-Skull Base. 2022; 83. DOI:10.1055/s-0041-1725029. PMID:35832977. IF:0,9 (Q4/9D). Document type: Article.
Arendt J, Aulinas A.2022 Oct 30. Physiology of the Pineal Gland and Melatonin.In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–.PMID: 31841296 Free Books & Documents. Document type: Review.
Asla Q, Sarda H, Lerma E, Hanzu FA, Rodrigo MT, Urgell E, Perez JI, Webb SM, Aulinas A. 11-Deoxycorticosterone Producing Adrenal Hyperplasia as a Very Unusual Cause of Endocrine Hypertension: Case Report and Systematic Review of the Literature. Frontiers in Endocrinology. 2022; 13:846865. DOI:10.3389/fendo.2022.846865. PMID:35432204. IF:5,2 (Q1/3D). Document type: Review.
Aulinas A, Stantonyonge N, Garcia A, Adelantado JM, Medina C, Espinos JJ, Lopez E, Webb SM, Corcoy R. Hypopituitarism and pregnancy: clinical characteristics, management and pregnancy outcome. 2022; 25(2). DOI:10.1007/s11102-021-01196-7. PMID:34846622. IF:3,8 (Q2/5D). Document type: Article.
Biagetti B, Iglesias P, Villar R, Moure MD, Paja M, Araujo M, Ares J, Alvarez C, Vicente A, Guivernau EA, Novoa I, Perez FG, Camara R, Lecumberri B, Gomez CG, Bernabeu I, Manjon L, Gaztambide S, Cordido F, Webb SM, Menendez EL, Diez JJ, Simo R, Puig M. Factors associated with therapeutic response in acromegaly diagnosed in the elderly in Spain. Frontiers in Endocrinology. 2022; 13:984877. DOI:10.3389/fendo.2022.984877. PMID:36187107. IF:5,2 (Q1/3D). Document type: Article.
Gil J, Marques M, Sampedro M, Webb SM, Serra G, Salinas I, Blanco A, Valassi E, Carrato C, Pico A, Garcia A, Martel L, Sardon T, Simo A, Biagetti B, Villabona C, Camara R, Fajardo C, Alvarez C, Lamas C, Alvarez CV, Bernabeu I, Marazuela M, Jorda M, Puig M. Data mining analyses for precision medicine in acromegaly: a proof of concept. Scientific Reports. 2022; 12(1):8979. DOI:10.1038/s41598-022-12955-2. PMID:35643771. IF:4,6 (Q2/3D). Document type: Article.
Gil J, Marques M, Valassi E, Garcia A, Serra G, Hostalot C, Fajardo C, Carrato C, Bernabeu I, Marazuela M, Rodriguez H, Camara R, Salinas I, Lamas C, Biagetti B, Simo A, Webb SM, Pico A, Jorda M, Puig M, REMAH I. Implications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response. Biomedicines. 2022; 10(2):460. DOI:10.3390/biomedicines10020460. PMID:35203668. IF:4,7 (Q1/3D). Document type: Article.
Luque J, Mendes I, Gomez B, Morte B, de Heredia ML, Herreras E, Corrochano V, Bueren J, Gallano P, Artuch R, Fillat C, Perez LA, Montoliu L, Carracedo A, Millan JM, Webb SM, Palau F, Lapunzina P. CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative. CLINICAL GENETICS. 2022; 101(5-6). DOI:10.1111/cge.14113. PMID:35060122. IF:3,5 (Q2/4D). Document type: Review.
Pardo JC, de Porras VR, Gil J, Font A, Puig M, Jorda M. Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer. 2022; 14(4):851. DOI:10.3390/nu14040851. PMID:35215499. IF:5,9 (Q1/2D). Document type: Article.
Pupier E, Santos A, Etchamendy N, Lavielle A, Ferriere A, Marighetto A, Resmini E, Cota D, Webb SM, Tabarin A. Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission. Frontiers in Endocrinology. 2022; 13:934347. DOI:10.3389/fendo.2022.934347. PMID:36004342. IF:5,2 (Q1/3D). Document type: Article.
Salvatori R, Maffei P, Webb SM, Brue T, Loftus J, Valluri SR, Gomez R, Wajnrajch MP, Fleseriu M. Patient-reported outcomes in patients with acromegaly treated with pegvisomant in the ACROSTUDY extension: A real-world experience. 2022; 25(3). DOI:10.1007/s11102-022-01206-2. PMID:35022929. IF:3,8 (Q2/5D). Document type: Article.
Santos A, Crespo I, Perez A, Beltran M, Puebla M, Garcia J. Attachment-Based Compassion Therapy for Reducing Anxiety and Depression in Fibromyalgia. International Journal of Environmental Research and Public Health. 2022; 19(13):8152. DOI:10.3390/ijerph19138152. PMID:35805810. Document type: Article.
Tritos NA, Fazeli PK, McCormack A, Mallea SM, Pineyro MM, Christ M, Frara S, Labadzhyan A, Ioachimescu AG, Shimon I, Takahashi Y, Gurnell M, Fleseriu M, Valassi E, Wierman ME. Pituitary Society Delphi Survey: An international perspective on endocrine management of patients undergoing transsphenoidal surgery for pituitary adenomas. 2022; 25(1). DOI:10.1007/s11102-021-01170-3. PMID:34283370. IF:3,8 (Q2/5D). Document type: Article.
Valassi E, Castinetti F, Ferriere A, Tsagarakis S, Feelders RA, Netea RT, Droste M, Strasburger CJ, Maiter D, Kastelan D, Chanson P, Webb SM, Demtröder F, Pirags V, Chabre O, Franz H, Santos A, Reincke M. Corticotroph tumor progression after bilateral adrenalectomy: data from ERCUSYN. ENDOCRINE-RELATED CANCER. 2022; 29(12). DOI:10.1530/ERC-22-0074. PMID:36197784. IF:3,9 (Q2/5D). Document type: Article.
van FM, Kaya M, Pelsma ICM, Cannegieter SC, Huisman MV, van BJM, Feelders RA, Stochholm K, Fliers E, Castinetti F, Brue T, Bertherat J, Scaroni C, Colao A, Giordano R, Druce MR, Beckers A, Spranger J, Driessens N, Maiter D, Feldt U, Feelders R, Webb SM, Dattani M, Husebye E, Zilaitiene B, Gaztambide S, Gatto F, Ferone D, Persani L, Chiodini I, Höybye C, Pereira AM, Biermasz NR, et al. Current clinical practice for thromboprophylaxis management in patients with Cushing’s syndrome across reference centers of the European Reference Network on Rare Endocrine Conditions (Endo-ERN). Orphanet Journal of Rare Diseases. 2022; 17(1):178. DOI:10.1186/s13023-022-02320-x. PMID:35505430. IF:3,7 (Q2/4D). Document type: Article.
Webb SM, Kristensen J, Nordenstrom A, Vitali D, Amodru V, Wiehe LK, Bolz M. Patient journey experiences may contribute to improve healthcare for patients with rare endocrine diseases. Endocrine Connections. 2022; 11(12):e220385. DOI:10.1530/EC-22-0385. PMID:36228311. IF:2,9 (Q3/8D). Document type: Review.
Webb SM, Valassi E. Consequences of Cushing’s Syndrome: Health Versus Personal Costs. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2022; 107(9). DOI:10.1210/clinem/dgac269. PMID:35511590. IF:5,8 (Q1/3D). Document type: Editorial material.
Webb SM, Valassi E. Quality of life impairment after a diagnosis of Cushing’s syndrome. 2022; 25(5)DOI:10.1007/s11102-022-01245-9. PMID:35767164. IF:3,8 (Q2/5D). Document type: Article.

Publications 2021

Aulinas A, Stantonyonge N, Garcia A, Adelantado JM, Medina C, Espinos JJ, Lopez E, Webb SM, Corcoy R. Hypopituitarism and pregnancy: clinical characteristics, management and pregnancy outcome. Pituitary. 2022; 25(2). DOI:10.1007/s11102-021-01196-7. PMID:34846622. IF:3,599.
Biagetti B, Aulinas A, Casteras A, Pérez-Hoyos S, Simó R. HOMA-IR in acromegaly: a systematic review and meta-analysis. Pituitary. 2021;24(2):146-158. DOI:10.1007/s11102-020-01092-6. PMID: 33085039. IF:3,599.
Calderon-Mediavilla M, Vila-Badia R, Dolz M, Butjosa A, Barajas A, Del Cacho N, Sánchez B, Pardo M, Baños I, Usall J, Ochoa S; GENIPE Group; PROFEP Group [Santos A, Nuñez C]. Depressive symptoms and their relationship with negative and other psychotic symptoms in early onset psychosis. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY. 2021;30(9):1383-1390. DOI:10.1007/s00787-020-01618-0. PMID: 32865655. IF:5,349.
de La Piscina IM, Najera NP, Rica I, Gaztambide S, Webb SM, Santos A, Moure MD, Fano MP, Hernandez MI, Chueca MJ, Hernandez LC, Soto A, Valdes N, Castano L, Hispanic A. Clinical and genetic characteristics in patients under 30 years with sporadic pituitary adenomas. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 185(4). DOI:10.1530/EJE-21-0075. PMID:34313605. IF:6,558.
Fleseriu M, Auchus R, Bancos I, Ben A, Bertherat J, Biermasz NR, Boguszewski CL, Bronstein MD, Buchfelder M, Carmichael JD, Casanueva FF, Castinetti F, Chanson P, Findling J, Gadelha M, Geer EB, Giustina A, Grossman A, Gurnell M, Ho K, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Kelly DF, Lacroix A, McCormack A, Melmed S, et al. [Valassi E, Webb SM]. Consensus on diagnosis and management of Cushing’s disease: a guideline update. Lancet Diabetes & Endocrinology. 2021; 9(12). DOI:10.1016/S2213-8587(21)00235-7. PMID:34687601. IF:44,867.
Gil J, Marques M, Jorda M, Fajardo C, Garcia A, Sampedro M, Serra G, Salinas I, Blanco A, Valassi E, Sesmilo G, Carrato C, Camara R, Lamas C, Casano P, Alvarez CV, Bernabeu I, Webb SM, Pico A, Marazuela M, Puig M, Santos A, Vida JI. Molecular determinants of enhanced response to somatostatin receptor ligands after debulking in large GH-producing adenomas. CLINICAL ENDOCRINOLOGY. 2021; 94(5). DOI:10.1111/cen.14339. PMID:32978826. IF:3,523.
Iglesias P, Nocete I, Rodriguez MDM, Venegas E, Ares J, Biagetti B, Berrocal VR, Guerrero F, Vicente A, Villar R, Cordido F, Paja M, Glerean M, Rivera NG, Fuentes ED, Blanco C, Alvarez C, Martin T, Webb SM, Bernabeu I, Villabona C, Soto A, Gaztambide S, Diez JJ. Craniopharyngioma in the Elderly: A Multicenter and Nationwide Study in Spain. NEUROENDOCRINOLOGY. 2021; 111(10). DOI:10.1159/000512161. PMID:33040060. IF:5,135.
Iglesias P, Peiro I, Biagetti B, Paja M, Cobo DA, Gomez CG, Mateu M, Genua I, Majem M, Riudavets M, Gavira J, Lamas C, Pombo AF, Guerrero F, Villabona C, Agricola JMC, Webb SM, Diez JJ. Immunotherapy-induced isolated ACTH deficiency in cancer therapy. ENDOCRINE-RELATED CANCER. 2021; 28(12). DOI:10.1530/ERC-21-0228. PMID:34609950. IF:5,900.
Lee RS, Zandi PP, Santos A, Aulinas A, Carey JL, Webb SM, McCaul ME, Resmini E, Wand GS. Cross-species Association Between Telomere Length and Glucocorticoid Exposure. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2021; 106(12). DOI:10.1210/clinem/dgab519. PMID:34265046. IF:6,134.
Losa M, Resmini E, Barzaghi LR, Albano L, Bailo M, Webb SM, Mortini P. Resistance to first-generation somatostatin receptor ligands does not impair the results of gamma knife radiosurgery in acromegaly. CLINICAL ENDOCRINOLOGY. 2021; 95(6). DOI:10.1111/cen.14547. PMID:34219264. IF:3,523.
Luger A, Broersen L, Biermasz NR, Biller BMK, Buchfelder M, Chanson P, Jorgensen J, Kelestimur F, Llahana S, Maiter D, Mintziori G, Petraglia F, Verkauskiene R, Webb SM, Dekkers OM. ESE Clinical Practice Guideline on functioning and nonfunctioning pituitary adenomas in pregnancy. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 185(3). DOI:10.1530/EJE-21-0462. PMID:34425558. IF:6,558.
Martel L, Alonso A, Bascunana H, Diaz J, Llauger J, Nunez C, Montesinos P, Webb SM, Valassi E. Prevalence of sarcopenia after remission of hypercortisolism and its impact on HRQoL. CLINICAL ENDOCRINOLOGY. 2021; 95(5). DOI:10.1111/cen.14568. PMID:34323296. IF:3,523.
Martel L, Alonso J, Bascunana H, Diaz J, Llauger J, Nunez C, Montesinos P, Webb SM, Valassi E. Intramuscular fatty infiltration and physical function in controlled acromegaly. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 185(1). DOI:10.1530/EJE-21-0209. PMID:33950861. IF:6,558.
Martel L, Jorgensen J, Korbonits M, Johannsson G, Webb SM, ESE AGHD Study Pan GRP. ESE audit on management of adult growth hormone deficiency in clinical practice. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 184(2). DOI:10.1530/EJE-20-1180. PMID:33320830. IF:6,558.
Mc M, Crespo I, Webb SM, Valassi E. Quality of life in Cushing’s syndrome. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM. 2021; 35(1):101505. DOI:10.1016/j.beem.2021.101505. IF:5,667.
Nan MN, Roig R, Martinez S, Rives J, Urgell E, Espinos JJ, Tirado M, Carreras G, Aulinas A, Webb SM, Corcoy R, Blanco F, Tondo M. Comprehensive Genetic Testing of CYP21A2: A Retrospective Analysis in Patients with Suspected Congenital Adrenal Hyperplasia. Journal of Clinical Medicine. 2021; 10(6):1183. DOI:10.3390/jcm10061183. PMID:33809035. IF:4,964.
Reincke M, Albani A, Assie G, Bancos I, Brue T, Buchfelder M, Chabre O, Ceccato F, Daniele A, Detomas M, Di G, Elenkova A, Findling J, Grossman AB, Gomez CE, Heaney AP, Honegger J, Karavitaki N, Lacroix A, Laws ER, Losa M, Murakami M, Newell J, Giraldi FP, Perez LG, Pivonello R, Rainey WE, Sbiera S, Schopohl J, Stratakis CA, Theodoropoulou M, et al. [Valassi E]. Corticotroph tumor progression after bilateral adrenalectomy (Nelson’s syndrome): systematic review and expert consensus recommendations. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 184(2). DOI:10.1530/EJE-20-1088. PMID:33444221. IF:6,558.
Santos A, Webb SM, Resmini E. Psychological complications of Cushing’s syndrome. Current Opinion in Endocrinology Diabetes and Obesity. 2021; 28(3). DOI:10.1097/MED.0000000000000633. PMID:33764929. IF:3,626.
Valassi E. Pituitary disease and pregnancy. Endocrinologia Diabetes y Nutricion. 2021; 68(3). DOI:10.1016/j.endinu.2020.07.007. PMID:33358152. IF:1,833.
Webb SM, Kristensen J, Vitali D, van S, van C, Santos A, Nordenstrom A. EndoERN patient survey on their perception of health care experience and of unmet needs for rare endocrine diseases. ENDOCRINE. 2021; 71(3). DOI:10.1007/s12020-021-02625-0. PMID:33544353. IF:3,925.

Introduction

Main lines of research

Morbimortality, low-grade inflammation and cardiovascular risk in patients with acromegaly or Cushing syndrome.
ERCUSYN: European Registry on Cushing syndrome. Initiated with funding from SANCO, EU Public Health Programme.
Neuroradiological, neuropsychological and clinical study of endogenous hypercortisolism: comparison of Cushing syndrome and chronic major depressive disorder.
Validation of psychological properties of specific questionnaires to evaluate health-related quality of life (HRQoL) in Cushing syndrome and acromegaly.
Study of signal transduction of GH in muscle by gene expression in a C2C12 cell line stimulated with GH.
Aetiology of cardiopathy in acromegaly and its relation to body composition.
Role of telomeres in endocrine diseases.

Challenges

Investigate the neuropsychological, neuroradiological and clinical correlation of patients with endogenous hypercortisolism (due to Cushing syndrome or chronic major depressive disorder) or exogenous exposure to low-dose glucocorticoids (due to treatment of adrenal insufficiency or rheumatoid arthritis). Similar studies for acromegaly.
Study gene expression in cultured muscle cells after exposure to GH using microarrays.
Correlate neuropsychological status and circadian rhythm of cortisol in patients with hypercortisolism (Cushing syndrome) and without hypercortisolism (non-functioning pituitary adenomas) compared to normal controls.
Evaluate long-term morbidity and mortality in patients who have had Cushing syndrome or acromegaly in the last 25 years.
Analyse and update the European database of patients with Cushing syndrome (ERCUSYN), which at the end of 2013 included over 1100 patients from 57 centres in 36 countries.
Conduct in vitro molecular analysis of operated pituitary adenomas within the REMAH (Molecular Registry of Pituitary Adenomas) study, sponsored by the Spanish Endocrinology and Nutrition Society.
Investigate correlations of telomere length and different clinical and biochemical parameters in patients with Cushing syndrome.

2017 Scientific Report – Pituitary Gland Disorders

Team

Group coordination

WEBB YOUDALE, SUSANA UAB
swebb@santpau.cat

Members

Asla Roca, Queralt FGS
Aulinas Maso, Anna FGS
Gil Ortega, Joan CIBERER
Mateu Salat, Manuel IR
Santos Vives, Alicia IR

Scientific output

Publications 2023

(JIF 2022)

Publications 2022

(JIF 2022)

Aibar JA, Oladotun M, Asencio C, Valassi E, Webb S, Gras JR, Monserrat J, Ribo PT, Munoz F. Complication Rates after Endoscopic Transsphenoidal Surgery for ACTH-Secreting Pituitary Adenomas: A Comparative Analysis with GH and Nonfunctioning Adenomas. Journal of Neurological Surgery Part B-Skull Base. 2022; 83. DOI:10.1055/s-0041-1725029. PMID:35832977. IF:0,9 (Q4/9D). Document type: Article.
Arendt J, Aulinas A.2022 Oct 30. Physiology of the Pineal Gland and Melatonin.In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–.PMID: 31841296 Free Books & Documents. Document type: Review.
Asla Q, Sarda H, Lerma E, Hanzu FA, Rodrigo MT, Urgell E, Perez JI, Webb SM, Aulinas A. 11-Deoxycorticosterone Producing Adrenal Hyperplasia as a Very Unusual Cause of Endocrine Hypertension: Case Report and Systematic Review of the Literature. Frontiers in Endocrinology. 2022; 13:846865. DOI:10.3389/fendo.2022.846865. PMID:35432204. IF:5,2 (Q1/3D). Document type: Review.
Aulinas A, Stantonyonge N, Garcia A, Adelantado JM, Medina C, Espinos JJ, Lopez E, Webb SM, Corcoy R. Hypopituitarism and pregnancy: clinical characteristics, management and pregnancy outcome. 2022; 25(2). DOI:10.1007/s11102-021-01196-7. PMID:34846622. IF:3,8 (Q2/5D). Document type: Article.
Biagetti B, Iglesias P, Villar R, Moure MD, Paja M, Araujo M, Ares J, Alvarez C, Vicente A, Guivernau EA, Novoa I, Perez FG, Camara R, Lecumberri B, Gomez CG, Bernabeu I, Manjon L, Gaztambide S, Cordido F, Webb SM, Menendez EL, Diez JJ, Simo R, Puig M. Factors associated with therapeutic response in acromegaly diagnosed in the elderly in Spain. Frontiers in Endocrinology. 2022; 13:984877. DOI:10.3389/fendo.2022.984877. PMID:36187107. IF:5,2 (Q1/3D). Document type: Article.
Gil J, Marques M, Sampedro M, Webb SM, Serra G, Salinas I, Blanco A, Valassi E, Carrato C, Pico A, Garcia A, Martel L, Sardon T, Simo A, Biagetti B, Villabona C, Camara R, Fajardo C, Alvarez C, Lamas C, Alvarez CV, Bernabeu I, Marazuela M, Jorda M, Puig M. Data mining analyses for precision medicine in acromegaly: a proof of concept. Scientific Reports. 2022; 12(1):8979. DOI:10.1038/s41598-022-12955-2. PMID:35643771. IF:4,6 (Q2/3D). Document type: Article.
Gil J, Marques M, Valassi E, Garcia A, Serra G, Hostalot C, Fajardo C, Carrato C, Bernabeu I, Marazuela M, Rodriguez H, Camara R, Salinas I, Lamas C, Biagetti B, Simo A, Webb SM, Pico A, Jorda M, Puig M, REMAH I. Implications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response. Biomedicines. 2022; 10(2):460. DOI:10.3390/biomedicines10020460. PMID:35203668. IF:4,7 (Q1/3D). Document type: Article.
Luque J, Mendes I, Gomez B, Morte B, de Heredia ML, Herreras E, Corrochano V, Bueren J, Gallano P, Artuch R, Fillat C, Perez LA, Montoliu L, Carracedo A, Millan JM, Webb SM, Palau F, Lapunzina P. CIBERER: Spanish national network for research on rare diseases: A highly productive collaborative initiative. CLINICAL GENETICS. 2022; 101(5-6). DOI:10.1111/cge.14113. PMID:35060122. IF:3,5 (Q2/4D). Document type: Review.
Pardo JC, de Porras VR, Gil J, Font A, Puig M, Jorda M. Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer. 2022; 14(4):851. DOI:10.3390/nu14040851. PMID:35215499. IF:5,9 (Q1/2D). Document type: Article.
Pupier E, Santos A, Etchamendy N, Lavielle A, Ferriere A, Marighetto A, Resmini E, Cota D, Webb SM, Tabarin A. Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission. Frontiers in Endocrinology. 2022; 13:934347. DOI:10.3389/fendo.2022.934347. PMID:36004342. IF:5,2 (Q1/3D). Document type: Article.
Salvatori R, Maffei P, Webb SM, Brue T, Loftus J, Valluri SR, Gomez R, Wajnrajch MP, Fleseriu M. Patient-reported outcomes in patients with acromegaly treated with pegvisomant in the ACROSTUDY extension: A real-world experience. 2022; 25(3). DOI:10.1007/s11102-022-01206-2. PMID:35022929. IF:3,8 (Q2/5D). Document type: Article.
Santos A, Crespo I, Perez A, Beltran M, Puebla M, Garcia J. Attachment-Based Compassion Therapy for Reducing Anxiety and Depression in Fibromyalgia. International Journal of Environmental Research and Public Health. 2022; 19(13):8152. DOI:10.3390/ijerph19138152. PMID:35805810. Document type: Article.
Tritos NA, Fazeli PK, McCormack A, Mallea SM, Pineyro MM, Christ M, Frara S, Labadzhyan A, Ioachimescu AG, Shimon I, Takahashi Y, Gurnell M, Fleseriu M, Valassi E, Wierman ME. Pituitary Society Delphi Survey: An international perspective on endocrine management of patients undergoing transsphenoidal surgery for pituitary adenomas. 2022; 25(1). DOI:10.1007/s11102-021-01170-3. PMID:34283370. IF:3,8 (Q2/5D). Document type: Article.
Valassi E, Castinetti F, Ferriere A, Tsagarakis S, Feelders RA, Netea RT, Droste M, Strasburger CJ, Maiter D, Kastelan D, Chanson P, Webb SM, Demtröder F, Pirags V, Chabre O, Franz H, Santos A, Reincke M. Corticotroph tumor progression after bilateral adrenalectomy: data from ERCUSYN. ENDOCRINE-RELATED CANCER. 2022; 29(12). DOI:10.1530/ERC-22-0074. PMID:36197784. IF:3,9 (Q2/5D). Document type: Article.
van FM, Kaya M, Pelsma ICM, Cannegieter SC, Huisman MV, van BJM, Feelders RA, Stochholm K, Fliers E, Castinetti F, Brue T, Bertherat J, Scaroni C, Colao A, Giordano R, Druce MR, Beckers A, Spranger J, Driessens N, Maiter D, Feldt U, Feelders R, Webb SM, Dattani M, Husebye E, Zilaitiene B, Gaztambide S, Gatto F, Ferone D, Persani L, Chiodini I, Höybye C, Pereira AM, Biermasz NR, et al. Current clinical practice for thromboprophylaxis management in patients with Cushing’s syndrome across reference centers of the European Reference Network on Rare Endocrine Conditions (Endo-ERN). Orphanet Journal of Rare Diseases. 2022; 17(1):178. DOI:10.1186/s13023-022-02320-x. PMID:35505430. IF:3,7 (Q2/4D). Document type: Article.
Webb SM, Kristensen J, Nordenstrom A, Vitali D, Amodru V, Wiehe LK, Bolz M. Patient journey experiences may contribute to improve healthcare for patients with rare endocrine diseases. Endocrine Connections. 2022; 11(12):e220385. DOI:10.1530/EC-22-0385. PMID:36228311. IF:2,9 (Q3/8D). Document type: Review.
Webb SM, Valassi E. Consequences of Cushing’s Syndrome: Health Versus Personal Costs. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2022; 107(9). DOI:10.1210/clinem/dgac269. PMID:35511590. IF:5,8 (Q1/3D). Document type: Editorial material.
Webb SM, Valassi E. Quality of life impairment after a diagnosis of Cushing’s syndrome. 2022; 25(5)DOI:10.1007/s11102-022-01245-9. PMID:35767164. IF:3,8 (Q2/5D). Document type: Article.

Publications 2021

Aulinas A, Stantonyonge N, Garcia A, Adelantado JM, Medina C, Espinos JJ, Lopez E, Webb SM, Corcoy R. Hypopituitarism and pregnancy: clinical characteristics, management and pregnancy outcome. Pituitary. 2022; 25(2). DOI:10.1007/s11102-021-01196-7. PMID:34846622. IF:3,599.
Biagetti B, Aulinas A, Casteras A, Pérez-Hoyos S, Simó R. HOMA-IR in acromegaly: a systematic review and meta-analysis. Pituitary. 2021;24(2):146-158. DOI:10.1007/s11102-020-01092-6. PMID: 33085039. IF:3,599.
Calderon-Mediavilla M, Vila-Badia R, Dolz M, Butjosa A, Barajas A, Del Cacho N, Sánchez B, Pardo M, Baños I, Usall J, Ochoa S; GENIPE Group; PROFEP Group [Santos A, Nuñez C]. Depressive symptoms and their relationship with negative and other psychotic symptoms in early onset psychosis. EUROPEAN CHILD & ADOLESCENT PSYCHIATRY. 2021;30(9):1383-1390. DOI:10.1007/s00787-020-01618-0. PMID: 32865655. IF:5,349.
de La Piscina IM, Najera NP, Rica I, Gaztambide S, Webb SM, Santos A, Moure MD, Fano MP, Hernandez MI, Chueca MJ, Hernandez LC, Soto A, Valdes N, Castano L, Hispanic A. Clinical and genetic characteristics in patients under 30 years with sporadic pituitary adenomas. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 185(4). DOI:10.1530/EJE-21-0075. PMID:34313605. IF:6,558.
Fleseriu M, Auchus R, Bancos I, Ben A, Bertherat J, Biermasz NR, Boguszewski CL, Bronstein MD, Buchfelder M, Carmichael JD, Casanueva FF, Castinetti F, Chanson P, Findling J, Gadelha M, Geer EB, Giustina A, Grossman A, Gurnell M, Ho K, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Kelly DF, Lacroix A, McCormack A, Melmed S, et al. [Valassi E, Webb SM]. Consensus on diagnosis and management of Cushing’s disease: a guideline update. Lancet Diabetes & Endocrinology. 2021; 9(12). DOI:10.1016/S2213-8587(21)00235-7. PMID:34687601. IF:44,867.
Gil J, Marques M, Jorda M, Fajardo C, Garcia A, Sampedro M, Serra G, Salinas I, Blanco A, Valassi E, Sesmilo G, Carrato C, Camara R, Lamas C, Casano P, Alvarez CV, Bernabeu I, Webb SM, Pico A, Marazuela M, Puig M, Santos A, Vida JI. Molecular determinants of enhanced response to somatostatin receptor ligands after debulking in large GH-producing adenomas. CLINICAL ENDOCRINOLOGY. 2021; 94(5). DOI:10.1111/cen.14339. PMID:32978826. IF:3,523.
Iglesias P, Nocete I, Rodriguez MDM, Venegas E, Ares J, Biagetti B, Berrocal VR, Guerrero F, Vicente A, Villar R, Cordido F, Paja M, Glerean M, Rivera NG, Fuentes ED, Blanco C, Alvarez C, Martin T, Webb SM, Bernabeu I, Villabona C, Soto A, Gaztambide S, Diez JJ. Craniopharyngioma in the Elderly: A Multicenter and Nationwide Study in Spain. NEUROENDOCRINOLOGY. 2021; 111(10). DOI:10.1159/000512161. PMID:33040060. IF:5,135.
Iglesias P, Peiro I, Biagetti B, Paja M, Cobo DA, Gomez CG, Mateu M, Genua I, Majem M, Riudavets M, Gavira J, Lamas C, Pombo AF, Guerrero F, Villabona C, Agricola JMC, Webb SM, Diez JJ. Immunotherapy-induced isolated ACTH deficiency in cancer therapy. ENDOCRINE-RELATED CANCER. 2021; 28(12). DOI:10.1530/ERC-21-0228. PMID:34609950. IF:5,900.
Lee RS, Zandi PP, Santos A, Aulinas A, Carey JL, Webb SM, McCaul ME, Resmini E, Wand GS. Cross-species Association Between Telomere Length and Glucocorticoid Exposure. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2021; 106(12). DOI:10.1210/clinem/dgab519. PMID:34265046. IF:6,134.
Losa M, Resmini E, Barzaghi LR, Albano L, Bailo M, Webb SM, Mortini P. Resistance to first-generation somatostatin receptor ligands does not impair the results of gamma knife radiosurgery in acromegaly. CLINICAL ENDOCRINOLOGY. 2021; 95(6). DOI:10.1111/cen.14547. PMID:34219264. IF:3,523.
Luger A, Broersen L, Biermasz NR, Biller BMK, Buchfelder M, Chanson P, Jorgensen J, Kelestimur F, Llahana S, Maiter D, Mintziori G, Petraglia F, Verkauskiene R, Webb SM, Dekkers OM. ESE Clinical Practice Guideline on functioning and nonfunctioning pituitary adenomas in pregnancy. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 185(3). DOI:10.1530/EJE-21-0462. PMID:34425558. IF:6,558.
Martel L, Alonso A, Bascunana H, Diaz J, Llauger J, Nunez C, Montesinos P, Webb SM, Valassi E. Prevalence of sarcopenia after remission of hypercortisolism and its impact on HRQoL. CLINICAL ENDOCRINOLOGY. 2021; 95(5). DOI:10.1111/cen.14568. PMID:34323296. IF:3,523.
Martel L, Alonso J, Bascunana H, Diaz J, Llauger J, Nunez C, Montesinos P, Webb SM, Valassi E. Intramuscular fatty infiltration and physical function in controlled acromegaly. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 185(1). DOI:10.1530/EJE-21-0209. PMID:33950861. IF:6,558.
Martel L, Jorgensen J, Korbonits M, Johannsson G, Webb SM, ESE AGHD Study Pan GRP. ESE audit on management of adult growth hormone deficiency in clinical practice. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 184(2). DOI:10.1530/EJE-20-1180. PMID:33320830. IF:6,558.
Mc M, Crespo I, Webb SM, Valassi E. Quality of life in Cushing’s syndrome. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM. 2021; 35(1):101505. DOI:10.1016/j.beem.2021.101505. IF:5,667.
Nan MN, Roig R, Martinez S, Rives J, Urgell E, Espinos JJ, Tirado M, Carreras G, Aulinas A, Webb SM, Corcoy R, Blanco F, Tondo M. Comprehensive Genetic Testing of CYP21A2: A Retrospective Analysis in Patients with Suspected Congenital Adrenal Hyperplasia. Journal of Clinical Medicine. 2021; 10(6):1183. DOI:10.3390/jcm10061183. PMID:33809035. IF:4,964.
Reincke M, Albani A, Assie G, Bancos I, Brue T, Buchfelder M, Chabre O, Ceccato F, Daniele A, Detomas M, Di G, Elenkova A, Findling J, Grossman AB, Gomez CE, Heaney AP, Honegger J, Karavitaki N, Lacroix A, Laws ER, Losa M, Murakami M, Newell J, Giraldi FP, Perez LG, Pivonello R, Rainey WE, Sbiera S, Schopohl J, Stratakis CA, Theodoropoulou M, et al. [Valassi E]. Corticotroph tumor progression after bilateral adrenalectomy (Nelson’s syndrome): systematic review and expert consensus recommendations. EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2021; 184(2). DOI:10.1530/EJE-20-1088. PMID:33444221. IF:6,558.
Santos A, Webb SM, Resmini E. Psychological complications of Cushing’s syndrome. Current Opinion in Endocrinology Diabetes and Obesity. 2021; 28(3). DOI:10.1097/MED.0000000000000633. PMID:33764929. IF:3,626.
Valassi E. Pituitary disease and pregnancy. Endocrinologia Diabetes y Nutricion. 2021; 68(3). DOI:10.1016/j.endinu.2020.07.007. PMID:33358152. IF:1,833.
Webb SM, Kristensen J, Vitali D, van S, van C, Santos A, Nordenstrom A. EndoERN patient survey on their perception of health care experience and of unmet needs for rare endocrine diseases. ENDOCRINE. 2021; 71(3). DOI:10.1007/s12020-021-02625-0. PMID:33544353. IF:3,925.

TRANSLATIONAL MEDICINE

Pituitary Gland Disorders

Main lines of research

Challenges

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Main lines of research

Challenges

Group coordination

Members

Publications 2023

Publications 2022

Publications 2021

Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau